All Stories

  1. Unveiling the molecular crosstalk between the purinergic P2X7 receptor and cannabinoid subtype 2 receptor in human microglial HMC3 cells: New insights for multitarget therapies in neuroinflammation

    Article • Biomedicine & Pharmacotherapy, August 2026, Elsevier

    Professor Elena Adinolfi

  2. Methodological guidelines for P2X receptor assays and data interpretation

    Article • Cell Death and Disease, April 2026, Springer Science + Business Media

    Dr Kenneth A. Jacobson, Professor Elena Adinolfi

  3. P2X receptors in immune cells: key regulators of inflammation and immune function

    Article • Neuropharmacology, April 2026, Elsevier

    Professor Elena Adinolfi

  4. Synthesis and characterization of new P2X7 receptor antagonists as antitumor agents

    Article • Biomedicine & Pharmacotherapy, April 2026, Elsevier

    Professor Elena Adinolfi

  5. A Holistic Approach to Identifying a Positron Emission Tomography (PET) Tracer Candidate for In Vivo Imaging of Purinergic P2X7 Receptor in Neuroinflammation

    Article • ACS Pharmacology & Translational Science, March 2026, American Chemical Society (ACS)

    Professor Elena Adinolfi

  6. Latest advances on the role of P2X Receptors in colorectal inflammation and cancer

    Article • Purinergic Signalling, March 2026, Springer Science + Business Media

    Professor Elena Adinolfi

  7. In tribute to Francesco Di Virgilio, a great scientist and a wonderful friend

    Article • Purinergic Signalling, February 2026, Springer Science + Business Media

    Professor Elena Adinolfi

  8. A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma

    Article • Purinergic Signalling, March 2025, Springer Science + Business Media

    Professor Elena Adinolfi

  9. Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, March 2025, Elsevier

    Professor Elena Adinolfi

  10. In-vivo measurement of the extracellular ATP concentration by bio-luminescence: The pmeLUC probe

    Article • January 2025, Elsevier

    Professor Elena Adinolfi

  11. P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: role of the A2A/CD39/CD73 axis

    Article • November 2024, Springer Science + Business Media

    Professor Elena Adinolfi

  12. P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior

    Article • Purinergic Signalling, October 2024, Springer Science + Business Media

    Professor Elena Adinolfi

  13. P2X7 Variants in Pathophysiology

    Article • International Journal of Molecular Sciences, June 2024, MDPI AG

    Professor Elena Adinolfi

  14. The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation

    Article • Frontiers in Immunology, April 2024, Frontiers

    Professor Elena Adinolfi

  15. Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report

    Article • Purinergic Signalling, February 2024, Springer Science + Business Media

    Professor Elena Adinolfi

  16. The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia

    Article • Function, January 2024, Oxford University Press (OUP)

    Professor Elena Adinolfi

  17. Editorial: Therapy resistance in tumor microenvironment: metabolic reprogramming and purinergic signaling

    Article • Frontiers in Oncology, November 2023, Frontiers

    Professor Elena Adinolfi

  18. Bitter Taste Receptor Agonist Denatonium Inhibits Stemness Characteristics in Hematopoietic Stem/Progenitor Cells

    Article • Stem Cells, October 2023, Oxford University Press (OUP)

    Professor Elena Adinolfi

  19. The P2X7 Receptor in Oncogenesis and Metastatic Dissemination: New Insights on Vesicular Release and Adenosinergic Crosstalk

