All Stories

  1. Uncovering a previously unknown function of polyphosphate in polyadenylated RNA ‐induced amyloidogenesis of Hfq

    Article • European Journal of Biochemistry, February 2026, Wiley

    Dr. Frank Wien

  2. Far UV synchrotron radiation circular dichroism of guanine nucleosides

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2025, Taylor & Francis

    Dr. Frank Wien

  3. DNA methylation enhances cooperative disentanglement by the Hfq nucleoid-associated protein

    Article • European Biophysics Journal, October 2025, Springer Science + Business Media

    Dr. Frank Wien

  4. BeStSel: analysis site for protein CD spectra—2025 update

    Article • Nucleic Acids Research, May 2025, Oxford University Press (OUP)

    Dr. Frank Wien

  5. Monomers, Dimers, and Oligomers of Pyroglutamate-Modified α-Synuclein Fragments Exhibit Distinct Biophysical Characteristics

    Article • ACS Chemical Neuroscience, April 2025, American Chemical Society (ACS)

    Dr. Frank Wien

  6. DNA Transactions in Bacteria and Membranes: A Place for the Hfq Protein?

    Article • Membranes, April 2025, MDPI AG

    Dr. Frank Wien

  7. Amyloid-like DNA bridging: a new mode of DNA shaping

    Article • Nucleic Acids Research, February 2025, Oxford University Press (OUP)

    Professor Heloisa Bordallo, Dr. Frank Wien

  8. Structural Study of DNA in Simulated Crowded Fluids

    Article • ChemBioChem, February 2025, Wiley

    Dr. Frank Wien

  9. Guide to the structural characterization of protein aggregates and amyloid fibrils by CD spectroscopy

    Article • Protein Science, February 2025, Wiley

    Dr. Frank Wien

  10. Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2025, International Union of Crystallography

    Dr. Frank Wien

  11. A workflow to define structural classes and classify nucleic acids circular dichroism spectra

    Article • QRB Discovery, January 2025, Cambridge University Press

    Dr. Frank Wien

  12. Angle-Resolved Linear Dichroism to Probe the Organization of Highly Ordered Collagen Biomaterials

    Article • Biomacromolecules, August 2024, American Chemical Society (ACS)

    Dr. Frank Wien

  13. Human Serum Albumin in the Presence of Small Platinum Nanoparticles

    Article • Journal of Pharmaceutical Sciences, June 2024, Elsevier

    Dr. Frank Wien

  14. The Amyloid Assembly of the Bacterial Hfq Is Lipid-Driven and Lipid-Specific

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Dr. Frank Wien

  15. Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity

    Article • Chemistry of Materials, January 2024, American Chemical Society (ACS)

    Dr. Frank Wien

  16. Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA

    Article • Lab on a Chip, January 2024, Royal Society of Chemistry

    Dr. Frank Wien

  17. Role of the Bacterial Amyloid-like Hfq in Fluoroquinolone Fluxes

    Article • Microorganisms, December 2023, MDPI AG

    Dr. Frank Wien

  18. Significant influence of four highly conserved amino-acids in lipochaperon-active sHsps on the structure and functions of the Lo18 protein

    Article • Scientific Reports, November 2023, Springer Science + Business Media

    Dr. Frank Wien

  19. The Green Tea Polyphenol Epigallocatechin-Gallate (EGCG) Interferes with Microcin E492 Amyloid Formation

    Article • Molecules, October 2023, MDPI AG

    Dr. Frank Wien

  20. Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure

    Article • Communications Biology, October 2023, Springer Science + Business Media

    Dr. Frank Wien

  21. Synchrotron radiation circular dichroism spectroscopy of oligonucleotides at millimolar concentrations

    Article • Bioorganic & Medicinal Chemistry Letters, August 2023, Elsevier

    Dr. Frank Wien

  22. Interactions and Insertion of Escherichia coli Hfq into Outer Membrane Vesicles as Revealed by Infrared and Orientated Circular Dichroism Spectroscopies

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Dr. Frank Wien

  23. New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2

    Article • Free Radical Biology and Medicine, April 2023, Elsevier

    Dr. Frank Wien

  24. Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodeling by Hfq master regulator

    Article • Journal of Structural Biology, December 2022, Elsevier

    Dr. Frank Wien

  25. Biological effects of the loss of homochirality in a multicellular organism

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Dr. Frank Wien, Matthieu Refregiers

