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  1. Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

    Article • The Kaohsiung Journal of Medical Sciences, October 2025, Wiley

    Dr Chung-Hwan Chen

  2. Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats

    Article • International Journal of Molecular Sciences, September 2025, MDPI AG

    Dr Chung-Hwan Chen

  3. Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Enhance Chondrocyte Function by Reducing Oxidative Stress in Chondrocytes

    Article • International Journal of Molecular Sciences, August 2025, MDPI AG

    Dr Chung-Hwan Chen

  4. Engagement and Stress Concentration Evaluation of a Novel Two-Part Compression Screw: A Preliminary Finite Element Analysis

    Article • Bioengineering, May 2025, MDPI AG

    Dr Chung-Hwan Chen

  5. Modification of a Two-Part Cancellous Locking Screw: A Pilot Study on Increasing Resistance to Axial Pullout Strength

    Article • Bioengineering, April 2025, MDPI AG

    Dr Chung-Hwan Chen

  6. Psychometric Properties of the QuickDASH in Patients with Neck Pain

    Article • Journal of Clinical Medicine, February 2025, MDPI AG

    Dr Chung-Hwan Chen

  7. Minimally Invasive Plate Osteosynthesis with Mini-Open Technique and Supraclavicular Nerve Preservation Reduces Postoperative Numbness in Acute Displaced Midshaft Clavicle Fracture

    Article • Medicina, October 2024, MDPI AG

    Dr Chung-Hwan Chen

  8. Indoxyl Sulfate Inhibits Osteogenesis in Bone Marrow Mesenchymal Stem Cells through the AhR/Hes1 Pathway

    Article • International Journal of Molecular Sciences, August 2024, MDPI AG

    Dr. Chin wen Hsieh, Dr Chung-Hwan Chen

  9. Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells

    Article • Current Issues in Molecular Biology, May 2024, MDPI AG

    Dr Chung-Hwan Chen

  10. Compare the Quadriceps Activity between Mini-Midvastus and Mini-Medial Parapatellar Approach in Total Knee Arthroplasty with Electromyography

    Article • Journal of Clinical Medicine, May 2024, MDPI AG

    Dr Chung-Hwan Chen

  11. Role of Placenta fibrinogen-like 1 (FGL1) in the Pre-Eclampsia progression: a functional study

    Article • January 2024, Wiley

    Dr Chung-Hwan Chen

  12. Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression

    Article • International Journal of Molecular Sciences, August 2023, MDPI AG

    Dr Chung-Hwan Chen

  13. Treatment Persistence and Medication Switch Associated With Subsequent Fractures After Osteoporotic Fractures

    Article • The Journal of Clinical Endocrinology & Metabolism, August 2023, Endocrine Society

    Dr Chung-Hwan Chen

  14. In-vitro and in-vivo bio-corrosion and biocompatibility responses of bioactive TiTaNb films with various Ta contents on Ti6Al4V implants

    Article • Journal of Materials Research and Technology, July 2023, Elsevier

    Dr Chung-Hwan Chen

  15. Chondrocyte Thrombomodulin Protects against Osteoarthritis

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Dr Chung-Hwan Chen

  16. Polymorphisms within the Tumor Necrosis Factor-Alpha Gene Is Associated with Preeclampsia in Taiwanese Han Populations

    Article • Biomedicines, March 2023, MDPI AG

    Dr Chung-Hwan Chen

  17. Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population‐based study

    Article • Diabetes/Metabolism Research and Reviews, January 2023, Wiley

    Dr Chung-Hwan Chen

  18. In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Dr Chung-Hwan Chen

  19. Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty

    Article • JAMA, January 2023, American Medical Association (AMA)

    Dr Chung-Hwan Chen

  20. Clinical Outcomes and Cost-Effectiveness of Osteoporosis Screening With Dual-Energy X-ray Absorptiometry

    Article • Korean Journal of Radiology, January 2023, XMLink

    Dr Chung-Hwan Chen

  21. Clinical practice guidelines for the prevention and treatment of osteoporosis in Taiwan: 2022 update

    Article • Journal of the Formosan Medical Association, January 2023, Elsevier

    Dr Chung-Hwan Chen

  22. Characterization of collagen response to bone fracture healing using polarization-SHG

    Article • Scientific Reports, November 2022, Springer Science + Business Media

    Dr Chung-Hwan Chen

  23. Recent Developments in Additive-Manufactured Intermetallic Compounds for Bio-Implant Applications

    Article • Journal of Medical and Biological Engineering, October 2022, Springer Science + Business Media

    Dr Chung-Hwan Chen

  24. Correction: Liu et al. 3D-Printed Double-Helical Biodegradable Iron Suture Anchor: A Rabbit Rotator Cuff Tear Model Materials 2022, 15, 2801

    Article • Materials, October 2022, MDPI AG

    Dr Chung-Hwan Chen

  25. The Promotion of Migration and Myogenic Differentiation in Skeletal Muscle Cells by Quercetin and Underlying Mechanisms

