All Stories

  1. Angiotensin II cyclic analogs as tools to investigate AT 1 R biased signaling mechanisms

    Article • Biochemical Pharmacology, August 2018, Elsevier

    Elie Besserer-Offroy

  2. Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8–13)

    Article • Journal of Medicinal Chemistry, July 2018, American Chemical Society (ACS)

    Elie Besserer-Offroy

  3. Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses

    Article • Pharmacological Research, June 2018, Elsevier

    Elie Besserer-Offroy

  4. The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment

    Article • Pharmacological Research, May 2018, Elsevier

    Elie Besserer-Offroy

  5. In Search of the Optimal Macrocyclization Site for Neurotensin

    Article • ACS Medicinal Chemistry Letters, January 2018, American Chemical Society (ACS)

    Elie Besserer-Offroy

  6. Agonist-Antagonist Transition in CXCR4 Ligands

    Article • Journal of Pharmacological and Toxicological Methods, November 2017, Elsevier

    Elie Besserer-Offroy

  7. Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues

    Article • Journal of Medicinal Chemistry, April 2017, American Chemical Society (ACS)

    Elie Besserer-Offroy

  8. The signaling signature of the neurotensin type 1 receptor with endogenous ligands

    Article • European Journal of Pharmacology, March 2017, Elsevier

    Elie Besserer-Offroy

  9. Structure–activity relationship of novel macrocyclic biased apelin receptor agonists

    Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

    Elie Besserer-Offroy

  10. Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

    Article • ACS Chemical Neuroscience, September 2016, American Chemical Society (ACS)

    Elie Besserer-Offroy

  11. Structure–Activity Relationship and Signaling of New Chimeric CXCR4 Agonists

    Article • Journal of Medicinal Chemistry, August 2016, American Chemical Society (ACS)

    Elie Besserer-Offroy

  12. Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions

    Article • Journal of Medicinal Chemistry, April 2016, American Chemical Society (ACS)

    Elie Besserer-Offroy

  13. Stereoselective Synthesis of β-(5-Arylthiazolyl) α-Amino Acids and Use in Neurotensin Analogues

    Article • European Journal of Organic Chemistry, January 2016, Wiley

    Elie Besserer-Offroy

  14. Design, synthesis, and biological evaluation of CXCR4 ligands

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Elie Besserer-Offroy

  15. Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues

    Article • Journal of Medicinal Chemistry, October 2015, American Chemical Society (ACS)

    Elie Besserer-Offroy

  16. C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action

    Article • Journal of Medicinal Chemistry, March 2015, American Chemical Society (ACS)

    Elie Besserer-Offroy

  17. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

    Article • Journal of Clinical Investigation, February 2014, American Society for Clinical Investigation

    Elie Besserer-Offroy

  18. Synthetic Agonists for the CXCR4 Receptor: SAR, Signaling Pathways and Peptidomimetic Transition

    Article • January 2013, Prompt Scientific Publishing

    Elie Besserer-Offroy

  19. Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

    Article • ChemMedChem, December 2011, Wiley

    Elie Besserer-Offroy