All Stories

  1. Design, in Vitro Biological Activities and Molecular Dynamics Simulations of Novel Chalcone and Pyrazole Derivatives Targeting α-Glucosidase and PPAR-γ as Antidiabetic Agents

    Article • ACS Omega, August 2026, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  2. Therapeutic potential of sulfonate-based hydrazide hydrazones in neurodegenerative diseases: SAR insights and molecular modeling studies

    Article • Future Medicinal Chemistry, May 2026, Taylor & Francis

    Prof.Dr. Emine Elçin Oruç Emre

  3. Piperidine‐Based Hydrazones and Their Pt(II)/Pd(II) Complexes: Synthesis, Structural Characterization, In Vitro Anticancer Evaluation, and In Silico Studies

    Article • Drug Development Research, March 2026, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  4. New Sulfonate-Semicarbazone Hybrid Molecules: Synthesis, Theoretical Evaluations, Molecular Simulations, and Butyrylcholinesterase Inhibition Activity

    Article • ACS Omega, December 2025, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  5. Investigation of In vitro and In Silico Anticholinesterase Activities of Hydrazones Bearing 4-Iodobenzohydrazide Scaffolds

    Article • International Journal of Chemistry and Technology, November 2025, Kilis 7 Aralik Universitesi - International Journal of Chemistry and Technology

    Prof.Dr. Emine Elçin Oruç Emre

  6. Structure‐Based Design of Chiral Thioureas as Anticholinesterase Inhibitors Using Enantiopure α‐Methylbenzylamines: Synthesis, Enzyme Inhibition, and In Silico Studies

    Article • Archiv der Pharmazie, October 2025, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  7. Novel Pyrrolidine-Based Pyrazolines as α-Glucosidase Inhibitors: Microwave-Assisted Synthesis, Antidiabetic Activity, In Silico ADMET Prediction, Molecular Docking, and Molecular Dynamics Simulations

    Article • ACS Omega, September 2025, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  8. Design, Synthesis, Antidiabetic Activity and In Silico Studies of New Hydrazone Derivatives Derived from Acetohexamide

    Article • ACS Omega, September 2025, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  9. Design, Synthesis, Tyrosinase Inhibitors Activities and Molecular Docking of Novel Methylated Chalcones and Pyrazoles Having A Pyrrolidine Ring

    Article • Journal of Molecular Structure, September 2025, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  10. Synthesis, Conformational Analysis, Antioxidant and Enzyme Inhibition Activity, Molecular Docking, and DFT Studies of New Chiral Hydrazide–Hydrazone Derivatives

    Article • Chirality, June 2025, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  11. Thiophene-based hydrazones and their metal complexes: Synthesis, structure affirmation, antioxidant and cytotoxic activity, photoluminescence, molecular docking, and ADMET studies

    Article • Journal of Molecular Structure, June 2025, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  12. Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α-Amylase and α-Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening

    Article • ACS Omega, February 2025, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  13. Chiral thioureas containing naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, cholinesterase inhibition activity and molecular docking studies

    Article • Journal of Molecular Structure, January 2025, Elsevier

    Prof. Dr Tugba Taskin-Tok, Prof.Dr. Emine Elçin Oruç Emre

  14. Development of new chiral 1,2,4-triazole-3-thiones and 1,3,4-thiadiazoles with promising in vivo anticonvulsant activity targeting GABAergic system and voltage-gated sodium channels (VGSCs)

    Article • Bioorganic Chemistry, October 2024, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  15. Homoleptic metal complexes derived from hydrazones as ligand; synthesis, cytotoxic activity, photoluminescence properties and ADMET studies

    Article • Journal of Molecular Structure, May 2024, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  16. Discovery of New Dual-Target Agents Against PPAR-γ and α-Glucosidase Enzymes with Molecular Modeling Methods: Molecular Docking, Molecular Dynamic Simulations, and MM/PBSA Analysis