    Article • Nutrients, October 2022, MDPI AG

    Dr Chung-Hwan Chen

  26. The Role of Autophagy in Osteoarthritic Cartilage

    Article • Biomolecules, September 2022, MDPI AG

    Dr Chung-Hwan Chen

  27. Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)3-Functionalized PEG-PLGA Biopolymer Encapsulating Simvastatin for the Treatment of Osteoporosis in Rat Models

    Article • International Journal of Molecular Sciences, September 2022, MDPI AG

    Dr Chung-Hwan Chen

  28. Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis

    Article • Biomedicines, September 2022, MDPI AG

    Dr Chung-Hwan Chen

  29. Anabolic Effects of a Novel Simvastatin Derivative on Treating Rat Bone Defects

    Article • Biomedicines, August 2022, MDPI AG

    Dr Chung-Hwan Chen

  30. Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial

    Article • Medicina, August 2022, MDPI AG

    Dr Chung-Hwan Chen

  31. Enhancement of Osteoblast Function through Extracellular Vesicles Derived from Adipose-Derived Stem Cells

    Article • Biomedicines, July 2022, MDPI AG

    Dr Chung-Hwan Chen

  32. Treatment patterns of long-dose-interval medication for persistent management of osteoporosis in Taiwan

    Article • Archives of Osteoporosis, July 2022, Springer Science + Business Media

    Dr Chung-Hwan Chen

  33. Chlorogenic Acid Inhibition of Esophageal Squamous Cell Carcinoma Metastasis via EGFR/p-Akt/Snail Signaling Pathways

    Article • Anticancer Research, July 2022, International Institute of Anticancer Research

    Dr Chung-Hwan Chen

  34. The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis

    Article • Biomedicines, June 2022, MDPI AG

    Dr Chung-Hwan Chen

  35. Correction: Liu et al. Less Fluctuation in Hemodynamics of the Wide-Awake Local Anesthesia No Tourniquet Technique Than General Anesthesia in Distal Radius Plating Surgery: A Prospective Case-Control Study. J. Clin. Med. 2022, 11, 1123

    Article • Journal of Clinical Medicine, June 2022, MDPI AG

    Dr Chung-Hwan Chen

  36. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53

    Article • Cell Death Discovery, June 2022, Springer Science + Business Media

    Dr Chung-Hwan Chen

  37. Predicting the Poor Clinical and Radiographic Outcomes after the Anatomical Reduction and Internal Fixation of Posterior Wall Acetabular Fractures: A Retrospective Analysis

    Article • Journal of Clinical Medicine, June 2022, MDPI AG

    Dr Chung-Hwan Chen

  38. Analysis of collagen types I and II at bone fracture healing tissue using polarization SHG

    Article • May 2022, SPIE

    Dr Chung-Hwan Chen

  39. Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort

    Article • Nutrients, May 2022, MDPI AG

    Dr Chung-Hwan Chen

  40. Global Impact of the COVID-19 Pandemic on Orthopedics and the Implications of Telemedicine: A Systematic Review of the Literature

    Article • Journal of Clinical Medicine, May 2022, MDPI AG

    Dr Chung-Hwan Chen

  41. Characteristic and Chondrogenic Differentiation Analysis of Hybrid Hydrogels Comprised of Hyaluronic Acid Methacryloyl (HAMA), Gelatin Methacryloyl (GelMA), and the Acrylate-Functionalized Nano-Silica Crosslinker

    Article • Polymers, May 2022, MDPI AG

    Dr Chung-Hwan Chen

  42. 3D-Printed Double-Helical Biodegradable Iron Suture Anchor: A Rabbit Rotator Cuff Tear Model

    Article • Materials, April 2022, MDPI AG

    Dr Chung-Hwan Chen

  43. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma

    Article • Cell Cycle, March 2022, Taylor & Francis

    Dr Chung-Hwan Chen

  44. Less Fluctuation in Hemodynamics of the Wide-Awake Local Anesthesia No Tourniquet Technique Than General Anesthesia in Distal Radius Plating Surgery: A Prospective Case-Control Study

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    Dr Chung-Hwan Chen

  45. Kidney Function Change and All-Cause Mortality in Denosumab Users with and without Chronic Kidney Disease

    Article • Journal of Personalized Medicine, January 2022, MDPI AG

    Dr Chung-Hwan Chen

  46. A cross-sectional study of disability and quality of life in patients with low back pain: Focus on sex and gender

    Article • Journal of Back and Musculoskeletal Rehabilitation, January 2022, IOS Press

    Dr Chung-Hwan Chen

  47. Upregulation of Fibrinogen-Like 1 Expression Contributes to Reducing the Progression of Preeclampsia

    Article • Frontiers in Cell and Developmental Biology, December 2021, Frontiers

    Dr Chung-Hwan Chen

  48. Impact of Wedge Effect on Outcomes of Intertrochanteric Fractures Treated with Intramedullary Proximal Femoral Nail

    Article • Journal of Clinical Medicine, October 2021, MDPI AG

    Dr Chung-Hwan Chen

  49. The Essential Role of Stathmin in Myoblast C2C12 for Vertical Vibration-Induced Myotube Formation

    Article • Biomolecules, October 2021, MDPI AG

    Dr Chung-Hwan Chen

  50. Severe cellular stress activates apoptosis independently of p53 in osteosarcoma

    Article • Cell Death Discovery, October 2021, Springer Science + Business Media

    Dr Chung-Hwan Chen

  51. Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats

    Article • Journal of Orthopaedic Translation, September 2021, Elsevier

    Dr Chung-Hwan Chen

  52. Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

    Article • Biomedicines, August 2021, MDPI AG

    Dr Chung-Hwan Chen

  53. The Effect of Teriparatide Treatment on the Risk of Fragility Fractures in Postmenopausal Women with Osteoporosis: Results from the Asian and Latin America Fracture Observational Study (ALAFOS)

