All Stories

  1. Homologous HipA ‐like kinases are controlled by internal translational initiation and genetic organisation

    Article • FEBS Letters, December 2025, Wiley

    Dr Ditlev E Brodersen

  2. Catalytic mechanism and differential alarmone regulation of a conserved stringent nucleosidase

    Article • Structure, November 2025, Elsevier

    Dr Ditlev E Brodersen

  3. Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, July 2025, Elsevier

    Dr Ditlev E Brodersen

  4. Structural basis for higher-order DNA binding by a bacterial transcriptional regulator

    Article • PLoS Genetics, June 2025, PLOS

    Dr Ditlev E Brodersen

  5. Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca2+ Ions and Conformational Dynamics in Psychrophilicity

    Article • Biomolecules, March 2025, MDPI AG

    Dr Ditlev E Brodersen

  6. Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca<sup>2+</sup> Ions and Conformational Dynamics in Psychrophilicity

    Article • February 2025, MDPI AG

    Dr Ditlev E Brodersen

  7. Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system

    Article • mBio, February 2025, ASM Journals

    Dr Ditlev E Brodersen

  8. Breaking bad nucleotides: understanding the regulatory mechanisms of bacterial small alarmone hydrolases

    Article • Trends in Microbiology, August 2024, Elsevier

    Dr Ditlev E Brodersen

  9. Structural basis for higher-order DNA binding by a bacterial transcriptional regulator

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  10. Structural Variations and Rearrangements in Bacterial Type II Toxin-Antitoxin Systems

    Article • January 2024, Springer Science + Business Media

    Dr Ditlev E Brodersen

  11. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

    Article • eLife, November 2023, eLife

    Dr Ditlev E Brodersen

  12. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

    Article • eLife, November 2023, eLife

    Dr Ditlev E Brodersen

  13. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system

    Article • October 2023, eLife

    Dr Ditlev E Brodersen

  14. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system

    Article • August 2023, eLife

    Dr Ditlev E Brodersen

  15. Structural remodelling of the carbon–phosphorus lyase machinery by a dual ABC ATPase

    Article • Nature Communications, February 2023, Springer Science + Business Media

    Dr Ditlev E Brodersen

  16. A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL

    Article • The Biophysicist, December 2022, Biophysical Society

    Dr Ditlev E Brodersen

  17. Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response

    Article • Journal of Biological Chemistry, July 2022, Elsevier

    Dr Ditlev E Brodersen

  18. Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  19. Structural Remodelling of the Carbon‐Phosphorus Enzymatic Machinery by a Dual ATP‐Binding Cassette Module

    Article • The FASEB Journal, May 2022, Wiley

    Dr Ditlev E Brodersen

  20. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  21. Two P or Not Two P: Understanding Regulation by the Bacterial Second Messengers (p)ppGpp

    Article • Annual Review of Microbiology, October 2021, Annual Reviews

    Dr Ditlev E Brodersen

  22. Evolving complex insulation

    Article • Nature Chemical Biology, September 2021, Springer Science + Business Media

    Dr Ditlev E Brodersen

  23. Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations

    Article • mBio, June 2021, ASM Journals

    Dr Ditlev E Brodersen

  24. Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System

    Article • Structure, February 2021, Elsevier

    Dr Ditlev E Brodersen

  25. Structural basis for inhibition of an archaeal CRISPR–Cas type I-D large subunit by an anti-CRISPR protein

    Article • Nature Communications, November 2020, Springer Science + Business Media

    Dr Ditlev E Brodersen

  26. Structure and Function of the Bacterial Protein Toxin Phenomycin

    Article • Structure, May 2020, Elsevier

    Dr Ditlev E Brodersen

  27. The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain

    Article • Structure, November 2019, Elsevier

    Dr Ditlev E Brodersen

  28. Evolution of the bacterial nucleosidase PpnN and its relation to the stringent response

    Article • Microbial Cell, September 2019, Shared Science Publishers OG

    Dr Ditlev E Brodersen

  29. Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

    Article • mBio, June 2019, ASM Journals

    Dr Ditlev E Brodersen

  30. (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch

    Article • Molecular Cell, June 2019, Elsevier

    Dr Ditlev E Brodersen

  31. The Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism

    Article • Microbiology and Molecular Biology Reviews, December 2018, ASM Journals

