All Stories

  1. Insulin edema in slowly progressive type 1 diabetes: improvement following adjustment of insulin therapy
  2. Improvement of Symptoms in a Patient With Glycogen Storage Disease Through Nutritional Guidance and Exercise Therapy
  3. Response to commentary on ‘A prediction model for diabetes complications using the Kokuho Database and its application to public health services in Japan’
  4. Cardiovascular risk reduction with glucagon‐like peptide‐1 receptor agonists is proportional to HbA1c lowering in type 2 diabetes: An updated meta‐regression analysis incorporating ...
  5. Heterogeneous cardiovascular effects of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes: a causal forest and target trial emulation study
  6. Insulinoma diagnosis and characterization with intratumoral heterogeneity employing [18F]FB(ePEG12)12-exendin-4 PET/MRI
  7. A multicenter, prospective, real‐world study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice ( PIONEER REAL Japan): Subgroup analyses
  8. Accelerating innovation and ensuring the thoughtful withdrawal of lifeline medicines for people living with diabetes in Asia
  9. Evolving incretin-based therapies in Japan: optimizing treatment strategies for diverse clinical and socioeconomical profiles in type 2 diabetes
  10. Correction: Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial
  11. Depression risk associated with spouses’ diabetes and cardiovascular events: a nationwide cohort study
  12. A prediction model for diabetes complications using the Kokuho Database and its application to public health services in Japan
  13. Voltage-gated calcium channel α2δ-1 subunit is involved in the regulation of glucose-stimulated GLP-1 secretion in mice
  14. Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial
  15. Toward a cure for diabetes: iPSC and ESC‐derived islet cell transplantation trials
  16. The Ulaanbaatar agreement: Revising diabetes terminology in Asia to combat stigma
  17. Quality of Life in Japanese People with Type 2 Diabetes Switching from Multiple Daily Insulin Injections to Once-Daily iGlarLixi: SIMPLIFY Japan
  18. PIONEER REAL Japan: Primary results from a multicenter, prospective, real‐world study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice
  19. Safety and effectiveness of tofogliflozin in Japanese people with type 2 diabetes: A multicenter prospective observational study in routine clinical practice
  20. Sporadic Parathyroid Carcinoma Treated With Lenvatinib, Exhibiting a Novel Somatic MEN1 Mutation
  21. A consensus statement from the Japan Diabetes Society: A proposed algorithm for pharmacotherapy in people with type 2 diabetes – 2nd edition (English version)
  22. A Study on the Compatibility of a Food-Recording Application with Questionnaire-Based Methods in Healthy Japanese Individuals
  23. Obsessive‐compulsive disorder as an initial manifestation of anti‐glutamic acid decarboxylase antibody‐associated encephalitis
  24. PIONEER REAL Japan: Baseline characteristics of a multicenter, prospective, real‐world study of oral semaglutide in adults with type 2 diabetes in clinical practice in Japan
  25. Japanese 17q12 Deletion Syndrome with Complex Clinical Manifestations
  26. Impact of Participant Characteristics on Clinical Outcomes with iGlarLixi in Type 2 Diabetes: Post Hoc Analysis of SPARTA Japan
  27. Visceral Adipose Tissue Quality and its Impact on Metabolic Health
  28. Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation
  29. [<sup>18</sup>F]FB(ePEG12)12-exendin-4 noninvasive imaging of insulinoma negative for insulin immunostaining on specimen from endoscopic ultrasonography-guided fine needle aspiration: a case report with review of literature
  30. Lifestyle factors associated with a rapid decline in the estimated glomerular filtration rate over two years in older adults with type 2 diabetes–Evidence from a large national database in Japan
  31. Front Cover
  32. Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients
  33. Long‐term safety and efficacy of SGLT2 inhibitor use in older east Asians with type 2 diabetes
  34. Dietary and Nutritional Guidelines for People with Diabetes
  35. Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
  36. Efficacy and safety of the sodium‐glucose co‐transporter‐2 inhibitor empagliflozin in elderly Japanese adults (≥65 years) with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, 52‐week clinical trial (EMPA‐ELDERLY)
  37. Effect of Roxadustat on Thyroid Function in Patients With Renal Anemia
  38. Impact of the angiotensin receptor‐neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls
  39. Effectiveness of countermeasure for polypharmacy by multidisciplinary team review in patients with diabetes mellitus
