All Stories

  1. Epigenetic mechanisms linking early-life adversities and mental health

    Article • Biochemical Journal, May 2024, Portland Press Ltd.

    Dr Eduardo T Canepa

  2. Oxidative stress associated with spatial memory impairment and social olfactory deterioration in female mice reveals premature aging aroused by perinatal protein malnutrition

    Article • Experimental Neurology, October 2023, Elsevier

    Dr Eduardo T Canepa

  3. Early life stress induces visual dysfunction and retinal structural alterations in adult mice

    Article • Journal of Neurochemistry, January 2023, Wiley

    Dr Eduardo T Canepa

  4. Impaired social cognition caused by perinatal protein malnutrition evokes neurodevelopmental disorder symptoms and is intergenerationally transmitted

    Article • Experimental Neurology, January 2022, Elsevier

    Dr Eduardo T Canepa

  5. Limited contextual memory and transcriptional dysregulation in the medial prefrontal cortex of mice exposed to early protein malnutrition are intergenerationally transmitted

    Article • Journal of Psychiatric Research, July 2021, Elsevier

    Dr Eduardo T Canepa

  6. Perinatal protein malnutrition results in genome-wide disruptions of 5-hydroxymethylcytosine at regions that can be restored to control levels by an enriched environment

    Article • Epigenetics, November 2020, Taylor & Francis

    Dr Eduardo T Canepa

  7. Perinatal protein malnutrition induces the emergence of enduring effects and age-related impairment behaviors, increasing the death risk in a mouse model

    Article • Nutritional Neuroscience, October 2020, Taylor & Francis

    Dr Eduardo T Canepa

  8. Nutritional stress timing differentially programs cognitive abilities in young adult male mice

    Article • Nutritional Neuroscience, April 2020, Taylor & Francis

    Dr Eduardo T Canepa

  9. Effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice

    Article • Psychopharmacology, July 2019, Springer Science + Business Media

    Dr Eduardo T Canepa

  10. Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology

    Article • Neuroscience, June 2019, Elsevier

    Dr Eduardo T Canepa

  11. Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine

    Article • Neuropsychopharmacology, March 2019, Springer Science + Business Media

    Dr Agustin Ibanez, Dr Eduardo T Canepa

  12. Intergenerational transmission of maternal care deficiency and offspring development delay induced by perinatal protein malnutrition

    Article • Nutritional Neuroscience, August 2018, Taylor & Francis

    Dr Eduardo T Canepa

  13. Altered miRNA biogenesis in early life malnutrition

    Article • Neuroscience Letters, April 2017, Elsevier

    Dr Eduardo T Canepa

  14. Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection

    Article • Molecular and Cellular Biochemistry, November 2016, Springer Science + Business Media

    Dr Eduardo T Canepa

  15. Depressive-like behavior in perinatal malnutrition

    Article • Genes Brain & Behavior, September 2016, Wiley

    Dr Eduardo T Canepa

  16. E2F transcription factor and maintenance of genomic stability

    Article • Cell Cycle, April 2015, Taylor & Francis

    Dr Eduardo T Canepa

  17. Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation

    Article • Molecular and Cellular Biochemistry, September 2014, Springer Science + Business Media

    Dr Eduardo T Canepa

  18. CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2014, Elsevier

    Dr Eduardo T Canepa

  19. p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2014, Elsevier

    Dr Eduardo T Canepa

  20. Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors

    Article • Physiology & Behavior, April 2014, Elsevier

    Dr Eduardo T Canepa

  21. Chromatin Relaxation-Mediated Induction of p19INK4d Increases the Ability of Cells to Repair Damaged DNA

    Article • PLOS One, April 2013, PLOS

    Dr Eduardo T Canepa

  22. Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways

    Article • Molecular and Cellular Biochemistry, March 2013, Springer Science + Business Media

    Dr Eduardo T Canepa

  23. CDK2 and PKA Mediated-Sequential Phosphorylation Is Critical for p19INK4d Function in the DNA Damage Response

    Article • PLOS One, April 2012, PLOS

    Dr Eduardo T Canepa

  24. E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation

    Article • Molecular and Cellular Biochemistry, April 2012, Springer Science + Business Media

    Dr Eduardo T Canepa

  25. E2F1-Mediated Upregulation of p19INK4d Determines Its Periodic Expression during Cell Cycle and Regulates Cellular Proliferation

    Article • PLOS One, July 2011, PLOS

    Dr Eduardo T Canepa

  26. Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response

    Article • The International Journal of Biochemistry & Cell Biology, June 2009, Elsevier