    Bjarne Hove-Jensen, Dr Ditlev E Brodersen

  32. The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+

    Article • Molecular Microbiology, October 2018, Wiley

    Kenn Gerdes, Dr Ditlev E Brodersen

  33. The Abc of Phosphonate Breakdown: A Mechanism for Bacterial Survival

    Article • BioEssays, September 2018, Wiley

    Dr Ditlev E Brodersen

  34. Publisher Correction: Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

    Article • Nature Microbiology, June 2018, Springer Science + Business Media

    Dr Ditlev E Brodersen

  35. Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

    Article • Molecular Cell, June 2018, Elsevier

    Dr Ditlev E Brodersen

  36. Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

    Article • Nature Microbiology, March 2018, Springer Science + Business Media

    Dr Ditlev E Brodersen

  37. Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP

    Article • Journal of Biological Chemistry, January 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ditlev E Brodersen

  38. Structural conservation of the PIN domain active site across all domains of life

    Article • Protein Science, May 2017, Wiley

    Dr Ditlev E Brodersen

  39. Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes

    Article • January 2017, Springer Science + Business Media

    Dr Ditlev E Brodersen

  40. Toxin inhibition inC. crescentusVapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding

    Article • Nucleic Acids Research, December 2016, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  41. The transcriptional regulator GalR self-assembles to form highly regular tubular structures

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Dr Ditlev E Brodersen

  42. RRM domain of human RBM7: purification, crystallization and structure determination

    Article • Acta Crystallographica Section F Structural Biology Communications, April 2016, International Union of Crystallography

    Dr Ditlev E Brodersen

  43. Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri

    Article • Proteins Structure Function and Bioinformatics, April 2016, Wiley

    Dr Ditlev E Brodersen

  44. Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide in Fusarium solani

    Article • Current Genetics, March 2016, Springer Science + Business Media

    Dr Ditlev E Brodersen

  45. Structural basis for RNA-genome recognition during bacteriophage Qβ replication

    Article • Nucleic Acids Research, November 2015, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  46. Computational discovery of specificity-conferring sites in non-ribosomal peptide synthetases

    Article • Bioinformatics, October 2015, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  47. Structural studies of the human Nuclear EXosome Targeting complex

    Article • Acta Crystallographica Section A Foundations and Advances, August 2015, International Union of Crystallography

    Dr Ditlev E Brodersen

  48. Structural insights into the bacterial carbon–phosphorus lyase machinery

    Article • Nature, August 2015, Nature

    Bjarne Hove-Jensen, Dr Ditlev E Brodersen

  49. Cut to the chase–Regulating translation through RNA cleavage

    Article • Biochimie, July 2015, Elsevier

    Dr Ditlev E Brodersen

  50. An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium

    Article • Fungal Genetics and Biology, February 2015, Elsevier

    Dr Ditlev E Brodersen

  51. Investigation of exponential RNA amplification by the Qβ replicase complex

    Article • Acta Crystallographica Section A Foundations and Advances, August 2014, International Union of Crystallography

    Dr Ditlev E Brodersen

  52. Crystal Structure of the Carbon-Phosphorus Lyase Complex from Escherichia coli

    Article • Acta Crystallographica Section A Foundations and Advances, August 2014, International Union of Crystallography

    Dr Ditlev E Brodersen

  53. Structural Characterization of the Saccharomyces cerevisiae THO Complex by Small-Angle X-Ray Scattering

    Article • PLOS One, July 2014, PLOS

    Dr Ditlev E Brodersen

  54. Structural analysis of the yeast exosome Rrp6p–Rrp47p complex by small-angle X-ray scattering

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Dr Ditlev E Brodersen

  55. Fungal NRPS-Dependent Siderophores: From Function to Prediction

    Article • January 2014, Springer Science + Business Media

    Dr Ditlev E Brodersen

  56. VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

    Article • Nature Communications, November 2013, Nature

    Dr Ditlev E Brodersen

  57. Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability

    Article • RNA, August 2013, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  58. Mimer: an automated spreadsheet-based crystallization screening system

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2013, International Union of Crystallography

    Dr Ditlev E Brodersen

  59. Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolatedShigella flexneriVapC toxin