  40. Device-supported automated basal insulin titration in adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
  41. Efficacy and Safety of 6-Month High Dietary Protein Intake in Hospitalized Adults Aged 75 or Older at Nutritional Risk: An Exploratory, Randomized, Controlled Study
  42. Effectiveness, safety, initial optimal dose, and optimal maintenance dose range of basal insulin regimens for type 2 diabetes: A systematic review with meta‐analysis
  43. Effect of the Diabetic Nephropathy Aggravation Prevention Program on medical visit behavior in individuals under the municipal national health insurance
  44. Use of iGlarLixi for the Management of Type 2 Diabetes in Japanese Clinical Practice: Prior Treatment Subgroup Analysis of the SPARTA Japan Study
  45. Erdheim-Chester Disease With BRAF V600E Mutation and Central Diabetes Insipidus Successfully Treated With Glucocorticoid
  46. Current status of the rapid decline in renal function due to diabetes mellitus and its associated factors: analysis using the National Database of Health Checkups in Japan
  47. Empagliflozin is associated with lower risk of cardiovascular events and all‐cause mortality in routine care in East Asia: Results from the EMPRISE study
  48. Two cases of systemic lupus erythematosus after administration of severe acute respiratory syndrome coronavirus 2 vaccine
  49. Editorial: Advances in the research of diabetic nephropathy, volume II
  50. Editorial: Advances in the research of diabetic nephropathy
  51. Increased expression of glucagon-like peptide-1 and cystic fibrosis transmembrane conductance regulator in the ileum and colon in mouse treated with metformin
  52. Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
  53. Use of iGlarLixi for Management of Type 2 Diabetes in Japanese Clinical Practice: SPARTA Japan, a Retrospective Observational Study
  54. Cover Image, Volume 24, Issue 12
  55. An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging
  56. Graves' Disease with Thymic Hyperplasia: The Response of the Thyroid Function, Thyrotropin Receptor Autoantibody, and Thymic Size to Thiamazole Treatment
  57. Advances in insulin therapy from discovery to β‐cell replacement
  58. Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan
  59. d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice
  60. Graves' Disease after Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in a Type 1 Diabetes Patient
  61. Long-term safety and effectiveness of linagliptin by baseline body mass index in Japanese patients with type 2 diabetes: a 3-year post-marketing surveillance study
  62. Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index
  63. Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A subgroup analysis by baseline variables in the PIONEER 9 and PIONEER 10 trials
  64. Healthcare resource utilization in patients treated with empagliflozin in East Asia
  65. Unmet needs in current clinical practice for insulinoma: Lessons from nationwide studies in Japan
  66. Safety and tolerability of linagliptin in Asians with type 2 diabetes: a pooled analysis of 4457 patients from 21 randomized, double-blind, placebo-controlled clinical trials
  67. Efficacy and safety of oral semaglutide by baseline age in Japanese patients with type 2 diabetes: A subgroup analysis of the PIONEER 9 and 10 Japan trials
  68. Benefit of insulin glargine/lixisenatide for reducing residual hyperglycaemia in Japan: Post hoc analysis of the LixiLan JP‐O2 trial
  69. Effects of physician’s diabetes self‐management education using Japan Association of Diabetes Education and Care Diabetes Education Card System Program and a self‐monitoring of blood glucose readings analyzer in individuals with type 2 diabetes: An exp...
  70. Voxel‐based specific regional analysis system for Alzheimer’s disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study
  71. iGlarLixi reduces residual hyperglycemia in Japanese patients with type 2 diabetes uncontrolled on basal insulin: A post‐hoc analysis of the LixiLan JP‐L trial
  72. Effects of glucagon‐like peptide‐1 receptor agonists on secretions of insulin and glucagon and gastric emptying in Japanese individuals with type 2 diabetes: A prospective, observational study
  73. Elevation of Fasting GLP-1 Levels in Child and Adolescent Obesity: Friend or Foe?
  74. Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids
  75. Rationale and design of the EMPA-ELDERLY trial: a randomised, double-blind, placebo-controlled, 52-week clinical trial of the efficacy and safety of the sodium–glucose cotransporter-2 inhibitor empagliflozin in elderly Japanese patients with type 2 dia...