  26. NACDDB: Nucleic Acid Circular Dichroism Database

    Article • Nucleic Acids Research, October 2022, Oxford University Press (OUP)

    Dr. Frank Wien

  27. Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq

    Article • International Journal of Molecular Sciences, August 2022, MDPI AG

    Dr. Frank Wien

  28. Electronic Structure and Solvation Effects from Core and Valence Photoelectron Spectroscopy of Serum Albumin

    Article • International Journal of Molecular Sciences, July 2022, MDPI AG

    Dr. Frank Wien

  29. Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis

    Article • Scientific Reports, July 2022, Springer Science + Business Media

    Dr. Frank Wien

  30. BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy

    Article • Nucleic Acids Research, May 2022, Oxford University Press (OUP)

    Dr. Frank Wien, Matthieu Refregiers

  31. Disordered–Ordered Protein Binary Classification by Circular Dichroism Spectroscopy

    Article • Frontiers in Molecular Biosciences, May 2022, Frontiers

    Dr. Frank Wien, Matthieu Refregiers

  32. Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis

    Article • March 2022, Research Square

    Dr. Frank Wien

  33. Synchrotron Radiation Circular Dichroism, a New Tool to Probe Interactions between Nucleic Acids Involved in the Control of ColE1-Type Plasmid Replication

    Article • Applied Sciences, March 2022, MDPI AG

    Dr. Frank Wien

  34. Amyloid-like Hfq interaction with single-stranded DNA: involvement in recombination and replication inEscherichia coli

    Article • QRB Discovery, January 2022, Cambridge University Press

    Dr. Frank Wien

  35. Analysis of Bacterial Amyloid Interaction with Lipidic Membrane by Orientated Circular Dichroism and Infrared Spectroscopies

    Article • January 2022, Springer Science + Business Media

    Dr. Frank Wien

  36. Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival

    Article • January 2022, Springer Science + Business Media

    Dr. Frank Wien

  37. Evaluation of the Role of Bacterial Amyloid on Nucleoid Structure Using Cryo-Soft X-Ray Tomography

    Article • January 2022, Springer Science + Business Media

    Dr. Frank Wien

  38. Structural Information on Bacterial Amyloid and Amyloid-DNA Complex Obtained by Small-Angle Neutron or X-Ray Scattering

    Article • January 2022, Springer Science + Business Media

    Dr. Frank Wien

  39. Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodelling by Hfq master regulator

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr. Frank Wien

  40. Supramolecular organization and biological interaction of squalenoyl siRNA nanoparticles

    Article • International Journal of Pharmaceutics, November 2021, Elsevier

    Dr. Frank Wien

  41. The Amyloid Region of Hfq Riboregulator Promotes DsrA:rpoS RNAs Annealing

    Article • Biology, September 2021, MDPI AG

    Dr. Frank Wien

  42. β-Hairpin Miniprotein Stabilization in Trehalose Glass Is Facilitated by an Emergent Compact Non-Native State

    Article • The Journal of Physical Chemistry Letters, August 2021, American Chemical Society (ACS)

    Dr. Frank Wien

  43. SAXS-WAXS monitoring of the amyloid fibril assembly of a hormone peptide analogue upon pH change.

    Article • August 2021, American Chemical Society (ACS)

    Dr. Frank Wien

  44. Folding Dynamics of DNA G-Quadruplexes Probed by Millisecond Temperature Jump Circular Dichroism

    Article • The Journal of Physical Chemistry B, July 2021, American Chemical Society (ACS)

    Dr. Frank Wien

  45. Investigation by Synchrotron Radiation Circular Dichroism of the Secondary Structure Evolution of Pepsin under Oxidative Environment

    Article • Foods, May 2021, MDPI AG

    Dr. Frank Wien, Matthieu Refregiers

  46. Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq

    Article • Antibiotics, March 2021, MDPI AG

    Dr. Frank Wien

  47. Identification and characterization of the Hfq bacterial amyloid region DNA interactions

    Article • BBA Advances, January 2021, Elsevier

    Dr. Frank Wien

  48. SRCD and FTIR Spectroscopies to Monitor Protein-Induced Nucleic Acid Remodeling

    Article • November 2020, Springer Science + Business Media

    Dr. Frank Wien

  49. Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability

    Article • Microorganisms, October 2020, MDPI AG

    Dr. Frank Wien

  50. Interactions between DNA and the Hfq Amyloid-like Region Trigger a Viscoelastic Response

    Article • Biomacromolecules, July 2020, American Chemical Society (ACS)

    Dr. Frank Wien

  51. In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation

    Article • ACS Nano, July 2020, American Chemical Society (ACS)

    Dr. Frank Wien

  52. Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction

    Article • International Journal of Molecular Sciences, June 2020, MDPI AG

    Dr. Frank Wien

  53. Native Collagen: Electrospinning of Pure, Cross-Linker-Free, Self-Supported Membrane

    Article • ACS Applied Bio Materials, April 2020, American Chemical Society (ACS)

    Dr. Frank Wien

  54. Albumin-driven disassembly of lipidic nanoparticles: the specific case of the squalene-adenosine nanodrug

    Article • Nanoscale, January 2020, Royal Society of Chemistry

    Dr. Frank Wien

  55. RNA Spectroscopy

    Article • January 2020, Springer Science + Business Media

    Dr. Frank Wien

  56. Application of Synchrotron Radiation Circular Dichroism for RNA Structural Analysis

    Article • January 2020, Springer Science + Business Media

    Dr. Frank Wien

  57. Role of Hfq in Genome Evolution: Instability of G-Quadruplex Sequences in E. coli

    Article • Microorganisms, December 2019, MDPI AG

    Dr. Frank Wien

  58. The Bacterial Amyloid-Like Hfq Promotes In Vitro DNA Alignment

    Article • Microorganisms, December 2019, MDPI AG

    Dr. Frank Wien

  59. Time Resolved Transient Circular Dichroism Spectroscopy Using Synchrotron Natural Polarisation

    Article • September 2019, American Chemical Society (ACS)

    Matthieu Refregiers, Dr. Frank Wien

  60. Time resolved transient circular dichroism spectroscopy using synchrotron natural polarization

    Article • Structural Dynamics, September 2019, American Institute of Physics

    Dr. Frank Wien, Matthieu Refregiers

  61. Electrospinning of pure, native, cross-linker free self-supported collagen membrane

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr. Frank Wien

  62. In Situ Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study

    Article • Pathogens, March 2019, MDPI AG

    Dr. Frank Wien

  63. Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival

    Article • Pathogens, December 2018, MDPI AG

    Dr. Frank Wien

  64. Revised role for Hfq bacterial regulator on DNA topology

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Dr. Frank Wien

  65. Probing Structural Changes during Self-assembly of Surface-Active Hydrophobin Proteins that Form Functional Amyloids in Fungi

    Article • Journal of Molecular Biology, October 2018, Elsevier

    Dr. Frank Wien

  66. BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

    Article • Nucleic Acids Research, June 2018, Oxford University Press (OUP)

    Matthieu Refregiers, Dr. Frank Wien

  67. Reversible Assembly of a Drug Peptide into Amyloid Fibrils: A Dynamic Circular Dichroism Study

    Article • Langmuir, June 2018, American Chemical Society (ACS)

    Dr. Frank Wien

  68. Techniques to Analyze sRNA Protein Cofactor Self-Assembly In Vitro

    Article • January 2018, Springer Science + Business Media

    Dr. Frank Wien

  69. Conversion of NOX2 into a constitutive enzyme in vitro and in living cells, after its binding with a chimera of the regulatory subunits

    Article • Free Radical Biology and Medicine, December 2017, Elsevier

    Dr. Frank Wien

  70. Publisher Correction: Membrane association of the bacterial riboregulator Hfq and functional perspectives

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Dr. Frank Wien

  71. Structural proteomics: Topology and relative accessibility of plant lipid droplet associated proteins

    Article • Journal of Proteomics, October 2017, Elsevier

    Dr. Frank Wien

  72. Membrane association of the bacterial riboregulator Hfq and functional perspectives

    Article • Scientific Reports, September 2017, Springer Science + Business Media

    Dr. Frank Wien

  73. A Reactive Eremophilane and Its Antibacterial 2(1H)-Naphthalenone Rearrangement Product, Witnesses of a Microbial Chemical Warfare

    Article • Organic Letters, July 2017, American Chemical Society (ACS)

    Dr. Frank Wien

  74. The effect of origin of the gelatine and ageing on the secondary structure and water dissolution

    Article • Food Hydrocolloids, May 2017, Elsevier

    Matthieu Refregiers, Dr. Frank Wien

  75. The physicochemical properties of membranes correlate with the NADPH oxidase activity

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2017, Elsevier

    Matthieu Refregiers, Dr. Frank Wien

  76. Chiroptical properties of cryptophane-111

    Article • Physical Chemistry Chemical Physics, January 2017, Royal Society of Chemistry