    Dr Eduardo T Canepa

  27. E2F1 transcription is induced by genotoxic stress through ATM/ATR activation

    Article • IUBMB Life, May 2009, Wiley

    Dr Eduardo T Canepa

  28. Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair

    Article • DNA Repair, May 2007, Elsevier

    Dr Eduardo T Canepa

  29. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions

    Article • IUBMB Life, January 2007, Wiley

    Dr Eduardo T Canepa

  30. Cell growth-dependent subcellular localization of p8

    Article • Journal of Cellular Biochemistry, January 2006, Wiley

    Dr Eduardo T Canepa

  31. Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways

    Article • Archives of Biochemistry and Biophysics, April 2005, Elsevier

    Dr Eduardo T Canepa

  32. Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells

    Article • Oncogene, March 2005, Nature

    Dr Eduardo T Canepa

  33. Hepatic Nuclear Factor 3 and Nuclear Factor 1 Regulate 5-Aminolevulinate Synthase Gene Expression and Are Involved in Insulin Repression

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eduardo T Canepa

  34. Inhibitory Effect of AP-1 Complex on 5-Aminolevulinate Synthase Gene Expression through Sequestration of cAMP-response Element Protein (CRE)-binding Protein (CBP) Coactivator

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eduardo T Canepa

  35. Cloning and expression of the human p8, a nuclear protein with mitogenic activity

    Article • European Journal of Biochemistry, December 2001, Wiley

    Dr Eduardo T Canepa

  36. Phosphatidylinositol 3-Kinase and Ras/Mitogen-Activated Protein Kinase Signaling Pathways Are Required for the Regulation of 5-Aminolevulinate Synthase Gene Expression by Insulin

    Article • Experimental Cell Research, December 2001, Elsevier

    Dr Eduardo T Canepa

  37. Transforming growth factor β-1 enhances Smad transcriptional activity through activation of p8 gene expression

    Article • Biochemical Journal, June 2001, Portland Press Ltd.

    Dr Eduardo T Canepa

  38. 5-Aminolaevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB)

    Article • Biochemical Journal, January 2001, Portland Press Ltd.

    Dr Eduardo T Canepa

  39. Human p8 Is a HMG-I/Y-like Protein with DNA Binding Activity Enhanced by Phosphorylation

    Article • Journal of Biological Chemistry, October 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eduardo T Canepa

  40. Transcriptional Regulation of 5-Aminolevulinate Synthase by Phenobarbital and cAMP-Dependent Protein Kinase

    Article • Archives of Biochemistry and Biophysics, December 1999, Elsevier

    Dr Eduardo T Canepa

  41. Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein α (C/EBPα) and C/EBPβ trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter

    Article • Biochemical Journal, October 1999, Portland Press Ltd.

    Dr Eduardo T Canepa

  42. Insulin Inhibits δ-Aminolevulinate Synthase Gene Expression in Rat Hepatocytes and Human Hepatoma Cells

    Article • Experimental Cell Research, November 1998, Elsevier

    Dr Eduardo T Canepa

  43. Evidence That Protein Kinase C Is Involved in δ-Aminolevulinate Synthase Expression in Rat Hepatocytes

    Article • Archives of Biochemistry and Biophysics, May 1997, Elsevier

    Dr Eduardo T Canepa

  44. cAMP regulation of phenobarbital-mediated induction of δ-aminolevulinate synthase mRNA in hepatocytes from normal and experimental diabetic rats

    Article • Biochemistry and Cell Biology, September 1994, Canadian Science Publishing

    Dr Eduardo T Canepa

  45. Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes

    Article • Biochemistry and Cell Biology, January 1992, Canadian Science Publishing

    Dr Eduardo T Canepa

  46. Studies on induction of δ-aminolevulinic acid synthase, ferrochelatase, cytochrome P-450 and cyclic AMP by phenformin

    Article • Biochemical Pharmacology, July 1990, Elsevier

    Dr Eduardo T Canepa

  47. Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin

    Article • Biochemistry and Cell Biology, June 1990, Canadian Science Publishing

    Dr Eduardo T Canepa

  48. Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of cAMP

    Article • Biochemistry and Cell Biology, November 1989, Canadian Science Publishing

    Dr Eduardo T Canepa

  49. Purification and characterization of ferro- and cobalto-chelatases

    Article • Biochemistry and Cell Biology, January 1988, Canadian Science Publishing

    Dr Eduardo T Canepa

  50. Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, November 1985, Elsevier

    Dr Eduardo T Canepa

  51. Effect of glucose on induction of δ-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450 hemoproteins in isolated rat hepatocytes by phenobarbital and lead

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, August 1985, Elsevier

    Dr Eduardo T Canepa

  52. Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, May 1984, Elsevier

    Dr Eduardo T Canepa