All Stories

  1. Evaluating Cefepime Dosing Strategies in Pseudomonas aeruginosa Bacteremia: A Retrospective Cohort Analysis

    Article • Annals of Pharmacotherapy, May 2025, SAGE Publications

    Dr Christopher J Destache

  2. Cost analysis of urine testing for hospitalized patients in the emergency department

    Article • Baylor University Medical Center Proceedings, March 2025, Taylor & Francis

    Dr Christopher J Destache

  3. Impact of Extracorporeal Membrane Oxygenation (ECMO) on Serum Concentrations of Cefepime

    Article • Antibiotics, October 2024, MDPI AG

    Dr Christopher J Destache

  4. Impact of Extra-Corporeal Membrane Oxygenation (ECMO) on Serum Concentrations of Cefepime

    Article • October 2024, MDPI AG

    Dr Christopher J Destache

  5. Assessment of the impact of centralized bioMérieux BACT/ALERT® VIRTUO® blood culture system (VIRTUO) implementation on outcomes in patients with gram-negative bacteremia

    Article • Diagnostic Microbiology and Infectious Disease, December 2023, Elsevier

    Dr Christopher J Destache

  6. A comparison of clinical outcomes associated with dosing metronidazole every 8 hours versus every 12 hours: a systematic review and metaanalysis

    Article • Baylor University Medical Center Proceedings, November 2023, Taylor & Francis

    Dr Christopher J Destache

  7. Diagnosis and Outcomes of Fungal Co-Infections in COVID-19 Infections: A Retrospective Study

    Article • Microorganisms, September 2023, MDPI AG

    Dr Christopher J Destache

  8. Doxycycline Induced Pancreatitis: An Uncommon Complication of a Common Drug

    Article • Pharmacy, October 2022, MDPI AG

    Dr Christopher J Destache

  9. COVID-19 Mortality and Therapeutics in Nebraska and Southwest Iowa during Early Pandemic

    Article • Pharmacy, June 2022, MDPI AG

    Dr Christopher J Destache

  10. Targeted Immuno-Antiretroviral to Promote Dual Protection against HIV: A Proof-of-Concept Study

    Article • Nanomaterials, June 2022, MDPI AG

    Dr Christopher J Destache

  11. Improving understanding and utilization of the antibiogram among medical residents

    Article • Antimicrobial Stewardship & Healthcare Epidemiology, January 2022, Cambridge University Press

    Dr Christopher J Destache

  12. Beta-Lactam vs. Fluoroquinolone Monotherapy for Pseudomonas aeruginosa Infection: A Systematic Review and Meta-Analysis

    Article • Antibiotics, December 2021, MDPI AG

    Dr Christopher J Destache

  13. Bamlanivimab use in mild‐to‐moderate COVID‐19 disease: A matched cohort design

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, August 2021, Wiley

    Dr Christopher J Destache

  14. A Concept Evaluation Study of a New Combination Bictegravir plus Tenofovir Alafenamide Nanoformulation with Prolonged Sustained-Drug-Release Potency for HIV-1 Preexposure Prophylaxis

    Article • Antimicrobial Agents and Chemotherapy, March 2021, ASM Journals

    Dr Christopher J Destache

  15. Targeted Immuno-Antiretroviral HIV Therapeutic Approach to Provide Dual Protection and Boosts Cellular Immunity: A Proof-of-Concept Study

    Article • November 2020, Research Square

    Dr Christopher J Destache

  16. Targeted immuno-antiretroviral HIV therapeutic approach to provide dual protection and boosts cellular immunity: A proof-of-concept study

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr Christopher J Destache

  17. Implementation of a Health-System Wide Antimicrobial Stewardship Program in Omaha, NE

    Article • Pharmacy, November 2019, MDPI AG

    Dr Christopher J Destache

  18. Corrigendum to “Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission” [Journal of Controlled Release 29...

    Article • Journal of Controlled Release, June 2019, Elsevier

    Dr Christopher J Destache

  19. Effect of antimicrobial stewardship with rapid MALDI-TOF identification and Vitek 2 antimicrobial susceptibility testing on hospitalization outcome

    Article • Diagnostic Microbiology and Infectious Disease, June 2019, Elsevier

    Dr Christopher J Destache

  20. Correction to: Pharmacokinetic and Tissue Distribution Profile of Long Acting Tenofovir Alafenamide and Elvitegravir Loaded Nanoparticles in Humanized Mice Model

