David Clapham
HHMI, Boston Children's Hospital, Harvard Medical School
Professor, Health Sciences
United States
My co-authors include
Dr Benjamin A Hall
Prof. MASAHIRO ITO
Terry Ann Krulwich
My Publications
Ionic selectivity and thermal adaptations within the voltage-gated sodium channel fami...
eLife
November 2014
The TRPM7 Chanzyme Is Cleaved to Release a Chromatin-Modifying Kinase
Cell
May 2014
Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chl...
JAMA Neurology
May 2014
Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Pho...
Cell
May 2014
Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1
Cell Reports
March 2014
Direct recording and molecular identification of the calcium channel of primary cilia
Nature
December 2013
Primary cilia are specialized calcium signalling organelles
Nature
December 2013
TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation
Cell Reports
December 2013
The mother of all endocytosis
eLife
November 2013
Sperm BerserKers
eLife
October 2013
Role of the C-terminal domain in the structure and function of tetrameric sodium channels
Nature Communications
September 2013
MCU encodes the pore conducting mitochondrial calcium currents
eLife
June 2013
Rheotaxis Guides Mammalian Sperm
Current Biology
March 2013
mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State
Cell
February 2013
Properties of the Mitochondrial Permeability Transition in Drosophila S2R+ Cells
Biophysical Journal
January 2013
Sperm Patch-Clamp
January 2013
Catsper Channel Organizes and Regulates Calcium Signaling Molecules in Spermatozoa
Biophysical Journal
January 2013
The Ion Channel-Kinase, TRPM7, is Required for Cardiac Automaticity
Biophysical Journal
January 2013
Analysis of the selectivity filter of the voltage-gated sodium channel NavRh
Cell Research
December 2012
Anion-Sensitive Fluorophore Identifies the Drosophila Swell-Activated Chloride Channel ...
PLoS ONE
October 2012
TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes...
Cell
October 2012
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
Cell
September 2012
Cleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Par...
Developmental Cell
June 2012
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
Nature
May 2012
The Control of Male Fertility by Spermatozoan Ion Channels
Annual Review of Physiology
March 2012
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke
Nature Neuroscience
March 2012
Drosophila Bestrophin 1 is a Swell Activated Chloride Channel
Biophysical Journal
January 2012
A Thermodynamic Framework for Understanding Temperature-Sensitivity in TRP Channels
Biophysical Journal
January 2012
Super-Resolution Imaging Reveals a Multi-Array Arrangement of Catsper Channel on the Sp...
Biophysical Journal
January 2012
Controlled delivery of bioactive molecules into live cells using the bacterial mechanos...
Nature Communications
January 2012
Novel Na+-Selective Channels in the Lysosome
Biophysical Journal
January 2012
Cardiac-Targeted TRPM7 Deletion Induces Heart Block and Cardiomyopathy via Disrupted Em...
Biophysical Journal
January 2012
A novel Gene Required for Male Fertility and Functional Catsper Channel Formation in Sp...
Biophysical Journal
February 2011
A novel gene required for male fertility and functional CATSPER channel formation in sp...
Nature Communications
January 2011
Mechanisms of Transmembrane Signaling
January 2011
TRPM7, the Mg2+ Inhibited Channel and Kinase
December 2010
An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1
Nature Structural & Molecular Biology
June 2010
Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Lig...
Nano Letters
June 2010
TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation
Cell
April 2010
A Single S4 Arginine is Sufficient for Voltage Sensitivity in the Hv1 Proton Channel
Biophysical Journal
January 2010
Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter
Science
October 2009
Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior
Cell
May 2009
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels
The Journal of General Physiology
April 2009
A STIMulus Package Puts Orai Calcium Channels to Work
Cell
March 2009
Voltage and proton gradient sensing in Hv1 proton channels
Biophysical Journal
February 2009
H+ Permeation in Hv1 Voltage-gated Proton Channels
Biophysical Journal
February 2009
Phenotyping sensory nerve endings in vitro in the mouse
Nature Protocols
January 2009
Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm...
PLoS ONE
October 2008
The MUPP1–SynGAPα protein complex does not mediate activity-induced LTP☆
Molecular and Cellular Neuroscience
June 2008
Citral Sensing by TRANSient Receptor Potential Channels in Dorsal Root Ganglion Neurons
PLoS ONE
May 2008
Ion channels that control fertility in mammalian spermatozoa
The International Journal of Developmental Biology
January 2008
Calcium Signaling
Cell
December 2007
SnapShot: Mammalian TRP Channels
Cell
April 2007
Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in th...