    Article • Calcified Tissue International, August 2021, Springer Science + Business Media

    Dr Chung-Hwan Chen

  54. G-Protein-Coupled Estrogen Receptor-1 Positively Regulates the Growth Plate Chondrocyte Proliferation in Female Pubertal Mice

    Article • Frontiers in Cell and Developmental Biology, August 2021, Frontiers

    Dr Chung-Hwan Chen

  55. Novel Aptamer-Based Small-Molecule Drug Screening Assay to Identify Potential Sclerostin Inhibitors against Osteoporosis

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Dr Chung-Hwan Chen

  56. Intra-articular low-dose parathyroid hormone (1-34) improves mobility and articular cartilage quality in a preclinical age-related knee osteoarthritis model

    Article • Bone and Joint Research, August 2021, Bone & Joint

    Dr Chung-Hwan Chen

  57. Molecular Weight of Hyaluronic Acid Has Major Influence on Its Efficacy and Safety for Viscosupplementation in Hip Osteoarthritis: A Systematic Review and Meta-Analysis

    Article • Cartilage, June 2021, SAGE Publications

    Dr Chung-Hwan Chen

  58. Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment

    Article • Biomedicines, May 2021, MDPI AG

    Dr Chung-Hwan Chen

  59. Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures

    Article • International Journal of Molecular Sciences, May 2021, MDPI AG

    Dr Chung-Hwan Chen

  60. Dual-LC PSHG microscopy for imaging collagen type I and type II gels with pixel-resolution analysis

    Article • Biomedical Optics Express, April 2021, Optical Society of America (OSA)

    Dr Chung-Hwan Chen

  61. The Potential of Calcium/Phosphate Containing MAO Implanted in Bone Tissue Regeneration and Biological Characteristics

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Dr Chung-Hwan Chen

  62. An Intermediate Concentration of Calcium with Antioxidant Supplement in Culture Medium Enhances Proliferation and Decreases the Aging of Bone Marrow Mesenchymal Stem Cells

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr Chung-Hwan Chen

  63. Intra-Articular Injection of (−)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis

    Article • Antioxidants, January 2021, MDPI AG

    Dr Chung-Hwan Chen

  64. Impact of the COVID-19 pandemic and its related psychological effect on orthopedic surgeries conducted in different types of hospitals in Taiwan

    Article • Journal of Orthopaedic Surgery, January 2021, SAGE Publications

    Dr Chung-Hwan Chen

  65. Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound [Corrigendum]

    Article • International Journal of Nanomedicine, January 2021, Taylor & Francis

    Dr Chung-Hwan Chen

  66. To safely reopen after a lockdown, masks are crucial: lessons from Taiwan

    Article • Public Health, January 2021, Elsevier

    Dr Chung-Hwan Chen

  67. Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model

    Article • Antioxidants, December 2020, MDPI AG

    Dr Chung-Hwan Chen

  68. Pharmacologic intervention for prevention of fractures in osteopenic and osteoporotic postmenopausal women: Systemic review and meta-analysis

    Article • Bone Reports, December 2020, Elsevier

    Dr Chung-Hwan Chen

  69. Osteoprotective Roles of Green Tea Catechins

    Article • Antioxidants, November 2020, MDPI AG

    Dr Chung-Hwan Chen

  70. Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition

    Article • Antioxidants, October 2020, MDPI AG

    Dr Chung-Hwan Chen

  71. Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Chung-Hwan Chen

  72. Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Chung-Hwan Chen

  73. G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Chung-Hwan Chen

  74. Proton pump inhibitor use and risk of hip fracture in patients with type 2 diabetes

    Article • Scientific Reports, August 2020, Springer Science + Business Media

    Dr Chung-Hwan Chen

  75. Mg-Zn-Ca Alloys for Hemostasis Clips for Vessel Ligation: In Vitro and In Vivo Studies of Their Degradation and Response

    Article • Materials, July 2020, MDPI AG

    Dr Chung-Hwan Chen

  76. Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Dr Chung-Hwan Chen

  77. Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice

    Article • Journal of Bone and Mineral Research, May 2020, Wiley

    Dr Chung-Hwan Chen

  78. Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound

    Article • International Journal of Nanomedicine, May 2020, Taylor & Francis

    Dr Chung-Hwan Chen

  79. Green Tea Catechin (-)-Epigallocatechin-3-Gallate (EGCG) Facilitates Fracture Healing

    Article • Biomolecules, April 2020, MDPI AG

    Dr Chung-Hwan Chen

  80. The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head

    Article • The Journal of Arthroplasty, April 2020, Elsevier

    Dr Chung-Hwan Chen, Mr Vikas Khanduja

  81. Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

    Article • The FASEB Journal, March 2020, Wiley

    Dr Chung-Hwan Chen

  82. Teriparatide in East Asian Postmenopausal Women with Osteoporosis in a Real-World Setting: A Baseline Analysis of the Asia and Latin America Fracture Observational Study (ALAFOS) [Corrigendum]