    Article • Pharmaceutical Research, May 2019, Springer Science + Business Media

    Dr Christopher J Destache

  21. A potential long-acting bictegravir loaded nano-drug delivery system for HIV-1 infection: A proof-of-concept study

    Article • Antiviral Research, April 2019, Elsevier

    Dr Christopher J Destache

  22. Effect of Antimicrobial Stewardship with Rapid MALDI-TOF Identification and Vitek 2 Antimicrobial Susceptibility Testing on Hospitalization Outcome

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Dr Christopher J Destache

  23. A review of CCR5 antibodies against HIV: current and future aspects

    Article • Therapeutic Delivery, February 2019, Future Science

    Dr Christopher J Destache

  24. Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection

    Article • Antimicrobial Agents and Chemotherapy, January 2019, ASM Journals

    Dr Christopher J Destache

  25. Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission

    Article • Journal of Controlled Release, January 2019, Elsevier

    Dr Christopher J Destache

  26. Ceftaroline fosamil for the treatment of Gram-positive endocarditis: CAPTURE study experience

    Article • International Journal of Antimicrobial Agents, January 2019, Elsevier

    Dr Christopher J Destache

  27. Development and validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

    Article • Biomedical Chromatography, October 2018, Wiley

    Dr Christopher J Destache

  28. Long-acting parenteral combination antiretroviral loaded nano-drug delivery system to treat chronic HIV-1 infection: A humanized mouse model study

    Article • Antiviral Research, August 2018, Elsevier

    Dr Christopher J Destache

  29. LC-MS/MS method for the simultaneous determination of tenofovir, emtricitabine, elvitegravir and rilpivirine in dried blood spots

    Article • Biomedical Chromatography, May 2018, Wiley

    Dr Christopher J Destache

  30. Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

    Article • Antiviral Research, March 2018, Elsevier

    Dr Christopher J Destache, Professor Asit K Pattnaik

  31. Review of NRTIs

    Article • Current HIV Research, January 2018, Bentham Science Publishers

    Dr Christopher J Destache, Subhra Mandal

  32. Pharmacokinetic and Tissue Distribution Profile of Long Acting Tenofovir Alafenamide and Elvitegravir Loaded Nanoparticles in Humanized Mice Model

    Article • Pharmaceutical Research, September 2017, Springer Science + Business Media

    Dr Christopher J Destache

  33. Cellulose Acetate Phthalate and Antiretroviral Nanoparticle Fabrications for HIV Pre-Exposure Prophylaxis

    Article • Polymers, September 2017, MDPI AG

    Dr Christopher J Destache

  34. Evaluation of Staphylococcus aureus Bacteremia: Academic and Community-Based Management Within the Same Health System

    Article • Infection Control and Hospital Epidemiology, March 2017, Cambridge University Press

    Dr Christopher J Destache

  35. Tenofovir alafenamide and elvitegravir loaded nanoparticles for long-acting prevention of HIV-1 vaginal transmission

    Article • AIDS, February 2017, Wolters Kluwer Health

    Dr Christopher J Destache

  36. Nanoformulation of emtricitabine for HIV

    Article • Antimicrobial Agents and Chemotherapy, November 2016, ASM Journals

    Dr Christopher J Destache, Subhra Mandal

  37. Brief review of HIV cure strategies.

    Article • October 2016, Mondal I-Sciences

    Dr Christopher J Destache

  38. Education and Communication in an Interprofessional Antimicrobial Stewardship Program

    Article • Journal of Osteopathic Medicine, September 2016, De Gruyter

    Dr Christopher J Destache

  39. LC-MS/MS quantification of NRTI, NNRTI, and INSTI in mice

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2016, Elsevier

    Dr Christopher J Destache

  40. topical TDF NP

    Article • Antimicrobial Agents and Chemotherapy, April 2016, ASM Journals

    Dr Christopher J Destache

  41. Early versus late surgical intervention or medical management for infective endocarditis: a systematic review and meta-analysis

