All Stories

  1. In VitroBiochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus

    Article • Antimicrobial Agents and Chemotherapy, October 2015, ASM Journals

    Professor Steven L Kelly, Professor Diane Kelly

  2. Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase

    Article • Applied and Environmental Microbiology, March 2015, ASM Journals

    Professor Diane Kelly, Professor Steven L Kelly

  3. Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock

    Article • Biotechnology for Biofuels, September 2014, Springer Science + Business Media

    Professor Diane Kelly

  4. The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

    Article • Antimicrobial Agents and Chemotherapy, September 2014, ASM Journals

    Professor Diane Kelly, Professor Steven L Kelly

  5. Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept

    Article • AMB Express, September 2014, Springer Science + Business Media

    Professor Diane Kelly

  6. Resistance to antifungals that target CYP51

    Article • Journal of Chemical Biology, August 2014, Springer Science + Business Media

    Professor Diane Kelly

  7. Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51)

    Article • Applied and Environmental Microbiology, August 2014, ASM Journals

    Professor Diane Kelly, Professor Steven L Kelly

  8. Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock

    Article • Biotechnology for Biofuels, January 2014, Springer Science + Business Media

    Professor Diane Kelly

  9. Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

    Article • PLoS ONE, June 2013, PLOS

    Professor Diane Kelly

  10. An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example

    Article • Computers in Biology and Medicine, June 2013, Elsevier

    Professor Diane Kelly

  11. The cytochrome P450 complement (CYPome) ofMycosphaerella graminicola

    Article • Biotechnology and Applied Biochemistry, January 2013, Wiley

    Professor Diane Kelly

  12. Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola

    Article • PLoS ONE, June 2011, PLOS

    Professor Diane Kelly

  13. The CYPome (Cytochrome P450 complement) of Aspergillus nidulans

    Article • Fungal Genetics and Biology, March 2009, Elsevier

    Professor Diane Kelly, Nada Kraševec

  14. Expression and Characterization of CYP51, the Ancient Sterol 14‐demethylase Activity for Cytochromes P450 (CYP), in the White‐Rot Fungus Phanerochaete chrysosporium

    Article • Lipids, October 2008, Wiley

    Professor Diane Kelly

  15. Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole

    Article • Biochemical and Biophysical Research Communications, October 2003, Elsevier

    Professor Diane Kelly

  16. Rewiring yeast for drug synthesis

    Article • Nature Biotechnology, February 2003, Springer Science + Business Media

    Professor Diane Kelly

  17. Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis

    Article • Biochemical and Biophysical Research Communications, February 2003, Elsevier

    Professor Diane Kelly

  18. The biodiversity of microbial cytochromes P450

    Article • January 2003, Elsevier

    Professor Diane Kelly

  19. Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism

    Article • Biochemical and Biophysical Research Communications, November 2002, Elsevier

    Professor Diane Kelly

  20. Sterol 14α-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family

    Article • Biochemical Journal, June 2002, Portland Press Ltd.

    Professor Diane Kelly

  21. Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5

    Article • Archives of Biochemistry and Biophysics, November 2001, Elsevier

    Professor Diane Kelly

  22. Activities and Kinetic Mechanisms of Native and Soluble NADPH–Cytochrome P450 Reductase

    Article • Biochemical and Biophysical Research Communications, August 2001, Elsevier

    Professor Diane Kelly

  23. Plant Sterol 14α-Demethylase Affinity for Azole Fungicides

    Article • Biochemical and Biophysical Research Communications, June 2001, Elsevier

    Professor Diane Kelly

  24. Genome-Wide Generation of Yeast Gene Deletion Strains

    Article • Comparative and Functional Genomics, January 2001, Hindawi Publishing Corporation

    Professor Diane Kelly

  25. Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis

    Article • FEMS Microbiology Letters, November 2000, Oxford University Press (OUP)

    Professor Diane Kelly

  26. Engineering of Heterologous Cytochrome P450 in Acinetobacter sp.: Application for Pollutant Degradation

    Article • Biochemical and Biophysical Research Communications, September 2000, Elsevier

    Professor Diane Kelly

  27. Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents

    Article • Chemico-Biological Interactions, March 2000, Elsevier

    Professor Diane Kelly

  28. Molecular aspects of azole antifungal action and resistance

    Article • Drug Resistance Updates, December 1999, Elsevier

    Professor Diane Kelly

  29. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction

    Article • FEBS Letters, November 1999, Wiley

    Professor Diane Kelly

  30. Y132H substitution in Candida albicans sterol 14α-demethylase confers fluconazole resistance by preventing binding to haem