    Article • Clinical Interventions in Aging, March 2020, Taylor & Francis

    Dr Chung-Hwan Chen

  83. Impact of type 2 diabetes on postoperative outcome after hip fracture: nationwide population-based study in Taiwan

    Article • BMJ Open Diabetes Research & Care, February 2020, BMJ

    Dr Chung-Hwan Chen

  84. Teriparatide in East Asian Postmenopausal Women with Osteoporosis in a Real-World Setting: A Baseline Analysis of the Asia and Latin America Fracture Observational Study (ALAFOS)

    Article • Clinical Interventions in Aging, January 2020, Taylor & Francis

    Dr Chung-Hwan Chen

  85. Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Dr Chung-Hwan Chen

  86. Frailty is Associated with an Increased Risk of Major Adverse Outcomes in Elderly Patients Following Surgical Treatment of Hip Fracture

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr Chung-Hwan Chen

  87. Impact of orthogeriatric care, comorbidity, and complication on 1-year mortality in surgical hip fracture patients

    Article • Medicine, November 2019, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  88. Medication-Taking Habit and Outcome of Glucosamine Sulfate for Osteoarthritis Patients Influenced by National Health Insurance Regulations in Taiwan

    Article • Journal of Clinical Medicine, October 2019, MDPI AG

    Dr Chung-Hwan Chen

  89. The Safety of Continuing Antiplatelet Medication Among Elderly Patients Undergoing Urgent Hip Fracture Surgery

    Article • Orthopedics, July 2019, SLACK, Inc.

    Dr Chung-Hwan Chen

  90. 6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

    Article • Drug Design Development and Therapy, May 2019, Dove Medical Press

    Dr Chung-Hwan Chen

  91. Corrigendum to “The Efficacy of Combined Use of Intraarticular and Intravenous Tranexamic Acid on Reducing Blood Loss and Transfusion Rate in Total Knee Arthroplasty” [Journal of Arthroplasty (2015) 776-780]

    Article • The Journal of Arthroplasty, May 2019, Elsevier

    Dr Chung-Hwan Chen

  92. Biomechanical investigation of dynamic hip screw and wire fixation on an unstable intertrochanteric fracture

    Article • BioMedical Engineering OnLine, April 2019, Springer Science + Business Media

    Dr Chung-Hwan Chen

  93. Consensus Statement on the Use of Bone Turnover Markers for Short-Term Monitoring of Osteoporosis Treatment in the Asia-Pacific Region

    Article • Journal of Clinical Densitometry, March 2019, Elsevier

    Dr Chung-Hwan Chen

  94. Current Status and Changes in Pain and Activities of Daily Living in Elderly Patients with Osteoarthritis Before and After Unilateral Total Knee Replacement Surgery

    Article • Journal of Clinical Medicine, February 2019, MDPI AG

    Dr Chung-Hwan Chen

  95. Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells

    Article • International Journal of Molecular Sciences, January 2019, MDPI AG

    Dr Chung-Hwan Chen

  96. (−)-Epigallocatechin-3-Gallate Decreases Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin

    Article • Molecules, January 2019, MDPI AG

    Dr Chung-Hwan Chen

  97. Hand tendinopathy risk factors in Taiwan

    Article • Medicine, January 2019, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  98. The Impact of Diabetes on Postoperative Outcome after Hip Fracture: A Nationwide Population-Based Study in Taiwan

    Article • SSRN Electronic Journal, January 2019, Elsevier

    Dr Chung-Hwan Chen

  99. (−)-Epigallocatechin-3-Gallate (EGCG) Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

    Article • Molecules, December 2018, MDPI AG

    Dr Chung-Hwan Chen

  100. Study description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS)

    Article • Current Medical Research and Opinion, November 2018, Taylor & Francis

    Dr Chung-Hwan Chen, Abdulaziz Elsalmawy, Prof. Francisco Marin

  101. Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon

    Article • PLOS One, October 2018, PLOS

    Dr Chung-Hwan Chen

  102. P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage

    Article • Cell Cycle, September 2018, Taylor & Francis

    Dr Chung-Hwan Chen

  103. Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 1: Glucocorticoid-Associated Osteonecrosis

    Article • The Journal of Arthroplasty, September 2018, Elsevier

    Dr Chung-Hwan Chen, Mr Vikas Khanduja

  104. Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2: Alcohol-Associated Osteonecrosis

    Article • The Journal of Arthroplasty, September 2018, Elsevier

    Dr Chung-Hwan Chen, Mr Vikas Khanduja

  105. Dementia predicted one-year mortality for patients with first hip fracture

    Article • The Bone & Joint Journal, September 2018, Bone & Joint

    Dr Chung-Hwan Chen

  106. Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Dr Chung-Hwan Chen

  107. Correction to: Consensus on best practice standards for Fracture Liaison Service in the Asia-Pacific region

    Article • Archives of Osteoporosis, July 2018, Springer Science + Business Media

    Dr Chung-Hwan Chen

  108. Hyaluronan microenvironment enhances cartilage regeneration of human adipose-derived stem cells in a chondral defect model

