All Stories

  1. Longitudinal basal forebrain atrophy in association with amyloid‐β positivity and dementia severity

    Article • Alzheimer s & Dementia, June 2023, Wiley

    Prof Elizabeth J Coulson

  2. Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment

    Article • Alzheimer s & Dementia, June 2023, Wiley

    Prof Elizabeth J Coulson

  3. Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory

    Article • Journal of Neurochemistry, January 2023, Wiley

    Prof Elizabeth J Coulson

  4. Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Prof Elizabeth J Coulson

  5. The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model

    Article • Neurobiology of Aging, September 2022, Elsevier

    Prof Elizabeth J Coulson

  6. Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Prof Elizabeth J Coulson

  7. Frailty and Treatment-Resistant Schizophrenia: A Retrospective Cohort Study

    Article • Community Mental Health Journal, July 2022, Springer Science + Business Media

    Prof Elizabeth J Coulson

  8. Frailty and severe mental illness: A systematic review and narrative synthesis

    Article • Journal of Psychiatric Research, March 2022, Elsevier

    Prof Elizabeth J Coulson

  9. High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair

    Article • Journal of Biological Chemistry, March 2022, Elsevier

    Prof Elizabeth J Coulson

  10. Up-regulation of proBDNF/p75 NTR signaling in antibody-secreting cells drives systemic lupus erythematosus

    Article • Science Advances, January 2022, American Association for the Advancement of Science

    Prof Elizabeth J Coulson

  11. Sleep and circadian rhythms in Parkinson’s disease and preclinical models

    Article • Molecular Neurodegeneration, January 2022, Springer Science + Business Media

    Prof Elizabeth J Coulson

  12. Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment

    Article • NeuroImage Clinical, January 2022, Elsevier

    Prof Elizabeth J Coulson

  13. Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?

    Article • Journal of Neurochemistry, July 2021, Wiley

    Prof Elizabeth J Coulson

  14. Fast-Trk(B)ing the mechanism of antidepressants

    Article • Neuron, May 2021, Elsevier

    Prof Elizabeth J Coulson

  15. Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions

    Article • The International Journal of Biochemistry & Cell Biology, May 2021, Elsevier

    Prof Elizabeth J Coulson

  16. Identification of 14-3-3 epsilon as a regulator of the neural apoptotic pathway for chronic-stress-induced depression

    Article • iScience, February 2021, Elsevier

    Prof Elizabeth J Coulson

  17. A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

    Article • Journal of Neurochemistry, July 2020, Wiley

    Prof Elizabeth J Coulson

  18. Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease

    Article • Clinical and Experimental Pharmacology and Physiology, July 2020, Wiley

    Prof Elizabeth J Coulson

  19. Partial deletion of p75 NTR in large‐diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo

    Article • Journal of Neuroscience Research, June 2020, Wiley

    Prof Elizabeth J Coulson

  20. Cholinergic basal forebrain degeneration due to obstructive sleep apnoea increases Alzheimer’s pathology in mice

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Prof Elizabeth J Coulson

  21. A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Prof Elizabeth J Coulson

  22. Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus

    Article • Developmental Neurobiology, September 2019, Wiley

    Prof Elizabeth J Coulson

  23. p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model

    Article • Journal of Neuroscience, July 2019, Society for Neuroscience

    Prof Elizabeth J Coulson

  24. Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI

    Article • NeuroImage, July 2019, Elsevier

    Prof Elizabeth J Coulson

  25. Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression

    Article • Frontiers in Cellular Neuroscience, May 2019, Frontiers

    Prof Elizabeth J Coulson

  26. Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model

    Article • Neurobiology of Aging, May 2019, Elsevier

    Prof Elizabeth J Coulson

  27. Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

    Article • Neuronal Signaling, February 2019, Portland Press Ltd.