  76. Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study
  77. The Asian Association for the Study of Diabetes: The first 10 years and the next 10 years
  78. Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
  79. SGLT2 Inhibitor and GLP-1 Receptor Agonist Combination Therapy Substantially Improved the Renal Function in a Patient with Type 2 Diabetes: Implications for Additive Renoprotective Effects of the Two Drug Classes
  80. The Role of Metagenomics in Precision Nutrition
  81. Association of glucagon‐like peptide‐1 receptor‐targeted imaging probe with in vivo glucagon‐like peptide‐1 receptor agonist glucose‐lowering effects
  82. Tumor‐like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin‐induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat
  83. Alcohol‐induced impaired insulin secretion in a Japanese population: 5‐year follow up in the Gifu Diabetes Study
  84. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial
  85. Utility of microcatheter in adrenal venous sampling for primary aldosteronism
  86. Factory-calibrated continuous glucose monitoring and capillary blood glucose monitoring in a case with insulinoma: usefulness and possible pitfall under chronic hyperinsulinemic hypoglycemia
  87. Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial
  88. Ceritinib‐associated hyperglycemia in the Japanese Adverse Drug Event Report Database
  89. Low-carbohydrate diet by staple change attenuates postprandial GIP and CPR levels in type 2 diabetes patients
  90. GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells
  91. Dietary recommendations for type 2 diabetes patients: Lessons from recent clinical and basic research in Asia
  92. Sodium–glucose cotransporter 2 inhibitor and sarcopenia in a lean elderly adult with type 2 diabetes: A case report
  93. The journey to understanding incretin systems: Theory, practice and more theory
  94. Bullous pemphigoid with dipeptidyl peptidase‐4 inhibitors: Clinical features and pathophysiology
  95. A rare case of autoimmune polyglandular syndrome with Sjögren’s syndrome and primary hypoparathyroidism
  96. Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion
  97. Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity
  98. Safety and tolerability of empagliflozin in East Asian patients with type 2 diabetes: Pooled analysis of phase I-III clinical trials
  99. Reply to the comment of Wilbrink et al. on Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β-cell function and the achievement of the HbA1c target 1 year after init
  100. Mental distress and health-related quality of life among type 1 and type 2 diabetes patients using self-monitoring of blood glucose: A cross-sectional questionnaire study in Japan
  101. Relationship between deterioration of glycated hemoglobin-lowering effects in dipeptidyl peptidase-4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes
  102. Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes patients: The association between remaining β-cell function and the achievement of the glycated hemoglobin target 1 year after initiation
  103. Beta-cell replacement strategies for diabetes
  104. Safety and efficacy of semaglutide once weekly vs sitagliptin once daily, both as monotherapy in Japanese people with type 2 diabetes
  105. Incretin concept revised: The origin of the insulinotropic function of glucagon-like peptide-1 - the gut, the islets or both?
  106. Sodium glucose co-transporter 2 inhibitor luseogliflozin in the management of type 2 diabetes: a drug safety evaluation
  107. Sodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: A 52-week, open-label, singl
  108. Bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors: A report of five cases
  109. Efficacy and safety of sitagliptin as compared with glimepiride in Japanese patients with type 2 diabetes mellitus aged ≥ 60 years (START-J trial)
  110. Sodium-glucose co-transporter-2 inhibitor use and dietary carbohydrate intake in Japanese individuals with type 2 diabetes: A randomized, open-label, 3-arm parallel comparative, exploratory study
  111. Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: A randomized, open-label, 2-arm parallel comparative, exploratory trial