    Article • International Journal of Molecular Sciences, September 2023, MDPI AG

    Professor Elena Adinolfi

  20. EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report

    Article • Purinergic Signalling, July 2023, Springer Science + Business Media

    Professor Elena Adinolfi

  21. P2X7-dependent exchange of extracellular microparticles and mitochondria by mouse microglia

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Professor Elena Adinolfi

  22. Emerging roles of purinergic signaling in anti-cancer therapy resistance

    Article • Frontiers in Cell and Developmental Biology, September 2022, Frontiers

    Professor Elena Adinolfi

  23. P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

    Article • Frontiers in Oncology, August 2022, Frontiers

    Professor Elena Adinolfi

  24. A2A Receptor Contributes to Tumor Progression in P2X7 Null Mice

    Article • Frontiers in Cell and Developmental Biology, May 2022, Frontiers

    Professor Elena Adinolfi

  25. A2A Receptor contributes to tumor progression in P2X7 null mice

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Professor Elena Adinolfi

  26. Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma

    Article • Cell Death and Disease, January 2022, Springer Science + Business Media

    Professor Elena Adinolfi

  27. Administration of P2X7 Receptor Blockers in Oncological Experimental Models

    Article • January 2022, Springer Science + Business Media

    Professor Elena Adinolfi

  28. Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation

    Article • Theranostics, January 2022, Ivyspring International Publisher

    Professor Elena Adinolfi

  29. The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

    Article • Journal of Bone Oncology, December 2021, Elsevier

    Professor Elena Adinolfi

  30. P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells

    Article • Cell Death and Disease, November 2021, Springer Science + Business Media

    Professor Elena Adinolfi

  31. Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor

    Article • Cells, July 2021, MDPI AG

    Professor Elena Adinolfi

  32. Astrocytes‐derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

    Article • Journal of Extracellular Vesicles, July 2021, Wiley

    Professor Elena Adinolfi

  33. Editorial: Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics

    Article • Frontiers in Pharmacology, June 2021, Frontiers

    Professor Elena Adinolfi

  34. The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia

    Article • Purinergic Signalling, June 2021, Springer Science + Business Media

    Professor Elena Adinolfi

  35. The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Professor Elena Adinolfi

  36. Corrigendum: Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells

    Article • Frontiers in Oncology, April 2021, Frontiers

    Professor Elena Adinolfi

  37. Role of ATP in Extracellular Vesicle Biogenesis and Dynamics

    Article • Frontiers in Pharmacology, March 2021, Frontiers

    Professor Elena Adinolfi

  38. P2X7 Receptor in Hematological Malignancies

    Article • Frontiers in Cell and Developmental Biology, March 2021, Frontiers

    Professor Elena Adinolfi

  39. P2X7 Variants in Oncogenesis

    Article • Cells, January 2021, MDPI AG

    Professor Elena Adinolfi

  40. Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression

    Article • Cell Death and Disease, October 2020, Springer Science + Business Media

    Professor Elena Adinolfi

  41. Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells

    Article • Frontiers in Oncology, July 2020, Frontiers

    Professor Elena Adinolfi

  42. Editorial: Emerging Mechanisms in Purinergic Signaling: From Cell Biology to Therapeutic Perspectives

    Article • Frontiers in Pharmacology, July 2020, Frontiers

    Professor Elena Adinolfi

  43. P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

    Article • Frontiers in Pharmacology, June 2020, Frontiers

    Professor Elena Adinolfi

  44. The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility

    Article • Frontiers in Pharmacology, February 2020, Frontiers

    Professor Elena Adinolfi

  45. Detection of Extracellular ATP in the Tumor Microenvironment, Using the pmeLUC Biosensor

    Article • October 2019, Springer Science + Business Media

    Professor Elena Adinolfi

  46. Role of the P2X7 receptor in tumor-associated inflammation

    Article • Current Opinion in Pharmacology, August 2019, Elsevier

    Professor Elena Adinolfi

  47. Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Professor Elena Adinolfi

  48. Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue

    Article • Stem Cell Reviews and Reports, April 2019, Springer Science + Business Media

    Professor Elena Adinolfi

  49. The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

    Article • Oncogene, January 2019, Springer Science + Business Media

    Professor Elena Adinolfi

  50. Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells

    Article • January 2019, Elsevier

    Professor Elena Adinolfi

  51. Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

    Article • Nature Reviews Drug Discovery, July 2018, Springer Science + Business Media

