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  1. Cigarette smoke destabilizes G-quadruplex structures and antagonizes G4-ligand effects in macrophages

    Article • Scientific Reports, December 2025, Springer Science + Business Media

    Prof. Ph.D Giuseppe Spaziano

  2. Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque

    Article • Environmental Science & Technology, December 2025, American Chemical Society (ACS)

    Prof. Ph.D Giuseppe Spaziano

  3. Cigarette Smoke Drives Polystyrene Nanoparticles-Associated Airway Epithelial Damage

    Article • September 2025, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  4. Late Breaking Abstract - Human lung bronchial cells exposed to cigarette smoke: role of Adiponectin in Epithelial-Mesenchymal Transition

    Article • September 2025, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  5. Protective Action of 3,5-Diiodo-L-Thyronine on Cigarette Smoke-Induced Mitochondrial Dysfunction in Human Alveolar Epithelial Cells

    Article • Biomedicines, April 2025, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  6. miRNA Signatures in Alveolar Macrophages Related to Cigarette Smoke: Assessment and Bioinformatics Analysis

    Article • International Journal of Molecular Sciences, February 2025, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  7. Cigarette Smoke modulates microRNA expression in primary human alveolar macrophages.

    Article • September 2024, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  8. Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness

    Article • September 2024, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  9. Human lung alveolar cells exposed to cigarette smoke: role of 3,5-diiodothyronine in mitochondrial dysfunction

    Article • September 2024, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  10. Macrophage-Derived Exosomes Promote Lung Fibroblast Activation in Response to Cigarette Smoke

    Article • September 2024, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  11. Correction to ‘Sphingosine‐1‐phosphate/TGF‐β axis drives epithelial mesenchymal transition in asthma‐like disease’

    Article • British Journal of Pharmacology, May 2024, Wiley

    Prof. Ph.D Giuseppe Spaziano

  12. Cigarette Smoke Exposure and microRNA in Human Alveolar Macrophages: A Pilot Study

    Article • May 2024, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  13. MicroRNA Monitoring in Human Alveolar Macrophages from Patients with Smoking-Related Lung Diseases: A Preliminary Study

    Article • Biomedicines, May 2024, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  14. MicroRNAs Monitoring in Human Alveolar Macrophages from Patients with Smoking-Related Lung Diseases: A Preliminary Study

    Article • April 2024, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  15. Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, March 2024, New England Journal of Medicine (NEJM/MMS)

    Prof. Ph.D Giuseppe Spaziano

  16. Cigarette smoke exposure promotes tumorigenesis via G-quadruplex destabilization in a vitro model of macrophages

    Article • September 2023, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  17. Distinct Lung miRNAs Are Associated with the Control of Cell Proliferation in NSCLC and COPD

    Article • September 2023, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  18. A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with Klippel–Trenaunay Syndrome

    Article • Reports — Medical Cases Images and Videos, July 2023, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  19. Association between Sex-Related ALOX5 Gene Polymorphisms and Lung Atopy Risk

    Article • Journal of Clinical Medicine, April 2023, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  20. Lung microRNAs Expression in Lung Cancer and COPD: A Preliminary Study

    Article • Biomedicines, February 2023, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  21. The Role of MMPs in the Era of CFTR Modulators: An Additional Target for Cystic Fibrosis Patients?

    Article • Biomolecules, February 2023, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  22. Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience

    Article • Journal of Clinical Medicine, December 2022, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  23. Similar programmed death ligand 1 (PD-L1) expression profile in patients with mild COPD and lung cancer

    Article • Scientific Reports, December 2022, Springer Science + Business Media

    Prof. Ph.D Giuseppe Spaziano

  24. Design and synthesis of functionalized 4-aryl-Catechol derivatives as new antiinflammtory agents with in vivo efficacy

    Article • European Journal of Medicinal Chemistry, December 2022, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  25. Overview of Antiviral Drug Therapy for COVID-19: Where Do We Stand?

