Dr Eugeen Vanmechelen
ADx NeuroSciences
Business / Corporate Professional, Life Sciences
Belgium
My co-authors include
Prof. Dr. Otto W. Witte
My Publications
Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison...
Clinical Chemistry
March 2018
The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive D...
Journal of Alzheimer s Disease
August 2016
Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Dia...
Journal of Alzheimer s Disease
April 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, ...
PLoS ONE
April 2016
Validation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers f...
Journal of Neurochemistry
January 2016
The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systemat...
Biomarkers in Medicine
January 2016
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in A...
Alzheimer s & Dementia
December 2015
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wi...
Neurobiology of Aging
September 2015
A Practical Guide to Immunoassay Method Validation
Frontiers in Neurology
August 2015
A monoclonal antibody-based elisa for neurogranin
Alzheimer s & Dementia
July 2015
Standardization of a method for diagnostic biomarker validation for neurodegenerative d...
Alzheimer s & Dementia
July 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic revi...
Acta Neuropathologica Communications
April 2015
Tau Monoclonal Antibody Generation Based on Humanized Yeast Models
Journal of Biological Chemistry
December 2014
Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels
Alzheimer s & Dementia
October 2014
TDP-43 AS A BIOMARKER FOR FRONTOTEMPORAL LOBE DEGENERATION: A SYSTEMATIC REVIEW OF EXIS...
Alzheimer s & Dementia
July 2014
Tau as a molecular biomarker in cerebrospinal fluid and plasma
Neurobiology of Aging
March 2014
Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury
Journal of Neurotrauma
January 2014
A new era of CSF biomarker testing in the field of Alzheimer's disease
Alzheimer s & Dementia
July 2013
Detection and quantification of novel tau/phospho-tau epitopes in CSF using a multiplex...
Alzheimer s & Dementia
July 2013
Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis o...
Archives of Neurology
November 2012
Analytical aspects of molecular Alzheimer’s disease biomarkers
Biomarkers in Medicine
August 2012
Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Par...
Biomarkers in Medicine
August 2012
Potential sources of interference on Abeta immunoassays in biological samples
Alzheimer s Research & Therapy
January 2012
Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301...
Respiratory Physiology & Neurobiology
September 2011
Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online N...
Neurochemical Research
June 2011
Tau protein analysis after hypothermia treatment after cardiac arrest—A pilot study
Resuscitation
December 2010
Added diagnostic value of CSF biomarkers in differential dementia diagnosis
Neurobiology of Aging
November 2010
Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's ...
Brain Research
November 2010
CSF tau as a diagnostic marker and therapeutic drug treatment monitor
Alzheimer s & Dementia
July 2010
Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease i...
Neurobiology of Aging
March 2010
Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?
Neuroscience Letters
February 2009
Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia
Neurobiology of Aging
August 2008
Tau as a biomarker of neurodegenerative diseases
Biomarkers in Medicine
August 2008
P3-071: Mass spectrometric characterization of tau in cerebrospinal fluid
Alzheimer s & Dementia
July 2008
Multiplexed quantification of dementia biomarkers in the CSF of patients with early dem...
Neurobiology of Aging
June 2008
Characterization of Tau in Cerebrospinal Fluid Using Mass Spectrometry
Journal of Proteome Research
May 2008
Biochemistry of Tau in Alzheimer’s disease and related neurological disorders
Expert Review of Proteomics
April 2008
P-064
Alzheimer s & Dementia
July 2007
P2-142
Alzheimer s & Dementia
July 2006
P2-146
Alzheimer s & Dementia
July 2006
O3-01-06
Alzheimer s & Dementia
July 2006
P3-090
Alzheimer s & Dementia
July 2006
Analytical performance and clinical utility of the INNOTEST® PHOSPHO-TAU(181P) assay fo...
Clinical Chemistry and Laboratory Medicine (CCLM)
January 2006
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processi...
Neurobiology of Disease
November 2005
AB42 peptides, tau, and P-tau181P as biomarkers for early diagnosis: A multiparametric ...
Alzheimer s & Dementia
July 2005
Subgroups of Alzheimer disease based on cerebrospinal fluid levels of molecular markers
Alzheimer s & Dementia
July 2005
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
Annals of Neurology
January 2005
P3-049 Multiparametric biomarker quantification in cerebrospinal fluid (CSF) for early ...
Neurobiology of Aging
July 2004
P3-031 A novel β-amyloid42 index in cerebrospinal fluid for specific determination of A...
Neurobiology of Aging
July 2004
P4-386 The effect of simvastatin treatmnt the processing of the amyloid precursor prote...
