All Stories

  1. Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

    Article • Cells, November 2020, MDPI AG

    Dr. Fabian Schumacher

  2. Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)

    Article • Chemistry - A European Journal, November 2020, Wiley

    Dr. Fabian Schumacher, Dr Essa M. Saied

  3. Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory

    Article • Cerebral Cortex, October 2020, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  4. Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers

    Article • Pharmaceutics, September 2020, MDPI AG

    Dr. Fabian Schumacher

  5. The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

    Article • Cells, May 2020, MDPI AG

    Dr. Fabian Schumacher

  6. A Role of Sphingosine in the Intracellular Survival of Neisseria gonorrhoeae

    Article • Frontiers in Cellular and Infection Microbiology, May 2020, Frontiers

    Dr. Fabian Schumacher

  7. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

    Article • Journal of Hepatology, May 2020, Elsevier

    Dr. Fabian Schumacher

  8. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

    Article • Nature Communications, March 2020, Springer Science + Business Media

    Dr. Fabian Schumacher

  9. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

    Article • Journal of Lipid Research, March 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  10. S1P and Plasmalogen Derived Fatty Aldehydes in Cellular Signaling and Functions

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, March 2020, Elsevier

    Dr. Fabian Schumacher

  11. A photocaged inhibitor of acid sphingomyelinase

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Dr. Fabian Schumacher

  12. Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects

    Article • Cellular Physiology and Biochemistry, December 2019, Cell Physiol Biochem Press GmbH and Co KG

    Dr. Fabian Schumacher

  13. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease

    Article • International Journal of Molecular Sciences, December 2019, MDPI AG

    Dr. Fabian Schumacher

  14. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury

    Article • Journal of Surgical Research, December 2019, Elsevier

    Dr. Fabian Schumacher

  15. Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  16. Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  17. Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro

    Article • Frontiers in Cell and Developmental Biology, October 2019, Frontiers

    Dr. Fabian Schumacher

  18. Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

    Article • Epigenetics, September 2019, Taylor & Francis

    Mr Burkhard Kleuser, Dr. Fabian Schumacher, Christian Gerecke

  19. Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity

    Article • Journal of Neurochemistry, August 2019, Wiley

    Dr. Fabian Schumacher

  20. Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

    Article • Pharmaceutics, August 2019, MDPI AG

    Dr. Fabian Schumacher

  21. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia

    Article • Journal of Molecular Medicine, June 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  22. Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

    Article • Frontiers in Immunology, June 2019, Frontiers

    Dr. Fabian Schumacher

  23. Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium

    Article • Frontiers in Immunology, June 2019, Frontiers

    Dr. Fabian Schumacher

  24. Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

    Article • Molecular Metabolism, June 2019, Elsevier

    Dr. Fabian Schumacher

  25. Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration

    Article • Analytical Chemistry, May 2019, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  26. 1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

    Article • Archives of Toxicology, April 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  27. Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin

    Article • Journal of Controlled Release, April 2019, Elsevier

    Dr. Fabian Schumacher

  28. Methionine restriction prevents onset of type 2 diabetes in NZO mice

    Article • The FASEB Journal, March 2019, Federation of American Societies For Experimental Biology (FASEB)

    Thomas Laeger, Mr Burkhard Kleuser, Dr. Fabian Schumacher

  29. Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  30. Interleukin-22 protects intestinal stem cells against genotoxic stress

    Article • Nature, January 2019, Springer Science + Business Media

    Dr. Fabian Schumacher

  31. Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins

    Article • The FASEB Journal, January 2019, Federation of American Societies For Experimental Biology (FASEB)

    Mr Burkhard Kleuser, Dr. Fabian Schumacher

  32. Antidepressants regulate autophagy by targeting acid sphingomyelinase

    Article • Molecular Psychiatry, December 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  33. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice

    Article • Critical Care, October 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  34. Pathological manifestations of Farber disease in a new mouse model

    Article • Biological Chemistry, September 2018, De Gruyter

    Dr. Fabian Schumacher

  35. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

    Article • Oncotarget, August 2018, Impact Journals, LLC

    Dr. Fabian Schumacher

  36. Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

    Article • Molecular Psychiatry, July 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  37. Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells

    Article • Archives of Toxicology, March 2018, Springer Science + Business Media

    Dr. Fabian Schumacher

  38. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2

    Article • Critical Care Medicine, March 2018, Wolters Kluwer Health

    Dr. Fabian Schumacher

  39. How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

    Article • Journal of Investigative Dermatology, February 2018, Elsevier

    Dr. Fabian Schumacher

  40. Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Dr. Fabian Schumacher

  41. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Dr. Fabian Schumacher

  42. Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice

    Article • The Journal of Nutritional Biochemistry, October 2017, Elsevier

    Dr. Fabian Schumacher

  43. Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in NSCL Carcinoma.

    Article • Cancer Research, September 2017, American Association for Cancer Research (AACR)

    Prof Susetta Finotto, Dr. Fabian Schumacher

  44. The sphingosine 1-phosphate breakdown product, (2 E )-hexadecenal, forms protein adducts and glutathione conjugates in vitro

    Article • Journal of Lipid Research, June 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  45. Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2017, Elsevier

    Dr. Fabian Schumacher

  46. Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

    Article • Nanotoxicology, February 2017, Taylor & Francis

    Dr. Fabian Schumacher

  47. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

    Article • Cellular Physiology and Biochemistry, January 2017, Karger Publishers

    Dr. Fabian Schumacher

  48. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers

    Article • Journal of Controlled Release, November 2016, Elsevier

    Dr. Fabian Schumacher

  49. In SilicoPrediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Fabian Schumacher

  50. Highly sensitive isotope-dilution liquid-chromatography–electrospray ionization–tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans

    Article • Talanta, November 2015, Elsevier

    Dr. Fabian Schumacher

  51. Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

    Article • Journal of Agricultural and Food Chemistry, September 2015, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  52. The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens

    Article • Molecular Nutrition & Food Research, February 2015, Wiley

    Dr. Fabian Schumacher

  53. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

    Article • Metallomics, January 2015, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  54. Simultaneous Detection of Multiple DNA Adducts in Human Lung Samples by Isotope-Dilution UPLC-MS/MS

    Article • Analytical Chemistry, December 2014, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  55. Method to Simultaneously Determine the Sphingosine 1-Phosphate Breakdown Product (2E)-Hexadecenal and Its Fatty Acid Derivatives Using Isotope-Dilution HPLC–Electrospray Ionization–Quadrupole/Time-of-Flight Mass Spectrometry

    Article • Analytical Chemistry, September 2014, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  56. A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells

    Article • Archives of Toxicology, October 2013, Springer Science + Business Media

    Dr. Fabian Schumacher

  57. Optimized enzymatic hydrolysis of DNA for LC–MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol

    Article • Analytical Biochemistry, March 2013, Elsevier

    Dr. Fabian Schumacher

  58. Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

    Article • Carcinogenesis, January 2013, Oxford University Press (OUP)

    Dr. Fabian Schumacher

  59. Detection of DNA Adducts Originating from 1-Methoxy-3-indolylmethyl Glucosinolate Using Isotope-Dilution UPLC-ESI-MS/MS

    Article • Analytical Chemistry, July 2012, American Chemical Society (ACS)

    Dr. Fabian Schumacher

  60. 1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation

    Article • Chemico-Biological Interactions, June 2011, Elsevier

    Dr. Fabian Schumacher