    Dr. Frank Wien

  77. Unusual Chiroptical Properties of the Cryptophane-222 Skeleton

    Article • The Journal of Physical Chemistry B, December 2016, American Chemical Society (ACS)

    Dr. Frank Wien

  78. Refolding of Aggregation-Prone ScFv Antibody Fragments Assisted by Hydrophobically Modified Poly(sodium acrylate) Derivatives

    Article • Macromolecular Bioscience, August 2016, Wiley

    Dr. Frank Wien

  79. Can Changes in Temperature or Ionic Conditions Modify the DNA Organization in the Full Bacteriophage Capsid?

    Article • The Journal of Physical Chemistry B, July 2016, American Chemical Society (ACS)

    Dr. Frank Wien

  80. Structure Change from β -Strand and Turn to α -Helix in Histone H2A-H2B Induced by DNA Damage Response

    Article • Biophysical Journal, July 2016, Elsevier

    Matthieu Refregiers, Dr. Frank Wien

  81. Exploring the arachidonic acid-induced structural changes in phagocyte NADPH oxidase p47phoxand p67phoxvia thiol accessibility and SRCD spectroscopy

    Article • European Journal of Biochemistry, June 2016, Wiley

    Matthieu Refregiers, Dr. Frank Wien

  82. Combination of acoustic levitation with small angle scattering techniques and synchrotron radiation circular dichroism. Application to the study of protein solutions

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, May 2016, Elsevier

    Dr. Frank Wien, Matthieu Refregiers

  83. Titanium Dioxide Nanoparticles Increase Superoxide Anion Production by Acting on NADPH Oxidase

    Article • PLOS One, December 2015, PLOS

    Dr. Frank Wien

  84. Neurodegenerative disease-associated mutants of a human mitochondrial aminoacyl-tRNA synthetase present individual molecular signatures

    Article • Scientific Reports, December 2015, Nature

    Dr. Frank Wien

  85. Structural Basis of IgE Binding to α- and γ-Gliadins: Contribution of Disulfide Bonds and Repetitive and Nonrepetitive Domains

    Article • Journal of Agricultural and Food Chemistry, July 2015, American Chemical Society (ACS)

    Dr. Frank Wien

  86. Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

    Article • Proceedings of the National Academy of Sciences, June 2015, Proceedings of the National Academy of Sciences

    Dr. Frank Wien, Matthieu Refregiers

  87. RRP6 from Trypanosoma brucei: Crystal Structure of the Catalytic Domain, Association with EAP3 and Activity towards Structured and Non-Structured RNA Substrates

    Article • PLOS One, February 2014, PLOS

    Dr. Frank Wien

  88. Fold of an oleosin targeted to cellular oil bodies

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2013, Elsevier

    Dr. Frank Wien

  89. Fibrate treatment induced quantitative and qualitative HDL changes associated with an increase of SR-BI cholesterol efflux capacities in rabbits

    Article • Biochimie, June 2013, Elsevier

    Dr. Frank Wien

  90. Calibration and quality assurance procedures at the far UV linear and circular dichroism experimental station DISCO

    Article • Journal of Physics Conference Series, March 2013, Institute of Physics Publishing

    Matthieu Refregiers, Dr. Frank Wien

  91. The Single T65S Mutation Generates Brighter Cyan Fluorescent Proteins with Increased Photostability and pH Insensitivity

    Article • PLOS One, November 2012, PLOS

    Dr. Frank Wien

  92. New insights into pb5, the receptor binding protein of bacteriophage T5, and its interaction with its Escherichia coli receptor FhuA

    Article • Biochimie, September 2012, Elsevier

    Dr. Frank Wien

  93. Immunoglobulin-E Reactivity and Structural Analysis of Wheat Low-Molecular-Weight Glutenin Subunits and Their Repetitive and Nonrepetitive Halves

    Article • Journal of Agricultural and Food Chemistry, August 2012, American Chemical Society (ACS)

    Dr. Frank Wien

  94. DISCO synchrotron-radiation circular-dichroism endstation at SOLEIL

    Article • Journal of Synchrotron Radiation, July 2012, International Union of Crystallography