    Professor Elena Adinolfi

  52. Emerging Roles of Purinergic Signaling in Diabetes

    Article • Medicinal Chemistry, July 2018, Bentham Science Publishers

    Professor Diego Dal Ben, Professor Elena Adinolfi

  53. Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

    Article • Frontiers in Pharmacology, May 2018, Frontiers

    Professor Elena Adinolfi

  54. The P2X7 receptor: A main player in inflammation

    Article • Biochemical Pharmacology, May 2018, Elsevier

    Professor Elena Adinolfi

  55. ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

    Article • Frontiers in Immunology, December 2017, Frontiers

    Professor Elena Adinolfi

  56. P2X7 receptor orchestrates multiple signalling pathways triggering inflammation, autophagy and metabolic/trophic responses.

    Article • Current Medicinal Chemistry, March 2017, Bentham Science Publishers

    Professor Elena Adinolfi

  57. Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Professor Elena Adinolfi

  58. P2 receptors in cancer progression and metastatic spreading

    Article • Current Opinion in Pharmacology, August 2016, Elsevier

    Professor Elena Adinolfi

  59. Extracellular purines, purinergic receptors and tumor growth

    Article • Oncogene, June 2016, Nature

    Professor Elena Adinolfi

  60. new insights on the therapeutic potential of P2X7 antagonists in human pathology

    Article • January 2016, Elsevier

    Professor Elena Adinolfi, Professor Diego Dal Ben

  61. Emerging Roles of P2X Receptors in Cancer

    Article • Current Medicinal Chemistry, February 2015, Bentham Science Publishers

    Professor Elena Adinolfi

  62. Editorial (Thematic Issue: Purinergic P2X Receptors: Physiological and Pathological Roles and Potential as Therapeutic Targets)

    Article • Current Medicinal Chemistry, February 2015, Bentham Science Publishers

    Professor Diego Dal Ben, Professor Elena Adinolfi

  63. The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

    Article • Oncogene, January 2015, Nature

    Professor Elena Adinolfi

  64. Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7

    Article • Cancer Research, December 2014, American Association for Cancer Research (AACR)

    Professor Paolo Pinton, Professor Elena Adinolfi

  65. Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma

    Article • PLOS One, September 2014, PLOS

    Professor Elena Adinolfi

  66. P2X receptors: New players in cancer pain

    Article • World Journal of Biological Chemistry, January 2014, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Elena Adinolfi

  67. New intriguing roles of ATP and its receptors in promoting tumor metastasis

    Article • Purinergic Signalling, November 2013, Springer Science + Business Media

    Professor Elena Adinolfi

  68. Purinergic Signaling in Bone

    Article • Journal of Osteoporosis, January 2013, Hindawi Publishing Corporation

    Professor Elena Adinolfi, Peter Schwarz

  69. The P2X7 receptor is a key modulator of aerobic glycolysis

    Article • Cell Death and Disease, August 2012, Nature

    Professor Elena Adinolfi

  70. First in vivo demonstration that P2X7 receptor is an oncogene

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Professor Elena Adinolfi

  71. role of P2X7 receptor in bone cancer and bone metastasis

    Article • Journal of Osteoporosis, January 2012, Hindawi Publishing Corporation

    Professor Elena Adinolfi

  72. Purinergic signaling in giant cell formation

    Article • Frontiers in Bioscience-Elite, January 2012, IMR Press

    Professor Elena Adinolfi

  73. The dominant-negative von Willebrand factor gene deletion p.P1127_C1948delinsR: molecular mechanism and modulation

    Article • Blood, June 2010, American Society of Hematology

    Professor Elena Adinolfi

  74. Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

    Article • The FASEB Journal, May 2010, Federation of American Societies For Experimental Biology (FASEB)