    Article • FEMS Microbiology Letters, November 1999, Oxford University Press (OUP)

    Professor Diane Kelly

  31. The G464S Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Fluconazole Resistance in the Clinic through Reduced Affinity

    Article • Biochemical and Biophysical Research Communications, August 1999, Elsevier

    Professor Diane Kelly

  32. Characteristics of the heterologously expressed human lanosterol 14α-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human andCandida albicans CYP51 with azole antifungal agents

    Article • Yeast, June 1999, Wiley

    Professor Diane Kelly

  33. Generation of a Complete, Soluble, and Catalytically Active Sterol 14α-Demethylase−Reductase Complex

    Article • Biochemistry, June 1999, American Chemical Society (ACS)

    Professor Diane Kelly

  34. Systematic analysis of yeast strains with possible defects in lipid metabolism

    Article • Yeast, May 1999, Wiley

    Professor Diane Kelly

  35. Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals

    Article • January 1999, Springer Science + Business Media

    Professor Diane Kelly

  36. Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14α-demethylase (CYP51; P450 14DM )

    Article • FEMS Microbiology Letters, December 1998, Oxford University Press (OUP)

    Professor Diane Kelly

  37. A sterol biosynthetic pathway in Mycobacterium

    Article • FEBS Letters, October 1998, Wiley

    Professor Diane Kelly

  38. Molecular diversity of sterol 14α‐demethylase substrates in plants, fungi and humans

    Article • FEBS Letters, March 1998, Wiley

    Professor Diane Kelly

  39. Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism

    Article • FEBS Letters, July 1997, Wiley

    Professor Diane Kelly

  40. Cytochrome P450 3A4 mediated metabolism of 2,4-dichlorophenol

    Article • Chemosphere, June 1997, Elsevier

    Professor Diane Kelly

  41. Human cytochrome P450 3A4 is involved in the biotransformation of the herbicide 2,4-dichlorophenoxyacetic acid

    Article • Environmental Toxicology and Pharmacology, December 1996, Elsevier

    Professor Diane Kelly

  42. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

    Article • The Lancet, November 1996, Elsevier

    Professor Diane Kelly

  43. Studies on the Toxicity of Analogues of Dapsone In-vitro Using Rat, Human and Heterologously Expressed Metabolizing Systems†

    Article • Journal of Pharmacy and Pharmacology, September 1996, Oxford University Press (OUP)

    Professor Diane Kelly

  44. Metabolism of organochlorine pesticides: The role of human cytochrome P450 3A4

    Article • Chemosphere, August 1996, Elsevier

    Professor Diane Kelly

  45. Involvement of Human Cytochrome P450 3A4 in the metabolism of Vamidothion

    Article • Pesticide Science, March 1996, Wiley

    Professor Diane Kelly

  46. Role of Sterol Δ5(6)Desaturase in Azole Antifungal Mode of Action and Resistance

    Article • Pesticide Science, March 1996, Wiley

    Professor Diane Kelly

  47. Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol Δ22‐desaturase

    Article • FEBS Letters, December 1995, Wiley

    Professor Diane Kelly

  48. Metabolism of the herbicide chlortoluron by human cytochrome P450 3A4

    Article • Chemosphere, December 1995, Elsevier

    Professor Diane Kelly

  49. Investigation of the role of sterol Δ 8 → 7 -isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph

    Article • FEMS Microbiology Letters, October 1994, Oxford University Press (OUP)

    Professor Diane Kelly

  50. Studies on azole-induced cell death in Saccharomyces cerevisiae

    Article • FEMS Microbiology Letters, January 1994, Oxford University Press (OUP)

    Professor Diane Kelly

  51. Role of Cytochrome P450 in Tulip Bulb Probed by Substrate‐Binding Studies

    Article • Pesticide Science, January 1992, Wiley

    Professor Diane Kelly

  52. The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae

    Article • Biochemical Pharmacology, July 1991, Elsevier

    Professor Diane Kelly

  53. Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiaeWHI2 gene

    Article • Gene, June 1988, Elsevier

    Professor Diane Kelly

  54. The Diversity and Importance of Microbial Cytochromes P450

    Article • Springer Science + Business Media

    Professor Diane Kelly