All Stories

  1. Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy

    Article • Cell, March 2026, Elsevier

    Dr. Fabian Schumacher

  2. Kidney disease reprograms microbiome-host signaling to promote heart failure

    Article • January 2026, openRxiv

    Dr. Fabian Schumacher

  3. Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

    Article • Gut, December 2025, BMJ

    Dr. Fabian Schumacher

  4. Deactivation of ceramide de novo synthesis induces cerebral angiogenesis and microvascular remodeling post-ischemia/reperfusion in mice via mechanisms not predominated by extracellular vesicles

    Article • Journal of Cerebral Blood Flow & Metabolism, November 2025, SAGE Publications

    Dr. Fabian Schumacher

  5. Influence of amitriptyline therapy on T cell phenotype in chronic pain patients

    Article • Biomedicine & Pharmacotherapy, October 2025, Elsevier

    Dr. Fabian Schumacher

  6. Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation

    Article • mBio, September 2025, ASM Journals

    Dr. Fabian Schumacher

  7. Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply

    Article • PLoS Biology, August 2025, PLOS

    Dr. Fabian Schumacher

  8. Amitriptyline inhibits Plasmodium development in infected red blood cells by modulating sphingolipid metabolism and glucose uptake

    Article • Biomedicine & Pharmacotherapy, August 2025, Elsevier

    Dr. Fabian Schumacher

  9. Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1–phosphate receptor 1

    Article • Fluids and Barriers of the CNS, July 2025, Springer Science + Business Media

    Dr. Fabian Schumacher

  10. Immune cells in dorsal root ganglia are associated with pruritus in a mouse model of allergic contact dermatitis and co-culture study

    Article • Journal of Neuroimmunology, July 2025, Elsevier

    Dr. Fabian Schumacher

  11. Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes

    Article • mBio, May 2025, ASM Journals

    Dr. Fabian Schumacher

  12. Development of an iPSC-derived immunocompetent skin model for identification of skin sensitizing substances

    Article • Journal of Tissue Engineering, May 2025, SAGE Publications

    Dr. Fabian Schumacher

  13. Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction

    Article • Journal of Lipid Research, April 2025, Elsevier

    Dr. Fabian Schumacher

  14. Development and validation of an LC-MS/MS assay for quantification of fosfomycin in Mueller-Hinton broth for application in profiling antibacterial efficacy against clinical bacterial isolates

    Article • Journal of Chromatography B, April 2025, Elsevier

    Dr. Fabian Schumacher

  15. Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections

    Article • Journal of Molecular Medicine, March 2025, Springer Science + Business Media

    Dr. Fabian Schumacher

  16. Psychosomatic - psychotherapeutic treatment of stress-related disorders impacts the sphingolipid metabolism towards increased sphingosine and sphingosine-1-phosphate levels

    Article • European Archives of Psychiatry and Clinical Neuroscience, March 2025, Springer Science + Business Media

    Dr. Fabian Schumacher

  17. Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease

    Article • Journal of Extracellular Vesicles, March 2025, Wiley

    Dr. Fabian Schumacher

  18. Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia

    Article • Molecular Psychiatry, January 2025, Springer Science + Business Media

    Dr. Fabian Schumacher

  19. Lebendzell‐Identifizierung von Inhibitoren des Lipid‐Transfer Proteins CERT Mithilfe von Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET)

    Article • Angewandte Chemie, November 2024, Wiley

    Dr. Fabian Schumacher

  20. Live‐Cell Identification of Inhibitors of the Lipid Transfer Protein CERT Using Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET)

    Article • Angewandte Chemie, November 2024, Wiley

    Dr. Fabian Schumacher

  21. The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells

    Article • Journal of Lipid Research, October 2024, Elsevier

    Dr. Fabian Schumacher

  22. Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

    Article • Acta Physiologica, September 2024, Wiley

    Dr. Fabian Schumacher

  23. Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells

    Article • Redox Biology, September 2024, Elsevier

    Dr. Fabian Schumacher

  24. Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy

    Article • Nature Communications, August 2024, Springer Science + Business Media

    Dr. Fabian Schumacher

  25. The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells

    Article • mBio, August 2024, ASM Journals

    Dr. Fabian Schumacher

  26. Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells

    Article • Frontiers in Immunology, July 2024, Frontiers

    Dr. Fabian Schumacher

  27. Gut dysbiosis contributes to TMAO accumulation in CKD

    Article • Nephrology Dialysis Transplantation, July 2024, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  28. Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice

    Article • Tuberculosis, July 2024, Elsevier

    Dr. Fabian Schumacher

  29. Dissecting Acute Drug‐Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver‐On‐A‐Chip Model

    Article • Advanced Science, June 2024, Wiley

    Dr. Fabian Schumacher

  30. Acid ceramidase expression reduces IFNγ secretion by mouse CD4+ T cells and is crucial for maintaining B-cell numbers in mice

    Article • Frontiers in Immunology, June 2024, Frontiers

    Dr. Fabian Schumacher

  31. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles

    Article • European Journal of Cell Biology, June 2024, Elsevier

    Dr. Fabian Schumacher

  32. Fertilization by short-term stored sperm alters DNA methylation patterns at single-base resolution in common carp (Cyprinus carpio) embryos

    Article • Reviews in Fish Biology and Fisheries, May 2024, Springer Science + Business Media

    Dr. Fabian Schumacher

  33. Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status—Wild-Type, Knockout or Humanised

    Article • International Journal of Molecular Sciences, March 2024, MDPI AG

    Dr. Fabian Schumacher

  34. The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells

    Article • International Journal of Molecular Sciences, March 2024, MDPI AG

    Dr. Fabian Schumacher

  35. Plant defensive responses to insect eggs are inducible by general egg-associated elicitors

    Article • Scientific Reports, January 2024, Springer Science + Business Media

    Dr. Fabian Schumacher

  36. Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

    Article • Pharmaceuticals, January 2024, MDPI AG

    Dr. Fabian Schumacher

  37. Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells

    Article • PLoS Pathogens, November 2023, PLOS

    Dr. Fabian Schumacher

  38. Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans

    Article • Chemical Research in Toxicology, October 2023, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  39. Follicular Delivery of Caffeine from a Shampoo for Hair Retention

    Article • Cosmetics, July 2023, MDPI AG

    Dr. Fabian Schumacher

  40. Aging of common carp (Cyprinus carpio L.) sperm induced by short-term storage does not alter global DNA methylation and specific histone modifications in offspring

    Article • Aquaculture, June 2023, Elsevier

    Dr. Fabian Schumacher

  41. Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

    Article • Cells, May 2023, MDPI AG

    Dr. Fabian Schumacher

  42. New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism

    Article • January 2023, Springer Science + Business Media

    Dr. Fabian Schumacher

  43. Efficient skin interactions of graphene derivatives: challenge, opportunity or both?

    Article • Nanoscale Advances, January 2023, Royal Society of Chemistry

    Dr. Fabian Schumacher

  44. Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Dr. Fabian Schumacher

  45. Cell-intrinsic ceramides determine T cell function during melanoma progression

    Article • eLife, November 2022, eLife

    Dr. Fabian Schumacher

  46. Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    Dr. Fabian Schumacher

  47. The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

    Article • eLife, September 2022, eLife

    Dr. Fabian Schumacher

  48. Cell-intrinsic ceramides determine T cell function during melanoma progression

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr. Fabian Schumacher

  49. Biodegradable core-multishell nanocarrier: Topical tacrolimus delivery for treatment of dermatitis

    Article • Journal of Controlled Release, September 2022, Elsevier

    Dr. Fabian Schumacher

  50. Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact

    Article • Biochimie, September 2022, Elsevier

    Dr. Fabian Schumacher

  51. Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma

    Article • Journal of Molecular Medicine, August 2022, Springer Science + Business Media

    Dr. Fabian Schumacher

  52. Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles

    Article • Basic Research in Cardiology, August 2022, Springer Science + Business Media

    Dr. Fabian Schumacher

  53. Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance

    Article • Journal of the American Society of Nephrology, August 2022, American Society of Nephrology