    Prof Elizabeth J Coulson

  28. The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex

    Article • Development, January 2019, The Company of Biologists

    Prof Elizabeth J Coulson

  29. Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice

    Article • Molecular Neurobiology, October 2018, Springer Science + Business Media

    Prof Elizabeth J Coulson

  30. Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling

    Article • Translational Psychiatry, September 2018, Springer Science + Business Media

    Prof Elizabeth J Coulson

  31. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

    Article • Frontiers in Molecular Neuroscience, February 2018, Frontiers

    Prof Elizabeth J Coulson

  32. G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

    Article • Frontiers in Neuroscience, August 2017, Frontiers

    Prof Elizabeth J Coulson

  33. [P3–350]: GLOBAL TAU BURDEN CORRELATES WITH BASAL FOREBRAIN ATROPHY IN HEALTHY AGING SUBJECTS

    Article • Alzheimer s & Dementia, July 2017, Wiley

    Prof Elizabeth J Coulson

  34. An exercise path to preventing Alzheimer's disease

    Article • Journal of Neurochemistry, May 2017, Wiley

    Prof Elizabeth J Coulson

  35. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice

    Article • Journal of Alzheimer s Disease, December 2016, IOS Press

    Prof Elizabeth J Coulson

  36. Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

    Article • Nature Communications, September 2016, Springer Science + Business Media

    Prof Elizabeth J Coulson

  37. Signaling and Function of Death Receptors of the Tumor Necrosis Factor Receptor Superfamily

    Article • January 2016, Elsevier

    Prof Elizabeth J Coulson

  38. The A‐B‐C for SORting APP

    Article • Journal of Neurochemistry, September 2015, Wiley

    Prof Elizabeth J Coulson

  39. Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

    Article • Journal of Cell Science, January 2015, The Company of Biologists

    Prof Elizabeth J Coulson

  40. Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease

    Article • NeuroImage Clinical, January 2015, Elsevier

    Prof Elizabeth J Coulson

  41. Ab-Induced Zn 2+ Influx: Short-Term Cognition Deficits

    Article • PLoS ONE, December 2014, PLOS

    Prof Elizabeth J Coulson

  42. Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease

    Article • Clinical and Experimental Pharmacology and Physiology, October 2014, Wiley

    Professor Maree Therese Smith, Prof Elizabeth J Coulson

  43. The Role of p75NTRin Cholinergic Basal Forebrain Structure and Function

    Article • Journal of Neuroscience, September 2014, Society for Neuroscience

    Prof Elizabeth J Coulson

  44. Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport

    Article • Seminars in Cell and Developmental Biology, July 2014, Elsevier

    Prof Elizabeth J Coulson

  45. A role for SNAREs in neuronal survival?

    Article • Journal of Neurochemistry, April 2014, Wiley

    Prof Elizabeth J Coulson

  46. Up‐regulation of sortilin mediated by amyloid‐β and p75NTR: safety lies in the middle course

    Article • Journal of Neurochemistry, August 2013, Wiley

    Prof Elizabeth J Coulson

  47. An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function

    Article • Journal of Biological Chemistry, April 2013, Elsevier

    Prof Elizabeth J Coulson

  48. Inhibiting PIKfyve with YM-201636: Autophagy Dysregulation and Apoptosis-Free Neuronal Cell Death

    Article • PLoS ONE, March 2013, PLOS

    Prof Elizabeth J Coulson

  49. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Prof Elizabeth J Coulson

  50. Spatial navigation in young versus older adults

    Article • Frontiers in Aging Neuroscience, January 2013, Frontiers

    Prof Elizabeth J Coulson

  51. Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

    Article • Journal of Biological Chemistry, December 2012, Elsevier

    Prof Elizabeth J Coulson

  52. The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase

    Article • Journal of Biological Chemistry, December 2012, Elsevier

    Prof Elizabeth J Coulson

  53. Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

    Article • BioEssays, March 2012, Wiley

    Prof Elizabeth J Coulson

  54. Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

    Article • BioEssays, June 2011, Wiley

    Prof Elizabeth J Coulson

  55. Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease

    Article • Progress in Neurobiology, April 2011, Elsevier

    Prof Elizabeth J Coulson

  56. Reduction in Post-Synaptic Scaffolding PSD-95 and SAP-102 Protein Levels in the Alzheimer Inferior Temporal Cortex is Correlated with Disease Pathology

    Article • Journal of Alzheimer s Disease, September 2010, IOS Press

    Prof Elizabeth J Coulson

  57. p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis

    Article • Experimental Brain Research, July 2009, Springer Science + Business Media