Neurobiology of Aging
July 2004
S1-02-01 Amino-truncated abeta 42 species as early diagnostic and etiological biomarker...
Neurobiology of Aging
July 2004
Plasma Levels of β-Amyloid(1-40), β-Amyloid(1-42), and Total β-Amyloid Remain Unaffecte...
Archives of Neurology
March 2004
Measurement of Phosphorylated Tau Epitopes in the Differential Diagnosisof Alzheimer Di...
Archives of General Psychiatry
January 2004
CSF markers for pathogenic processes in Alzheimer’s disease: diagnostic implications an...
Brain Research Bulletin
August 2003
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targe...
Journal of Neurochemistry
May 2003
Cerebrospinal fluid levels of total-tau, phospho-tau and Abeta42 predicts development o...
Acta Neurologica Scandinavica
February 2003
Unaltered Plasma Levels of β-Amyloid<sub>(1–40)</sub> and β-Amyloid<sub>(1–42)</sub> up...
Dementia and Geriatric Cognitive Disorders
January 2003
Association of CSF apolipoprotein E, Aβ42 and cognition in Alzheimer’s disease
Neurobiology of Aging
March 2002
Decreased CSF-β-Amyloid 42 in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis May...
Dementia and Geriatric Cognitive Disorders
January 2002
Low cerebrospinal fluid β-amyloid 42 in patients with acute bacterial meningitis and no...
Neuroscience Letters
November 2001
Cerebrospinal fluid τ and β-amyloid(1-42) in dementia disorders
Mechanisms of Ageing and Development
November 2001
An in vitro model for the study of microglia-induced neurodegeneration: involvement of ...
Neurochemistry International
June 2001
Evaluation of CSF-tau and CSF-Aβ42 as Diagnostic Markers for Alzheimer Disease in Clini...
Archives of Neurology
March 2001
CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from...
Neurological Sciences
February 2001
CSF Total tau, Aβ42 and Phosphorylated tau Protein as Biomarkers for Alzheimer's Disease
Molecular Neurobiology
January 2001
Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after ...
Neuroscience Letters
January 2001
Identification of two-dimensionally separated human cerebrospinal fluid proteins byN-te...
Electrophoresis
June 2000
Plasma Aβ42 as a diagnostic marker in sporadic Alzheimer's disease
Neurobiology of Aging
May 2000
CSF tau and beta amyloid may predict conversion from MCI to dementia
Neurobiology of Aging
May 2000
Unusual Aß amyloid deposition in Alzheimer's disease due to an APP T7141 mutation at th...
Neurobiology of Aging
May 2000
CSF-phospho-tau as a promising marker for discriminating Alzheimer disease from Lewy bo...
Neurobiology of Aging
May 2000
Subgroups of Alzheimer disease based on levels of CSF tau, ubiquitin and Aβ1−42
Neurobiology of Aging
May 2000
Standardization of measurement of β-amyloid(1-42)in cerebrospinal fluid and plasma
Amyloid
January 2000
Evidence That Aβ42 Plasma Levels in Presenilin-1 Mutation Carriers Do not Allow for Pre...
Neurobiology of Disease
August 1999
Cerebrospinal Fluid β-Amyloid(1-42) in Alzheimer Disease
Archives of Neurology
June 1999
The Glu318Gly Substitution in Presenilin 1 Is Not Causally Related to Alzheimer Disease
The American Journal of Human Genetics
January 1999
<i>Tau</i> Immunoreactivity Detected in Human Plasma, But No Obvious Increase in Dementia
Dementia and Geriatric Cognitive Disorders
January 1999
Postmortem changes in the phosphorylation state of tau-protein in the rat brain
Neurobiology of Aging
November 1998
Tau protein in the diagnosis of old-age dementia
Archives of Gerontology and Geriatrics
January 1998
Combination of the different biological markers for increasing specificity of in vivo A...
January 1998
Microtubule-associated protein tau in human fibroblasts with the Swedish Alzheimer muta...
Neuroscience Letters
December 1996
Developmental expression of tau proteins in the chicken and rat brain: Rapid down-regul...
International Journal of Developmental Neuroscience
October 1995
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and th...
Neuroscience Letters
April 1995
Tau protein in Alzheimer's disease
Biochemical Society Transactions
February 1995
Generation and characterization of mouse microglial cell lines
Journal of Neuroimmunology
July 1994
Detection of Proteins in Normal and Alzheimer's Disease Cerebrospinal Fluid with a Sens...
Journal of Neurochemistry
November 1993
Specific Neisseria gonorrhoeae DNA-Probes Derived from Ribosomal RNA
Microbiology
June 1989
CSF Markers for Early Alzheimer's Disease
