All Stories

  1. In VitroBiochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus
  2. Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase
  3. Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock
  4. The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme
  5. Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept
  6. Resistance to antifungals that target CYP51
  7. Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51)
  8. Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock
  9. Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy
  10. An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example
  11. The cytochrome P450 complement (CYPome) ofMycosphaerella graminicola
  12. Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola
  13. The CYPome (Cytochrome P450 complement) of Aspergillus nidulans
  14. Expression and Characterization of CYP51, the Ancient Sterol 14‐demethylase Activity for Cytochromes P450 (CYP), in the White‐Rot Fungus Phanerochaete chrysosporium
  15. Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole
  16. Rewiring yeast for drug synthesis
  17. Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis
  18. The biodiversity of microbial cytochromes P450
  19. Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism
  20. Sterol 14α-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family
  21. Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5
  22. Activities and Kinetic Mechanisms of Native and Soluble NADPH–Cytochrome P450 Reductase
  23. Plant Sterol 14α-Demethylase Affinity for Azole Fungicides
  24. Genome-Wide Generation of Yeast Gene Deletion Strains
  25. Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis
  26. Engineering of Heterologous Cytochrome P450 in Acinetobacter sp.: Application for Pollutant Degradation
  27. Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents
  28. Molecular aspects of azole antifungal action and resistance
  29. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction
  30. Y132H substitution in Candida albicans sterol 14α-demethylase confers fluconazole resistance by preventing binding to haem
  31. The G464S Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Fluconazole Resistance in the Clinic through Reduced Affinity
  32. Characteristics of the heterologously expressed human lanosterol 14α-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human andCandida albicans CYP51 with azole antifungal agents
  33. Generation of a Complete, Soluble, and Catalytically Active Sterol 14α-Demethylase−Reductase Complex
  34. Systematic analysis of yeast strains with possible defects in lipid metabolism
  35. Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals
  36. Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14α-demethylase (CYP51; P450 14DM )
  37. A sterol biosynthetic pathway in Mycobacterium
  38. Molecular diversity of sterol 14α‐demethylase substrates in plants, fungi and humans
  39. Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism
  40. Cytochrome P450 3A4 mediated metabolism of 2,4-dichlorophenol
  41. Human cytochrome P450 3A4 is involved in the biotransformation of the herbicide 2,4-dichlorophenoxyacetic acid
  42. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients
  43. Studies on the Toxicity of Analogues of Dapsone In-vitro Using Rat, Human and Heterologously Expressed Metabolizing Systems†
  44. Metabolism of organochlorine pesticides: The role of human cytochrome P450 3A4
  45. Involvement of Human Cytochrome P450 3A4 in the metabolism of Vamidothion
  46. Role of Sterol Δ5(6)Desaturase in Azole Antifungal Mode of Action and Resistance
  47. Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol Δ22‐desaturase
  48. Metabolism of the herbicide chlortoluron by human cytochrome P450 3A4
  49. Investigation of the role of sterol Δ 8 → 7 -isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph
  50. Studies on azole-induced cell death in Saccharomyces cerevisiae
  51. Role of Cytochrome P450 in Tulip Bulb Probed by Substrate‐Binding Studies
  52. The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae
  53. Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiaeWHI2 gene
  54. The Diversity and Importance of Microbial Cytochromes P450