    Article • International Journal of Biological Macromolecules, July 2018, Elsevier

    Dr Chung-Hwan Chen

  109. (-)-Epigallocatechin-3-gallate (EGCG) enhances healing of femoral bone defect

    Article • Phytomedicine, July 2018, Elsevier

    Dr Chung-Hwan Chen

  110. The development of Taiwan Fracture Liaison Service network

    Article • Osteoporosis and Sarcopenia, June 2018, Elsevier

    Dr Chung-Hwan Chen

  111. Development and Validation of Taiwanese Version of the Neck Disability Index

    Article • Spine, June 2018, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  112. Consensus on best practice standards for Fracture Liaison Service in the Asia-Pacific region

    Article • Archives of Osteoporosis, May 2018, Springer Science + Business Media

    Dr Chung-Hwan Chen

  113. Parathyroid hormone-(1–34) ameliorated knee osteoarthritis in rats via autophagy

    Article • Journal of Applied Physiology, May 2018, American Physiological Society

    Dr Chung-Hwan Chen

  114. Identifying characteristics of an effective fracture liaison service: systematic literature review

    Article • Osteoporosis International, March 2018, Springer Science + Business Media

    Dr Chung-Hwan Chen

  115. Thermal pain tolerance and pain rating in normal subjects: Gender and age effects

    Article • European Journal of Pain, February 2018, Wiley

    Dr Chung-Hwan Chen

  116. Hyaluronan size alters chondrogenesis of adipose-derived stem cells via the CD44/ERK/SOX-9 pathway

    Article • Acta Biomaterialia, January 2018, Elsevier

    Dr Chung-Hwan Chen

  117. Intravenous drug abuse is a risk factor in the failure of two-stage treatment for infected total hip arthroplasty

    Article • The Kaohsiung Journal of Medical Sciences, December 2017, Wiley

    Dr Chung-Hwan Chen

  118. Enhancement of Bone Marrow-Derived Mesenchymal Stem Cell Osteogenesis and New Bone Formation in Rats by Obtusilactone A

    Article • International Journal of Molecular Sciences, November 2017, MDPI AG

    Dr Chung-Hwan Chen

  119. In-vivo investigations and cytotoxicity tests on Ti/Zr-based metallic glasses with various Cu contents

    Article • Materials Science and Engineering C, August 2017, Elsevier

    Dr Chung-Hwan Chen

  120. Evaluations of clinical-grade bone substitute-combined simvastatin carriers to enhance bone growth: In vitro and in vivo analyses

    Article • Journal of Bioactive and Compatible Polymers, July 2017, SAGE Publications

    Dr Chung-Hwan Chen

  121. Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats

    Article • Menopause The Journal of The North American Menopause Society, June 2017, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  122. Liposomal Encapsulation for Systemic Delivery of Propranolol via Transdermal Iontophoresis Improves Bone Microarchitecture in Ovariectomized Rats

    Article • International Journal of Molecular Sciences, April 2017, MDPI AG

    Dr Chung-Hwan Chen

  123. The stiffness of a crosslinked hyaluronan hydrogel affects its chondro-induction activity on hADSCs

    Article • Journal of Biomedical Materials Research Part B Applied Biomaterials, April 2017, Wiley

    Dr Chung-Hwan Chen

  124. 2-Phenylnaphthalene Derivatives Inhibit Lipopolysaccharide-Induced Pro-Inflammatory Mediators by Downregulating of MAPK/NF-κB Pathways in RAW 264.7 Macrophage Cells

    Article • PLOS One, January 2017, PLOS

    Dr Chung-Hwan Chen

  125. The Fractionated Toona sinensis Leaf Extract Induces Apoptosis of Human Osteosarcoma Cells and Inhibits Tumor Growth in a Murine Xenograft Model

    Article • Integrative Cancer Therapies, November 2016, SAGE Publications

    Dr Chung-Hwan Chen

  126. Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes

    Article • Toxicology, August 2016, Elsevier

    Dr Chung-Hwan Chen

  127. Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss

    Article • Scientific Reports, June 2016, Nature

    Dr Chung-Hwan Chen

  128. PLGA-linked alendronate enhances bone repair in diaphysis defect model

    Article • Journal of Tissue Engineering and Regenerative Medicine, June 2016, Wiley

    Dr Chung-Hwan Chen

  129. Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects

    Article • International Journal of Nanomedicine, December 2015, Dove Medical Press