    Article • Heart, February 2016, BMJ

    Dr Christopher J Destache

  42. Natural polyphenols: potential in the prevention of sexually transmitted viral infections

    Article • Drug Discovery Today, February 2016, Elsevier

    Dr Christopher J Destache

  43. Correction: Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

    Article • PLoS Pathogens, October 2015, PLOS

    Dr Christopher J Destache

  44. Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

    Article • PLoS Pathogens, August 2015, PLOS

    Dr Christopher J Destache

  45. Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells

    Article • AIP Advances, August 2015, American Institute of Physics

    Dr Christopher J Destache, Subhra Mandal

  46. Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice

    Article • JAIDS Journal of Acquired Immune Deficiency Syndromes, August 2015, Wolters Kluwer Health

    Dr Christopher J Destache

  47. Direct Differentiation of Adult Ocular Progenitors into Striatal Dopaminergic Neurons

    Article • International Journal of Stem Cells, May 2015, Korean Society for Stem Cell Research

    Dr Christopher J Destache

  48. Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles for Prevention of HIV-1 Infection

    Article • Journal of Biomedical Nanotechnology, March 2015, American Scientific Publishers

    Dr Christopher J Destache

  49. Hepatitis C therapy: Looking toward interferon-sparing regimens

    Article • Journal of the American Pharmacists Association, March 2015, Elsevier

    Dr Christopher J Destache

  50. Review of treatments for hepatitis C.

    Article • Journal of the American Pharmacists Association, March 2015, Elsevier

    Dr Christopher J Destache

  51. Assessing Appropriateness of Antimicrobial Therapy: In the Eye of the Interpreter

    Article • Clinical Infectious Diseases, October 2014, Oxford University Press (OUP)

    Dr Christopher J Destache

  52. Breaking Down the Barriers: Challenges With Development and Implementation of an Industry-Sponsored Antimicrobial Stewardship Data Collection and Analysis Tool

    Article • Clinical Infectious Diseases, October 2014, Oxford University Press (OUP)

    Dr Christopher J Destache

  53. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates

    Article • Biomedical Chromatography, October 2014, Wiley

    Dr Christopher J Destache

  54. Aminoglycoside-Induced Nephrotoxicity—A Focus on Monitoring

    Article • Journal of Pharmacy Practice, August 2014, SAGE Publications

    Dr Christopher J Destache

  55. Antimicrobial Treatment of Asymptomatic Bacteriuria in Noncatheterized Adults: A Systematic Review

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, May 2014, Wiley

    Dr Christopher J Destache

  56. A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

    Article • Biomaterials, August 2013, Elsevier

    Dr Christopher J Destache

  57. Polymeric Nanoparticles Containing Combination Antiretroviral Drugs for HIV Type 1 Treatment

    Article • AIDS Research and Human Retroviruses, May 2013, Mary Ann Liebert Inc

    Dr Christopher J Destache

  58. Does Antibiotic De-escalation for Nosocomial Pneumonia Impact Intensive Care Unit Length of Stay?

    Article • Infectious Diseases in Clinical Practice, May 2013, Wolters Kluwer Health

    Dr Christopher J Destache

  59. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis

    Article • Antiviral Research, December 2012, Elsevier

    Dr Christopher J Destache

  60. Lopinavir/Ritonavir: A Review for 2011

    Article • Clinical Medicine Insights Therapeutics, January 2011, SAGE Publications

    Dr Christopher J Destache

  61. Letter in Response to the Infectious Diseases Society of America’s 10 × ‘20 Initiative

    Article • Clinical Infectious Diseases, September 2010, Oxford University Press (OUP)

    Dr Christopher J Destache

  62. A Survey of Pharmacy Students' Experiences With Gambling

    Article • American Journal of Pharmaceutical Education, September 2010, American Journal of Pharmaceutical Education

    Dr Christopher J Destache

  63. Teaching Heart Failure Treatment Guidelines and Assessing Heart Failure Therapy

    Article • American Journal of Pharmaceutical Education, September 2010, American Journal of Pharmaceutical Education

    Dr Christopher J Destache

  64. Research Spotlight: Antiretroviral nanoparticles: an extended drug delivery modality

    Article • Therapeutic Delivery, September 2010, Future Science

    Dr Christopher J Destache

  65. Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice

    Article • Journal of Antimicrobial Chemotherapy, August 2010, Oxford University Press (OUP)

    Dr Christopher J Destache

  66. Combination antiretroviral drugs in PLGA nanoparticle for HIV-1

    Article • BMC Infectious Diseases, December 2009, Springer Science + Business Media

