All Stories

  1. Chronic and acute modulator treatment restore wild-type-like activity and stability to the primary cystic fibrosis–causing CFTR variant

    Article • Proceedings of the National Academy of Sciences, January 2026, Proceedings of the National Academy of Sciences

    Dr David N Sheppard

  2. CFTR potentiators partially restore channel function to A561E‐CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del‐CFTR

    Article • Bone Marrow Transplantation, September 2014, Wiley

    Dr David N Sheppard

  3. Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D‐CFTR

    Article • The Journal of Physiology, March 2014, Wiley

    Dr David N Sheppard

  4. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

    Article • Bone Marrow Transplantation, December 2013, Wiley

    Dr David N Sheppard

  5. Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms

    Article • AJP Cell Physiology, June 2013, American Physiological Society

    Dr David N Sheppard

  6. Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth

    Article • AJP Renal Physiology, August 2012, American Physiological Society

    Dr David N Sheppard