    Dr Chung-Hwan Chen

  130. Polysaccharides of Trametes Versicolor Improve Bone Properties in Diabetic Rats

    Article • Osteoporosis and Sarcopenia, December 2015, Elsevier

    Dr Chung-Hwan Chen

  131. The High Volume Hip Surgeon Acting as Ortho-Geriatric Reduced Mortality in Elderly Hip Fracture after Surgery

    Article • Osteoporosis and Sarcopenia, December 2015, Elsevier

    Dr Chung-Hwan Chen

  132. Estrogen receptor mediates simvastatin-stimulated osteogenic effects in bone marrow mesenchymal stem cells

    Article • Biochemical Pharmacology, December 2015, Elsevier

    Dr Chung-Hwan Chen

  133. Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats

    Article • Journal of Agricultural and Food Chemistry, October 2015, American Chemical Society (ACS)

    Dr Chung-Hwan Chen

  134. Rivaroxaban in preventing venous thromboembolism after arthroplastic surgery in Taiwan

    Article • The Kaohsiung Journal of Medical Sciences, October 2015, Elsevier

    Dr Chung-Hwan Chen

  135. Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

    Article • International Journal of Nanomedicine, September 2015, Dove Medical Press

    Dr Chung-Hwan Chen

  136. The protective effect of green tea catechins on ketamine-induced cystitis in a rat model

    Article • Urological Science, September 2015, Elsevier

    Dr Chung-Hwan Chen

  137. Suppression of ornithine decarboxylase promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

    Article • FEBS Letters, June 2015, Wiley

    Dr Chung-Hwan Chen

  138. The Efficacy of Combined Use of Intraarticular and Intravenous Tranexamic Acid on Reducing Blood Loss and Transfusion Rate in Total Knee Arthroplasty

    Article • The Journal of Arthroplasty, May 2015, Elsevier

    Dr Chung-Hwan Chen

  139. Modified Mitchell osteotomy alone does not have higher rate of residual metatarsalgia than combined first and lesser metatarsal osteotomy

    Article • The Kaohsiung Journal of Medical Sciences, April 2015, Elsevier

    Dr Chung-Hwan Chen

  140. Combining Paclitaxel with ABT-263 Has a Synergistic Effect on Paclitaxel Resistant Prostate Cancer Cells

    Article • PLOS One, March 2015, PLOS

    Dr Chung-Hwan Chen

  141. 17β-Estradiol protects against glucosamine-induced pancreatic β-cell dysfunction

    Article • Menopause The Journal of The North American Menopause Society, November 2014, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  142. Electrochemical and biocompatibility response of newly developed TiZr-based metallic glasses

    Article • Materials Science and Engineering C, October 2014, Elsevier

    Dr Chung-Hwan Chen

  143. Umbilical Cord Blood-Derived CD34+ Cells Improve Outcomes of Traumatic Brain Injury in Rats by Stimulating Angiogenesis and Neurogenesis

    Article • Cell Transplantation, August 2014, SAGE Publications

    Dr Chung-Hwan Chen

  144. Computer-navigated minimally invasive total knee arthroplasty for patients with retained implants in the femur

    Article • The Kaohsiung Journal of Medical Sciences, August 2014, Elsevier

    Dr Chung-Hwan Chen

  145. An association study of interleukin-4 gene and preeclampsia in Taiwan

    Article • Taiwanese Journal of Obstetrics and Gynecology, June 2014, Elsevier

    Dr Chung-Hwan Chen

  146. Characterization and evaluation of the differentiation ability of human adipose-derived stem cells growing in scaffold-free suspension culture

    Article • Cytotherapy, April 2014, Elsevier

    Dr Chung-Hwan Chen

  147. A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair

    Article • PLOS One, March 2014, PLOS

    Dr Chung-Hwan Chen

  148. Promising antimicrobial capability of thin film metallic glasses

    Article • Materials Science and Engineering C, March 2014, Elsevier

    Dr Chung-Hwan Chen

  149. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture

    Article • January 2014, Elsevier

    Dr Chung-Hwan Chen

  150. Alendronate in the Prevention of Collapse of the Femoral Head in Nontraumatic Osteonecrosis

    Article • January 2014, Springer Science + Business Media

    Dr Chung-Hwan Chen

  151. Characterization and human osteoblastic proliferation- and differentiation-stimulatory effects of phosphatidylcholine liposomes-encapsulated propranolol hydrochloride

    Article • Bio-Medical Materials and Engineering, January 2014, IOS Press

    Dr Chung-Hwan Chen

  152. Rapid screening of potential metallic glasses for biomedical applications

    Article • Materials Science and Engineering C, December 2013, Elsevier

    Dr Chung-Hwan Chen

  153. Functions and Mechanisms of Green Tea Catechins in Regulating Bone Remodeling

    Article • Current Drug Targets, November 2013, Bentham Science Publishers

    Dr Chung-Hwan Chen

  154. Preparation of porous bioceramics using reverse thermo-responsive hydrogels in combination with rhBMP-2 carriers: In vitro and in vivo evaluation

    Article • Journal of the Mechanical Behavior of Biomedical Materials, November 2013, Elsevier

    Dr Chung-Hwan Chen

  155. Bicondylar tibial plateau fracture treated by open reduction and fixation with unilateral locked plating

    Article • The Kaohsiung Journal of Medical Sciences, October 2013, Elsevier

    Dr Chung-Hwan Chen

  156. Neuroprotective effects of Hu-Yi-Neng, a diet supplement, On SH-SY5Y human neuroblastoma cells

    Article • The journal of nutrition health & aging, September 2013, Springer Science + Business Media

