All Stories

  1. Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

    Article • JACC Basic to Translational Science, July 2024, Elsevier

    Ekaterina Legchenko

  2. ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport

    Article • Cardiovascular Research, April 2024, Oxford University Press (OUP)

    Ekaterina Legchenko

  3. Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension

    Article • Nature Cardiovascular Research, June 2022, Springer Science + Business Media

    Ekaterina Legchenko, Prof. Markus Ralser

  4. Pulmonary Arterial Hypertension and Consecutive Right Heart Failure Lead to Liver Fibrosis

    Article • Frontiers in Cardiovascular Medicine, March 2022, Frontiers

    Ekaterina Legchenko

  5. Circulating Interleukin-7 in Human Pulmonary Arterial Hypertension

    Article • Frontiers in Cardiovascular Medicine, December 2021, Frontiers

    Ekaterina Legchenko

  6. Letter by Legchenko et al Regarding Article, “Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure”

    Article • Circulation Heart Failure, December 2021, Wolters Kluwer Health

    Ekaterina Legchenko

  7. Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Ekaterina Legchenko

  8. Emerging therapies for right ventricular dysfunction and failure

    Article • Cardiovascular Diagnosis and Therapy, October 2020, AME Publishing Company

    Ekaterina Legchenko

  9. Protein truncating mutations in ATP13A3 promote pulmonary arterial hypertension

    Article • September 2020, European Respiratory Society (ERS)

    Ekaterina Legchenko

  10. Trans-Right–Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension*

    Article • Pediatric Critical Care Medicine, April 2020, Wolters Kluwer Health

    Ekaterina Legchenko

  11. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

    Article • Nature Communications, March 2020, Springer Science + Business Media

    Ekaterina Legchenko

  12. Protein truncating mutations in ATP13A3 promote pulmonary arterial hypertension in mice

    Article • March 2020, European Respiratory Society (ERS)

    Ekaterina Legchenko

  13. The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still “the One:” A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman

    Article • American Review of Respiratory Disease, March 2020, American Thoracic Society

    Ekaterina Legchenko

  14. PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis

    Article • Current Opinion in Nephrology & Hypertension, March 2020, Wolters Kluwer Health

    Ekaterina Legchenko

  15. Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension

    Article • American Review of Respiratory Disease, December 2019, American Thoracic Society

    Ekaterina Legchenko

  16. Hypoxia drives cardiac miRNAs and inflammation in the right and left ventricle

    Article • Journal of Molecular Medicine, July 2019, Springer Science + Business Media

    Ekaterina Legchenko

  17. Chronic TGF-β1 Signaling in Pulmonary Arterial Hypertension Induces Sustained Canonical Smad3 Pathways in Vascular Smooth Muscle Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2019, American Thoracic Society

    Ekaterina Legchenko

  18. PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

    Article • Science Translational Medicine, April 2018, American Association for the Advancement of Science

    Ekaterina Legchenko

  19. Transforming Growth Factor β1– and Bone Morphogenetic Protein 2/PPARγ–regulated MicroRNAs in Pulmonary Arterial Hypertension

    Article • American Review of Respiratory Disease, November 2017, American Thoracic Society

    Ekaterina Legchenko

  20. PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism

    Article • Cell Metabolism, May 2017, Elsevier

    Ekaterina Legchenko

  21. Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension

    Article • Heart, February 2016, BMJ

    Ekaterina Legchenko