    Dr Christopher J Destache

  67. Rotation Students' Perceptions of Clinical Workload Documentation Using a Personal Digital Assistant

    Article • Hospital Pharmacy, November 2009, SAGE Publications

    Dr Estella M Davis, Dr Christopher J Destache

  68. Impact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting

    Article • Diabetes Spectrum, October 2009, American Diabetes Association

    Dr Christopher J Destache

  69. Nurse Satisfaction Using Insulin Pens in Hospitalized Patients

    Article • The Diabetes Educator, September 2009, SAGE Publications

    Dr Christopher J Destache

  70. Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS

    Article • The Journal of Immunology, June 2009, The American Association of Immunologists

    Dr Christopher J Destache

  71. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E2, Ex Vivo

    Article • Neurochemical Research, June 2009, Springer Science + Business Media

    Dr Christopher J Destache

  72. Brain as an HIV sequestered site

    Article • January 2009, Elsevier

    Dr Christopher J Destache

  73. Nursing Satisfaction Survey

    Article • January 2009, American Psychological Association (APA)

    Dr Christopher J Destache

  74. National Survey of Volunteer Pharmacy Preceptors

    Article • American Journal of Pharmaceutical Education, September 2008, American Journal of Pharmaceutical Education

    Dr Christopher J Destache

  75. Patient satisfaction and costs associated with insulin administered by pen device or syringe during hospitalization

    Article • American Journal of Health-System Pharmacy, July 2008, Oxford University Press (OUP)

    Dr Christopher J Destache

  76. A randomized trial of the peri-operative use of COX-2 inhibitors in Lichtenstein herniorrhaphy

    Article • Hernia, June 2008, Springer Science + Business Media

    Dr Christopher J Destache

  77. ANTIMICROBIAL PHARMACODYNAMICS IN THEORY AND CLINICAL PRACTICE, 2ND EDITION

    Article • Shock, January 2008, Wolters Kluwer Health

    Dr Christopher J Destache

  78. Regulation of retinal morphology and posterior segment amino acids by 8-isoprostaglandin E2 in bovine eyes ex vivo

    Article • Methods and Findings in Experimental and Clinical Pharmacology, January 2008, Prous Science

    Dr Christopher J Destache

  79. EFFICACY OF ANTIMICROBIALS FOR ACUTE EXACERBATION OF CHRONIC BRONCHITIS EPISODES

    Article • CHEST Journal, October 2007, Elsevier

    Dr Christopher J Destache

  80. Preprinted risk assessment and prophylaxis order form for venous thromboembolism

    Article • American Journal of Health-System Pharmacy, June 2007, Oxford University Press (OUP)

    Dr Christopher J Destache

  81. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages

    Article • Virology, February 2007, Elsevier

    Dr Christopher J Destache

  82. Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

    Article • Blood, October 2006, American Society of Hematology

    Dr Christopher J Destache

  83. Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery

    Article • Journal of Leukocyte Biology, August 2006, Wiley

    Dr Christopher J Destache

  84. Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System

    Article • Journal of Neuroimmune Pharmacology, August 2006, Springer Science + Business Media

    Dr Christopher J Destache

  85. Neuroimaging and Proteomic Tracking of Neurodegeneration in MPTP-Treated Mice

    Article • Annals of the New York Academy of Sciences, January 2006, Wiley

    Dr Christopher J Destache

  86. Quantitative 1H Magnetic Resonance Spectroscopic Imaging Determines Therapeutic Immunization Efficacy in an Animal Model of Parkinson's Disease

    Article • Journal of Neuroscience, February 2005, Society for Neuroscience

    Dr Christopher J Destache

  87. Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations

    Article • Glia, January 2005, Wiley

    Dr Christopher J Destache

  88. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

    Article • Proceedings of the National Academy of Sciences, June 2004, Proceedings of the National Academy of Sciences

    Dr Christopher J Destache

  89. Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report

    Article • Journal of Neuroimmunology, February 2004, Elsevier

    Dr Christopher J Destache

  90. Comparison of Gemfibrozil and Fenofibrate in Patients with Dyslipidemic Coronary Heart Disease

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, December 2002, Wiley

    Dr Christopher J Destache

  91. Maximizing Outcomes in Respiratory Tract Infections in the Age of Resistance

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, January 2002, Wiley

    Dr Christopher J Destache

  92. Optimizing Economic Outcomes in Acute Exacerbations of Chronic Bronchitis

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, January 2002, Wiley

    Dr Christopher J Destache

  93. Antibacterials and Acute Exacerbation of Chronic Bronchitis

    Article • Disease Management & Health Outcomes, January 2002, Springer Science + Business Media