    Johannes Holle, Dr. Fabian Schumacher

  54. Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations

    Article • Journal of Functional Biomaterials, August 2022, MDPI AG

    Dr. Fabian Schumacher

  55. Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice

    Article • Journal of Biological Chemistry, August 2022, Elsevier

    Dr. Fabian Schumacher

  56. Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs

    Article • PLOS One, July 2022, PLOS

    Dr. Fabian Schumacher

  57. CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosis

    Article • Journal of Cystic Fibrosis, July 2022, Elsevier

    Dr. Fabian Schumacher

  58. Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

    Article • Cancers, April 2022, MDPI AG

    Dr. Fabian Schumacher

  59. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming

    Article • Cell Metabolism, April 2022, Elsevier

    Dr. Fabian Schumacher

  60. S1P Signalling Axis Is Necessary for Adiponectin-Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes

    Article • Cells, February 2022, MDPI AG

    Dr. Fabian Schumacher

  61. A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2022, Elsevier

    Dr. Fabian Schumacher, Robin Michelet

  62. COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Dr. Fabian Schumacher

  63. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Dr. Fabian Schumacher

  64. Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs

    Article • Scientific Reports, September 2021, Springer Science + Business Media

    Dr. Fabian Schumacher

  65. Sphingolipids: Effectors and Achilles Heals in Viral Infections?

    Article • Cells, August 2021, MDPI AG

    Dr. Fabian Schumacher

  66. Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells

    Article • Cell Biochemistry and Biophysics, June 2021, Springer Science + Business Media

    Dr. Fabian Schumacher

  67. Sphingosine 1-phosphate metabolism and insulin signaling

    Article • Cellular Signalling, June 2021, Elsevier

    Dr. Fabian Schumacher

  68. Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis

    Article • International Journal of Molecular Sciences, May 2021, MDPI AG

    Dr. Fabian Schumacher

  69. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus

    Article • Antioxidants, April 2021, MDPI AG

    Dr. Fabian Schumacher

  70. Inhibition of acid sphingomyelinase increases regulatory T cells in humans

    Article • Brain Communications, March 2021, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  71. Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria

    Article • Scientific Reports, February 2021, Springer Science + Business Media

    Dr. Fabian Schumacher

  72. Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis

    Article • Organic & Biomolecular Chemistry, January 2021, Royal Society of Chemistry

    Dr. Fabian Schumacher

  73. Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide

    Article • Shock, December 2020, Wolters Kluwer Health

    Dr. Fabian Schumacher

  74. Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

    Article • Cells, November 2020, MDPI AG

    Dr. Fabian Schumacher

  75. Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)

    Article • Chemistry - A European Journal, November 2020, Wiley

    Dr. Fabian Schumacher, Dr Essa M. Saied

  76. Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory

    Article • Cerebral Cortex, October 2020, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  77. Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers

    Article • Pharmaceutics, September 2020, MDPI AG

    Dr. Fabian Schumacher

  78. The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

    Article • Cells, May 2020, MDPI AG

    Dr. Fabian Schumacher

  79. A Role of Sphingosine in the Intracellular Survival of Neisseria gonorrhoeae

    Article • Frontiers in Cellular and Infection Microbiology, May 2020, Frontiers

    Dr. Fabian Schumacher

  80. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

    Article • Journal of Hepatology, May 2020, Elsevier

    Dr. Fabian Schumacher

  81. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

    Article • Nature Communications, March 2020, Springer Science + Business Media

    Dr. Fabian Schumacher

  82. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

    Article • Journal of Lipid Research, March 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  83. S1P and Plasmalogen Derived Fatty Aldehydes in Cellular Signaling and Functions

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, March 2020, Elsevier

    Dr. Fabian Schumacher

  84. A photocaged inhibitor of acid sphingomyelinase

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Dr. Fabian Schumacher

  85. Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects

    Article • Cellular Physiology and Biochemistry, December 2019, Cell Physiol Biochem Press GmbH and Co KG

    Dr. Fabian Schumacher

  86. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease

    Article • International Journal of Molecular Sciences, December 2019, MDPI AG

    Dr. Fabian Schumacher

  87. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury

    Article • Journal of Surgical Research, December 2019, Elsevier

    Dr. Fabian Schumacher

  88. Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  89. Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  90. Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  91. Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

    Article • Epigenetics, September 2019, Taylor & Francis

    Mr Burkhard Kleuser, Dr. Fabian Schumacher, Christian Gerecke

  92. Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity

    Article • Journal of Neurochemistry, August 2019, Wiley

    Dr. Fabian Schumacher

  93. Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

    Article • Pharmaceutics, August 2019, MDPI AG

    Dr. Fabian Schumacher

  94. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia

    Article • Journal of Molecular Medicine, June 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  95. Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

    Article • Frontiers in Immunology, June 2019, Frontiers

    Dr. Fabian Schumacher

  96. Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium

    Article • Frontiers in Immunology, June 2019, Frontiers

    Dr. Fabian Schumacher

  97. Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

    Article • Molecular Metabolism, June 2019, Elsevier

    Dr. Fabian Schumacher

  98. Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration

    Article • Analytical Chemistry, May 2019, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  99. 1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