  112. Cardiovascular safety trials of incretin-based drugs: What do they mean?
  113. Efficacy of lixisenatide in patients with type 2 diabetes: A post hoc analysis of patients with diverse β-cell function in the GetGoal-M and GetGoal-S trials
  114. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin
  115. Incretin‐based drugs for type 2 diabetes: Focus on East Asian perspectives
  116. Alogliptin for the treatment of type 2 diabetes: a drug safety evaluation
  117. Type 2 diabetes via β-cell dysfunction in east Asian people
  118. Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance
  119. Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial
  120. Long-term safety of once-daily lixisenatide in Japanese patients with type 2 diabetes mellitus: GetGoal-Mono-Japan
  121. Retrospective analysis of safety and efficacy of liraglutide monotherapy and sulfonylurea-combination therapy in Japanese type 2 diabetes: Association of remaining β-cell function and achievement of HbA1c target one year after initiation
  122. Evidence-based practice guideline for the treatment for diabetes in Japan 2013
  123. Efficacy and Safety of Lixisenatide in Japanese Patients with Type 2 Diabetes Insufficiently Controlled with Basal Insulin±Sulfonylurea: A Subanalysis of the GetGoal-L-Asia Study
  124. Glucagon-like peptide-1 receptor agonist therapeutics for total diabetes management: assessment of composite end-points
  125. β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians
  126. Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events
  127. A case of hypoglycemia due to illegitimate sexual enhancement medication
  128. Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients
  129. A case of insulinoma with non-alcoholic fatty liver disease: Roles of hyperphagia and hyperinsulinemia in pathogenesis of the disease
  130. Alogliptin for the treatment of Type 2 diabetes
  131. Efficacy and safety of lixisenatide in Japanese patients with type 2 diabetes mellitus inadequately controlled by sulfonylurea with or without metformin: Subanalysis of G et G oal‐ S
  132. Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: comparison of DPP ‐4 inhibitors with other oral antidiabetic drugs
  133. Defining the role of GLP-1 receptor agonists for individualized treatment of Type 2 diabetes
  134. Time to do more: Addressing clinical inertia in the management of type 2 diabetes mellitus
  135. The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes
  136. Dipeptidyl peptidase‐4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe?
  137. Relationship and factors responsible for regulating fasting and post‐challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus
  138. Alogliptin benzoate for the treatment of type 2 diabetes
  139. Factors influencing the durability of the glucose‐lowering effect of sitagliptin combined with a sulfonylurea
  140. Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects
  141. Incretin actions beyond the pancreas: lessons from knockout mice
  142. Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: Implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo
  143. Retrospective analysis of safety and efficacy of insulin-to-liraglutide switch in Japanese type 2 diabetes: A caution against inappropriate use in patients with reduced β-cell function
  144. Improvement of Fasting Plasma Glucose Level After Ingesting Moderate Amount of Dietary Fiber in Japanese Men With Mild Hyperglycemia and Visceral Fat Obesity
  145. Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
  146. Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes
  147. Drug-Induced Generalized Skin Eruption in a Diabetes Mellitus Patient Receiving a Dipeptidyl Peptidase-4 Inhibitor Plus Metformin
  148. Dipeptidyl-peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations
  149. Dipeptidyl peptidase-4 inhibitors and prevention of bone fractures: Effects beyond glyemic control
  150. Predicting efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes: Association of glycated hemoglobin reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels
  151. Insulin secretory capacity and insulin sensitivity in impaired fasting glucose in Japanese
  152. Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males: Potential mechanism of resistance to weight loss among Japanese obese smokers
  153. Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation
  154. Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener
  155. Liraglutide in Adults with Type 2 Diabetes: Global Perspective on Safety, Efficacy and Patient Preference
  156. Comparison of incretin immunoassays with or without plasma extraction: Incretin secretion in Japanese patients with type 2 diabetes
  157. Circadian rhythms and diabetes
  158. Smoking, white blood cell counts, and TNF system activity in Japanese male subjects with normal glucose tolerance
  159. GIP and GLP-1, the two incretin hormones: Similarities and differences
  160. Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls
  161. The Role of Family Nutritional Support in Japanese Patients with Type 2 Diabetes Mellitus
  162. Intact Glucagon-like Peptide-1 Levels are not Decreased in Japanese Patients with Type 2 Diabetes
  163. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase
  164. A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion
  165. Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development
  166. Multiple roles of Notch signaling in cochlear development
  167. Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP
  168. Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
  169. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
  170. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
  171. Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
  172. Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol
  173. Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
  174. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols
  175. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
  176. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
  177. Crucial Step in Cholesterol Homeostasis
  178. Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes
  179. DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries
  180. Molecular Cloning, Characterization, and Chromosomal Localization of FKBP23, a Novel FK506-Binding Protein with Ca2+-Binding Ability
  181. Human Calumenin Gene (CALU): cDNA Isolation and Chromosomal Mapping to 7q32
  182. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
  183. Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF