All Stories

  1. Multi‐Target Rational Design and Synthesis of Some 2‐Quinolinone Antitumor Candidates Downregulating the Expression of EGFR, VEGFR‐2, and Telomerase With Apoptotic Potential

    Article • Drug Development Research, October 2025, Wiley

    Dr Eman A. E. El-Helw

  2. Synthesis and In Silico Evaluation of Thiazole, Thiazolidinone, and Pyrimidinethione Candidates Bearing A Benzo[ h ]Quinoline Scaffold as Potential Antiproliferative Agents

    Article • Polycyclic Aromatic Compounds, September 2025, Taylor & Francis

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  3. Synthesis of Benzo[h]quinoline derivatives and evaluation of their insecticidal activity against Culex pipiens L. larvae

    Article • European Journal of Medicinal Chemistry, June 2025, Elsevier

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  4. Design, synthesis, and in silico studies of pyrazolyl-thiazole and thiazolidinone hybrids as potential antiproliferative agents

    Article • Synthetic Communications, June 2025, Taylor & Francis

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  5. Antioxidant activity, molecular docking, and modeling pharmacokinetics study of some benzo[f]quinoline candidates

    Article • Scientific Reports, May 2025, Springer Science + Business Media

    Dr Eman A. E. El-Helw

  6. Design, Synthesis, Antiproliferative Activity and In Silico Studies of 2-Oxo-1,2-Dihydroquinolin Derivatives

    Article • Polycyclic Aromatic Compounds, February 2025, Taylor & Francis

    Dr Eman A. E. El-Helw

  7. Synthesis, in vivo evaluation, and in silico molecular docking of benzo[h]quinoline derivatives as potential Culex pipiens L. larvicides

    Article • Bioorganic Chemistry, January 2025, Elsevier

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  8. Synthesis, antiproliferative activity, and in silico studies of quinoline-based pyrimidinedione and thiazolidinedione derivatives

    Article • Synthetic Communications, October 2024, Taylor & Francis

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  9. Synthesis, insecticidal Activity, and molecular docking analysis of some benzo[h]quinoline derivatives against Culex pipiens L. Larvae

    Article • Bioorganic Chemistry, September 2024, Elsevier

    Dr Eman A. E. El-Helw

  10. Synthesis and in silico studies of certain benzo[f]quinoline-based heterocycles as antitumor agents

    Article • Scientific Reports, July 2024, Springer Science + Business Media

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  11. Synthesis and Biological Applications of Coumarinyl-Chalcones

    Article • Current Organic Chemistry, June 2024, Bentham Science Publishers

    Dr Eman A. E. El-Helw, Professor sameh rizk, Dr. Sayed K. Ramadan, Professor Sameh Ahmed Rizk

  12. Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide

    Article • Future Medicinal Chemistry, February 2024, Taylor & Francis

    Dr Eman A. E. El-Helw

  13. Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone derivatives

    Article • RSC Advances, January 2024, Royal Society of Chemistry

    Dr Eman A. E. El-Helw, doctor Amna s. Elgubbi, Dr. Sayed K. Ramadan

  14. β-Enaminonitrile in the synthesis of tetrahydrobenzo[b]thiophene candidates with DFT simulation, in vitro antiproliferative assessment, molecular docking, and modeling pharmacokinetics

    Article • RSC Advances, January 2024, Royal Society of Chemistry

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  15. Synthesis, Cytotoxic, and Antioxidant Activity of Some Benzoquinoline-Based Heterocycles

    Article • Polycyclic Aromatic Compounds, October 2023, Taylor & Francis

    Dr Eman A. E. El-Helw

  16. Synthesis and Antioxidant Activity of Some Benzoquinoline-Based Heterocycles Derived from 2-((3-Chlorobenzo[f]quinolin-2-yl)methylene)hydrazine-1-carbothioamide

    Article • Journal of the Iranian Chemical Society, September 2023, Springer Science + Business Media

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  17. Synthesis and cytotoxicity evaluation of novel 1,8-acridinedione derivatives bearing phthalimide moiety as potential antitumor agents

    Article • Scientific Reports, September 2023, Springer Science + Business Media

    Dr Eman A. E. El-Helw

  18. Synthesis and antioxidant, antimicrobial, and antiviral activity of some pyrazole-based heterocycles using a 2(3H)-furanone derivative

    Article • Journal of the Iranian Chemical Society, June 2023, Springer Science + Business Media

    Dr Eman A. E. El-Helw

  19. Facile Synthesis and Antioxidant Activity Screening of Some Novel 3-Substituted Indole Derivatives

    Article • Polycyclic Aromatic Compounds, May 2023, Taylor & Francis

    Dr Eman A. E. El-Helw, doctor Amna s. Elgubbi

  20. Synthesis and antioxidant activity of some pyrazole-based heterocycles using a 2(3H)-furanone building block

    Article • Synthetic Communications, February 2023, Taylor & Francis

    Dr Eman A. E. El-Helw

  21. Synthesis, Density Functional Theory, Insecticidal Activity, and Molecular Docking of Some N-Heterocycles Derived from 2-((1,3-Diphenyl-1H-Pyrazol-4-yl)Methylene)Malonyl Diisothiocyanate

    Article • Polycyclic Aromatic Compounds, November 2022, Taylor & Francis

    Dr Eman A. E. El-Helw, Professor Sameh Ahmed Rizk

  22. Synthesis and Antiproliferative Screening of Some Heterocycles Derived from 4-((5-Chloro-3-Methyl-1-Phenyl-1H-Pyrazol-4-yl)Methylene)-2-Phenyloxazol-5(4H)-One

    Article • Polycyclic Aromatic Compounds, October 2022, Taylor & Francis

    Dr Eman A. E. El-Helw

  23. Facile Synthesis, Biological Evaluation, DFT Studies and in Silico Prediction ADME/Pharmacokinetics Properties of N-(1-(2-Chlorobenzo[h]Quinolin-3-yl)-1-Substituted-vin-2-yl)Benzamide Derivatives

    Article • Polycyclic Aromatic Compounds, September 2022, Taylor & Francis

    Dr Eman A. E. El-Helw, Professor Sameh Ahmed Rizk

  24. 3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and Reactions with Binucleophiles Targeting Heterocycles

    Article • Egyptian Journal of Chemistry, August 2022, Egypts Presidential Specialized Council for Education and Scientific Research

    prof. Ahmed Kamel EL-ziaty, Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  25. Ultrasonic Promoted Regioselective Reactions of the Novel Spiro 3,1-Benzoxazon-Isobenzofuranone Dye Toward Some Organic Base Reagents

    Article • Polycyclic Aromatic Compounds, April 2022, Taylor & Francis

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan, Professor Sameh Ahmed Rizk

  26. Synthesis, DFT and Antitumor Activity Screening of Some New Heterocycles Derived from 2,2'-(2-(1,3-Diphenyl-1H-Pyrazol-4-yl)Ethene-1,1-Diyl)Bis(4H-Benzo[d][1,3]Oxazin-4-One)

    Article • Polycyclic Aromatic Compounds, December 2021, Taylor & Francis

    Dr Eman A. E. El-Helw, Professor Sameh Ahmed Rizk

  27. Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-2-phenyloxazol-5(4H)-one

    Article • Bioorganic Chemistry, July 2021, Elsevier

    Dr Eman A. E. El-Helw

  28. New potential fungicides pyrazole-based heterocycles derived from 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl) acryloyl isothiocyanate

    Article • Journal of Sulfur Chemistry, March 2021, Taylor & Francis

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  29. Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

    Article • Synthetic Communications, February 2021, Taylor & Francis

    Dr Eman A. E. El-Helw, prof. Ahmed Kamel EL-ziaty, Dr. Sayed K. Ramadan

  30. Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as antioxidant agents

    Article • Journal of Sulfur Chemistry, January 2021, Taylor & Francis

    Dr Eman A. E. El-Helw

  31. Evaluation of Some New Heterocycles Bearing 2‐Oxoquinolyl Moiety as Immunomodulator Against Highly Pathogenic Avian Influenza Virus ( H 5 N 8 ...

    Article • Journal of Heterocyclic Chemistry, January 2021, Wiley

    Dr Eman A. E. El-Helw

  32. Synthesis and antioxidant screening of new 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl amide derivatives and some pyrazole-based heterocycles

    Article • Synthetic Communications, May 2020, Taylor & Francis

    Dr Eman A. E. El-Helw

  33. Synthesis of chromenone, pyrimidinone, thiazoline, and quinolone derivatives as prospective antitumor agents

    Article • Journal of Heterocyclic Chemistry, March 2020, Wiley

    Dr Eman A. E. El-Helw

  34. Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one

    Article • Synthetic Communications, February 2020, Taylor & Francis

    Dr Eman A. E. El-Helw

  35. Synthesis and anti-rotavirus activity of some nitrogen heterocycles integrated with pyrazole scaffold

    Article • Journal of the Iranian Chemical Society, February 2020, Springer Science + Business Media

    Dr Eman A. E. El-Helw, prof. Ahmed Kamel EL-ziaty

  36. Development of Chromone–Pyrazole-Based Anticancer Agents

    Article • Russian Journal of Bioorganic Chemistry, January 2020, Pleiades Publishing Ltd

    Dr Eman A. E. El-Helw

  37. 2-Cyano-N′-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]acetohydrazide in the Synthesis of Nitrogen Heterocycles

    Article • Russian Journal of Organic Chemistry, December 2019, Pleiades Publishing Ltd

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  38. Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

    Article • Heterocyclic Communications, November 2019, De Gruyter

    Dr. Sayed K. Ramadan, Dr Eman A. E. El-Helw

  39. Efficient Microwave-Assisted Synthesis of Some N-Heterocycles Integrated with a Pyrazole Moiety

    Article • Russian Journal of Organic Chemistry, October 2019, Pleiades Publishing Ltd

    Dr Eman A. E. El-Helw, Dr. Sayed K. Ramadan

  40. Antioxidant activity of some N-heterocycles derived from 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide

    Article • Synthetic Communications, August 2019, Taylor & Francis

    Dr Eman A. E. El-Helw, doctor Amna s. Elgubbi

  41. Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety

    Article • Russian Journal of Bioorganic Chemistry, January 2019, Pleiades Publishing Ltd

    Dr Eman A. E. El-Helw

  42. Synthesis and antimicrobial activity evaluation

    Article • Journal of Chemical Research, June 2018, SAGE Publications

    Dr. Sayed K. Ramadan, Dr Eman A. E. El-Helw