All Stories

  1. Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies
  2. The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease
  3. ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells
  4. Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease
  5. GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species
  6. Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling
  7. Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation
  8. Treatment of atherosclerotic plaque: perspectives on theranostics
  9. Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes
  10. Endothelial function and dysfunction: Impact of metformin
  11. Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells
  12. Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics
  13. Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation
  14. Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis
  15. G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors
  16. Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2
  17. Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis
  18. RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells
  19. Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes
  20. Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors
  21. Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors andde novoprotein synthesis
  22. Gaq proteins: molecular pharmacology and therapeutic potential
  23. The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
  24. Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response
  25. Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling
  26. Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells
  27. Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes
  28. Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11
  29. Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
  30. The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
  31. 25Years of endothelin research: the next generation
  32. Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells
  33. Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools
  34. Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
  35. Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools
  36. Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation
  37. Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells
  38. (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells
  39. Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors
  40. Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle