All Stories

  1. Infection with Mycobacterium tuberculosis depletes host fatty acids in humans and non-human primates

    Article • EBioMedicine, March 2026, Elsevier

    Eric Anthony Ortlund

  2. Epitope mapping of diagnostic antibodies targeting SARS-CoV-2 nucleocapsid protein using hydrogen-deuterium exchange mass spectrometry

    Article • Biophysical Journal, December 2025, Elsevier

    Eric Anthony Ortlund

  3. Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancy

    Article • iScience, December 2025, Elsevier

    Eric Anthony Ortlund

  4. Integrative brain omics approach highlights sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia

    Article • Nature Communications, October 2025, Springer Science + Business Media

    Eric Anthony Ortlund

  5. The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins

    Article • Science Translational Medicine, September 2025, American Association for the Advancement of Science

    Eric Anthony Ortlund

  6. Abstract Fri166: Novel Insights into the Regulation of Cardiac Hydrogen Sulfide Production

    Article • Circulation Research, August 2025, Wolters Kluwer Health

    Eric Anthony Ortlund

  7. The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases

    Article • Nature Communications, July 2025, Springer Science + Business Media

    Eric Anthony Ortlund

  8. Abstract 2076 Antagonist-induced changes in coregulator preference of the nuclear receptor, liver receptor homolog-1

    Article • Journal of Biological Chemistry, May 2025, Elsevier

    Eric Anthony Ortlund

  9. Abstract 1477 Mapping affinity and allostery of human IgG antibody Fc region interactions with endoglycosidases, and comparison of fucosylated/afucosylated Fc region interactions with activating and inhibitory Fc γ Receptors

    Article • Journal of Biological Chemistry, May 2025, Elsevier

    Eric Anthony Ortlund

  10. Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung—Findings from MoTrPAC

    Article • April 2025, openRxiv

    Eric Anthony Ortlund

  11. Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  12. The Design and Immunogenicity of an HIV-1 Clade C Pediatric Envelope Glycoprotein Stabilized by Multiple Platforms

    Article • Vaccines, January 2025, MDPI AG

    Eric Anthony Ortlund

  13. Epitope mapping via in vitro deep mutational scanning methods and its applications

    Article • Journal of Biological Chemistry, January 2025, Elsevier

    Eric Anthony Ortlund

  14. Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog

    Article • Journal of Biological Chemistry, January 2025, Elsevier

    Eric Anthony Ortlund

  15. A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

    Article • npj Vaccines, December 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  16. Structural dynamics and binding of Caenorhabditis elegans lifespan‐extending lipid binding protein‐3 to polyunsaturated fatty acids

    Article • Protein Science, December 2024, Wiley

    Eric Anthony Ortlund

  17. Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

    Article • Nature, December 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  18. Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  19. Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study

    Article • November 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  20. Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance

    Article • Journal of Biological Chemistry, November 2024, Elsevier

    Eric Anthony Ortlund

  21. Structural basis of SARS-Cov-2 spike recognition by engineered synthetic multivalent VHH antibodies

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  22. Design and immunogenicity of an HIV-1 clade C pediatric envelope glycoprotein stabilized by multiple platforms

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  23. Structure, function, and lipid sensing activity in the thioesterase superfamily

    Article • Biochemical Society Transactions, August 2024, Portland Press Ltd.

    Eric Anthony Ortlund

  24. FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells

    Article • PLOS One, June 2024, PLOS

    Professor Brad E Morrison, Eric Anthony Ortlund

  25. Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

    Article • Nature Metabolism, May 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  26. Temporal dynamics of the multi-omic response to endurance exercise training

    Article • Nature, May 2024, Springer Science + Business Media

    Eric Anthony Ortlund

  27. 0035 Characterization of Metabolites in a Randomized, Controlled Trial of Clarithromycin for Pathological Sleepiness

    Article • SLEEP, April 2024, Oxford University Press (OUP)

