All Stories

  1. High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials

    Article • ACS Infectious Diseases, May 2021, American Chemical Society (ACS)

    Esther Fernandez

  2. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

    Article • ACS Chemical Biology, July 2020, American Chemical Society (ACS)

    Esther Fernandez

  3. A decade of malaria phenotypic screenings: Key lessons on the discovery and development of new antimalarial drugs

    Article • January 2019, Elsevier

    Esther Fernandez

  4. Efforts Aimed To Reduce Attrition in Antimalarial Drug Discovery: A Systematic Evaluation of the Current Antimalarial Targets Portfolio

    Article • ACS Infectious Diseases, January 2018, American Chemical Society (ACS)

    Esther Fernandez

  5. The first example in literature of a termination of an oral drug based on IV microdose data

    Article • British Journal of Clinical Pharmacology, December 2017, Wiley

    Malek Okour, Esther Fernandez

  6. The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Esther Fernandez

  7. Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Esther Fernandez

  8. Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives

    Article • ACS Medicinal Chemistry Letters, March 2014, American Chemical Society (ACS)

    Esther Fernandez

  9. A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery

    Article • PLoS ONE, June 2013, PLOS

    Esther Fernandez

  10. A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold

    Article • ACS Medicinal Chemistry Letters, February 2012, American Chemical Society (ACS)

    Esther Fernandez

  11. Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

    Article • Antimicrobial Agents and Chemotherapy, October 2011, ASM Journals

    Esther Fernandez

  12. Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS)

    Article • ACS Medicinal Chemistry Letters, September 2011, American Chemical Society (ACS)

    Esther Fernandez

  13. An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS

    Article • ACS Medicinal Chemistry Letters, August 2011, American Chemical Society (ACS)

    Esther Fernandez

  14. Corrections to Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series

    Article • Journal of Medicinal Chemistry, November 2010, American Chemical Society (ACS)

    Esther Fernandez

  15. Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series†

    Article • Journal of Medicinal Chemistry, August 2010, American Chemical Society (ACS)

    Esther Fernandez

  16. Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials

    Article • Journal of Medicinal Chemistry, May 2008, American Chemical Society (ACS)

    Esther Fernandez

  17. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 8. Computational Simulation of Ligand−Receptor Interaction of 5-HT1AR Agonists with Selectivity over α1-Adrenoceptors

    Article • Journal of Medicinal Chemistry, March 2005, American Chemical Society (ACS)

    Esther Fernandez

  18. Design and synthesis of S-(−)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

    Article • Bioorganic & Medicinal Chemistry Letters, April 2003, Elsevier

    Esther Fernandez

  19. Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines

    Article • Tetrahedron Letters, July 2002, Elsevier

    Esther Fernandez

  20. An improved two-resin method for the cleavage of tertiary amines from REM resin

    Article • Tetrahedron Letters, September 2001, Elsevier

    Dr Jose Luis Chiara, Esther Fernandez

  21. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT1A/α1-Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Lig...

    Article • Journal of Medicinal Chemistry, December 2000, American Chemical Society (ACS)

    Esther Fernandez

  22. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 5. Study of the Physicochemical Influence of the Pharmacophore on 5-HT1A/α1-Adrenergic Receptor Affinity:  Synthesis of a New Derivative with Mixed ...

    Article • Journal of Medicinal Chemistry, December 2000, American Chemical Society (ACS)

    Esther Fernandez

  23. Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl)piperazin-1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazole (EF-7412) using neural networks. A selective derivative with mixed antagonist properties

    Article • Bioorganic & Medicinal Chemistry Letters, June 1999, Elsevier

    Esther Fernandez

  24. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 4. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirem...

    Article • Journal of Medicinal Chemistry, December 1998, American Chemical Society (ACS)

    Esther Fernandez

  25. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT1A receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity

    Article • Bioorganic & Medicinal Chemistry Letters, March 1998, Elsevier

    Esther Fernandez

  26. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines:  Study of the Influence of the Terminal Amide F...

    Article • Journal of Medicinal Chemistry, August 1997, American Chemical Society (ACS)

    Esther Fernandez

  27. Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 2. Three-Dimensional Quantitative Structure−Activity Relationships of Hydantoin−Phenylpiperazine Derivatives with Affinity for 5-HT1A and α1 Recepto...

    Article • Journal of Medicinal Chemistry, May 1997, American Chemical Society (ACS)

    Esther Fernandez

  28. 1H and13C NMR Spectra ofN- Ethyl- andN-Phenyl-β-carboline-1- carboxamides. Assignments by One- and Two-Dimensional Methods

    Article • Magnetic Resonance in Chemistry, September 1996, Wiley

    Esther Fernandez

  29. .ALPHA.1-Adrenoceptor Reagents. Synthesis of Some 5,6,11,11a-Tetrahydro-1H-imidazo(1',5':1,6)pyrido and 5,6,11,11b-Tetrahydro-1H-imidazo(1',5':1,2)pyrido(3,4-b)indole-1,3(2H)-diones.

    Article • Chemical and Pharmaceutical Bulletin, January 1995, Pharmaceutical Society of Japan

    Esther Fernandez

  30. Reaction of 6-Hydroxytetrahydro-.BETA.-carboline-3-carboxylic Acids with Isocyanates and Isothiocyanates.

    Article • Chemical and Pharmaceutical Bulletin, January 1994, Pharmaceutical Society of Japan

    Esther Fernandez