All Stories

  1. In silico and pharmacological evaluation of GPR65 as a cancer immunotherapy target regulating T-cell functions

    Article • Frontiers in Immunology, October 2024, Frontiers

    Dr Fernando Ramon Olayo

  2. IMI European Lead Factory — democratizing access to high-throughput screening

    Article • Nature Reviews Drug Discovery, December 2021, Springer Science + Business Media

    Dr Fernando Ramon Olayo

  3. Penicillin Acylase from Streptomyces lavendulae and Aculeacin A Acylase from Actinoplanes utahensis: Two Versatile Enzymes as Useful Tools for Quorum Quenching Processes

    Article • Catalysts, July 2020, MDPI AG

    Dr Fernando Ramon Olayo

  4. Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

    Article • Science Advances, March 2019, American Association for the Advancement of Science

    Dr Fernando Ramon Olayo

  5. Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

    Article • Scientific Reports, March 2018, Nature

    Dr Fernando Ramon Olayo

  6. 2′-Deoxyribosyltransferase from Bacillus psychrosaccharolyticus: A Mesophilic-Like Biocatalyst for the Synthesis of Modified Nucleosides from a Psychrotolerant Bacterium

    Article • Catalysts, January 2018, MDPI AG

    Dr Fernando Ramon Olayo

  7. Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

    Article • Scientific Reports, December 2016, Nature

    Dr Fernando Ramon Olayo

  8. Discovery of novel MIF inhibitors

    Article • SLAS DISCOVERY, June 2016, SAGE Publications

    Dr Fernando Ramon Olayo

  9. Discovery of Enhancers of the Secretion of Leukemia Inhibitory Factor for the Treatment of Multiple Sclerosis

    Article • SLAS DISCOVERY, June 2016, SAGE Publications

    Dr Fernando Ramon Olayo

  10. Development of a High-Throughput Cell-Based Assay for Superoxide Production in HL-60 Cells

    Article • SLAS DISCOVERY, March 2010, SAGE Publications

    Dr Fernando Ramon Olayo

  11. Utilization of Substrate-Induced Quenching for Screening Targets Promoting NADH and NADPH Consumption

    Article • SLAS DISCOVERY, February 2006, SAGE Publications

    Dr Fernando Ramon Olayo

  12. ?-Cystine inhibits aspartate-β-semialdehyde dehydrogenase by covalently binding to the essential 135Cys of the enzyme

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, January 2004, Elsevier

    Dr Fernando Ramon Olayo

  13. A Modular, Fully Integrated Ultra-High-Throughput Screening System Based on Confocal Fluorescence Analysis Techniques

    Article • SLAS DISCOVERY, December 2003, SAGE Publications

    Dr Fernando Ramon Olayo

  14. A Standard Operating Procedure for Assessing Liquid Handler Performance in High-Throughput Screening

    Article • SLAS DISCOVERY, December 2002, SAGE Publications

    Dr Fernando Ramon Olayo

  15. Effect of hydrogen peroxide on d-amino acid oxidase from Rhodotorula gracilis

    Article • Enzyme and Microbial Technology, August 2000, Elsevier

    Dr Fernando Ramon Olayo

  16. Chemical modification of tryptophan residues of d-amino acid oxidase from Rhodotorula gracilis

    Article • Journal of Molecular Catalysis B Enzymatic, March 2000, Elsevier

    Dr Fernando Ramon Olayo

  17. Enhanced production of penicillin V acylase from Streptomyces lavendulae

    Article • Applied Microbiology and Biotechnology, December 1999, Springer Science + Business Media

    Dr Isabel de la Mata, Dr Fernando Ramon Olayo

  18. Chemical mechanism of D-amino acid oxidase from Rhodotorula gracilis: pH dependence of kinetic parameters

    Article • Biochemical Journal, February 1998, Portland Press Ltd.

    Dr Fernando Ramon Olayo

  19. Oxidation by hydrogen peroxide of D-amino acid oxidase from Rhodotorula gracilis

    Article • January 1998, Elsevier

    Dr Fernando Ramon Olayo

  20. Chemical Modification of Histidyl Residues in D-Amino Acid Oxidase from Rhodotorula gracilis

    Article • The Journal of Biochemistry, October 1995, Oxford University Press (OUP)

    Dr Fernando Ramon Olayo

  21. Kinetic study of the aggregation and lipid mixing produced by alpha-sarcin on phosphatidylglycerol and phosphatidylserine vesicles: stopped-flow light scattering and fluorescence energy transfer measurements

    Article • Biophysical Journal, September 1994, Elsevier

    Dr Fernando Ramon Olayo

  22. Confocal detection in ultra-high throughput screening

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Dr Fernando Ramon Olayo