    Eric Anthony Ortlund

  28. Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease

    Article • Metabolites, March 2024, MDPI AG

    Eric Anthony Ortlund

  29. Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer's dementia

    Article • February 2024, Research Square

    Eric Anthony Ortlund

  30. Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes

    Article • Molecular and Cellular Endocrinology, December 2023, Elsevier

    Eric Anthony Ortlund

  31. High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

    Article • Molecular Metabolism, December 2023, Elsevier

    Eric Anthony Ortlund

  32. Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers

    Article • iScience, November 2023, Elsevier

    Eric Anthony Ortlund

  33. Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants

    Article • Journal of Clinical Microbiology, October 2023, ASM Journals

    Eric Anthony Ortlund

  34. The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits

    Article • Protein Science, September 2023, Wiley

    Eric Anthony Ortlund

  35. Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron

    Article • Cell Reports, September 2023, Elsevier

    Eric Anthony Ortlund

  36. Correction to ‘DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining’

    Article • Nucleic Acids Research, August 2023, Oxford University Press (OUP)

    Eric Anthony Ortlund

  37. Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators

    Article • Journal of Biological Chemistry, August 2023, Elsevier

    Eric Anthony Ortlund

  38. DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining

    Article • Nucleic Acids Research, July 2023, Oxford University Press (OUP)

    Eric Anthony Ortlund

  39. Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund

    Article • Structure, July 2023, Elsevier

    Eric Anthony Ortlund

  40. Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis

    Article • Cancer Letters, July 2023, Elsevier

    Eric Anthony Ortlund

  41. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

    Article • Structure, July 2023, Elsevier

    Eric Anthony Ortlund

  42. APOE expression and secretion are modulated by mitochondrial dysfunction

    Article • eLife, May 2023, eLife

    Eric Anthony Ortlund

  43. Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice

    Article • Nature Communications, May 2023, Springer Science + Business Media

    Eric Anthony Ortlund

  44. START domain-mediated nuclear translocation of Them1 regulates the expression of metabolic genes relative to thermogenesis in brown adipocytes

    Article • Physiology, May 2023, American Physiological Society

    Eric Anthony Ortlund

  45. Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19

    Article • Nature Communications, April 2023, Springer Science + Business Media

    Eric Anthony Ortlund

  46. Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants

    Article • February 2023, openRxiv

    Eric Anthony Ortlund

  47. Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

    Article • February 2023, openRxiv

    Eric Anthony Ortlund

  48. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  49. African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids

    Article • Nutrients, December 2022, MDPI AG

    Eric Anthony Ortlund

  50. Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity

    Article • PLOS One, December 2022, PLOS

    Eric Anthony Ortlund

  51. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

    Article • Nature, November 2022, Springer Science + Business Media

    Eric Anthony Ortlund

  52. SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Eric Anthony Ortlund

  53. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

    Article • October 2022, openRxiv

    Eric Anthony Ortlund

  54. High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

    Article • October 2022, openRxiv

    Eric Anthony Ortlund

  55. Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody

    Article • Science Advances, October 2022, American Association for the Advancement of Science

    Eric Anthony Ortlund

  56. Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

    Article • Cell, September 2022, Elsevier

    Eric Anthony Ortlund

  57. A phospholipid mimetic targeting LRH-1 ameliorates colitis

    Article • Cell Chemical Biology, July 2022, Elsevier

    Eric Anthony Ortlund

  58. Lysosome lipid signalling from the periphery to neurons regulates longevity

    Article • Nature Cell Biology, June 2022, Springer Science + Business Media

    Eric Anthony Ortlund

  59. Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

    Article • May 2022, openRxiv

    Eric Anthony Ortlund

  60. APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  61. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket

    Article • Journal of Medicinal Chemistry, May 2022, American Chemical Society (ACS)

    Eric Anthony Ortlund

  62. Development and Characterization of Novel LRH‐1 Antagonist Using Structural and Computational Techniques

    Article • The FASEB Journal, May 2022, Wiley

    Eric Anthony Ortlund

  63. Don’t forget about human factors: Lessons learned from COVID-19 point-of-care testing

    Article • Cell Reports Methods, May 2022, Elsevier

    Eric Anthony Ortlund

  64. Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice

    Article • Journal of Lipids, March 2022, Hindawi Publishing Corporation

    Eric Anthony Ortlund

  65. Microbial metabolite delta-valerobetaine is a diet-dependent obesogen

    Article • Nature Metabolism, December 2021, Springer Science + Business Media

    Eric Anthony Ortlund

  66. Up‐regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice

    Article • Hepatology, December 2021, Wolters Kluwer Health

    Eric Anthony Ortlund

  67. Structural insights into glucocorticoid receptor function

    Article • Biochemical Society Transactions, October 2021, Portland Press Ltd.

    Eric Anthony Ortlund

  68. TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

    Article • PLoS Pathogens, September 2021, PLOS

    Eric Anthony Ortlund

  69. Evolutionary tuning of a key helix drove androgen selectivity

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  70. Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

    Article • Nucleic Acids Research, July 2021, Oxford University Press (OUP)

    Eric Anthony Ortlund

  71. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation

    Article • Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  72. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

    Article • Nature Communications, June 2021, Springer Science + Business Media

    Eric Anthony Ortlund

  73. Targeting Them1 for the Management of Obesity‐Related Disorders

    Article • The FASEB Journal, May 2021, Wiley

    Eric Anthony Ortlund

  74. Uniting features from strongly activating small molecules to develop chimeric LRH‐1 agonist

    Article • The FASEB Journal, May 2021, Wiley

    Eric Anthony Ortlund

  75. Suppression of Fatty Acid Oxidation by Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  76. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling

    Article • Nature Chemical Biology, January 2021, Springer Science + Business Media

    Eric Anthony Ortlund

  77. TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

    Article • January 2021, openRxiv

    Eric Anthony Ortlund

  78. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Eric Anthony Ortlund

  79. RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests

    Article • IEEE Open Journal of Engineering in Medicine and Biology, January 2021, Institute of Electrical & Electronics Engineers (IEEE)

    Eric Anthony Ortlund

  80. Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

    Article • Scientific Reports, December 2020, Springer Science + Business Media

    Eric Anthony Ortlund

  81. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  82. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

    Article • Nature Communications, October 2020, Springer Science + Business Media

    Eric Anthony Ortlund

  83. Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

    Article • Proceedings of the National Academy of Sciences, September 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  84. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

    Article • September 2020, openRxiv

    Eric Anthony Ortlund

  85. Acyl‐Coenzyme A Thioesterase 9 Traffics Mitochondrial Short‐Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver

    Article • Hepatology, September 2020, Wolters Kluwer Health

    Eric Anthony Ortlund

  86. A novel phospholipid mimetic targeting LRH-1 ameliorates colitis

    Article • September 2020, openRxiv

    Eric Anthony Ortlund

  87. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  88. A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  89. Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet

    Article • Gastroenterology, August 2020, Elsevier

    Eric Anthony Ortlund

  90. Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

    Article • Bioorganic & Medicinal Chemistry Letters, August 2020, Elsevier

    Eric Anthony Ortlund

  91. Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

    Article • Vaccines, July 2020, MDPI AG

    Eric Anthony Ortlund

  92. The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions

    Article • Cell Reports, July 2020, Elsevier

    Eric Anthony Ortlund

  93. Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling

    Article • June 2020, openRxiv

    Eric Anthony Ortlund

  94. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients

    Article • Cell Reports Medicine, June 2020, Elsevier

    Eric Anthony Ortlund

  95. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise

    Article • Science, May 2020, American Association for the Advancement of Science

    Eric Anthony Ortlund

  96. Development of picomolar liver receptor homolog‐1 agonist

    Article • The FASEB Journal, April 2020, Wiley

    Eric Anthony Ortlund

  97. Fragment‐Based Screening to Identify Thioesterase Superfamily Member 2 (Them2) Inhibitors for the Management of Obesity‐Related Disorders

    Article • The FASEB Journal, April 2020, Wiley

    Eric Anthony Ortlund

  98. The Them1 START Domain Regulates Nuclear Trafficking in Brown Adipocytes

    Article • The FASEB Journal, April 2020, Wiley

    Eric Anthony Ortlund

  99. Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl‐CoA Hydrolysis in Brown Adipose Tissue

    Article • The FASEB Journal, April 2020, Wiley

    Eric Anthony Ortlund

  100. Thioesterase Superfamily Member 1 Undergoes Stimulus‐coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue

    Article • The FASEB Journal, April 2020, Wiley

    Eric Anthony Ortlund

  101. Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

    Article • March 2020, openRxiv

    Eric Anthony Ortlund

  102. Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  103. Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolism

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  104. Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors

    Article • Structure, February 2020, Elsevier

    Eric Anthony Ortlund

  105. A behavioral polymorphism caused by a single gene inside a supergene

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  106. Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2020, Elsevier

    Eric Anthony Ortlund

  107. Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors

    Article • ACS Medicinal Chemistry Letters, November 2019, American Chemical Society (ACS)

    Eric Anthony Ortlund

  108. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Eric Anthony Ortlund

  109. First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain–Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

    Article • Molecular Pharmacology, August 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  110. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Eric Anthony Ortlund

  111. The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry

    Article • Biomolecules, May 2019, MDPI AG

    Eric Anthony Ortlund

  112. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

    Article • May 2019, openRxiv

    Eric Anthony Ortlund

  113. Distinct amino acid and lipid perturbations characterize acute versus chronic malaria

    Article • JCI Insight, May 2019, American Society for Clinical Investigation

    Professor Jessica C Kissinger, Eric Anthony Ortlund

  114. Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis

    Article • Hepatology, March 2019, Wolters Kluwer Health

    Eric Anthony Ortlund

  115. The nuclear receptor superfamily: A structural perspective

    Article • Protein Science, October 2018, Wiley

    Eric Anthony Ortlund

  116. High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans

    Article • PLOS One, October 2018, PLOS

    Eric Anthony Ortlund

  117. Ligand modulation of allosteric networks in an ancestral steroid receptor

    Article • September 2018, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  118. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Eric Anthony Ortlund

  119. Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1

    Article • ACS Medicinal Chemistry Letters, September 2018, American Chemical Society (ACS)

    Eric Anthony Ortlund

  120. Delimiting the autoinhibitory module of von Willebrand factor

    Article • Journal of Thrombosis and Haemostasis, August 2018, Wiley

    Eric Anthony Ortlund

  121. Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

    Article • Immunity, July 2018, Elsevier

    Eric Anthony Ortlund

  122. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

    Article • Nature Communications, April 2018, Springer Science + Business Media

    Eric Anthony Ortlund

  123. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus

    Article • Structure, January 2018, Elsevier

    Eric Anthony Ortlund

  124. Nucleotide Binding to ARL2 in the TBCD ∙ ARL2 ∙ β-Tubulin Complex Drives Conformational Changes in β-Tubulin

    Article • Journal of Molecular Biology, November 2017, Elsevier

    Eric Anthony Ortlund

  125. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

    Article • Nucleic Acids Research, June 2017, Oxford University Press (OUP)

    Eric Anthony Ortlund

  126. Elucidating the mechanism of LBP-8 shuttling of lysosomal lipids into the nucleus in C. elegans

    Article • Acta Crystallographica Section A Foundations and Advances, May 2017, International Union of Crystallography

    Eric Anthony Ortlund

  127. Targeting the nuclear receptor LRH-1 with synthetic agonists

    Article • Acta Crystallographica Section A Foundations and Advances, May 2017, International Union of Crystallography

    Eric Anthony Ortlund

  128. Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

    Article • Molecular Pharmacology, April 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  129. Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex

    Article • Molecular Pharmacology, March 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  130. Glucocorticoid receptor control of transcription: precision and plasticity via allostery

    Article • Nature Reviews Molecular Cell Biology, January 2017, Springer Science + Business Media

    Eric Anthony Ortlund

  131. A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1)

    Article • Journal of Molecular Biology, December 2016, Elsevier

    Eric Anthony Ortlund

  132. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists

    Article • Journal of Biological Chemistry, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  133. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  134. Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  135. Identification of a lipid scrambling domain in ANO6/TMEM16F

    Article • eLife, June 2015, eLife

    Eric Anthony Ortlund

  136. Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)

    Article • Journal of Biological Chemistry, February 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  137. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

    Article • Science, January 2015, American Association for the Advancement of Science

    Eric Anthony Ortlund

  138. Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

    Article • Nature Communications, November 2014, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund, Dr Graeme L Conn

  139. The structure, function and evolution of proteins that bind DNA and RNA

    Article • Nature Reviews Molecular Cell Biology, October 2014, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  140. Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA

    Article • PLOS One, September 2014, PLOS

    Mr William H Hudson, Eric Anthony Ortlund

  141. Evolution of DNA Specificity in a Transcription Factor Family Produced a New Gene Regulatory Module

    Article • Cell, September 2014, Elsevier

    Eric Anthony Ortlund

  142. Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway

    Article • Journal of Biological Chemistry, April 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  143. Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