    Professor Elena Adinolfi

  75. cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter

    Article • Molecular Human Reproduction, March 2010, Oxford University Press (OUP)

    Professor Elena Adinolfi

  76. P2X7: a growth-promoting receptor—implications for cancer

    Article • Purinergic Signalling, March 2009, Springer Science + Business Media

    Francesco Di Virgilio, Professor Elena Adinolfi

  77. Expression of the P2X7 Receptor Increases the Ca2+ Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis

    Article • Journal of Biological Chemistry, February 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Paolo Pinton, Professor Elena Adinolfi

  78. Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions

    Article • Placenta, August 2008, Elsevier

    Professor Elena Adinolfi

  79. The P2X7 receptor: a key player in IL-1 processing and release

    Article • The Journal of Immunology, December 2007, The American Association of Immunologists

    Professor Elena Adinolfi

  80. Stimulation of Purinergic Receptors Modulates Chemokine Expression in Human Keratinocytes

    Article • Journal of Investigative Dermatology, March 2007, Elsevier

    Professor Elena Adinolfi

  81. Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles

    Article • The FASEB Journal, February 2007, Federation of American Societies For Experimental Biology (FASEB)

    Professor Elena Adinolfi

  82. The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration

    Article • Blood, January 2007, American Society of Hematology

    Professor Elena Adinolfi

  83. Stimulation of P2 receptors causes release of IL-1β–loaded microvesicles from human dendritic cells

    Article • Blood, December 2006, American Society of Hematology

    Professor Elena Adinolfi

  84. Involvement of the Purinergic P2X7 Receptor in the Formation of Multinucleated Giant Cells

    Article • The Journal of Immunology, November 2006, The American Association of Immunologists

    Professor Elena Adinolfi

  85. The P2X7 Receptor: A Key Player in IL-1 Processing and Release

    Article • The Journal of Immunology, March 2006, The American Association of Immunologists

    Professor Elena Adinolfi

  86. P2X7 receptor: Death or life?

    Article • Purinergic Signalling, July 2005, Springer Science + Business Media

    Professor Elena Adinolfi

  87. Pseudoapoptosis Induced by Brief Activation of ATP-gated P2X7 Receptors

    Article • Journal of Biological Chemistry, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Elena Adinolfi

  88. Basal Activation of the P2X7 ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth

    Article • Molecular Biology of the Cell, April 2005, American Society for Cell Biology (ASCB)

    Professor Elena Adinolfi

  89. The Antibiotic Polymyxin B Modulates P2X7 Receptor Function

    Article • The Journal of Immunology, September 2004, The American Association of Immunologists

    Professor Elena Adinolfi

  90. Enhanced P2X7 Activity in Human Fibroblasts From Diabetic Patients: A Possible Pathogenetic Mechanism for Vascular Damage in Diabetes

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2004, Wolters Kluwer Health

    Professor Elena Adinolfi

  91. Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors

    Article • Journal of Biological Chemistry, July 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Elena Adinolfi

  92. P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia

    Article • Blood, January 2002, American Society of Hematology

    Professor Elena Adinolfi

  93. Human Leukocyte Antigen-A,-B,-C and -DR Alleles and Soluble Human Leukocyte Antigen Class I Serum Level in Ménière's Disease

    Article • Acta Oto-Laryngologica, January 2002, Taylor & Francis

    Professor Elena Adinolfi

  94. Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7 ATP Receptor

    Article • Journal of Biological Chemistry, November 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Elena Adinolfi

  95. Homology modeling and active-site residues probing of the thermophilicAlicyclobacillus acidocaldariusesterase 2

    Article • Protein Science, January 1999, Wiley

    Professor Elena Adinolfi

  96. Overexpression and properties of a new thermophilic and thermostable esterase from Bacillus acidocaldarius with sequence similarity to hormone-sensitive lipase subfamily

    Article • Biochemical Journal, May 1998, Portland Press Ltd.

    Professor Elena Adinolfi