    Article • Archives of Toxicology, April 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  100. Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin

    Article • Journal of Controlled Release, April 2019, Elsevier

    Dr. Fabian Schumacher

  101. Methionine restriction prevents onset of type 2 diabetes in NZO mice

    Article • The FASEB Journal, March 2019, Federation of American Societies For Experimental Biology (FASEB)

    Thomas Laeger, Mr Burkhard Kleuser, Dr. Fabian Schumacher

  102. Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  103. Interleukin-22 protects intestinal stem cells against genotoxic stress

    Article • Nature, January 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  104. Antidepressants regulate autophagy by targeting acid sphingomyelinase

    Article • Molecular Psychiatry, December 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  105. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice

    Article • Critical Care, October 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  106. Pathological manifestations of Farber disease in a new mouse model

    Article • Biological Chemistry, September 2018, De Gruyter

    Dr. Fabian Schumacher

  107. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

    Article • Oncotarget, August 2018, Impact Journals, LLC

    Dr. Fabian Schumacher

  108. Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

    Article • Molecular Psychiatry, July 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  109. Down‐regulation of acid sphingomyelinase and neutral sphingomyelinase‐2 inversely determines the cellular resistance to plasmalemmal injury by pore‐forming toxins

    Article • The FASEB Journal, July 2018, Wiley

    Mr Burkhard Kleuser, Dr. Fabian Schumacher

  110. Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells

    Article • Archives of Toxicology, March 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  111. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2

    Article • Critical Care Medicine, March 2018, Wolters Kluwer Health

    Dr. Fabian Schumacher

  112. How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

    Article • Journal of Investigative Dermatology, February 2018, Elsevier

    Dr. Fabian Schumacher

  113. Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Dr. Fabian Schumacher

  114. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Dr. Fabian Schumacher

  115. Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice

    Article • The Journal of Nutritional Biochemistry, October 2017, Elsevier

    Dr. Fabian Schumacher

  116. Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in NSCL Carcinoma.

    Article • Cancer Research, September 2017, American Association for Cancer Research (AACR)

    Prof Susetta Finotto, Dr. Fabian Schumacher

  117. The sphingosine 1-phosphate breakdown product, (2 E )-hexadecenal, forms protein adducts and glutathione conjugates in vitro

    Article • Journal of Lipid Research, June 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  118. Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2017, Elsevier

    Dr. Fabian Schumacher

  119. Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

    Article • Nanotoxicology, February 2017, Taylor & Francis

    Dr. Fabian Schumacher

  120. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

    Article • Cellular Physiology and Biochemistry, January 2017, Karger Publishers

    Dr. Fabian Schumacher

  121. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers

    Article • Journal of Controlled Release, November 2016, Elsevier

    Dr. Fabian Schumacher

  122. In SilicoPrediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  123. Highly sensitive isotope-dilution liquid-chromatography–electrospray ionization–tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans

    Article • Talanta, November 2015, Elsevier

    Dr. Fabian Schumacher

  124. Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

    Article • Journal of Agricultural and Food Chemistry, September 2015, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  125. The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens

    Article • Molecular Nutrition & Food Research, February 2015, Wiley

    Dr. Fabian Schumacher

  126. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

    Article • Metallomics, January 2015, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  127. Simultaneous Detection of Multiple DNA Adducts in Human Lung Samples by Isotope-Dilution UPLC-MS/MS

    Article • Analytical Chemistry, December 2014, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  128. Method to Simultaneously Determine the Sphingosine 1-Phosphate Breakdown Product (2E)-Hexadecenal and Its Fatty Acid Derivatives Using Isotope-Dilution HPLC–Electrospray Ionization–Quadrupole/Time-of-Flight Mass Spectrometry

    Article • Analytical Chemistry, September 2014, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  129. A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells

    Article • Archives of Toxicology, October 2013, Springer Science + Business Media

    Dr. Fabian Schumacher

  130. Optimized enzymatic hydrolysis of DNA for LC–MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol

    Article • Analytical Biochemistry, March 2013, Elsevier

    Dr. Fabian Schumacher

  131. Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

    Article • Carcinogenesis, January 2013, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  132. Detection of DNA Adducts Originating from 1-Methoxy-3-indolylmethyl Glucosinolate Using Isotope-Dilution UPLC-ESI-MS/MS

    Article • Analytical Chemistry, July 2012, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  133. 1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation

    Article • Chemico-Biological Interactions, June 2011, Elsevier

    Dr. Fabian Schumacher