    Dr Christopher J Destache

  94. Potential Influence of Timing of Low-Density Lipoprotein Cholesterol Evaluation in Patients with Acute Coronary Syndrome

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, September 2001, Wiley

    Dr Christopher J Destache

  95. Individualized Pharmacokinetic Monitoring Results in Less Aminoglycoside-Associated Nephrotoxicity and Fewer Associated Costs

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, April 2001, Wiley

    Dr Christopher J Destache

  96. Diagnosis and Treatment of Complicated Tubercular Meningitis

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, October 1999, Wiley

    Dr Christopher J Destache

  97. Simple liquid chromatographic method for the analysis of the blood brain barrier permeability characteristics of ceftriaxone in an experimental rabbit meningitis model

    Article • Journal of Chromatography B Biomedical Sciences and Applications, May 1999, Elsevier

    Dr Christopher J Destache

  98. Pharmacodynamics and pharmacokinetics of A-80556 using microdialysis in a Streptococcus pneumoniae meningitis model

    Article • Journal of Antimicrobial Chemotherapy, January 1996, Oxford University Press (OUP)

    Dr Christopher J Destache

  99. Notes on Medical Bacteriology. 4Th Edition

    Article • Annals of Pharmacotherapy, November 1995, SAGE Publications

    Dr Christopher J Destache

  100. Cost Considerations in Therapeutic Drug Monitoring of Aminoglycosides

    Article • Clinical Pharmacokinetics, January 1994, Springer Science + Business Media

    Dr Christopher J Destache

  101. Use of Therapeutic Drug Monitoring in Pharmacoeconomics

    Article • Therapeutic Drug Monitoring, December 1993, Wolters Kluwer Health

    Dr Christopher J Destache

  102. Economic Aspects of Pharmacokinetic Services

    Article • PharmacoEconomics, June 1993, Springer Science + Business Media

    Dr Christopher J Destache

  103. Effect of Seven Fluoroquinolones on the Determination of Serum Creatinine by the Picric Acid and Enzymatic Methods

    Article • Annals of Pharmacotherapy, May 1993, SAGE Publications

    Dr Christopher J Destache

  104. Omeprazole: A Comprehensive Review

    Article • Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, January 1993, Wiley

    Dr Christopher J Destache

  105. Aminoglycoside Forecasting in Neutropenic Patients with Cancer

    Article • Clinical Pharmacokinetics, January 1993, Springer Science + Business Media

    Dr Christopher J Destache

  106. Impact of Food on the Bioavailability of Encainide

    Article • The Journal of Clinical Pharmacology, September 1992, Wiley

    Dr Christopher J Destache

  107. Predictive Performance of Bayesian and Nonlinear Least-Squares Regression Programs for Lidocaine

    Article • Therapeutic Drug Monitoring, August 1992, Wolters Kluwer Health

    Dr Christopher J Destache

  108. Efficacy and safety of early versus late initiation of warfarin during heparin therapy in acute thromboembolism

    Article • American Heart Journal, March 1992, Elsevier

    Dr Christopher J Destache

  109. Influence of Mexiletine on the Pharmacokinetics of Theophylline in Healthy Volunteers

    Article • The Journal of Clinical Pharmacology, April 1991, Wiley

    Dr Christopher J Destache

  110. Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides

    Article • Therapeutic Drug Monitoring, September 1990, Wolters Kluwer Health

    Dr Christopher J Destache

  111. Does Accepting Pharmacokinetic Recommendations Impact Hospitalization? A Cost-Benefit Analysis

    Article • Therapeutic Drug Monitoring, September 1990, Wolters Kluwer Health

    Dr Christopher J Destache

  112. Retrospective comparison of pharmacokinetic service and no service on patient outcomes

    Article • DICP, January 1989, SAGE Publications

    Dr Christopher J Destache

  113. Case report and literature review

    Article • Drug Intelligence & Clinical Pharmacy, September 1985, SAGE Publications

    Dr Christopher J Destache