    Dr Chung-Hwan Chen

  157. PPARγ silencing enhances osteogenic differentiation of human adipose-derived mesenchymal stem cells

    Article • Journal of Cellular and Molecular Medicine, August 2013, Wiley

    Dr Chung-Hwan Chen

  158. Open reduction and internal fixation of acute intra-articular displaced calcaneal fractures: A retrospective analysis of surgical timing and infection rates

    Article • Injury, July 2013, Elsevier

    Dr Chung-Hwan Chen

  159. Comparison of the clinical and radiological outcomes of three minimally invasive techniques for total knee replacement at two years

    Article • The Bone & Joint Journal, June 2013, Bone & Joint

    Dr Chung-Hwan Chen

  160. (−)-Epigallocatechin-3-gallate improves bone microarchitecture in ovariectomized rats

    Article • Menopause The Journal of The North American Menopause Society, June 2013, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  161. Longitudinal changes in bone mineral density of healthy elderly women in southern Taiwan

    Article • Taiwanese Journal of Obstetrics and Gynecology, March 2013, Elsevier

    Dr Chung-Hwan Chen

  162. Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells

    Article • Journal of Applied Physiology, February 2013, American Physiological Society

    Dr Chung-Hwan Chen

  163. An Alternative Technique for the Management of Phalangeal Enchondromas With Pathologic Fractures

    Article • The Journal Of Hand Surgery, January 2013, Elsevier

    Dr Chung-Hwan Chen

  164. Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro

    Article • Journal of Applied Physiology, December 2012, American Physiological Society

    Dr Chung-Hwan Chen

  165. Fruits and dietary phytochemicals in bone protection

    Article • Nutrition Research, December 2012, Elsevier

    Dr Chung-Hwan Chen

  166. Modified Mitchell Osteotomy with Screw Fixation for Correction of Hallux Valgus

    Article • Foot & Ankle International, December 2012, SAGE Publications

    Dr Chung-Hwan Chen

  167. Successful teriparatide treatment of atypical fracture after long-term use of alendronate without surgical procedure in a postmenopausal woman

    Article • Menopause The Journal of The North American Menopause Society, December 2012, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  168. Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses

    Article • Materials Science and Engineering C, December 2012, Elsevier

    Dr Chung-Hwan Chen

  169. Dietary polyphenols and mechanisms of osteoarthritis

    Article • The Journal of Nutritional Biochemistry, November 2012, Elsevier

    Dr Chung-Hwan Chen

  170. Atypical femoral fracture after long-term alendronate treatment: Report of a case evidenced with magnetic resonance imaging

    Article • The Kaohsiung Journal of Medical Sciences, October 2012, Elsevier

    Dr Chung-Hwan Chen

  171. Aggressive continuous passive motion exercise does not improve knee range of motion after total knee arthroplasty

    Article • Journal of Clinical Nursing, October 2012, Wiley

    Dr Chung-Hwan Chen

  172. Interleukin-1β gene is not associated with preeclampsia in Taiwanese

    Article • Taiwanese Journal of Obstetrics and Gynecology, June 2012, Elsevier

    Dr Chung-Hwan Chen

  173. Surgical treatment of melorheostosis: Report of two cases

    Article • The Kaohsiung Journal of Medical Sciences, May 2012, Elsevier

    Dr Chung-Hwan Chen

  174. Glucosamine-induced insulin resistance in ovariectomized rats is relevant to decreasing the expression of glucose transport protein subtype 4 in the skeletal muscle and in increasing the size of pancreatic islets

    Article • Menopause The Journal of The North American Menopause Society, May 2012, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  175. Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: A two-year multicenter, prospective, randomized, double-blind, placebo-controlled study

    Article • Arthritis & Rheumatism, April 2012, Wiley

    Dr Chung-Hwan Chen

  176. Successful treatment of a delayed presentation of a gunshot injury to the femoral neck in an elderly man: a case report

    Article • European Journal of Orthopaedic Surgery & Traumatology, March 2012, Springer Science + Business Media

    Dr Chung-Hwan Chen

  177. Neuroprotection of green tea catechins on surgical menopause-induced overactive bladder in a rat model

    Article • Menopause The Journal of The North American Menopause Society, March 2012, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  178. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures

    Article • Journal of Cellular and Molecular Medicine, February 2012, Wiley

    Dr Chung-Hwan Chen

  179. Research update for articles published in EJCI in 2009

    Article • European Journal of Clinical Investigation, October 2011, Wiley

    Dr Chung-Hwan Chen

  180. The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration

    Article • Biomaterials, November 2010, Elsevier

    Dr Chung-Hwan Chen

  181. 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a new potent apoptosis agent

