All Stories

  1. Probiotic Lactobacillus reuteri Y7 Protects Against Blue Light–Induced Retinal Degeneration via Antioxidant Defense, Anti-Inflammatory Action, and Gut–Retina Axis Modulation

    Article • Antioxidants, November 2025, MDPI AG

    Dr Chun-Hsu Pan

  2. Olaparib-Cediranib Hybrid as Dual PARP-VEGFR3 Inhibitor Elicits Antitumor Efficacy: Rational Design, Synthesis, Biological Evaluation and Construction of a Charge Convertible pH Responsive Nanoformulation

    Article • Bioorganic Chemistry, October 2025, Elsevier

    Dr Chun-Hsu Pan

  3. Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2025, Taylor & Francis

    Dr Chun-Hsu Pan

  4. Treadmill intervention attenuates motor deficit with 6-OHDA-induced Parkinson’s disease rat via changes in lipid profiles in brain and muscle

    Article • Aging, January 2025, Impact Journals, LLC

    Dr Chun-Hsu Pan

  5. Rationally designed febuxostat-based hydroxamic acid and its pH-Responsive nanoformulation elicits anti-tumor activity

    Article • European Journal of Medicinal Chemistry, December 2024, Elsevier

    Dr Chun-Hsu Pan

  6. Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions

    Article • European Journal of Medicinal Chemistry, June 2024, Elsevier

    Dr Chun-Hsu Pan

  7. Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

    Article • Food Science and Human Wellness, May 2024, Tsinghua University Press

    Dr Chun-Hsu Pan

  8. Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation

    Article • European Journal of Medicinal Chemistry, May 2024, Elsevier

    Dr Chun-Hsu Pan

  9. Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbi...

    Article • Food & Function, January 2024, Royal Society of Chemistry

    Dr Chun-Hsu Pan

  10. Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship

    Article • Bioorganic Chemistry, December 2023, Elsevier

    Dr Chun-Hsu Pan

  11. Prudent tactics to sail the boat of PARP inhibitors as therapeutics for diverse malignancies

    Article • Expert Opinion on Drug Discovery, July 2023, Taylor & Francis

    Dr Chun-Hsu Pan

  12. Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson’s Disease

    Article • Antioxidants, December 2022, MDPI AG

    Dr Chun-Hsu Pan

  13. Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats

    Article • Nutrients, November 2022, MDPI AG

    Dr Chun-Hsu Pan

  14. Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier

    Article • European Journal of Medicinal Chemistry, October 2022, Elsevier

    Dr. Ashwani K. Dhingra, Dr Chun-Hsu Pan

  15. Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice

    Article • Journal of Cachexia Sarcopenia and Muscle, November 2021, Wiley

    Dr Chun-Hsu Pan

  16. The immunomodulatory effects of long-term supplementation with Lactobacillus casei Shirota depend on ovalbumin presentation in BALB/c mice

    Article • Scientific Reports, September 2021, Springer Science + Business Media

    Dr Chun-Hsu Pan

  17. Pathological Role of Phosphoglycerate Kinase 1 in Balloon Angioplasty-Induced Neointima Formation

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Dr Chun-Hsu Pan

  18. Preventive Effect and Mechanism of Crossostephium chinense Extract on Balloon Angioplasty-Induced Neointimal Hyperplasia

    Article • Evidence-based Complementary and Alternative Medicine, June 2021, Wiley

    Dr Chun-Hsu Pan

  19. Lacticaseibacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

    Article • Nutrients, March 2021, MDPI AG

    Professor Shih-Yi Huang, Dr Chun-Hsu Pan

  20. Circulating level of microRNA-142-5p is a potential biomarker for predicting in-stent restenosis: a case–control study

    Article • BMC Cardiovascular Disorders, February 2021, Springer Science + Business Media

    Dr Chun-Hsu Pan

  21. Sclareol ameliorated ERCC1-mediated cisplatin resistance in A549 human lung adenocarcinoma cells and a murine xenograft tumor model by suppressing AKT-GSK3β-AP1/Snail and JNK-AP1 pathways

    Article • Chemico-Biological Interactions, December 2020, Elsevier

    Dr Chun-Hsu Pan

  22. Edible mushrooms: Novel medicinal agents to combat metabolic syndrome and associated diseases

    Article • Current Pharmaceutical Design, August 2020, Bentham Science Publishers

    Dr Chun-Hsu Pan

  23. Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

    Article • Nutrients, August 2020, MDPI AG

    Dr Chun-Hsu Pan

  24. Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta

    Article • Aging, October 2019, Impact Journals, LLC

    Dr Chun-Hsu Pan

  25. Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model

    Article • International Journal of Molecular Sciences, March 2018, MDPI AG

    Dr Chun-Hsu Pan

  26. Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

    Article • Phytotherapy Research, December 2017, Wiley

    Chih-Chuang Liaw, Dr Chun-Hsu Pan

  27. Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells

    Article • PLOS One, September 2017, PLOS

    Dr Chun-Hsu Pan

  28. Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

    Article • Journal of Functional Foods, June 2016, Elsevier

    Dr Chun-Hsu Pan

  29. Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

    Article • Journal of Natural Products, May 2016, American Chemical Society (ACS)

    Dr Chun-Hsu Pan

  30. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells

    Article • Marine Drugs, May 2015, MDPI AG

    Dr Chun-Hsu Pan

  31. K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2

    Article • Toxicology and Applied Pharmacology, January 2015, Elsevier

    Dr Chun-Hsu Pan

  32. Deep Sea Water Prevents Balloon Angioplasty-Induced Hyperplasia through MMP-2: An In Vitro and In Vivo Study

    Article • PLOS One, May 2014, PLOS

    Dr Chun-Hsu Pan

  33. Inhibitory Effect of Dihydroaustrasulfone Alcohol on the Migration of Human Non-Small Cell Lung Carcinoma A549 Cells and the Antitumor Effect on a Lewis Lung Carcinoma-Bearing Tumor Model in C57BL/6J Mice

    Article • Marine Drugs, January 2014, MDPI AG

    Dr Chun-Hsu Pan

  34. NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent Pathway

    Article • Journal of Pharmacological Sciences, January 2014, Japanese Pharmacological Society

    Dr Chun-Hsu Pan

  35. Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study

    Article • Marine Drugs, June 2013, MDPI AG

    Dr Chun-Hsu Pan

  36. Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model

    Article • Journal of the Science of Food and Agriculture, February 2013, Wiley

    Dr Chun-Hsu Pan

  37. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALB/C Allograft Tumor Model

    Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

    Dr Chun-Hsu Pan

  38. Alteration of the Tongue Manifestation Reflects Clinical Outcomes of Peptic Ulcer Disease

    Article • The Journal of Alternative and Complementary Medicine, November 2012, Mary Ann Liebert Inc

    Dr Chun-Hsu Pan

  39. Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model

    Article • Food and Chemical Toxicology, May 2012, Elsevier

    Dr Chun-Hsu Pan

  40. Sclareol Exhibits Anti-inflammatory Activity in Both Lipopolysaccharide-Stimulated Macrophages and the λ-Carrageenan-Induced Paw Edema Model

    Article • Journal of Natural Products, January 2012, American Chemical Society (ACS)

    Dr Chun-Hsu Pan

  41. Ethanolic Extract ofVitis thunbergiiExhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits

    Article • Evidence-based Complementary and Alternative Medicine, January 2012, Hindawi Publishing Corporation

    Dr Chun-Hsu Pan

  42. Salvianolic acid B inhibits SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor

    Article • Vascular Pharmacology, January 2012, Elsevier

    Dr Chun-Hsu Pan

  43. Total sleep deprivation augments balloon angioplasty-induced neointimal hyperplasia in rats

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, September 2011, Wiley

    Dr Chun-Hsu Pan

  44. Trilinolein Inhibits Proliferation of Human Non-Small Cell Lung Carcinoma A549 Through the Modulation of PI3K/Akt Pathway

    Article • The American Journal of Chinese Medicine, January 2011, World Scientific Pub Co Pte Lt

    Dr Chun-Hsu Pan

  45. Effects of a Chinese Herbal Health Formula, “Gan-Lu-Yin”, on Angiogenesis

    Article • Journal of Agricultural and Food Chemistry, July 2010, American Chemical Society (ACS)

    Dr Chun-Hsu Pan

  46. Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts

    Article • Peptides, July 2010, Elsevier

    Dr Chun-Hsu Pan

  47. Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, March 2008, Wiley

    Dr Chun-Hsu Pan

  48. Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation

    Article • Cellular and Molecular Life Sciences, March 2008, Springer Science + Business Media

    Dr Chun-Hsu Pan

  49. Altered expression of FHL1, CARP, TSC-22 and P311 provide insights into complex transcriptional regulation in pacing-induced atrial fibrillation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, March 2007, Elsevier

    Dr Chun-Hsu Pan

  50. Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation

    Article • FEBS Letters, January 2007, Wiley

    Dr Chun-Hsu Pan

  51. Detection of Proteins Related to Starch Synthase Activity in the Developing Mungbean (Vigna radiataL.)

    Article • Journal of Agricultural and Food Chemistry, February 2006, American Chemical Society (ACS)

    Dr Chun-Hsu Pan

  52. Detection of Proteins Related to Starch Synthase Activity in the Developing Mungbean (Vigna radiataL.)

    Article • Journal of Agricultural and Food Chemistry, June 2005, American Chemical Society (ACS)

    Dr Chun-Hsu Pan

  53. The molecular mechanism of actinomycin D in preventing neointimal formation in rat carotid arteries after balloon injury

    Article • Journal of Biomedical Science, May 2005, Springer Science + Business Media

    Dr Chun-Hsu Pan