All Stories

  1. Design of a Neonatal Orthotopic Metastatic Xenograft Model of Hepatoblastoma in Mice

    Article • Oncology, July 2025, Karger Publishers

    Dr Christophe F Grosset

  2. Enhancing cell instance segmentation in scanning electron microscopy images via a deep contour closing operator

    Article • Computers in Biology and Medicine, May 2025, Elsevier

    Dr Christophe F Grosset

  3. Improving Cell Instance Segmentation in Scanning Electron Microscopy via Semantic Image Synthesis

    Article • April 2025, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Christophe F Grosset

  4. Optimized zymogram protocol from 3D spheroid cultures to study MMP-2 and -9 activities in tumor cells

    Article • BMC Biotechnology, April 2025, Springer Science + Business Media

    Dr Christophe F Grosset

  5. DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis

    Article • Molecular Therapy, April 2024, Elsevier

    Dr Christophe F Grosset

  6. Functions and Therapeutic Use of Heat Shock Proteins in Hepatocellular Carcinoma

    Article • Livers, March 2024, MDPI AG

    Dr Christophe F Grosset

  7. Unfolded Protein Response Signaling in Liver Disorders: A 2023 Updated Review

    Article • International Journal of Molecular Sciences, September 2023, MDPI AG

    Dr Christophe F Grosset

  8. Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1

    Article • JHEP Reports, May 2023, Elsevier

    Doulaye Dembele, Dr Christophe F Grosset

  9. Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis

    Article • Cells, December 2022, MDPI AG

    Dr Christophe F Grosset

  10. Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer

    Article • Cancers, December 2022, MDPI AG

    Dr Christophe F Grosset

  11. miR-155 regulates physiological angiogenesis but an miR-155-rich microenvironment disrupts the process by promoting unproductive endothelial sprouting

    Article • Cellular and Molecular Life Sciences, March 2022, Springer Science + Business Media

    Dr Christophe F Grosset

  12. An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect

    Article • Neuro-Oncology Advances, January 2022, Oxford University Press (OUP)

    Dr Christophe F Grosset

  13. LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways

    Article • Liver Cancer, December 2021, Karger Publishers

    Dr Christophe F Grosset

  14. Deciphering tumour tissue organization by 3D electron microscopy and machine learning

    Article • Communications Biology, December 2021, Springer Science + Business Media

    Dr Christophe F Grosset

  15. DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Dr Christophe F Grosset

  16. Deciphering Tumour Tissue Organization by 3D Electron Microscopy and machine learning

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Dr Christophe F Grosset

  17. The ß-catenin-target Fascin-1, altering hepatocyte differentiation, is a new marker of immature cells in hepatoblastomas

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Christophe F Grosset

  18. 3e colloque de recherche fondamentale en oncologie pédiatrique

    Article • Bulletin du Cancer, December 2020, Elsevier

    Dr Christophe F Grosset

  19. The Nuclear Remodeling Induced by Helicobacter Cytolethal Distending Toxin Involves MAFB Oncoprotein

    Article • Toxins, March 2020, MDPI AG

    Dr Christophe F Grosset

  20. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53

    Article • Neuro-Oncology, November 2019, Oxford University Press (OUP)

    Dr Christophe F Grosset

  21. miR‐4510 Blocks Hepatocellular Carcinoma Development Through RAF1 Targeting and RAS/RAF/MEK/ERK Signaling Inactivation

    Article • Liver International, October 2019, Wiley

    Dr Christophe F Grosset

  22. Les microARNs, de petits régulateurs géniques à fort potentiel thérapeutique en cancérologie

    Article • Bulletin du Cancer, October 2019, Elsevier

    Dr Christophe F Grosset

  23. Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells

    Article • PLoS Pathogens, September 2019, PLOS

    Dr Christophe F Grosset

  24. Expression of miRNA-210 in human bone marrow-derived mesenchymal stromal cells under oxygen deprivation

    Article • Archives of Biological Sciences, January 2019, National Library of Serbia

    Dr Christophe F Grosset

  25. Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo

    Article • Oncotarget, February 2018, Impact Journals, LLC

    Dr Katarzyna B Hooks, Dr Christophe F Grosset

  26. Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells

    Article • Biochemistry, February 2018, American Chemical Society (ACS)

