All Stories

  1. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation

    Article • Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  2. Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

    Article • Proceedings of the National Academy of Sciences, September 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  3. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  4. A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  5. Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

    Article • Vaccines, July 2020, MDPI AG

    Eric Anthony Ortlund

  6. The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions

    Article • Cell Reports, July 2020, Elsevier

    Eric Anthony Ortlund

  7. Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  8. Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolism

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  9. A behavioral polymorphism caused by a single gene inside a supergene

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  10. Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors

    Article • ACS Medicinal Chemistry Letters, November 2019, American Chemical Society (ACS)

    Eric Anthony Ortlund

  11. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Eric Anthony Ortlund

  12. First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain–Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

    Article • Molecular Pharmacology, August 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  13. The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry

    Article • Biomolecules, May 2019, MDPI AG

    Eric Anthony Ortlund

  14. The nuclear receptor superfamily: A structural perspective

    Article • Protein Science, October 2018, Wiley

    Eric Anthony Ortlund

  15. Ligand modulation of allosteric networks in an ancestral steroid receptor

    Article • September 2018, Cold Spring Harbor Laboratory Press

    Eric Anthony Ortlund

  16. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

    Article • Nature Communications, April 2018, Springer Science + Business Media

    Eric Anthony Ortlund

  17. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus

    Article • Structure, January 2018, Elsevier

    Eric Anthony Ortlund

  18. Nucleotide Binding to ARL2 in the TBCD ∙ ARL2 ∙ β-Tubulin Complex Drives Conformational Changes in β-Tubulin

    Article • Journal of Molecular Biology, November 2017, Elsevier

    Eric Anthony Ortlund

  19. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

    Article • Nucleic Acids Research, June 2017, Oxford University Press (OUP)

    Eric Anthony Ortlund

  20. Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

    Article • Molecular Pharmacology, April 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  21. Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex

    Article • Molecular Pharmacology, March 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Eric Anthony Ortlund

  22. Glucocorticoid receptor control of transcription: precision and plasticity via allostery

    Article • Nature Reviews Molecular Cell Biology, January 2017, Springer Science + Business Media

    Eric Anthony Ortlund

  23. A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1)

    Article • Journal of Molecular Biology, December 2016, Elsevier

    Eric Anthony Ortlund

  24. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists

    Article • Journal of Biological Chemistry, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  25. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  26. Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  27. Identification of a lipid scrambling domain in ANO6/TMEM16F

    Article • eLife, June 2015, eLife

    Eric Anthony Ortlund

  28. Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)

    Article • Journal of Biological Chemistry, February 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  29. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

    Article • Science, January 2015, American Association for the Advancement of Science

    Eric Anthony Ortlund

  30. Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

    Article • Nature Communications, November 2014, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  31. The structure, function and evolution of proteins that bind DNA and RNA

    Article • Nature Reviews Molecular Cell Biology, October 2014, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  32. Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA

    Article • PLoS ONE, September 2014, PLOS

    Mr William H Hudson, Eric Anthony Ortlund

  33. Evolution of DNA Specificity in a Transcription Factor Family Produced a New Gene Regulatory Module

    Article • Cell, September 2014, Elsevier

    Eric Anthony Ortlund

  34. Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway

    Article • Journal of Biological Chemistry, April 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  35. Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

    Article • Diabetes, March 2014, American Diabetes Association

    Eric Anthony Ortlund

  36. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis

    Article • Molecular Biology of the Cell, March 2014, American Society for Cell Biology (ASCB)

    Eric Anthony Ortlund

  37. Evolutionary history and metabolic insights of ancient mammalian uricases

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  38. Structure of glycerol dehydrogenase from Serratia

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2014, International Union of Crystallography

    Eric Anthony Ortlund

  39. Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes

    Article • Proceedings of the National Academy of Sciences, January 2014, Proceedings of the National Academy of Sciences

    Mr William H Hudson, Eric Anthony Ortlund

  40. Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

    Article • PLoS Genetics, January 2014, PLOS

    Eric Anthony Ortlund

  41. X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface

    Article • PLoS ONE, November 2013, PLOS

    Eric Anthony Ortlund

  42. Expression, purification and crystallization of the ancestral androgen receptor–DHT complex

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2013, International Union of Crystallography

    Eric Anthony Ortlund

  43. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors

    Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  44. Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  45. Phospholipid - Driven gene regulation

    Article • FEBS Letters, January 2013, Wiley

    Eric Anthony Ortlund

  46. Hydrophobic environment is a key factor for the stability of thermophilic proteins

    Article • Proteins Structure Function and Bioinformatics, January 2013, Wiley

    Eric Anthony Ortlund

  47. The structural basis of direct glucocorticoid-mediated transrepression

    Article • Nature Structural & Molecular Biology, December 2012, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  48. Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

    Article • PLoS Genetics, November 2012, PLOS

    Eric Anthony Ortlund

  49. Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation

    Article • ChemMedChem, September 2012, Wiley

    Eric Anthony Ortlund

  50. Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

    Article • Nature Structural & Molecular Biology, April 2012, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  51. Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors

    Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Eric Anthony Ortlund

  52. Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2011, International Union of Crystallography

    Eric Anthony Ortlund

  53. Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

    Article • PLoS Genetics, June 2011, PLOS

    Eric Anthony Ortlund

  54. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

    Article • Nature, May 2011, Springer Science + Business Media

    Eric Anthony Ortlund

  55. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

    Article • Molecular Biology of the Cell, March 2011, American Society for Cell Biology (ASCB)

    Eric Anthony Ortlund

  56. Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

    Article • PLoS Biology, October 2010, PLOS

    Eric Anthony Ortlund

  57. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells

    Article • Breast Cancer Research and Treatment, July 2010, Springer Science + Business Media

    Mr William H Hudson, Eric Anthony Ortlund

  58. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Eric Anthony Ortlund

  59. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

    Article • Nature, September 2009, Springer Science + Business Media

    Eric Anthony Ortlund

  60. Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily

    Article • Molecular Cell, February 2008, Elsevier

    Eric Anthony Ortlund

  61. Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

    Article • Science, August 2007, American Association for the Advancement of Science

    Eric Anthony Ortlund

  62. Structural features of the ligand binding site on human complement protein C8γ: A member of the lipocalin family

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, May 2007, Elsevier

    Eric Anthony Ortlund

  63. Crystal Structure of the Human LRH-1 DBD–DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity

    Article • Journal of Molecular Biology, December 2005, Elsevier

    Eric Anthony Ortlund

  64. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

    Article • Nature Structural & Molecular Biology, February 2005, Springer Science + Business Media

    Eric Anthony Ortlund

  65. Crystal structure of a covalent intermediate of endogenous human arylsulfatase A

    Article • Journal of Inorganic Biochemistry, August 2003, Elsevier

    Eric Anthony Ortlund

  66. Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design†,‡

    Article • Biochemistry, January 2003, American Chemical Society (ACS)

    Eric Anthony Ortlund

  67. Crystal Structure of Human Complement Protein C8γ at 1.2 Å Resolution Reveals a Lipocalin Fold and a Distinct Ligand Binding Site†,‡

    Article • Biochemistry, June 2002, American Chemical Society (ACS)

    Dr Wladek Minor, Eric Anthony Ortlund

  68. Reactions ofPseudomonas7A Glutaminase-Asparaginase with Diazo Analogues of Glutamine and Asparagine Result in Unexpected Covalent Inhibitions and Suggests an Unusual Catalytic Triad Thr-Tyr-Glu†,‡

    Article • Biochemistry, February 2000, American Chemical Society (ACS)

    Eric Anthony Ortlund