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2013, International Union of Crystallography

    Dr Ditlev E Brodersen

  60. The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

    Article • Structure, October 2012, Elsevier

    Dr Ditlev E Brodersen

  61. Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

    Article • Journal of Molecular Biology, December 2011, Elsevier

    Dr Ditlev E Brodersen

  62. Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases

    Article • Nucleic Acids Research, September 2011, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  63. Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

    Article • Nucleic Acids Research, January 2011, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  64. The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE

    Article • Cell, December 2009, Elsevier

    Dr Ditlev E Brodersen

  65. Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties

    Article • European Journal of Biochemistry, July 2009, Wiley

    Dr Ditlev E Brodersen

  66. Origins and activities of the eukaryotic exosome

    Article • Journal of Cell Science, May 2009, The Company of Biologists

    Dr Ditlev E Brodersen

  67. The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site

    Article • RNA, March 2009, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  68. Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants

    Article • RNA, September 2008, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  69. Take the “A” tail – quality control of ribosomal and transfer RNA

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, September 2008, Elsevier

    Dr Ditlev E Brodersen

  70. An Hfq-like protein in archaea: Crystal structure and functional characterization of the Sm protein from Methanococcus jannaschii

    Article • RNA, September 2007, Cold Spring Harbor Laboratory Press

    Dr Ditlev E Brodersen

  71. The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme

    Article • Nucleic Acids Research, April 2007, Oxford University Press (OUP)

    Dr Ditlev E Brodersen

  72. Applications of single-wavelength anomalous dispersion at high and atomic resolution. Corrigendum

    Article • Acta Crystallographica Section D Biological Crystallography, August 2006, International Union of Crystallography

    Dr Ditlev E Brodersen

  73. Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain

    Article • Proceedings of the National Academy of Sciences, August 2006, Proceedings of the National Academy of Sciences

    Dr Ditlev E Brodersen

  74. Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon

    Article • Cell, December 2005, Elsevier

    Dr Ditlev E Brodersen

  75. The social life of ribosomal proteins

    Article • European Journal of Biochemistry, April 2005, Wiley

    Dr Ditlev E Brodersen

  76. Phasing the 30S ribosomal subunit structure

    Article • Acta Crystallographica Section D Biological Crystallography, October 2003, International Union of Crystallography

    Dr Ditlev E Brodersen

  77. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B

    Article • Antimicrobial Agents and Chemotherapy, May 2003, ASM Journals

    Dr Ditlev E Brodersen

  78. Shape can be seductive

    Article • Nature Structural Biology, February 2003, Nature

    Dr Ditlev E Brodersen

  79. Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNA

    Article • Journal of Molecular Biology, February 2002, Elsevier

    Dr Ditlev E Brodersen

  80. Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination

    Article • Journal of Molecular Biology, July 2001, Elsevier

    Dr Ditlev E Brodersen

  81. Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit

    Article • Science, May 2001, American Association for the Advancement of Science

    Dr Ditlev E Brodersen

  82. Crystal Structure of an Initiation Factor Bound to the 30S Ribosomal Subunit

    Article • Science, January 2001, American Association for the Advancement of Science

    Dr Ditlev E Brodersen

  83. The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit

    Article • Cell, December 2000, Elsevier

    Dr Ditlev E Brodersen

  84. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

    Article • Nature, September 2000, Springer Science + Business Media

    Dr Ditlev E Brodersen

  85. Structure of the 30S ribosomal subunit

    Article • Nature, September 2000, Springer Science + Business Media

    Dr Ditlev E Brodersen

  86. Applications of single-wavelength anomalous dispersion at high and atomic resolution

    Article • Acta Crystallographica Section D Biological Crystallography, April 2000, International Union of Crystallography

    Dr Ditlev E Brodersen

  87. Zinc-Binding Site of an S100 Protein Revealed. Two Crystal Structures of Ca2+-Bound Human Psoriasin (S100A7) in the Zn2+-Loaded and Zn2+-Free States†,‡

    Article • Biochemistry, February 1999, American Chemical Society (ACS)

    Dr Ditlev E Brodersen

  88. Enzymatic and Electron Transfer Activities in Crystalline Protein Complexes

    Article • Journal of Biological Chemistry, April 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ditlev E Brodersen