Cell
December 2006
The TRPM7 Ion Channel Functions in Cholinergic Synaptic Vesicles and Affects Transmitte...
Neuron
November 2006
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport
The EMBO Journal
June 2006
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP cha...
Nature Neuroscience
April 2006
A voltage-gated proton-selective channel lacking the pore domain
March 2006
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ ch...
February 2006
AN INTRODUCTION TO TRP CHANNELS
Annual Review of Physiology
January 2006
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relation...
Pharmacological Reviews
December 2005
International Union of Pharmacology. L. Nomenclature and Structure-Function Relationshi...
Pharmacological Reviews
December 2005
TRP channels and mice deficient in TRP channels
Pflügers Archiv - European Journal of Physiology
August 2005
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
Nature Genetics
May 2005
SynGAP-MUPP1-CaMKII Synaptic Complexes Regulate p38 MAP Kinase Activity and NMDA Recept...
Neuron
August 2004
Rapid vesicular translocation and insertion of TRP channels
Nature Cell Biology
July 2004
TRP ion channels in the nervous system
Current Opinion in Neurobiology
June 2004
A Spontaneous, Recurrent Mutation in Divalent Metal Transporter-1 Exposes a Calcium Ent...
PLoS Biology
March 2004
The mitochondrial calcium uniporter is a highly selective ion channel
January 2004
Intracellular Signaling and Regulation of Cardiac Ion Channels
January 2004
TRP channels as cellular sensors
December 2003
Symmetry, Selectivity, and the 2003 Nobel Prize
Cell
December 2003
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: T...
Pharmacological Reviews
December 2003
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B an...
Neuron
November 2003
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
Nature Neuroscience
July 2003
Mechanism of Persistent Protein Kinase D1 Translocation and Activation
Developmental Cell
April 2003
Real-Time Imaging of Nuclear Permeation by EGFP in Single Intact Cells
Biophysical Journal
February 2003
Modified herpes simplex virus delivery of enhanced GFP into the central nervous system
Journal of Neuroscience Methods
December 2002
Sorting out MIC, TRP, and CRAC Ion Channels
The Journal of General Physiology
July 2002
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Nature
June 2002
The TRPM7 channel is inactivated by PIP2 hydrolysis
Nature Cell Biology
April 2002
SIGNAL TRANSDUCTION: Hot and Cold TRP Ion Channels
Science
March 2002
Structural characterization of the mouse Girk genes
Gene
February 2002
A sperm ion channel required for sperm motility and male fertility
Nature
October 2001
The trp ion channel family
Nature Reviews Neuroscience
June 2001
Evaluation of the role of IKAChin atrial fibrillation using a mouse knockout model
Journal of the American College of Cardiology
June 2001
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
Neuron
March 2001
Excitability and Conduction
January 2001
How to Lose Your Hippocampus by Working on Chloride Channels
Neuron
January 2001
Distinct Ion Channel Classes Are Expressed on the Outer Nuclear Envelope of T- and B-Ly...
Biophysical Journal
July 2000
Remembering Eva Neer
Cell
April 2000
Conformational Changes of the in Situ Nuclear Pore Complex
Biophysical Journal
July 1999
Unlocking Family Secrets
Cell
May 1999
Molecular Determinants for Subcellular Localization of PSD-95 with an Interacting K+ Ch...
Neuron
May 1999
Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein-Gate...
Annals of the New York Academy of Sciences
April 1999
GIRK4 Confers Appropriate Processing and Cell Surface Localization to G-protein-gated P...
Journal of Biological Chemistry
January 1999
Chapter 16 G-Protein-Gated Potassium Channels: Implication for the weaver Mouse
January 1999
G βγ Binding Increases the Open Time of I KACh : Kinetic Evidence for Multiple G βγ B...
Biophysical Journal
January 1999
Touch Channels Sense Blood Pressure
Neuron
December 1998
Not So Funny Anymore
Neuron
July 1998
At last, the structure of an ion-selective channel
Nautre Structural Biology
May 1998
A Novel Inward Rectifier K+ Channel with Unique Pore Properties
Neuron
May 1998
Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swel...
The Journal of General Physiology
May 1998
Calcium regulation of nuclear pore permeability
Cell Calcium
February 1998
Abnormal Heart Rate Regulation in GIRK4 Knockout Mice
Neuron
January 1998
Nuclear calcium and the regulation of the nuclear pore complex
BioEssays
September 1997
Calcium release and influx colocalize to the endoplasmic reticulum
Current Biology
August 1997
Ion Channels — Basic Science and Clinical Disease
New England Journal of Medicine
May 1997
In Memoriam: Fredric S. Fay
Neuron
May 1997
G PROTEIN βγ SUBUNITS
The Annual Review of Pharmacology and Toxicology
April 1997
Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium...
Cell Calcium
April 1997
Partial Structure, Chromosome Localization, and Expression of the MouseIclnGene
Genomics
March 1997
Intracellular signalling: More jobs for Gβγ
Current Biology
July 1996
TRP Is Cracked but Is CRAC TRP?
Neuron
June 1996
The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-...
FEBS Letters
January 1996
The G-protein nanomachine
Nature
January 1996
Localization and Interaction of Epitope-tagged GIRK1 and CIR Inward Rectifier K + Chan...
Neuropharmacology
January 1996
Replenishing the stores
Nature
June 1995
G-protein regulation of ion channels
Current Opinion in Neurobiology
June 1995
Calcium signaling
Cell
January 1995
Calcium release from the nucleus by InsP3 receptor channels
Neuron
January 1995
1 Intracellular calcium waves
January 1995
Why testicles are cool
Nature
September 1994
Calcium channels activated by depletion of internal calcium stores in A431 cells
Biophysical Journal
July 1994
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
Nature
March 1994
Direct G Protein Activation of Ion Channels?
Annual Review of Neuroscience
March 1994
Molecular characterization of a swelling-induced chloride conductance regulatory protei...
Cell
February 1994
Simultaneous Ultraviolet and Visible Excitation Confocal Microscopy
January 1994
Simultaneous Ultraviolet and Visible Wavelength Confocal Microscopy
January 1994
[27] G-protein-mediated pathways assayed by electrophysiology and confocal microscopy
January 1994
Simultaneous Near Ultraviolet and Visible Excitation Confocal Microscopy of Calcium Tra...
January 1994
Mutations in G protein-linked receptors: Novel insights on disease
Cell
December 1993
New roles for G-protein (βγ-dimers in transmembrane signalling
Nature
September 1993
Specificity of receptor-G protein interactions: Searching for the structure behind the ...
Cellular Signalling
September 1993
A mysterious new influx factor?
Nature
August 1993
Fantastic voyagers? Review of B. C. Crandall and James Lewis, Nanotechnology: Research ...
Biophysical Journal
August 1993
Reply
Trends in Cardiovascular Medicine
July 1993
α-Helical distorting substitutions disrupt coupling between m3 muscarinic receptor and ...
FEBS Letters
June 1993
Calcium waves
Current Opinion in Neurobiology
June 1993
Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx
Science
April 1993
Calcium wave propagation by calcium-induced calcium release: An unusual excitable system
Bulletin of Mathematical Biology
March 1993
Cardiac chloride channels
Trends in Cardiovascular Medicine
January 1993
Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes
Cell
April 1992
New mammalian chloride channel identified by expression cloning
Nature
March 1992
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel
Nature
January 1992
Signal transduction through G proteins in the cardiac myocyte
Trends in Cardiovascular Medicine
January 1992
Spiral waves and intracellular calcium signalling
Journal of Physiology-Paris
January 1992
Chloride channels in the nuclear membrane
The Journal of Membrane Biology
July 1991
Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes
Science
April 1991
Subcellular patterns of calcium release determined by G protein-specific residues of mu...
Nature
April 1991
Cell Signalling. Noel G. Morgan
The Quarterly Review of Biology
March 1991
Intracellular Regulation of Ion Channels in Cell Membranes
Mayo Clinic Proceedings
August 1990
Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels i...
Biochemical Pharmacology
March 1990
Structure and Function of G-Protein βγ Subunit
January 1990
Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells
Pflügers Archiv - European Journal of Physiology
August 1989
Potassium channels in cardiac cells activated by arachidonic acid and phospholipids
Science
June 1989
G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2
Nature
February 1989
Muscarinic-activated K+ current in bovine aortic endothelial cells
Circulation Research
June 1988
Roles of G protein subunits in transmembrane signalling
Nature
May 1988
G protein opening of K+ channels
Nature
May 1987
The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
Nature
January 1987
Potassium channels and conductance in cultured mouse peritoneal macrophages
January 1985
Voltage-Activated K Channels in Embryonic Chick Heart
Biophysical Journal
January 1984
Small signal impedance of heart cell membranes
The Journal of Membrane Biology
December 1982
Intercellular Coupling between Embryonic Heart Cell Aggregates
January 1982
Second-Order Admittance in Squid Axon
January 1981
Development of electrical coupling and action potential synchrony between paired aggreg...
The Journal of Membrane Biology
March 1979
The theoretical small signal impedance of the frog node,Rana pipiens
Pflügers Archiv - European Journal of Physiology
January 1976
