All Stories

  1. 2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones

    Article • Journal of Fluorine Chemistry, June 2020, Elsevier

    Dr Enrique Larghi

  2. Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

    Article • RSC Advances, January 2020, Royal Society of Chemistry

    Dr Enrique Larghi

  3. Rhodium(III)-Catalyzed C–H Activation-Based First Total Synthesis of 6-O-Methyl Anciscochine, an Alkaloid Isolated from Ancistrocladus tectorius

    Article • Synthesis, October 2019, Thieme Publishing Group

    Dr Enrique Larghi

  4. Convergent First Total Synthesis of Melovinone: A Densely Substituted 3-Methoxy-4-quinolone Isolated from Melochia tomentosa L.

    Article • Synthesis, August 2019, Thieme Publishing Group

    Dr Enrique Larghi

  5. Concise Synthesis of the ABC-Ring System of the Azafluoranthene, Tropoisoquinoline and Proaporphine Alkaloids: An Olefin Hydroacylation/Pomeranz–Fritsch Cyclization Approach

    Article • Synthesis, January 2019, Thieme Publishing Group

    Dr Enrique Larghi

  6. First total synthesis of ampullosine, a unique isoquinoline alkaloid isolated from Sepedonium ampullosporum, and of the related permethylampullosine

    Article • RSC Advances, January 2019, Royal Society of Chemistry

    Dr Enrique Larghi

  7. The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

    Article • Natural Product Reports, January 2019, Royal Society of Chemistry

    Dr Enrique Larghi

  8. Synthesis of Polysubstituted 3-Methylisoquinolines through the 6π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine

    Article • European Journal of Organic Chemistry, September 2018, Wiley

    Dr Enrique Larghi

  9. Efficient total synthesis of neocryptolepine and synthetic access to 6-methylquinindoline from a common intermediate

    Article • RSC Advances, January 2017, Royal Society of Chemistry

    Dr Enrique Larghi

  10. First total synthesis of the only known 2-isopropyliden-2H-benzofuran-3-one isolated from V. luetzelburgii

    Article • RSC Advances, January 2017, Royal Society of Chemistry

    Dr Enrique Larghi

  11. The 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products

    Article • Natural Product Reports, January 2016, Royal Society of Chemistry

    Dr Enrique Larghi

  12. A convenient approach to an advanced intermediate toward the naturally occurring, bioactive 6-substituted 5-hydroxy-4-aryl-1H-quinolin-2-ones

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Enrique Larghi

  13. Correction: A convenient approach to an advanced intermediate toward the naturally occurring, bioactive 6-substituted 5-hydroxy-4-aryl-1H-quinolin-2-ones

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Enrique Larghi

  14. Synthesis of symmetrically substituted 3,3-dibenzyl-4-hydroxy-3,4-dihydro-1H-quinolin-2-ones, as novel quinoline derivatives with antibacterial activity

    Article • European Journal of Medicinal Chemistry, June 2014, Elsevier

    Dr Enrique Larghi

  15. Modulators of complement activation: a patent review (2008 – 2013)

    Article • Expert Opinion on Therapeutic Patents, March 2014, Informa Healthcare

    Dr Enrique Larghi

  16. Two for one. Use of one reaction conditions employing two oxidation state palladium conditions.

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Teodoro S Kaufman, Sebastián Osvaldo Simonetti, Dr Enrique Larghi

  17. Angular tricyclic benzofurans and related natural products of fungal origin. Isolation, biological activity and synthesis

    Article • Natural Product Reports, January 2013, Royal Society of Chemistry

    Dr Enrique Larghi

  18. Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH

    Article • European Journal of Medicinal Chemistry, September 2012, Elsevier

    Dr Enrique Larghi

  19. Synthesis of the unique angular tricyclic chromone structure proposed for aspergillitine, and its relationship with alkaloid TMC-120B

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Dr Enrique Larghi

  20. New inhibitors of the complement system inspired in K76-COOH. A SAR study of filifolinol derivatives through modifications of the C3′ position

    Article • Bioorganic & Medicinal Chemistry Letters, November 2009, Elsevier

    Dr Enrique Larghi