    Article • Biomedicines, November 2022, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  26. Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness

    Article • Pharmaceuticals, September 2022, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  27. Circulating MicroRNAs Expression Profile in Lung Inflammation: A Preliminary Study

    Article • Journal of Clinical Medicine, September 2022, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  28. Gender differences in gene polymorphisms are linked to up-reguated leukotriene pathway in asthma

    Article • September 2022, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  29. Similar Programmed Death Ligand 1 expression profile in COPD and NSCLC structural and immune cells

    Article • September 2022, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  30. Similar Programmed Death Ligand 1 (PD-L1) expression profile in patients with mild COPD and lung cancer

    Article • March 2022, Research Square

    Prof. Ph.D Giuseppe Spaziano

  31. Sphingosine‐1‐phosphate/TGF‐β axis drives epithelial mesenchymal transition in asthma‐like disease

    Article • British Journal of Pharmacology, January 2022, Wiley

    Prof. Ph.D Giuseppe Spaziano

  32. Drug–Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications

    Article • International Journal of Environmental Research and Public Health, December 2021, MDPI AG

    Prof. Ph.D Giuseppe Spaziano

  33. Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury

    Article • PLOS One, May 2021, PLOS

    Prof. Ph.D Giuseppe Spaziano

  34. SNPs in asthma patients: gender difference in anti-leukotriene therapy

    Article • September 2020, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  35. SPHINGOSINE-1-PHOSPHATE AS A KEY INDUCER OF EPITHELIAL MESENCHYMAL TRANSITION IN ASTHMATIC AIRWAYS

    Article • September 2020, European Respiratory Society (ERS)

    Fiorentina Roviezzo, Prof. Ph.D Giuseppe Spaziano

  36. 5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse

    Article • Pharmacological Research, August 2020, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  37. Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension

    Article • Frontiers in Pharmacology, February 2020, Frontiers

    Prof. Ph.D Giuseppe Spaziano

  38. Functional contribution of sphingosine‐1‐phosphate to airway pathology in cigarette smoke‐exposed mice

    Article • British Journal of Pharmacology, November 2019, Wiley

    Prof. Ph.D Giuseppe Spaziano

  39. RF22c, a 5-lipoxygenase inhibitor, in monocrotaline-induced PAH

    Article • September 2019, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  40. Montelukast induces better control of symptoms and management of lung function, and decreased inflammation in women compared with men

    Article • September 2019, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  41. Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men

    Article • Frontiers in Pharmacology, September 2019, Frontiers

    Prof. Ph.D Giuseppe Spaziano

  42. Panitumumab Induced Forearm Panniculitis in Two Women With Metastatic Colon Cancer

    Article • Current Drug Safety, September 2019, Bentham Science Publishers

    Prof. Ph.D Giuseppe Spaziano

  43. Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization

    Article • Pharmacological Research, January 2019, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  44. N/OFQ-NOP System and Airways

    Article • January 2019, Springer Science + Business Media

    Prof. Ph.D Giuseppe Spaziano

  45. Nociceptin/Orphanin Fq in inflammation and remodeling of the small airways in experimental model of airway hyperresponsiveness

    Article • Physiological Reports, October 2018, Wiley

    Prof. Ph.D Giuseppe Spaziano

  46. Leukotriene-mediated sex dimorphism in pulmonary arterial hypertensionmonocrotaline-induced rat.

    Article • September 2018, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  47. Relationship Between Gender and the Effectiveness of Montelukast: An Italian/Danish Register-Based Retrospective Cohort Study

    Article • Frontiers in Pharmacology, August 2018, Frontiers

    Prof. Ph.D Giuseppe Spaziano

  48. StAR protein and steroidogenic enzyme expressions in the rat Harderian gland

    Article • Comptes Rendus Biologies, March 2018, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  49. Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema

    Article • Stem Cells International, January 2018, Hindawi Publishing Corporation

    Prof. Ph.D Giuseppe Spaziano, Giuseppe Spaziano

  50. Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice

    Article • Frontiers in Immunology, October 2017, Frontiers

    Prof. Ph.D Giuseppe Spaziano

  51. Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma

    Article • European Journal of Medicinal Chemistry, October 2017, Elsevier

    Prof. Ph.D Giuseppe Spaziano, Prof. Antoni Sureda

  52. theophylline affect human bronchial epithelial cells

    Article • Drug Design Development and Therapy, January 2017, Dove Medical Press

    Dr Luca Gallelli, Dr Mariarita Perri, dr Roberto Cannataro, Giuseppe Spaziano, Prof. Ph.D Giuseppe Spaziano

  53. Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate

    Article • Pharmacological Research, November 2016, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  54. Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness

    Article • Clinical & Experimental Allergy, October 2016, Wiley

    Prof. Ph.D Giuseppe Spaziano

  55. Intratracheal administration of bone marrow-derived mesenchymal stem cells ameliorates lung function

    Article • September 2016, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  56. Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model

    Article • PLOS One, July 2016, PLOS

    Prof. Ph.D Giuseppe Spaziano

  57. The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

    Article • Biochemical Pharmacology, July 2016, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  58. Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma

    Article • British Journal of Pharmacology, March 2016, Wiley

    Prof. Ph.D Giuseppe Spaziano

  59. Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation

    Article • Pharmacological Research, January 2016, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  60. New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness

    Article • Mediators of Inflammation, January 2016, Hindawi Publishing Corporation

    Prof. Ph.D Giuseppe Spaziano

  61. Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation

    Article • Pharmacological Research, October 2015, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  62. Nociceptin modulates the inflammatory immune microenvironment in a conventional murine model of asthma

    Article • September 2015, European Respiratory Society (ERS)

    Prof. Ph.D Giuseppe Spaziano

  63. Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

    Article • European Journal of Medicinal Chemistry, April 2015, Elsevier

    Prof. Ph.D Giuseppe Spaziano

  64. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Prof. Ph.D Giuseppe Spaziano

  65. Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide

    Article • BMC Pharmacology and Toxicology, November 2014, Springer Science + Business Media

    Professor Michele Navarra, Prof. Ph.D Giuseppe Spaziano

  66. Effects of sex hormones on bronchial reactivity during the menstrual cycle

    Article • BMC Pulmonary Medicine, July 2014, Springer Science + Business Media

    Prof. Ph.D Giuseppe Spaziano

  67. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

    Article • Drug Design Development and Therapy, May 2014, Taylor & Francis

    Professor Bruno Amato, Dr Luca Gallelli, Giuseppe Spaziano, Prof. Ph.D Giuseppe Spaziano

  68. S18 Activation of nociceptin orphanin FQ (N/OFQ) – N/OFQ peptide (NOP) receptor system plays a key immunomodulatory role in asthma

    Article • Thorax, November 2013, BMJ

    Prof. Ph.D Giuseppe Spaziano

  69. Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice

    Article • AJP Lung Cellular and Molecular Physiology, May 2013, American Physiological Society

    Prof. Ph.D Giuseppe Spaziano

  70. Skeletal Muscle Oxidative Metabolism in an Animal Model of Pulmonary Emphysema

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2013, American Thoracic Society

    Prof. Ph.D Giuseppe Spaziano

  71. Plasma glutamine decreases immediately after surgery and is related to incisiveness

    Article • Journal of Cellular Physiology, January 2012, Wiley

    Prof. Ph.D Giuseppe Spaziano, Associate Professor VIncenzo Pota

  72. ANTI-REFLECTIVE POLYMER COATINGS IN OPTICAL MICROLITHOGRAPHY

    Article • Journal of Macromolecular Science Part A, March 2002, Taylor & Francis

    Prof. Ph.D Giuseppe Spaziano

  73. Adjustment of bilayer optical properties and the effect on imaging and etching performance

    Article • July 2000, SPIE

    Prof. Ph.D Giuseppe Spaziano

  74. Second-generation 193-nm bilayer resist

    Article • June 1999, SPIE

    Prof. Ph.D Giuseppe Spaziano