    Article • Diabetes, March 2014, American Diabetes Association

    Eric Anthony Ortlund

  144. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis

    Article • Molecular Biology of the Cell, March 2014, American Society for Cell Biology (ASCB)

    Eric Anthony Ortlund

  145. Evolutionary history and metabolic insights of ancient mammalian uricases

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  146. Structure of glycerol dehydrogenase from Serratia

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2014, International Union of Crystallography

    Eric Anthony Ortlund

  147. Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes

    Article • Proceedings of the National Academy of Sciences, January 2014, Proceedings of the National Academy of Sciences

    Mr William H Hudson, Eric Anthony Ortlund

  148. Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

    Article • PLoS Genetics, January 2014, PLOS

    Eric Anthony Ortlund

  149. X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface

    Article • PLOS One, November 2013, PLOS

    Eric Anthony Ortlund

  150. Expression, purification and crystallization of the ancestral androgen receptor–DHT complex

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2013, International Union of Crystallography

    Eric Anthony Ortlund

  151. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors

    Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  152. Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  153. Phospholipid - Driven gene regulation

    Article • FEBS Letters, January 2013, Wiley

    Eric Anthony Ortlund

  154. Hydrophobic environment is a key factor for the stability of thermophilic proteins

    Article • Proteins Structure Function and Bioinformatics, January 2013, Wiley

    Eric Anthony Ortlund

  155. The structural basis of direct glucocorticoid-mediated transrepression

    Article • Nature Structural & Molecular Biology, December 2012, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  156. Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

    Article • PLoS Genetics, November 2012, PLOS

    Eric Anthony Ortlund

  157. Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation

    Article • ChemMedChem, September 2012, Wiley

    Eric Anthony Ortlund, Dr Simak Ali

  158. Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

    Article • Nature Structural & Molecular Biology, April 2012, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  159. Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors

    Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  160. Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2011, International Union of Crystallography

    Eric Anthony Ortlund

  161. Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

    Article • PLoS Genetics, June 2011, PLOS

    Eric Anthony Ortlund

  162. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

    Article • Nature, May 2011, Springer Science + Business Media

    Eric Anthony Ortlund

  163. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

    Article • Molecular Biology of the Cell, March 2011, American Society for Cell Biology (ASCB)

    Eric Anthony Ortlund

  164. Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

    Article • PLoS Biology, October 2010, PLOS

    Eric Anthony Ortlund

  165. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells

    Article • Breast Cancer Research and Treatment, July 2010, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund, Dr Simak Ali

  166. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  167. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

    Article • Nature, September 2009, Springer Science + Business Media

    Eric Anthony Ortlund

  168. Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily

    Article • Molecular Cell, February 2008, Elsevier

    Eric Anthony Ortlund

  169. Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

    Article • Science, August 2007, American Association for the Advancement of Science

    Eric Anthony Ortlund

  170. Structural features of the ligand binding site on human complement protein C8γ: A member of the lipocalin family

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, May 2007, Elsevier

    Eric Anthony Ortlund

  171. Crystal Structure of the Human LRH-1 DBD–DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity

    Article • Journal of Molecular Biology, December 2005, Elsevier

    Eric Anthony Ortlund

  172. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

    Article • Nature Structural & Molecular Biology, February 2005, Springer Science + Business Media

    Eric Anthony Ortlund

  173. Crystal structure of a covalent intermediate of endogenous human arylsulfatase A

    Article • Journal of Inorganic Biochemistry, August 2003, Elsevier

    Eric Anthony Ortlund

  174. Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design†,‡

    Article • Biochemistry, January 2003, American Chemical Society (ACS)

    Eric Anthony Ortlund

  175. Crystal Structure of Human Complement Protein C8γ at 1.2 Å Resolution Reveals a Lipocalin Fold and a Distinct Ligand Binding Site†,‡

    Article • Biochemistry, June 2002, American Chemical Society (ACS)

    Dr Wladek Minor, Eric Anthony Ortlund

  176. Reactions ofPseudomonas7A Glutaminase-Asparaginase with Diazo Analogues of Glutamine and Asparagine Result in Unexpected Covalent Inhibitions and Suggests an Unusual Catalytic Triad Thr-Tyr-Glu†,‡

    Article • Biochemistry, February 2000, American Chemical Society (ACS)

    Eric Anthony Ortlund