    Prof Elizabeth J Coulson

  58. The Role of the p75 Neurotrophin Receptor in Cholinergic Dysfunction in Alzheimer's Disease

    Article • The Neuroscientist, May 2009, SAGE Publications

    Prof Elizabeth J Coulson

  59. The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours

    Article • European Journal of Neuroscience, August 2008, Wiley

    Prof Elizabeth J Coulson

  60. Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by γ-secretase

    Article • Molecular and Cellular Neuroscience, February 2008, Elsevier

    Prof Elizabeth J Coulson

  61. p75 Neurotrophin Receptor Mediates Neuronal Cell Death by Activating GIRK Channels through Phosphatidylinositol 4,5-Bisphosphate

    Article • Journal of Neuroscience, January 2008, Society for Neuroscience

    Prof Elizabeth J Coulson

  62. Zinc-mediated neuronal death is dependent on Trk activation

    Article • Experimental Neurology, June 2007, Elsevier

    Prof Elizabeth J Coulson

  63. Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines

    Article • Schizophrenia Research, May 2006, Elsevier

    Prof Elizabeth J Coulson

  64. Neural progenitor number is regulated by nuclear factor-κB p65 and p50 subunit-dependent proliferation rather than cell survival

    Article • Journal of Neuroscience Research, January 2006, Wiley

    Prof Elizabeth J Coulson

  65. A microarray study of post-mortem mRNA degradation in mouse brain tissue

    Article • Molecular Brain Research, August 2005, Elsevier

    Prof Elizabeth J Coulson

  66. Bee venom peptide blocks potassium channels

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Distinguished Professor David J. Adams, Prof Elizabeth J Coulson

  67. The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling

    Article • January 2004, Elsevier

    Prof Elizabeth J Coulson

  68. Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons

    Article • Clinical and Experimental Pharmacology and Physiology, April 2003, Wiley

    Prof Elizabeth J Coulson

  69. The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

    Article • Cell Death and Differentiation, December 2002, Springer Science + Business Media

    Prof Elizabeth J Coulson

  70. Systemic administration of antisense p75NTR oligodeoxynucleotides rescues axotomised spinal motor neurons

    Article • Journal of Neuroscience Research, March 2001, Wiley

    Prof Elizabeth J Coulson

  71. Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death

    Article • Journal of Biological Chemistry, September 2000, Elsevier

    Prof Elizabeth J Coulson

  72. Role Of Neurotrophin Receptor p75NTR In Mediating Neuronal Cell Death Following Injury

    Article • Clinical and Experimental Pharmacology and Physiology, July 2000, Wiley

    Prof Elizabeth J Coulson

  73. What the evolution of the amyloid protein precursor supergene family tells us about its function

    Article • Neurochemistry International, March 2000, Elsevier

    Prof Elizabeth J Coulson

  74. Signaling of neuronal cell death by the p75NTR neurotrophin receptor

    Article • Molecular Neurobiology, August 1999, Springer Science + Business Media

    Prof Elizabeth J Coulson

  75. p75 Neurotrophin Receptor-mediated Neuronal Death Is Promoted by Bcl-2 and Prevented by Bcl-xL

    Article • Journal of Biological Chemistry, June 1999, Elsevier

    Prof Elizabeth J Coulson

  76. Enhanced Downregulation of the p75 Nerve Growth Factor Receptor by Cholesteryl and Bis-Cholesteryl Antisense Oligonucleotides

    Article • Antisense and Nucleic Acid Drug Development, December 1998, Mary Ann Liebert Inc

    Prof Elizabeth J Coulson

  77. Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts

    Article • Trends in Biochemical Sciences, May 1998, Elsevier

    Prof Elizabeth J Coulson

  78. Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata

    Article • Brain Research, October 1997, Elsevier

    Prof Elizabeth J Coulson

  79. 324 The effect of oral zinc supplementation on the amyloid precursor protein of Alzheimer's disease in human plasma and rat brain

    Article • Neurobiology of Aging, January 1996, Elsevier

    Prof Elizabeth J Coulson

  80. BACULOVIRAL LESSONS IN APOPTOSIS

    Article • Taylor & Francis

    Prof Elizabeth J Coulson