All Stories

  1. Recent advances in amphotericin B delivery strategies for the treatment of leishmaniases

    Article • Expert Opinion on Drug Delivery, August 2019, Taylor & Francis

    MsC. Juliane JSL Lanza, Professor Frederic Frezard

  2. Efficacy of Meglumine Antimoniate in a Low Polymerization State Orally Administered in a Murine Model of Visceral Leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, June 2018, ASM Journals

    Professor Frederic Frezard, PhD JOSE DIAS CORREA JUNIOR

  3. Accelerated Blood Clearance (ABC) Phenomenon Favors the Accumulation of Tartar Emetic in Pegylated Liposomes in BALB/c Mice Liver

    Article • Pathology Research International, January 2018, Hindawi Publishing Corporation

    Professor Frederic Frezard, Tamara Cristina Lopes

  4. Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control

    Article • BioMed Research International, January 2018, Hindawi Publishing Corporation

    Professor Frederic Frezard, Cristiano Cheim Peixoto dos Santos

  5. Extracellular Vesicles from Adipose-Derived Mesenchymal Stem/Stromal Cells Accelerate Migration and Activate AKT Pathway in Human Keratinocytes and Fibroblasts Independently of miR-205 Activity

    Article • Stem Cells International, January 2017, Hindawi Publishing Corporation

    Professor Frederic Frezard

  6. Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells

    Article • Journal of Neuroscience Methods, November 2016, Elsevier

    Professor Frederic Frezard

  7. Injectable Liposomal Formulations: Systematic Analysis for Regulatory Purposes

    Article • Pharmaceutical Nanotechnology, June 2016, Bentham Science Publishers

    Professor Frederic Frezard

  8. Silver and Nitrate Oppositely Modulate Antimony Susceptibility through Aquaglyceroporin 1 in Leishmania (Viannia) Species

    Article • Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals

    Mr. Rubens MONTE NETO, Professor Frederic Frezard

  9. Oral nanocarrier for leishmaniasis treatment

    Article • International Journal of Nanomedicine, May 2016, Dove Medical Press

    PhD JOSE DIAS CORREA JUNIOR, Prof. Rogerio M Paniago, MsC. Juliane JSL Lanza, Professor Frederic Frezard, Jose Vilela

  10. α-Tocopherol succinate improves encapsulation and anticancer activity of doxorubicin loaded in solid lipid nanoparticles

    Article • Colloids and Surfaces B Biointerfaces, April 2016, Elsevier

    Professor Frederic Frezard

  11. Redox-Active Metal Complexes in Trypanosomatids

    Article • January 2016, Springer Science + Business Media

    Professor Frederic Frezard

  12. In vitro antileishmanial activity of Brazilian plant species

    Article • Planta Medica, November 2015, Thieme Publishing Group

    Professor Frederic Frezard

  13. Synthesis and characterization of bismuth(III) and antimony(V) porphyrins: high antileishmanial activity against antimony-resistant parasite

    Article • JBIC Journal of Biological Inorganic Chemistry, May 2015, Springer Science + Business Media

    Professor Frederic Frezard

  14. Nanoemulsions loaded with amphotericin B: A new approach for the treatment of leishmaniasis

    Article • European Journal of Pharmaceutical Sciences, April 2015, Elsevier

    Professor Frederic Frezard

  15. 0109 : Increase liposomes cardioprotective activity of pyridostigmine

    Article • Archives of Cardiovascular Diseases Supplements, April 2015, Elsevier

    Professor Frederic Frezard

  16. Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis

    Article • PLoS Neglected Tropical Diseases, February 2015, PLOS

    Professor Frederic Frezard

  17. Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system

    Article • Neuroscience, January 2015, Elsevier

    Professor Frederic Frezard

  18. Atoxic nanopartilce for leishmaniasis treatment

    Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

    PhD JOSE DIAS CORREA JUNIOR, Professor Frederic Frezard

  19. Nanocarriers for Improved Delivery of Angiotensin-(1-7)

    Article • January 2015, Elsevier

    Professor Frederic Frezard

  20. Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents

    Article • Bioinorganic Chemistry and Applications, January 2015, Hindawi Publishing Corporation

    Professor Frederic Frezard

  21. Association of Liposome-Encapsulated Trivalent Antimonial with Ascorbic Acid: An Effective and Safe Strategy in the Treatment of Experimental Visceral Leishmaniasis

    Article • PLoS ONE, August 2014, PLOS

    Professor Frederic Frezard

  22. Mixed formulation of conventional and pegylated liposomes as a novel drug delivery strategy for improved treatment of visceral leishmaniasis

    Article • Expert Opinion on Drug Delivery, June 2014, Informa Healthcare

    Professor Frederic Frezard

  23. Novel Triphenylantimony(V) and Triphenylbismuth(V) Complexes with Benzoic Acid Derivatives: Structural Characterization, in Vitro Antileishmanial and Antibacterial Activities and Cytotoxicity against Macrophages

    Article • Molecules, May 2014, MDPI AG

    Professor Frederic Frezard

  24. Mixed Antimony(V) Complexes with Different Sugars to Modulate the Oral Bioavailability of Pentavalent Antimonial Drugs

    Article • Molecules, April 2014, MDPI AG

    Professor Frederic Frezard

  25. Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against SbIII-sensitive and -resistant parasites

    Article • Journal of Inorganic Biochemistry, March 2014, Elsevier

    Professor Frederic Frezard

  26. Antimony transport mechanisms in resistant leishmania parasites

    Article • Biophysical Reviews, January 2014, Springer Science + Business Media

    Professor Frederic Frezard

  27. Association of water extract of green propolis and liposomal meglumine antimoniate in the treatment of experimental visceral leishmaniasis

    Article • Zeitschrift für Parasitenkunde Parasitology Research, November 2013, Springer Science + Business Media

    Professor Frederic Frezard

  28. Hepatotoxicity of Pentavalent Antimonial Drug: Possible Role of Residual Sb(III) and Protective Effect of Ascorbic Acid

    Article • Antimicrobial Agents and Chemotherapy, November 2013, ASM Journals

    Professor Frederic Frezard, PhD JOSE DIAS CORREA JUNIOR

  29. Relationship between clinical and pathological signs and severity of canine leishmaniasis

    Article • Revista Brasileira de Parasitologia Veterinária, September 2013, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  30. Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate

    Article • Pesquisa Veterinária Brasileira, August 2013, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  31. Activation of Leishmania spp. leishporin: evidence that dissociation of an inhibitor not only improves its lipid-binding efficiency but also endows it with the ability to form pores

    Article • Zeitschrift für Parasitenkunde Parasitology Research, June 2013, Springer Science + Business Media

    Professor Frederic Frezard

  32. Amphiphilic Antimony(V) Complexes for Oral Treatment of Visceral Leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, June 2013, ASM Journals

    Professor Frederic Frezard, PhD JOSE DIAS CORREA JUNIOR

  33. Development and characterization of multilamellar liposomes containing pyridostigmine

    Article • Pharmaceutical Development and Technology, May 2013, Taylor & Francis

    Professor Frederic Frezard

  34. Chemistry of antimony-based drugs in biological systems and studies of their mechanism of action

    Article • Reviews in Inorganic Chemistry, May 2013, De Gruyter

    Professor Frederic Frezard

  35. Unexpectedly high levels of antimony (III) in the pentavalent antimonial drug Glucantime: insights from a new voltammetric approach

    Article • Analytical and Bioanalytical Chemistry, April 2013, Springer Science + Business Media

    Professor Frederic Frezard

  36. Improved pharmacological profile of the lipophilic antitumor dichloro-(N-dodecyl)-propanediamine-platinum(II) complex after incorporation into pegylated liposomes

    Article • Anti-Cancer Drugs, February 2013, Wolters Kluwer Health

    Professor Frederic Frezard

  37. Improved Antileishmanial Activity of Dppz through Complexation with Antimony(III) and Bismuth(III): Investigation of the Role of the Metal

    Article • Molecules, October 2012, MDPI AG

    Professor Frederic Frezard

  38. Heparan Sulfate Proteoglycan-Mediated Entry Pathway for Charged Tri-Platinum Compounds: Differential Cellular Accumulation Mechanisms for Platinum

    Article • Molecular Pharmaceutics, June 2012, American Chemical Society (ACS)

    Professor Frederic Frezard

  39. Efficacy of Combined Therapy with Liposome-Encapsulated Meglumine Antimoniate and Allopurinol in Treatment of Canine Visceral Leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, March 2012, ASM Journals

    Professor Frederic Frezard

  40. Greater binding affinity of trivalent antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins

    Article • Metallomics, January 2012, Oxford University Press (OUP)

    Professor Frederic Frezard

  41. Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity

    Article • Molecules, December 2011, MDPI AG

    Professor Frederic Frezard

  42. Interaction of arsenite with a zinc finger CCHC peptide: Evidence for formation of an As–Zn-peptide mixed complex

    Article • Journal of Inorganic Biochemistry, December 2011, Elsevier

    Professor Frederic Frezard

  43. Occurrence of anti-Neospora caninum and anti-Toxoplasma gondii antibodies in dogs with visceral leishmaniasis

    Article • Pesquisa Veterinária Brasileira, June 2011, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  44. Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis

    Article • PLoS Neglected Tropical Diseases, May 2011, PLOS

    Professor Frederic Frezard

  45. Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase

    Article • Toxicon, March 2011, Elsevier

    Professor Frederic Frezard

  46. Liposome-Encapsulated Neuropeptides for Site-Specific Microinjection

    Article • January 2011, Springer Science + Business Media

    Professor Frederic Frezard

  47. Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats

    Article • Toxicology Letters, December 2010, Elsevier

    Professor Frederic Frezard

  48. New delivery strategies for the old pentavalent antimonial drugs

    Article • Expert Opinion on Drug Delivery, October 2010, Informa Healthcare

    Professor Frederic Frezard

  49. New insights into the mode of action of ultradeformable vesicles using calcein as hydrophilic fluorescent marker

    Article • European Journal of Pharmaceutical Sciences, January 2010, Elsevier

    Professor Frederic Frezard

  50. Prolonged cardioprotective effect of pyridostigmine encapsulated in liposomes

    Article • Life Sciences, January 2010, Elsevier

    Professor Frederic Frezard

  51. Novel platinum(II) complexes of long chain aliphatic diamine ligands with oxalato as the leaving group: comparative cytotoxic activity relative to chloride precursors

    Article • Journal of the Brazilian Chemical Society, January 2010, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  52. Influence of the nucleobase on the physicochemical characteristics and biological activities of SbV-ribonucleoside complexes

    Article • Journal of the Brazilian Chemical Society, January 2010, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  53. Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length

    Article • Journal of the Brazilian Chemical Society, January 2010, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  54. Membrane binding requirements for the cytolytic activity ofLeishmania amazonensisleishporin

    Article • FEBS Letters, September 2009, Wiley

    Professor Frederic Frezard

  55. Pentavalent Antimonials: New Perspectives for Old Drugs

    Article • Molecules, June 2009, MDPI AG

    Professor Frederic Frezard

  56. Chapter 3 Physicochemical and Pharmacokinetic Characterization of Ultradeformable Vesicles using Calcein as Hydrophilic Fluorescent Marker

    Article • January 2009, Elsevier

    Professor Frederic Frezard

  57. Reduced Tissue Parasitic Load and Infectivity to Sand Flies in Dogs Naturally Infected by Leishmania (Leishmania) chagasi following Treatment with a Liposome Formulation of Meglumine Antimoniate

    Article • Antimicrobial Agents and Chemotherapy, May 2008, ASM Journals

    Professor Frederic Frezard

  58. New insights into the chemical structure and composition of the pentavalent antimonial drugs, meglumine antimonate and sodium stibogluconate

    Article • Journal of Inorganic Biochemistry, April 2008, Elsevier

    Professor Frederic Frezard

  59. Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Professor Frederic Frezard

  60. Enhanced oral delivery of antimony from meglumine antimoniate/β-cyclodextrin nanoassemblies

    Article • International Journal of Pharmaceutics, January 2008, Elsevier

    Professor Frederic Frezard

  61. Effect of cholesterol on the interaction of the amphibian antimicrobial peptide DD K with liposomes

    Article • Peptides, January 2008, Elsevier

    Professor Frederic Frezard

  62. A novel approach based on nanotechnology for investigating the chronic actions of short-lived peptides in specific sites of the brain

    Article • Regulatory Peptides, February 2007, Elsevier

    Professor Frederic Frezard

  63. Kinetics of antimony(V) reduction by L-cysteine: pharmacological implications and application to the determination of antimony in pentavalent antimonial drugs

    Article • Journal of the Brazilian Chemical Society, December 2006, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  64. Mode of action of β-cyclodextrin as an absorption enhancer of the water-soluble drug meglumine antimoniate

    Article • International Journal of Pharmaceutics, November 2006, Elsevier

    Professor Frederic Frezard

  65. Characterization of reactions of antimoniate and meglumine antimoniate with a guanine ribonucleoside at different pH

    Article • BioMetals, October 2006, Springer Science + Business Media

    Professor Frederic Frezard

  66. Improved targeting of antimony to the bone marrow of dogs using liposomes of reduced size

    Article • International Journal of Pharmaceutics, June 2006, Elsevier

    Professor Frederic Frezard

  67. Role of residual Sb(III) in meglumine antimoniate cytotoxicity and MRP1-mediated resistance

    Article • Chemico-Biological Interactions, April 2006, Elsevier

    Professor Frederic Frezard

  68. Synthesis and characterization of Sb(V)–adenosine and Sb(V)–guanosine complexes in aqueous solution

    Article • Inorganica Chimica Acta, January 2006, Elsevier

    Professor Frederic Frezard

  69. Chapter 2 Liposomes as a Tool for the Study of the Chronic Actions of Short-lived Peptides in Specific Sites of the Brain

    Article • January 2006, Elsevier

    Professor Frederic Frezard

  70. Angiotensin-(1-7): Blood, Heart, and Blood Vessels

    Article • Current Medicinal Chemistry - Cardiovascular & Hematological Agents, October 2005, Bentham Science Publishers

    Professor Frederic Frezard

  71. Lipossomas: propriedades físico-químicas e farmacológicas, aplicações na quimioterapia à base de antimônio

    Article • Química Nova, June 2005, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  72. Pentavalent Antimonials: From Chemistry to the Design of New Drugs

    Article • Drug Design Reviews - Online, May 2005, Bentham Science Publishers

    Professor Frederic Frezard

  73. Site-specific microinjection of liposomes into the brain for local infusion of a short-lived peptide

    Article • Journal of Controlled Release, March 2004, Elsevier

    Professor Frederic Frezard

  74. Oral Delivery of Meglumine Antimoniate-β-Cyclodextrin Complex for Treatment of Leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, January 2004, ASM Journals

    Professor Frederic Frezard

  75. Enhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes

    Article • International Journal of Pharmaceutics, April 2003, Elsevier

    Professor Frederic Frezard

  76. Pentavalent organoantimonial derivatives: two simple and efficient synthetic methods for meglumine antimonate

    Article • Applied Organometallic Chemistry, March 2003, Wiley

    Professor Frederic Frezard

  77. Antimony(V) complex formation with adenine nucleosides in aqueous solution

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2002, Elsevier

    Professor Frederic Frezard

  78. Long-Lasting Cardiovascular Effects of Liposome-Entrapped Angiotensin-(1-7) at the Rostral Ventrolateral Medulla

    Article • Hypertension, December 2001, Wolters Kluwer Health

    Professor Frederic Frezard

  79. Diffusion limited field induced aggregation of magnetic liposomes

    Article • Brazilian Journal of Physics, September 2001, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  80. P-Glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine

    Article • European Journal of Biochemistry, March 2001, Wiley

    Professor Frederic Frezard

  81. Glutathione-Induced Conversion of Pentavalent Antimony to Trivalent Antimony in Meglumine Antimoniate

    Article • Antimicrobial Agents and Chemotherapy, March 2001, ASM Journals

    Professor Frederic Frezard

  82. P-Glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine

    Article • European Journal of Biochemistry, March 2001, Wiley

    Professor Frederic Frezard

  83. Vertical toxoplasmosis in a murine model. Protection after immunization with antigens of Toxoplasma gondii incorporated into liposomes

    Article • Memórias do Instituto Oswaldo Cruz, January 2001, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  84. SYNTHESIS OF TRIORGANOANTIMONY DERIVATIVES OF QUERCETIN

    Article • Main Group Metal Chemistry, January 2001, De Gruyter

    Professor Frederic Frezard

  85. Novel methods for the encapsulation of meglumine antimoniate into liposomes

    Article • July 2000, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  86. Protection against Toxoplasmosis in Mice Immunized with Different Antigens of Toxoplasma gondii Incorporated into Liposomes

    Article • Memórias do Instituto Oswaldo Cruz, July 1999, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  87. Energy-dependent efflux from Leishmania promastigotes of substrates of the mammalian multidrug resistance pumps

    Article • Molecular and Biochemical Parasitology, April 1999, Elsevier

    Professor Frederic Frezard

  88. Liposomes: from biophysics to the design of peptide vaccines

    Article • Brazilian Journal of Medical and Biological Research, February 1999, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  89. Permeability of lipid bilayer to anthracycline derivatives. Role of the bilayer composition and of the temperature

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, January 1998, Elsevier

    Professor Frederic Frezard

  90. The Use of Liposomes as Snake Venom Vehicles. Application in Protective Immunization

    Article • Journal of Toxicology Toxin Reviews, January 1998, Taylor & Francis

    Professor Frederic Frezard

  91. Evaluation of the schistosomicidal efficacy of liposome - Entrapped Oxamniquine

    Article • March 1997, FapUNIFESP (SciELO)

    Professor Frederic Frezard

  92. Encapsulation of native crotoxin in liposomes: A safe approach for the production of antivenom and vaccination against Crotalus durissus terrificus venom

    Article • Toxicon, January 1997, Elsevier

    Professor Frederic Frezard

  93. Analysis of Multidrug Transporter in Living Cells

    Article • December 1994, American Chemical Society (ACS)

    Professor Frederic Frezard

  94. Novel liposome systems based on the incorporation of (perfluoroalkyl) alkenes (FmHnE) into the bilayer of phospholipid liposomes

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, September 1994, Elsevier

    Professor Frederic Frezard

  95. Permeability and stability in buffer and in human serum of fluorinated phospholipid-based liposomes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, June 1994, Elsevier

    Professor Frederic Frezard

  96. Fluorometric determination in biological fluids of the release kinetics of liposome-entrapped doxorubicin

    Article • Journal of Liposome Research, January 1994, Taylor & Francis

    Professor Frederic Frezard

  97. Incorporation of a perfluoroalkylalkane (RFRH) into the phospholipid bilayer of dmpc liposomes results in greater encapsulation stability

    Article • Journal of Liposome Research, January 1994, Taylor & Francis

    Professor Frederic Frezard

  98. Extended in vivo blood circulation time of fluorinated liposomes

    Article • FEBS Letters, December 1993, Wiley

    Professor Frederic Frezard

  99. Resistance to Anthracyclines in Multidrug Resistant Cells. Role of the Membrane Transport

    Article • January 1992, Springer Science + Business Media

    Professor Frederic Frezard

  100. DNA-containing liposomes as a model for the study of cell membrane permeation by anthracycline derivatives

    Article • Biochemistry, May 1991, American Chemical Society (ACS)

    Professor Frederic Frezard

  101. Comparison of the membrane transport of anthracycline derivatives in drug-resistant and drug-sensitive K562 cells

    Article • European Journal of Biochemistry, March 1991, Wiley

    Professor Frederic Frezard

  102. Determination of the osmotic active drug concentration in the cytoplasm of anthracycline-resistant and -sensitive K562 cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 1991, Elsevier

    Professor Frederic Frezard

  103. Comparison of the binding of anthracycline derivatives to purified DNA and to cell nuclei

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 1990, Elsevier

    Professor Frederic Frezard

  104. Anthracycline incorporation in human lymphocytes. Kinetics of uptake and nuclear concentration

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 1989, Elsevier

    Professor Frederic Frezard

  105. Membrane-phorbol ester interactions monitored by circular dichroism

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 1989, Elsevier

    Professor Frederic Frezard