    Article • Bioorganic & Medicinal Chemistry, November 2009, Elsevier

    Dr Chung-Hwan Chen

  182. Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats

    Article • Arthritis & Rheumatism, October 2009, Wiley

    Dr Chung-Hwan Chen

  183. Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone

    Article • Biomaterials, September 2009, Elsevier

    Dr Chung-Hwan Chen

  184. Minimally Invasive Distal Metatarsal Osteotomy for Mild-to-Moderate Hallux Valgus Deformity

    Article • The Kaohsiung Journal of Medical Sciences, August 2009, Elsevier

    Dr Chung-Hwan Chen

  185. Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats

    Article • European Journal of Clinical Investigation, April 2009, Wiley

    Dr Chung-Hwan Chen

  186. Different Differentiation of Stroma Cells from Patients with Osteonecrosis: A Pilot Study

    Article • Clinical Orthopaedics and Related Research, March 2009, Springer Science + Business Media

    Dr Chung-Hwan Chen

  187. (−)-Epigallocatechin gallate inhibition of osteoclastic differentiation via NF-κB

    Article • Biochemical and Biophysical Research Communications, February 2009, Elsevier

    Dr Chung-Hwan Chen

  188. Carpal Tunnel Syndrome and Finger Movement Dysfunction Caused By Tophaceous Gout: A Case Report

    Article • The Kaohsiung Journal of Medical Sciences, January 2009, Elsevier

    Dr Chung-Hwan Chen

  189. Semitubular Plates for Acutely Displaced Midclavicular Fractures: A Retrospective Study of 111 Patients Followed for 2.5 to 6 Years

    Article • Journal of Orthopaedic Trauma, August 2008, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  190. Longitudinal Changes in Bone Mineral Density of Healthy Elderly Men in Southern Taiwan

    Article • Journal of the Formosan Medical Association, August 2008, Elsevier

    Dr Chung-Hwan Chen

  191. Effects of Pulsed Low-Intensity Ultrasound on Human Child Chondrocytes

    Article • Ultrasound in Medicine & Biology, July 2008, Elsevier

    Dr Chung-Hwan Chen

  192. Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

    Article • Life Sciences, March 2008, Elsevier

    Dr Chung-Hwan Chen

  193. A modified surgical method for treating Baker's cyst in children

    Article • The Knee, January 2008, Elsevier

    Dr Chung-Hwan Chen

  194. Minimally Invasive Total Hip Arthroplasty Using a Posterolateral Approach: Technique and Preliminary Results

    Article • The Kaohsiung Journal of Medical Sciences, December 2007, Wiley

    Dr Chung-Hwan Chen

  195. Effects of anti-inflammatory drugs on proliferation, cytotoxicity and osteogenesis in bone marrow mesenchymal stem cells

    Article • Biochemical Pharmacology, November 2007, Elsevier

    Dr Chung-Hwan Chen

  196. The Early Clinical Outcome of Minimally Invasive Quadriceps-Sparing Total Knee Arthroplasty

    Article • The Journal of Arthroplasty, October 2007, Elsevier

    Dr Chung-Hwan Chen

  197. Percutaneous antegrade screwing for anterior column fracture of acetabulum with fluoroscopic-based computerized navigation

    Article • Archives of Orthopaedic and Traumatic Surgery, June 2007, Springer Science + Business Media

    Dr Chung-Hwan Chen

  198. Snapping knee symptoms caused by an intra-articular ganglion cyst

    Article • The Knee, March 2007, Elsevier

    Dr Chung-Hwan Chen

  199. Surgical treatment of type II floating knee: comparisons of the results of type IIA and type IIB floating knee

    Article • Knee Surgery Sports Traumatology Arthroscopy, January 2007, Springer Science + Business Media

    Dr Chung-Hwan Chen

  200. QUANTITATIVE GAIT ANALYSIS AFTER UNILATERAL KNEE ARTHROPLASTY FOR PATIENTS WITH BILATERAL KNEE OSTEOARTHRITIS

    Article • Journal of Biomechanics, January 2007, Elsevier

    Dr Chung-Hwan Chen

  201. Osteogenic Gene Expression Decreases in Stromal Cells of Patients with Osteonecrosis

    Article • Clinical Orthopaedics and Related Research, December 2006, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  202. Eight-Year Results of Hydroxyapatite-Coated Hip Arthroplasty

    Article • The Journal of Arthroplasty, June 2006, Elsevier

    Dr Chung-Hwan Chen

  203. A novel terminal differentiation model of human articular chondrocytes in three-dimensional cultures mimicking chondrocytic changes in osteoarthritis

    Article • Cell Biology International, March 2006, Wiley

    Dr Chung-Hwan Chen

  204. Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line

    Article • Osteoporosis International, September 2005, Springer Science + Business Media

    Dr Chung-Hwan Chen

  205. Surgical treatment for ipsilateral fractures of the hip and femoral shaft

    Article • Injury, February 2004, Elsevier

    Dr Chung-Hwan Chen

  206. Open Reduction and Internal Fixation of Displaced Intra-articular Fractures of the Calcaneus

    Article • Journal of Trauma and Acute Care Surgery, May 2002, Wolters Kluwer Health

    Dr Chung-Hwan Chen

  207. Isolated Talonavicular Arthrodesis for Talonavicular Arthritis

    Article • Foot & Ankle International, August 2001, SAGE Publications

    Dr Chung-Hwan Chen

  208. Ipsilateral fractures of the femoral neck and shaft

    Article • Injury, November 2000, Elsevier

    Dr Chung-Hwan Chen