All Stories

  1. The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 + T cells

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Prof. dr. Fred van Leeuwen

  2. A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in S. cerevisiae

    Article • Journal of Cell Science, April 2020, The Company of Biologists

    Prof. dr. Fred van Leeuwen

  3. Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

    Article • Epigenetics, March 2020, Taylor & Francis

    Prof. dr. Fred van Leeuwen

  4. Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

    Article • Genome Research, March 2020, Cold Spring Harbor Laboratory Press

    Prof. dr. Fred van Leeuwen

  5. Chromatin modified in a molecular reaction chamber

    Article • Nature, March 2020, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  6. Strategy for Development of Site-Specific Ubiquitin Antibodies

    Article • Frontiers in Chemistry, February 2020, Frontiers

    Prof. dr. Fred van Leeuwen

  7. CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

    Article • Nature Communications, December 2019, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  8. A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma

    Article • Melanoma Research, December 2019, Wolters Kluwer Health

    Prof. dr. Fred van Leeuwen

  9. Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma

    Article • The EMBO Journal, June 2019, EMBO

    Prof. dr. Fred van Leeuwen

  10. Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq

    Article • January 2019, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  11. Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

    Article • Nucleic Acids Research, September 2018, Oxford University Press (OUP)

    Prof. dr. Fred van Leeuwen

  12. Decoding the chromatin proteome of a single genomic locus by DNA sequencing

    Article • PLoS Biology, July 2018, PLOS

    Prof. dr. Fred van Leeuwen

  13. Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine

    Article • Toxicology in Vitro, March 2018, Elsevier

    Prof. dr. Fred van Leeuwen

  14. Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

    Article • eLife, December 2016, eLife

    Prof. dr. Fred van Leeuwen

  15. Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties

    Article • Scientific Reports, May 2015, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  16. Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling

    Article • Molecular Cell, January 2015, Elsevier

    Prof. dr. Fred van Leeuwen

  17. N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

    Article • Journal of Cell Science, November 2014, The Company of Biologists

    Prof. dr. Fred van Leeuwen

  18. Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

    Article • EMBO Reports, August 2014, EMBO

    Prof. dr. Fred van Leeuwen

  19. The emerging roles of DOT1L in leukemia and normal development

    Article • Leukemia, May 2014, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  20. A UV-Induced Genetic Network Links the RSC Complex to Nucleotide Excision Repair and Shows Dose-Dependent Rewiring

    Article • Cell Reports, December 2013, Elsevier

    Prof. dr. Fred van Leeuwen

  21. Histone exchange: sculpting the epigenome

    Article • Frontiers in Life Science, June 2013, Taylor & Francis

    Prof. dr. Fred van Leeuwen

  22. Spatiotemporal analysis of organelle and macromolecular complex inheritance

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Prof. dr. Fred van Leeuwen

  23. An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

    Article • The EMBO Journal, July 2012, Wiley

    Prof. dr. Fred van Leeuwen

  24. A Key Role for Chd1 in Histone H3 Dynamics at the 3′ Ends of Long Genes in Yeast

    Article • PLoS Genetics, July 2012, PLOS

    Prof. dr. Fred van Leeuwen

  25. Crosstalk between aging and the epigenome

    Article • Epigenomics, February 2012, Future Medicine

    Prof. dr. Fred van Leeuwen

  26. News about old histones: A role for histone age in controlling the epigenome

    Article • Cell Cycle, January 2012, Taylor & Francis

    Prof. dr. Fred van Leeuwen

  27. A Barcode Screen for Epigenetic Regulators Reveals a Role for the NuB4/HAT-B Histone Acetyltransferase Complex in Histone Turnover

    Article • PLoS Genetics, October 2011, PLOS

    Prof. dr. Fred van Leeuwen

  28. Progressive methylation of ageing histones by Dot1 functions as a timer

    Article • EMBO Reports, July 2011, EMBO

    Prof. dr. Fred van Leeuwen

  29. Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast

    Article • PLoS Biology, June 2011, PLOS

    Prof. dr. Fred van Leeuwen

  30. Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms

    Article • Epigenetics & Chromatin, January 2011, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  31. A Modified Epigenetics Toolbox to Study Histone Modifications on the Nucleosome Core

    Article • ChemBioChem, December 2010, Wiley

    Prof. dr. Fred van Leeuwen

  32. Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei

    Article • Journal of Cell Science, November 2010, The Company of Biologists

    Prof. dr. Fred van Leeuwen

  33. Recombination-induced tag exchange to track old and new proteins

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Prof. dr. Fred van Leeuwen

  34. Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome

    Article • Nucleic Acids Research, September 2009, Oxford University Press (OUP)

    Prof. dr. Fred van Leeuwen

  35. Mutational Analysis of the Sir3 BAH Domain Reveals Multiple Points of Interaction with Nucleosomes

    Article • Molecular and Cellular Biology, March 2009, ASM Journals

    Prof. dr. Fred van Leeuwen

  36. Reconstitution of Yeast Silent Chromatin: Multiple Contact Sites and O-AADPR Binding Load SIR Complexes onto Nucleosomes In Vitro

    Article • Molecular Cell, February 2009, Elsevier

    Prof. dr. Fred van Leeuwen

  37. Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae

    Article • BMC Molecular Biology, January 2009, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  38. Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core

    Article • Molecular and Cellular Biology, April 2008, ASM Journals

    Prof. dr. Fred van Leeuwen

  39. CD8– dendritic cells preferentially cross-presentSaccharomyces cerevisiae antigens

    Article • European Journal of Immunology, February 2008, Wiley

    Prof. dr. Fred van Leeuwen

  40. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila

    Article • The EMBO Journal, November 2007, Wiley

    Prof. dr. Fred van Leeuwen

  41. Article • Genome Biology, January 2005, Springer Science + Business Media

    Prof. dr. Fred van Leeuwen

  42. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

    Article • Genes & Development, June 2004, Cold Spring Harbor Laboratory Press

    Prof. dr. Fred van Leeuwen

  43. The modified base J is the target for a novelDNA-binding protein in kinetoplastid protozoans

    Article • The EMBO Journal, November 1999, Wiley

    Prof. dr. Fred van Leeuwen

  44. The Modified DNA Base β-d-Glucosylhydroxymethyluracil Confers Resistance to Micrococcal Nuclease and Is Incompletely Recovered by32P-Postlabeling

    Article • Analytical Biochemistry, May 1998, Elsevier

    Prof. dr. Fred van Leeuwen