All Stories

  1. Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation

    Article • Communications Biology, May 2019, Springer Science + Business Media

    Dr Damian B S Yap

  2. Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer

    Article • Scientific Reports, October 2017, Nature

    Dr Damian B S Yap

  3. Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Article • eLife, March 2017, eLife

    Dr Damian B S Yap

  4. CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

    Article • Nature Communications, February 2017, Nature

    Dr Damian B S Yap

  5. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

    Article • Nature Genetics, May 2016, Nature

    Dr Damian B S Yap

  6. Clonal genotype and population structure inference from single-cell tumor sequencing

    Article • Nature Methods, May 2016, Nature

    Dr Damian B S Yap

  7. Weaver Syndrome‐Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

    Article • Human Mutation, January 2016, Wiley

    Dr Damian B S Yap

  8. The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

    Article • Neoplasia, August 2015, Elsevier

    Dr Damian B S Yap

  9. A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

    Article • Breast Cancer Research, January 2015, Springer Science + Business Media

    Dr Damian B S Yap

  10. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

    Article • Nature, November 2014, Nature

    Dr Damian B S Yap

  11. TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

    Article • Genome Research, July 2014, Cold Spring Harbor Laboratory Press

    Dr Damian B S Yap

  12. Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia

    Article • Haematologica, June 2014, Ferrata Storti Foundation (Haematologica)

    Dr Damian B S Yap

  13. A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

    Article • Blood, May 2014, American Society of Hematology

    Dr Damian B S Yap

  14. PyClone: statistical inference of clonal population structure in cancer

    Article • Nature Methods, March 2014, Nature

    Dr Damian B S Yap

  15. Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5

    Article • PLoS ONE, October 2013, PLOS

    Dr Damian B S Yap

  16. The clonal and mutational evolution spectrum of primary triple-negative breast cancers

    Article • Nature, April 2012, Nature

    Dr Damian B S Yap

  17. Mll5 Is Required for Normal Spermatogenesis

    Article • PLoS ONE, November 2011, PLOS

    Dr Damian B S Yap

  18. Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance

    Article • Experimental Hematology, August 2011, Elsevier

    Dr Damian B S Yap

  19. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

    Article • BMC Genomics, January 2011, Springer Science + Business Media

    Dr Damian B S Yap

  20. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

    Article • Blood, December 2010, American Society of Hematology

    Dr Damian B S Yap

  21. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

    Article • Nature Genetics, January 2010, Springer Science + Business Media

    Dr Damian B S Yap

  22. Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

    Article • Blood, September 2008, American Society of Hematology

    Dr Damian B S Yap

  23. ASPP1 and ASPP2 are new transcriptional targets of E2F

    Article • Cell Death and Differentiation, February 2005, Nature

    Dr Damian B S Yap

  24. Ser392 Phosphorylation Regulates the Oncogenic Function of Mutant p53

    Article • Cancer Research, July 2004, American Association for Cancer Research (AACR)

    Dr Damian B S Yap

  25. Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

    Article • Molecular and Cellular Biology, January 2002, ASM Journals

    Dr Damian B S Yap

  26. Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

    Article • Journal of Biological Chemistry, September 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Damian B S Yap

  27. Ligation of CD40 Potentiates Fas-Mediated Activation of the Cysteine Protease CPP32, Cleavage of Its Death Substrate PARP, and Apoptosis in Ramos–Burkitt Lymphoma B Cells

    Article • Cellular Immunology, November 1997, Elsevier

    Dr Damian B S Yap