    Matthieu Refregiers, Dr. Frank Wien

  95. Atmospheric pressure photoionization using tunable VUV synchrotron radiation

    Article • Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms, May 2012, Elsevier

    Matthieu Refregiers, Dr. Frank Wien

  96. Anisotropy Spectra of Amino Acids

    Article • Angewandte Chemie, March 2012, Wiley

    Dr. Frank Wien

  97. Synchrotron radiation circular dichroism (SRCD) spectroscopy: An emerging method in structural biology for examining protein conformations and protein interactions

    Article • Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, September 2011, Elsevier

    Dr. Frank Wien

  98. Amphipols From A to Z*

    Article • Annual Review of Biophysics, June 2011, Annual Reviews

    Professor Werner Kühlbrandt, Dr. Frank Wien

  99. High water solubility and fold in amphipols of proteins with large hydrophobic regions: Oleosins and caleosin from seed lipid bodies

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2011, Elsevier

    Dr. Frank Wien

  100. International comparability in spectroscopic measurements of protein structure by circular dichroism: CCQM-P59.1

    Article • Metrologia, October 2010, Institute of Physics Publishing

    Dr. Frank Wien

  101. Synchrotron UV Fluorescence Microscopy Uncovers New Probes in Cells and Tissues

    Article • Microscopy and Microanalysis, August 2010, Cambridge University Press

    Matthieu Refregiers, Dr. Frank Wien

  102. Structure and Assembly Properties of the N-Terminal Domain of the Prion Ure2p in Isolation and in Its Natural Context

    Article • PLOS One, March 2010, PLOS

    Dr. Frank Wien

  103. Spatio-temporal radiation biology: new insights and biomedical perspectives

    Article • Cell Death and Disease, January 2010, Nature

    Dr. Frank Wien

  104. DISCO: a low-energy multipurpose beamline at synchrotron SOLEIL

    Article • Journal of Synchrotron Radiation, September 2009, International Union of Crystallography

    Matthieu Refregiers, Dr. Frank Wien

  105. A reference database for circular dichroism spectroscopy covering fold and secondary structure space

    Article • Bioinformatics, June 2006, Oxford University Press (OUP)

    Dr. Frank Wien

  106. Calcium Fluoride Micro Cells for Synchrotron Radiation Circular Dichroism Spectroscopy

    Article • Applied Spectroscopy, September 2005, SAGE Publications

    Dr. Frank Wien

  107. VUV irradiation effects on proteins in high-flux synchrotron radiation circular dichroism spectroscopy

    Article • Journal of Synchrotron Radiation, June 2005, International Union of Crystallography

    Dr. Frank Wien

  108. Calibration and standardisation of synchrotron radiation and conventional circular dichroism spectrometers. Part 2: Factors affecting magnitude and wavelength

    Article • Journal of Spectroscopy, January 2005, Wiley

    Dr. Frank Wien

  109. Redetermination of the extinction coefficient of camphor-10-sulfonic acid, a calibration standard for circular dichroism spectroscopy

    Article • Analytical Biochemistry, December 2004, Elsevier

    Dr. Frank Wien

  110. CDtool—an integrated software package for circular dichroism spectroscopic data processing, analysis, and archiving

    Article • Analytical Biochemistry, September 2004, Elsevier

    Dr. Frank Wien

  111. Biomedical applications of synchrotron radiation circular dichroism spectroscopy: Identification of mutant proteins associated with disease and development of a reference database for fold motifs

    Article • Faraday Discussions, January 2004, Royal Society of Chemistry

    Dr. Frank Wien

  112. Calibration and Standardisation of Synchrotron Radiation Circular Dichroism and Conventional Circular Dichroism Spectrophotometers

    Article • Journal of Spectroscopy, January 2003, Wiley

    Dr. Frank Wien

  113. Database Searching for Thymidine and Thymidylate Kinase Inhibitors Using Three-dimensional Structure-based Methods

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2002, Taylor & Francis

    Dr. Frank Wien

  114. A DNA–porphyrin minor-groove complex at atomic resolution: The structural consequences of porphyrin ruffling

    Article • Proceedings of the National Academy of Sciences, August 2000, Proceedings of the National Academy of Sciences

    Dr. Frank Wien

  115. Structure to 1.9 Å resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir

    Article • FEBS Letters, January 1999, Wiley

    Dr. Frank Wien

  116. Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

    Article • Proteins Structure Function and Bioinformatics, August 1998, Wiley

    Dr. Frank Wien