All Stories

  1. Granzyme B as a therapeutic target for wound healing

    Article • Expert Opinion on Therapeutic Targets, September 2019, Taylor & Francis

    Dr David Granville

  2. Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling

    Article • Biological Chemistry, September 2016, De Gruyter

    Dr David Granville

  3. Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low‐dose ultraviolet light irradiation

    Article • Aging Cell, December 2014, Wiley

    Dr David Granville

  4. Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability

    Article • Laboratory Investigation, May 2014, Springer Science + Business Media

    Dr David Granville

  5. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

    Article • Nature Medicine, April 2014, Springer Science + Business Media

    Dr David Granville

  6. Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice

    Article • PLoS ONE, October 2013, PLOS

    Dr David Granville

  7. Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2013, American Thoracic Society

    Dr David Granville

  8. Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice

    Article • Cell Death and Differentiation, August 2013, Springer Science + Business Media

    Dr David Granville

  9. Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation

    Article • Matrix Biology, January 2013, Elsevier

    Dr David Granville

  10. Granzyme B in injury, inflammation, and repair

    Article • Trends in Molecular Medicine, December 2012, Elsevier

    Dr David Granville

  11. Correction: Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

    Article • PLoS ONE, May 2012, PLOS

    Dr David Granville

  12. Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

    Article • PLoS ONE, March 2012, PLOS

    Dr David Granville

  13. Erratum: Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm

    Article • Cell Death and Disease, October 2011, Springer Science + Business Media

    Dr David Granville

  14. Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm

    Article • Cell Death and Disease, September 2011, Springer Science + Business Media

    Dr David Granville

  15. 061 Extracellular matrix remodeling by granzyme B in aging tissues of apolipoprotein E knockout mice

    Article • Canadian Journal of Cardiology, September 2011, Elsevier

    Dr David Granville

  16. Granzyme K Activates Protease-Activated Receptor-1

    Article • PLoS ONE, June 2011, PLOS

    Dr David Granville

  17. Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

    Article • Experimental Gerontology, June 2011, Elsevier

    Dr David Granville

  18. Granzymes in age-related cardiovascular and pulmonary diseases

    Article • Cell Death and Differentiation, February 2010, Springer Science + Business Media

    Dr David Granville

  19. Perforin-Independent Extracellular Granzyme B Activity Contributes to Abdominal Aortic Aneurysm

    Article • American Journal Of Pathology, February 2010, Elsevier

    Dr David Granville

  20. Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

    Article • Laboratory Investigation, September 2009, Springer Science + Business Media

    Dr David Granville

  21. Characterization of Granzyme B Protein Expression in Blood from COPD Patients.

    Article • April 2009, American Thoracic Society

    Dr David Granville

  22. The Role of Granzyme B in the Pathogenesis of COPD.

    Article • April 2009, American Thoracic Society

    Dr David Granville

  23. Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice

    Article • AJP Renal Physiology, February 2009, American Physiological Society

    Dr David Granville

  24. Cytochrome p450 2C Enzymes Contribute to Peritransplant Ischemic Injury and Cardiac Allograft Vasculopathy

    Article • American Journal of Transplantation, August 2008, Wiley

    Dr David Granville

  25. Apolipoprotein E, an important player in longevity and age-related diseases

    Article • Experimental Gerontology, July 2008, Elsevier

    Dr David Granville

  26. Ramipril Improves Oxidative Stress-Related Vascular Endothelial Dysfunction in db/db Mice

    Article • The Journal of Physiological Sciences, January 2008, Physiological Society of Japan

    Dr David Granville

  27. Detection and Quantification of Apoptosis in the Vasculature

    Article • January 2007, Springer Science + Business Media

    Dr David Granville

  28. Allograft Vasculopathy Versus Atherosclerosis

    Article • Circulation Research, October 2006, Wolters Kluwer Health

    Dr David Granville

  29. Cytochromes P450 and ischemic heart injury: Potential role for inhibitors in the treatment of myocardial infarction

    Article • Drug Discovery Today Disease Mechanisms, March 2005, Elsevier

    Dr David Granville

  30. TAT-Mediated Protein Transduction

    Article • January 2005, Springer Science + Business Media

    Dr David Granville

  31. THE ROLE OF PERFORIN IN TRANSPLANT VASCULAR DISEASE

    Article • Cardiovascular Pathology, May 2004, Elsevier

    Dr David Granville

  32. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors

    Article • Proceedings of the National Academy of Sciences, January 2004, Proceedings of the National Academy of Sciences

    Dr David Granville

  33. APOPTOSIS IN CARDIAC TRANSPLANT REJECTION

    Article • Cardiology Clinics, February 2001, Elsevier

    Dr David Granville