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  1. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology
  2. Nanomaterials for targeted drug delivery to cancer stem cells
  3. Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine
  4. Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles
  5. Carbon nanotubes enhance the internalization of drugs by cancer cells and decrease their chemoresistance to cytostatics
  6. Role of carbonaceous nanomaterials in stimulating osteogenesis in mammalian bone cells
  7. The Use of Genomics in Model in Vitro Systems
  8. Progress in materials for thermal ablation of cancer cells
  9. Raman spectroscopy as a detection and analysis tool for in vitro specific targeting of pancreatic cancer cells by EGF‐conjugated, single‐walled carbon nanotubes
  10. Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
  11. Engineered nanostructural materials for application in cancer biology and medicine
  12. Electrically Conductive Gold-Coated Collagen Nanofibers for Placental-Derived Mesenchymal Stem Cells Enhanced Differentiation and Proliferation
  13. Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells
  14. Enhanced Bone Cells Growth and Proliferation on TiO2 Nanotubular Substrates Treated by RF Plasma Discharge
  15. Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells
  16. The Viracept-EMS case: Impact and outlook
  17. Cytotoxicity and biological effects of functional nanomaterials delivered to various cell lines
  18. Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization
  19. Nanotoxicity
  20. Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a nationally representative managed-care population
  21. Toxicogenomics: A Regulatory Perspective
  22. Effect of p53 genotype on gene expression profiles in murine liver
  23. Use of DNA Arrays in Understanding Hepatic Test Systems
  24. The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology
  25. Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative
  26. Empowering microarrays in the regulatory setting
  27. Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13–14, 2004
  28. Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
  29. Paving the Way for Safer, More Effective Drugs, Food, and Medical Products
  30. QA/QC: challenges and pitfalls facing the microarray community and regulatory agencies
  31. Median-of-Subsets Normalization of Intensities for cDNA Array Data
  32. Preface to mutation research special issue on toxicogenomics
  33. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
  34. Development of public toxicogenomics software for microarray data management and analysis
  35. Comparison of Basal Gene Expression in Cultured Primary Rat Hepatocytes and Freshly Isolated Rat Hepatocytes
  36. Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities
  37. ArrayTrack--Supporting Toxicogenomic Research at the U.S. Food and Drug Administration National Center for Toxicological Research
  38. ArrayTrack - Supporting Toxicogenomic Research at the U.S. Food and Drug Administration National Center for Toxicological Research
  39. Mutagenicity of Food-Derived Carcinogens and the Effect of Antioxidant Vitamins
  40. Activity Profile of Glutathione-Dependent Enzymes and Respiratory Chain Complexes in Rats Supplemented with Antioxidants and Treated with Carcinogens
  41. The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: Implications for chronic studies
  42. Decreasedin vitro interaction between p53 and nuclear stress proteins in thep53-deficient mouse
  43. Gene‐ and tissue‐specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N‐hydroxy‐2‐acetylaminofluorene†
  44. Neonatal Mouse Model: Review of Methods and Results
  45. Strategies and testing methods for identifying mutagenic risks
  46. DEVELOPMENT AND UTILIZATION OF PRIMARY HEPATOCYTE CULTURE SYSTEMS TO EVALUATE METABOLISM, DNA BINDING, AND DNA REPAIR OF XENOBIOTICS*
  47. In vivo transgenic mutation assays
  48. Effects of Bleomycin on Liver Antioxidant Enzymes and the Electron Transport System From Ad Libitum-Fed and Dietary-Restricted Female and Male Fischer 344 Rats
  49. An FDA Review of Sulfamethazine Toxicity
  50. Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens
  51. Differential protooncogene expression in Sprague Dawley and Fischer 344 rats during 1,2-dichlorobenzene-induced hepatocellular regeneration