    Article • The Protein Journal, April 2024, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  17. Determination Of Inhibitory Effects of Newly Synthesized Potential HIF Inhibitors on Non-Small Cell Lung Cancer Under Hypoxic Conditions

    Article • Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, October 2023, Mugla Sitki Kocman University Journal of Education

    Prof.Dr. Emine Elçin Oruç Emre

  18. Design, Synthesis, Pharmacological Activities, Structure–Activity Relationship, and In Silico Studies of Novel 5-Substituted-2-(morpholinoimino)-thiazolidin-4-ones

    Article • ACS Omega, October 2023, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr Tugba Taskin-Tok

  19. Investigation of α‐glucosidase and α‐amylase inhibitory effects of phenoxy chalcones and molecular modeling studies

    Article • Journal of Molecular Recognition, September 2023, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  20. Synthesis, Antiproliferative Activity and In Silico Studies of Chalcones Derived From 4-(Imidazole-1-yl)Acetophenone

    Article • Journal of the Turkish Chemical Society Section A Chemistry, August 2023, Journal of the Turkish Chemical Society, Section A: Chemistry

    Prof.Dr. Emine Elçin Oruç Emre

  21. Design, in Silico Studies and Biological Evaluation of New Chiral Thiourea and 1,3‐Thiazolidine‐4,5‐dione Derivatives

    Article • Chemistry & Biodiversity, August 2023, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  22. Chalcones bearing nitrogen‐containing heterocyclics as multi‐targeted inhibitors: Design, synthesis, biological evaluation and molecular docking studies

    Article • Journal of Molecular Recognition, May 2023, Wiley

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr Tugba Taskin-Tok

  23. Benzoik Asitli Kalkonların Ksantin Oksidaz İnhibitörü Üzerine Etkisinin İncelenmesi

    Article • International Journal of Chemistry and Technology, December 2022, Kilis 7 Aralik Universitesi - International Journal of Chemistry and Technology

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr. Sevki Adem

  24. Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

    Article • International Journal of Chemistry and Technology, July 2022, Kilis 7 Aralik Universitesi - International Journal of Chemistry and Technology

    Prof.Dr. Emine Elçin Oruç Emre

  25. Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations

    Article • Pharmaceutical Chemistry Journal, July 2022, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  26. Experimental, spectroscopic and theoretical investigation of (+)-(R)-5-[1-(Benzenesulfonamido)-2-phenylethyl]-4-phenethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

    Article • Journal of Molecular Structure, March 2022, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  27. Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding affinity, in vitro antitumoral activities and in silico studies

    Article • New Journal of Chemistry, January 2022, Royal Society of Chemistry

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr Tugba Taskin-Tok

  28. The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma

    Article • International Journal of Chemistry and Technology, June 2021, Kilis 7 Aralik Universitesi - International Journal of Chemistry and Technology

    Prof.Dr. Emine Elçin Oruç Emre

  29. Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities and moleculer modeling studies on enzyme inhibition activities

    Article • TURKISH JOURNAL OF CHEMISTRY, January 2021, The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS

    Prof.Dr. Emine Elçin Oruç Emre

  30. One pot synthesis and spectral characterization of 5-Substitutedfuran-2-carbaldehyde N4-cyclohexyl thiosemicarbazones and their Ni(II) complexes

    Article • Turkish Journal of Analytical Chemistry, December 2020, Turkish Journal of Analytical Chemistry.

    Prof.Dr. Emine Elçin Oruç Emre

  31. Synthesis, characterization, antituberculosis activity and computational studies on novel Schiff bases of 1,3,4-thiadiazole derivatives

    Article • Journal of Research in Pharmacy, October 2020, ASOS Yayinevi

    Prof.Dr. Emine Elçin Oruç Emre

  32. Design and Bioevaluation of Novel Hydrazide-Hydrazones Derived from 4-Acetyl-N-Substituted Benzenesulfonamide

    Article • Russian Journal of Bioorganic Chemistry, September 2020, Pleiades Publishing Ltd

    Prof.Dr. Emine Elçin Oruç Emre

  33. Designing heterocyclic chalcones, benzoyl/sulfonyl hydrazones: An insight into their biological activities and molecular docking study

    Article • Journal of Molecular Structure, July 2020, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr Tugba Taskin-Tok

  34. Effect of Gum, Protein and Emulsifier Use at Different Ratios and Gelatinization on Rice Pasta Quality

    Article • Akademik Gıda, April 2020, Akademik Gida

    Prof.Dr. Emine Elçin Oruç Emre

  35. Synthesis, characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives

    Article • Journal of Heterocyclic Chemistry, December 2019, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  36. Novel fluorine-containing chiral hydrazide-hydrazones: Design, synthesis, structural elucidation, antioxidant and anticholinesterase activity, and in silico studies

    Article • Chirality, June 2019, Wiley

    Prof. Dr Tugba Taskin-Tok, Prof.Dr. Emine Elçin Oruç Emre

  37. Synthesis, Biological Evaluation and Ligand Based Pharmacophore Modeling of New Aromatic Thiosemicarbazones as Potential Anticancer Agents

    Article • Pharmaceutical Chemistry Journal, May 2019, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr Tugba Taskin-Tok

  38. synthesis and activity of heterocyclic compounds

    Article • Letters in Drug Design & Discovery, April 2019, Bentham Science Publishers

    Prof.Dr. Emine Elçin Oruç Emre, Selin ENGÜR ÖZTÜRK

  39. Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents

    Article • Chirality, April 2019, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  40. Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties

    Article • Archiv der Pharmazie, August 2018, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  41. Synthesis, characterization, spectroscopy, X-ray structure and gaussian hybrid computational investigation of (−)-(S)-1-[2-(benzenesulfonamido)-3-phenylpropanoyl]-4-[(4-methyl)phenyl]thiosemicarbazide

    Article • Phosphorus Sulfur and Silicon and the Related Elements, July 2018, Taylor & Francis

    Associate Professor Necmi Dege, Prof.Dr. Emine Elçin Oruç Emre

  42. Synthesis and biological evaluation of novel chalcones bearing morpholine moiety as antiproliferative agents

    Article • TURKISH JOURNAL OF CHEMISTRY, April 2018, The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr. Sevki Adem

  43. Synthesis of novel fluorinated chalcones derived from 4′-morpholinoacetophenone and their antiproliferative effects

    Article • Journal of Molecular Structure, December 2017, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre, Prof. Dr. Sevki Adem

  44. Synthesis and structure-activity relationship study: Anticancer chalcones derived from 4'-morpholinoacetophenone

    Article • Marmara Pharmaceutical Journal, October 2017, Marmara Pharmaceutical Journal

    Prof.Dr. Emine Elçin Oruç Emre

  45. X-ray structures and spectroscopic properties of chiral thiosemicarbazides as studied by computational calculations

    Article • Phosphorus Sulfur and Silicon and the Related Elements, February 2017, Taylor & Francis

    Associate Professor Necmi Dege, Prof.Dr. Emine Elçin Oruç Emre

  46. Design and Synthesis of Novel Thioureas Derived from 4-(4-Fluorophenoxy)aniline as Anticancer Agents

    Article • Journal of the Chinese Chemical Society, February 2017, Wiley

    Hasan Bayram, Prof.Dr. Emine Elçin Oruç Emre

  47. The potential BChE inhibitor

    Article • European Journal of Medicinal Chemistry, November 2016, Elsevier

    Prof. Dr Tugba Taskin-Tok, Prof.Dr. Emine Elçin Oruç Emre

  48. Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived fromD-andL-Phenylalanine Esters as Potential Anti-Influenza Agents

    Article • Chirality, May 2016, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  49. Microwave-assisted synthesis of new sulfonyl hydrazones, screening of biological activities and investigation of structure–activity relationship

    Article • Medicinal Chemistry Research, May 2016, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  50. Studies on Hydrazide-Hydrazon Derivatives As Acetylcholinesterase Inhibitors

    Article • Journal of Marmara University Institute of Health Sciences, January 2015, AVES Publishing Co.

    Prof.Dr. Emine Elçin Oruç Emre

  51. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Chiral Thiosemicarbazone Derivatives as Potent Anticancer Agents

    Article • Chirality, November 2014, Wiley

    Prof. Dr Tugba Taskin-Tok, Hasan Bayram, Prof.Dr. Emine Elçin Oruç Emre

  52. Synthesis, Characterization, and Biological Evaluation of Some Novel Thiosemicarbazones as Possible Antibacterial and Antioxidant Agents

    Article • Phosphorus Sulfur and Silicon and the Related Elements, October 2013, Taylor & Francis

    Prof.Dr. Emine Elçin Oruç Emre, Prof Dr Mehmet Ozaslan

  53. Supercritical Carbon Dioxide Fractionation of Anhydrous Milk Fat

    Article • Oil & Soap, October 2013, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  54. Biting deterrence and insecticidal activity of hydrazide-hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti

    Article • Pest Management Science, November 2012, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  55. Synthesis and biological activity of hydrazide–hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles

    Article • Medicinal Chemistry Research, November 2011, Springer Science + Business Media

    Dr Fatih Demirci, Prof.Dr. Emine Elçin Oruç Emre

  56. Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

    Article • European Journal of Medicinal Chemistry, November 2011, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  57. Anticonvulsant activity of 3,5-dimethylpyrazole derivatives in animal models

    Article • Medicinal Chemistry Research, May 2010, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  58. Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

    Article • Medicinal Chemistry Research, October 2008, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  59. Synthesis and characterization of novel hydrazide–hydrazones and the study of their structure–antituberculosis activity

    Article • European Journal of Medicinal Chemistry, November 2006, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  60. Synthesis of Some Novel Azo Derivatives of 3,5-Dimethly-1-(2-hydroxyethyl)pyrazole as Potent Analgesic Agents

    Article • Archiv der Pharmazie, May 2006, Wiley

    Prof.Dr. Emine Elçin Oruç Emre

  61. The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats

    Article • European Journal of Drug Metabolism and Pharmacokinetics, March 2006, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  62. High-pressure liquid chromatographic analysis for identification of in vitro and in vivo metabolites of 4-phenethyl-5-[4-(1-(2-hydroxyethyl)-3,5-dimethyl-4-pyrazolylazo)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

    Article • Journal of Chromatography B, February 2006, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  63. 1,3,4-Thiadiazole Derivatives. Synthesis, Structure Elucidation, and Structure−Antituberculosis Activity Relationship Investigation

    Article • Journal of Medicinal Chemistry, December 2004, American Chemical Society (ACS)

    Prof.Dr. Emine Elçin Oruç Emre

  64. Thein vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

    Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2003, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  65. Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds

    Article • European Journal of Medicinal Chemistry, March 2002, Elsevier

    Prof.Dr. Emine Elçin Oruç Emre

  66. In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl) methylene] hydrazide in rats

    Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2000, Springer Science + Business Media

    Prof.Dr. Emine Elçin Oruç Emre

  67. THE IN VITRO HEPATIC MICROSOMAL METABOLISM OF 3,5-DIMETHYL-4-(PHENYLAZO)-(1H)-PYRAZOLE IN RATS

    Article • Drug Metabolism and Drug Interactions, January 1999, De Gruyter

    Prof.Dr. Emine Elçin Oruç Emre

  68. THE IN VIVO METABOLISM OF 5-(4-NITROPHENYL)- 4-PHENYL-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE IN RATS

    Article • Drug Metabolism and Drug Interactions, January 1999, De Gruyter

    Prof.Dr. Emine Elçin Oruç Emre