All Stories

  1. Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells

    Article • Brain Pathology, June 2024, Wiley

    Dr Felice Tirone

  2. Transcriptome analysis reveals genes associated with stem cell activation by physical exercise in the dentate gyrus of aged p16Ink4a knockout mice

    Article • Frontiers in Cell and Developmental Biology, October 2023, Frontiers

    Dr Felice Tirone

  3. Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy

    Article • The FASEB Journal, June 2023, Wiley

    Dr Felice Tirone

  4. Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

    Article • Nutrients, April 2023, MDPI AG

    Dr Felice Tirone

  5. Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine

    Article • Journal of Neurochemistry, January 2023, Wiley

    Dr Felice Tirone, Henrik Ahlenius

  6. Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis

    Article • Frontiers in Cell and Developmental Biology, August 2021, Frontiers

    Dr Felice Tirone

  7. Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611

    Article • Frontiers in Oncology, July 2021, Frontiers

    Giulia Gentile, Dr Felice Tirone

  8. Interaction Between Neurogenic Stimuli and the Gene Network Controlling the Activation of Stem Cells of the Adult Neurogenic Niches, in Physiological and Pathological Conditions

    Article • Frontiers in Cell and Developmental Biology, April 2020, Frontiers

    Dr Felice Tirone

  9. Deletion of Btg1 Induces Prmt1-Dependent Apoptosis and Increased Stemness in Shh-Type Medulloblastoma Cells Without Affecting Tumor Frequency

    Article • Frontiers in Oncology, March 2020, Frontiers

    Dr Felice Tirone

  10. Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival

    Article • The FASEB Journal, February 2020, Wiley

    Dr Felice Tirone

  11. Running-Activated Neural Stem Cells Enhance Subventricular Neurogenesis and Improve Olfactory Behavior in p21 Knockout Mice

    Article • Molecular Neurobiology, May 2019, Springer Science + Business Media

    Dr Felice Tirone

  12. p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise

    Article • Frontiers in Cellular Neuroscience, February 2019, Frontiers

    Dr Felice Tirone

  13. Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise

    Article • Brain Research Bulletin, October 2018, Elsevier

    Dr Felice Tirone

  14. Fluoxetine or Sox2 reactivate proliferation-defective stem and progenitor cells of the adult and aged dentate gyrus

    Article • Neuropharmacology, October 2018, Elsevier

    Dr Felice Tirone

  15. Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model

    Article • PLOS One, March 2018, PLOS

    Dr Felice Tirone

  16. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition

    Article • Brain, February 2018, Oxford University Press (OUP)

    MD, PhD Valeria D'Argenio, Dr Felice Tirone

  17. Tis21, Id3 and NeuoD2 control terminal differentiation of hippocampus neurons

    Article • Frontiers in Cellular Neuroscience, July 2017, Frontiers

    Dr Felice Tirone

  18. Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice

    Article • Brain Structure and Function, February 2017, Springer Science + Business Media

    Dr Felice Tirone

  19. HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression

    Article • Journal of Cellular Physiology, January 2017, Wiley

    Dr Felice Tirone

  20. Evidence for a novel therapy of brain tumors

    Article • Frontiers in Pharmacology, December 2016, Frontiers

    Dr Felice Tirone

  21. Functional Genomics Identifies Tis21-Dependent Mechanisms and Putative Cancer Drug Targets Underlying Medulloblastoma Shh-Type Development

    Article • Frontiers in Pharmacology, November 2016, Frontiers

    Dr Felice Tirone, Giulia Gentile

  22. THE BTG1 GENE CONTROLS CEREBELLUM DEVELOPMENT

    Article • Developmental Biology, December 2015, Elsevier

    Dr Felice Tirone

  23. REVIEW: EFFECT OF PHYSICAL EXERCISE ON NEURAL STEM CELLS SELF-RENEWAL

    Article • Brain Plasticity, October 2015, IOS Press

    Dr Felice Tirone

  24. BTG GENES AND NEURAL STEM CELL DEVELOPMENT

    Article • Journal of Cellular Physiology, August 2015, Wiley

    Dr Felice Tirone

  25. Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton

    Article • PLOS One, July 2015, PLOS

    Dr Felice Tirone

  26. Running Rescues Defective Adult Neurogenesis by Shortening the Length of the Cell Cycle of Neural Stem and Progenitor Cells

    Article • Stem Cells, June 2014, Wiley

    Dr Felice Tirone

  27. Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids

    Article • Frontiers in Cellular Neuroscience, April 2014, Frontiers

    Dr Felice Tirone

  28. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory

    Article • Neurobiology of Aging, November 2013, Elsevier

    Dr Felice Tirone

  29. REVIEW: GENES CONTROLLING NEURAL STEM CELLS DEVELOPMENT IN ADULT, AND EFFECT ON MEMORY.

    Article • Frontiers in Cellular Neuroscience, January 2013, Frontiers

    Dr Felice Tirone

  30. Medulloblastoma or not? Crucial role in tumorigenesis of the timing of migration of cerebellar granule precursor cells, regulated by Nos2 and Tis21

    Article • Frontiers in Neuroscience, January 2013, Frontiers

    Dr Felice Tirone

  31. Tis21 Knock-Out Enhances the Frequency of Medulloblastoma in Patched1 Heterozygous Mice by Inhibiting the Cxcl3-Dependent Migration of Cerebellar Neurons

    Article • Journal of Neuroscience, October 2012, Society for Neuroscience

    Dr Felice Tirone

  32. Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone

    Article • Frontiers in Neuroscience, January 2012, Frontiers

    Dr Felice Tirone

  33. PC4/Tis7/IFRD1Stimulates Skeletal Muscle Regeneration and Is Involved in Myoblast Differentiation as a Regulator of MyoD and NF-κB

    Article • Journal of Biological Chemistry, December 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Felice Tirone

  34. Impaired Terminal Differentiation of Hippocampal Granule Neurons and Defective Contextual Memory in PC3/Tis21 Knockout Mice

    Article • PLOS One, December 2009, PLOS

    Dr Felice Tirone

  35. The timing of differentiation of adult hippocampal neurons is crucial for spatial memory

    Article • Frontiers in Behavioral Neuroscience, January 2009, Frontiers

    Dr Felice Tirone

  36. The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory

    Article • PLoS Biology, October 2008, PLOS

    Dr Massimiliano Aceti , Dr Felice Tirone

  37. Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3

    Article • The FASEB Journal, March 2007, Federation of American Societies For Experimental Biology (FASEB)

    Dr Felice Tirone

  38. Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation

    Article • Molecular and Cellular Biology, July 2006, ASM Journals

    Dr Felice Tirone

  39. PC4 Coactivates MyoD by Relieving the Histone Deacetylase 4-Mediated Inhibition of Myocyte Enhancer Factor 2C

    Article • Molecular and Cellular Biology, March 2005, ASM Journals

    Dr Felice Tirone

  40. Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1

    Article • Journal of Neuroscience, March 2004, Society for Neuroscience

    Dr Felice Tirone, Prof Roberto Giovannoni

  41. PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis

    Article • Neuroreport, March 2002, Wolters Kluwer Health

    Dr Felice Tirone

  42. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith–Wiedemann syndrome and tumorigenesis

    Article • Biochemical Journal, May 2001, Portland Press Ltd.

    Dr Felice Tirone

  43. The gene PC3TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?

    Article • Journal of Cellular Physiology, January 2001, Wiley

    Dr Felice Tirone

  44. Cloning of PC3B, a Novel Member of the PC3/BTG/TOB Family of Growth Inhibitory Genes, Highly Expressed in the Olfactory Epithelium

    Article • Genomics, September 2000, Elsevier

    Dr Corrado Spadafora, Dr Felice Tirone

  45. Arrest of G1-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

    Article • Molecular and Cellular Biology, March 2000, ASM Journals

    Dr Felice Tirone

  46. Cloning of the Human Interferon-Related Developmental Regulator (IFRD1) Gene Coding for the PC4 Protein, a Member of a Novel Family of Developmentally Regulated Genes

    Article • Genomics, July 1998, Elsevier

    Dr Felice Tirone

  47. Expression of the PC4 gene in the developing rat nervous system

    Article • Brain Research, January 1996, Elsevier

    Dr Felice Tirone

  48. Developmental expression of PC3 gene is correlated with neuronal cell birthday

    Article • Mechanisms of Development, August 1994, Elsevier

    Dr Felice Tirone

  49. Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells

    Article • Journal of Neuroscience Research, April 1994, Wiley

    Dr Felice Tirone

  50. Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

    Article • Proceedings of the National Academy of Sciences, April 1991, Proceedings of the National Academy of Sciences

    Dr Felice Tirone

  51. Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene.

    Article • Proceedings of the National Academy of Sciences, March 1989, Proceedings of the National Academy of Sciences

    Dr Felice Tirone

  52. Effects of the desensitization by morphine of the opiate-dependent adenylate cyclase system in the rat striatum on the activity of the inhibitory regulatory G protein

    Article • Biochemical Pharmacology, March 1988, Elsevier

    Dr Felice Tirone

  53. Pertussis toxin inhibits the antinociceptive action of morphine in the rat

    Article • European Journal of Pharmacology, May 1986, Elsevier

    Dr Felice Tirone

  54. One Month of Streptozotocin-Diabetes Induces Different Neuroendocrine and Morphological Alterations in the Hypothalamo-Pituitary Axis of Male and Female Rats*

    Article • Endocrinology, July 1985, Endocrine Society

    Dr Felice Tirone

  55. Presence of opiate receptors on striatal serotoninergic nerve terminals

    Article • Brain Research, December 1983, Elsevier

    Dr Felice Tirone

  56. Opiate tolerance and dependence is associated with a decreased activity of GTPase in rat striatal membranes

    Article • Life Sciences, January 1983, Elsevier

    Dr Felice Tirone

  57. Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus

    Article • European Journal of Pharmacology, November 1982, Elsevier

    Dr Felice Tirone