  52. Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction
  53. Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative
  54. Induction of stress proteins by electromagnetic fields in cultured HL-60 cells
  55. Evaluation of the transgenic p53+/− mouse for detecting genotoxic liver carcinogens in a short-term bioassay
  56. The relationship of p53 and stress proteins in response to bleomycin and retinoic acid in the p53 heterozygous mouse
  57. Aflatoxin B1-induced Hprt mutations in splenic lymphocytes of Fischer 344 rats.
  58. Tk+/− mouse model for detecting in vivo mutation in an endogenous, autosomal gene
  59. Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
  60. Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
  61. Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the neonatal bioassay
  62. Genetic toxicology: Impact on the next generation of toxicology
  63. Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells
  64. Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester
  65. Mutational response at the splenic T‐Lymphocyte hprt locus in mice treated as neonates: Contrasting effects of the carcinogens N‐ethyl‐N‐nitrosourea, dimethylnitrosamine, and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
  66. Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
  67. Mutational response at the splenic T-Lymphocytehprt locus in mice treated as neonates: Contrasting effects of the carcinogensN-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
  68. Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice
  69. Development and utilization of the rat lymphocyte hprt mutation assay
  70. P XV.10 Quantitative and molecular analysis of DMBA-induced mutations in the model BlueRat™″: Comparison of mutagenesis in the transgene lacI with the endogenous gene hprt
  71. p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
  72. Modulation of antioxidant enzymes in bleomycin‐treated rats by vitamin c and β‐carotene
  73. Molecular analysis of lacI mutations in Rat2™ cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
  74. A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk+− human lymphoblastoid cells
  75. P48: A novel nuclear protein possibly associated with aging and mortality
  76. A mutation in the p53 tumor suppressor gene of AHH-1 tk+− human lymphoblastoid cells
  77. The effect of aging and dietary restriction on the retinoylation of nuclear matrix proteins in rats
  78. Development and characterization of an in vivo somatic mutation assay
  79. The use of transgenic cell lines for evaluating toxic metabolites of carbamazepine
  80. Characterization of rat lymphocyte primary culture for the development of an in-vitro mutagenesis assay: Effect of interleukin-2 and 2-mercaptoethanol on the activities of intermediary metabolism enzymes and cell proliferation
  81. Comparison of the cell cycle regulated synthesis and phosphorylation of stress proteins, actin isoforms and a novel actin-like protein following drug administration in cultured rat lymphocytes
  82. Calorie restriction modulates chemically induced in vivo somatic mutation frequency
  83. Other transgenic mutation assays: Development of a novel mousetk+/− embryonic stem cell line for use in mutagenicity studies
  84. Cell cycle traverse in AHH-1tk +/− human lymphoblastoid cells exposed to the chromosomal mutagen,m-amsa
  85. Effects of age and caloric restriction on cell proliferation in hepatocyte cultures from control and hepatectomized Fischer 344 rats
  86. Genotoxicity of tacrine in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats
  87. Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats
  88. International workshop on mouse lymphoma assay testing practices and data interpretations: Portland, Oregon, may 7,1994
  89. Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells
  90. The role of programmed cell death in the toxicity of the mutagens, ethyl methanesulfonate and N-ethyl-N′-nitrosourea, in AHH-1 human lymphoblastoid cells
  91. The temporal relationships of synthesis and phosphorylation in stress proteins 70 and 90 in aged caloric restricted rats exposed to bleomycin
  92. Cytochrome P450-dependent metabolism of acetaminophen in four human transgenic lymphoblastoid cell lines
  93. Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-l-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP) metabolism, PhIP–DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes
  94. The homology of a novel polypeptide with stress protein characteristics in embryonic mice brain and in the hypothalamus of caloric restricted rats as determined by ultramicro western blotting
  95. Aging and enzyme induction: Effect on chemically-induced DNA repair in non-proliferating Fischer F344 rat hepatocytes
  96. Histone variants, H1subtypes and other chromatin proteins as biomarkers of age and caloric restriction in rats
  97. Evidence that DNA repair may not be modified by age or chronic caloric restriction
  98. Cryopreservation: A reliable method for long-term storage and culture of isolated non-proliferating rat hepatocytes
  99. Comparative studies of synthesis, phosphorylation, DNA binding and proteolytic characteristics of a novel protein during phases of the mouse spleen cell cycle
  100. The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea
  101. Flow cytometric analysis of the cell-cycle distribution of spleen lymphocytes isolated from Fischer 344 rats exposed to ethyl nitrosourea
  102. HepG2 Cells: An in Vitro Model for P450-Dependent Metabolism of Acetaminophen
  103. Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay
  104. Cryopreservation and long-term storage of primary rat hepatocytes: Effects on substrate-specific cytochrome P450-dependent activities and unscheduled DNA synthesis
  105. A nuclear protein associated with lethal heat shock of HL-60 cells
  106. Nitrobenzo[a]pyrene‐induced DNA amplification in SV40‐transformed chinese hamster embryo cells
  107. Effect of bromodeoxyuridine on the proliferation and growth of ethyl methanesulfonate-exposed P3 cells: Relationship to the induction of sister-chromatid exchanges
  108. Metabolism of methapyrilene by Fischer-344 rat and B6C3F1mouse hepatocytes
  109. Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone
  110. The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation
  111. Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide
  112. Flow cytometric evaluation of cell‐cycle progression in ethyl methanesulfonate and methyl methanesulfonate‐exposed P3 Cells: Relationship to the induction of sister‐chromatid exchanges and cellular toxicity
  113. Modifications in Regulation of Intermediary Metabolism by Caloric Restriction in Rodents
  114. The induction of aneuploidy by 3-nitrobenzo[a]pyrene in Chinese hamster ovary cells
  115. Effects of selected chemicals on the glutathione status in the male reproductive system of rats
  116. Effect of interleukin‐2 on cell proliferation, sister‐chromatid exchange induction, and nuclear stress protein phosphorylation in Pha‐stimulated fischer 344 rat spleen lymphocytes: Modulation by 2‐mercaptoethanol
  117. Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay
  118. An evaluation of the cho/hgprt mutation assay involving suspension cultures and soft agar cloning: Results for 33 chemicals
  119. Modulation of SCE induction and cell proliferation by 2-mercaptoethanol in phytohemagglutinin-stimulated rat lymphocytes
  120. Triethylene melamine-induced sister-chromatid exchange in murine lymphocytes exposed in vivo
  121. Pretreatment with mixed‐function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay
  122. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats
  123. Inhibition of 7,12-dimethylbenz[a]anthracene-induced genotoxicity in Chinese hamster ovary cells by retinol and retinoic acid
  124. Metabolism of 2‐acetylaminofluorene in the chinese hamster ovary cell mutation assay
  125. Evaluation of Propanil and Its N-Oxidized Derivatives for Genotoxicity in the Salmonella typhimurium Reversion, Chinese Hamster 1 Ovary/Hypoxanthine Guanine Phosphoribosyl Transferase, and Rat Hepatocyte/DNA Repair Assays
  126. Comparative immunochemical and structural similarities of five stress proteins from various tissue types
  127. The turnover of radiolabeled nuclear proteins in rats exposed to environmental and chemical stress
  128. A protocol and guide for the in vitro rat hepatocyte DNA-repair assay
  129. A protocol and guide for the in vivo rat hepatocyte DNA-repair assay
  130. Micro-size polyacrylamide gel electrophoresis system
  131. Unscheduled DNA synthesis: Workshop overview
  132. Retinoic acid induction of stress proteins in fetal mouse limb buds
  133. Metabolism of Doxylamine Succinate in Fischer 344 Rats Part II: Nonconjugated Urinary and Fecal Metabolites
  134. Cell cycle-specific effects of sodium arsenite and hyperthermic exposure on incorporation of radioactive leucine and phosphate by stress proteins from mouse lymphoma cell nuclei
  135. Modulation of ultraviolet light‐, ethyl methanesulfonate‐, and 7, 12‐dimethylbenz[a]anthracene‐induced unscheduled dna synthesis by retinol and retinoic acid in the primary rat hepatocyte
  136. Identification of C8-modified deoxyinosine and N 2 -and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochry...
  137. Preface human cell carcinogenesis
  138. Use of the human liver cell line Hep G2 in a modified Salmonella reversion assay
  139. Hepatocyte-mediated mutagenicity of mononitrobenzo[a]pyrenes in Salmonella typhimurium strains
  140. Analysis of protein incorporation of radioactive isotopes in the chinese hamster ovary cell cycle by electronic sorting and gel microelectrophoresis
  141. Microscale electrophoresis of stress proteins induced by chemicals during the in vivo cell cycle
  142. The Effects of Various Lighting Schedules Upon the Orcadian Rhythms of 23 Liver or Brain Enzymes of C57Bl/6J Mice
  143. SHORT COMMUNICATION
  144. Involvement of Superoxide Radical in the Toxicity of Mineral Fibers
  145. Comparison of mutagenicities in a salmonella reversion assay mediated by uninduced hepatocytes and hepatocytes from rats pretreated for 1 or 5 days with aroclor 1254
  146. Insulin and glucagon's reciprocal mediation of a dual regulation mechanism for pyruvate kinase
  147. Synthesis, spectral analysis, and mutagenicity of 1-, 3-, and 6-nitrobenzo[a]pyrene
  148. Potentiation of dimethylnitrosamine genotoxicity in rat hepatocytes isolated following ethanol treatment in vivo
  149. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocytes/DNA repair assay
  150. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay
  151. Unscheduled DNA synthesis tests
  152. Statistical criteria for evaluating chemicals as positive or negative in the hepatocyte/DNA repair assay
  153. Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells
  154. A method for rapid, sensitive quantitation of short-patch DNA repair in cultured rat hepatocytes
  155. Detection of Enzyme Activity Variants in Mice
  156. Development of a new biochemical mutation test in mice based upon measurement of enzyme activities I. Theoretical concepts and basic procedure
  157. Biologically active aromatic amines derived from carcinogenic polycyclic aromatic hydrocarbons: synthesis and mutagenicity of aminobenzo[α]pyrenes
  158. Metabolism of the mutagenic environmental pollutant, 6-nitrobenzo[a]pyrene: Metabolic activation via ring oxidation
  159. The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals
  160. The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures
  161. Comparative induction of unscheduled DNA synthesis by physical and chemical agents in non-proliferating primary cultures of rat hepatocytes
  162. Assay for mouse tissue enzymes: Levels of activity and statistical variation for 29 enzymes of liver or brain
  163. Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography
  164. The isolation and primary culture of viable, nonproliferating rat hepatocytes
  165. 2-Acetylaminofluorene-induced unscheduled DNA synthesis in hepatocytes isolated from 3-methylcholanthrene treated rats
  166. Utility of isoelectric focusing techniques for detection of induced in vivo mammalian microlesions
  167. Isolation and characterization of intact adult liver parenchymal cells capable of metabolism of promutagens and procarcinogens
  168. Enzyme activity as a genetic marker to detect induced microlesions in mammals
  169. Metabolism of 17α‐ethynylestradiol by intact liver parenchymal cells isolated from mouse and rat
  170. An integrated approach to testing chemicals for mutagenic potential in mammals
  171. A specific and sensitive fluorometric assay for tryptophan oxygenase
  172. Isolation and characterization of an hydroxykynureninase from homogenates of adult mouse liver