    Dr Christophe F Grosset

  27. New insights into diagnosis and therapeutic options for proliferative hepatoblastoma

    Article • Hepatology, November 2017, Wiley

    Dr Katarzyna B Hooks, Dr Christophe F Grosset

  28. SimBA: A methodology and tools for evaluating the performance of RNA-Seq bioinformatic pipelines

    Article • BMC Bioinformatics, September 2017, Springer Science + Business Media

    Dr Christophe F Grosset

  29. New tumor suppressor microRNAs target glypican-3 in human liver cancer

    Article • Oncotarget, June 2017, Impact Journals, LLC

    Dr Katarzyna B Hooks, Dr Christophe F Grosset

  30. MicroRNA therapy inhibits hepatoblastoma growthin vivoby targeting β-catenin and Wnt signaling

    Article • Hepatology Communications, April 2017, Wiley

    Dr Katarzyna B Hooks, Dr Christophe F Grosset

  31. MicroRNA-1291-mediated silencing of IRE1  enhances Glypican-3 expression

    Article • RNA, April 2013, Cold Spring Harbor Laboratory Press

    Dr Christophe F Grosset

  32. A functional screening identifies five micrornas controlling glypican-3: role of mir-1271 down-regulation in hepatocellular carcinoma

    Article • Hepatology, January 2013, Wolters Kluwer Health

    Dr Christophe F Grosset

  33. Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model

    Article • Nucleic Acids Research, October 2011, Oxford University Press (OUP)

    Dr Christophe F Grosset

  34. Analysis of post-transcriptional regulation using the FunREG method

    Article • Biochemical Society Transactions, December 2010, Portland Press Ltd.

    Dr Christophe F Grosset

  35. A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia

    Article • Human Molecular Genetics, July 2010, Oxford University Press (OUP)

    Dr Christophe F Grosset

  36. A mutation in the 3′-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia

    Article • Human Molecular Genetics, February 2010, Oxford University Press (OUP)

    Dr Christophe F Grosset

  37. Analysis of Post-transcriptional Regulations by a Functional, Integrated, and Quantitative Method

    Article • Molecular & Cellular Proteomics, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Christophe F Grosset

  38. Ultrasound-Induced Expression of a Heat Shock Promoter-Driven Transgene Delivered in the Kidney by Genetically Modified Mesenchymal Stem Cells

    Article • September 2007, Taylor & Francis

    Dr Christophe F Grosset

  39. The ARE-associated factor AUF1 binds poly(A) in vitro in competition with PABP

    Article • Biochemical Journal, December 2006, Portland Press Ltd.

    Dr Christophe F Grosset

  40. Le CD154 plaquettaire : Une nouvelle interface dans l’hémostase et la réaction inflammatoire

    Article • médecine/sciences, October 2005, EDP Sciences

    Dr Christophe F Grosset, Dr julien villeneuve

  41. Platelet-associated CD154 in immune thrombocytopenic purpura

    Article • Blood, January 2005, American Society of Hematology

    Dr Christophe F Grosset

  42. In Vivo MR Imaging of Intravascularly Injected Magnetically Labeled Mesenchymal Stem Cells in Rat Kidney and Liver1

    Article • Radiology, December 2004, Radiological Society of North America (RSNA)

    Dr Christophe F Grosset

  43. In VivoStudies of Translational Repression Mediated by the Granulocyte-Macrophage Colony-stimulating Factor AU-rich Element

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Christophe F Grosset

  44. Prostaglandin E2modulates dendritic cell function via EP2and EP4receptor subtypes

    Article • Journal of Leukocyte Biology, June 2003, Wiley

    Dr Christophe F Grosset

  45. Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4- and VLA-5-dependent mechanism

    Article • British Journal of Haematology, March 2003, Wiley

    Dr Christophe F Grosset, Dr Legembre Patrick

  46. Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis

    Article • Blood, April 2002, American Society of Hematology

    Dr Christophe F Grosset

  47. Dendritic Cells Issued in Vitro from Bone Marrow Produce PGE2 That Contributes to the Immunomodulation Induced by Antigen-Presenting Cells

    Article • Cellular Immunology, April 2001, Elsevier

    Dr Christophe F Grosset

  48. A Mechanism for Translationally Coupled mRNA Turnover

    Article • Cell, September 2000, Elsevier

    Dr Christophe F Grosset

  49. Differential effect of interferon alpha on chronic myelogenous leukaemia and normal haematopoietic progenitors in a stromal cell co-culture context: role of the flt3 ligand

    Article • British Journal of Haematology, May 2000, Wiley

    Dr Christophe F Grosset

  50. Expression of Flt3-ligand by the endothelial cell

    Article • Leukemia, January 2000, Springer Science + Business Media

    Dr Christophe F Grosset

  51. LEUKAEMIA INHIBITORY FACTOR EXPRESSION IS INHIBITED BY GLUCOCORTICOIDS THROUGH POST-TRANSCRIPTIONAL MECHANISMS

    Article • Cytokine, January 1999, Elsevier

    Dr Christophe F Grosset

  52. Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids

    Article • Leukemia, August 1998, Springer Science + Business Media

    Dr Christophe F Grosset

  53. CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells.

    Article • The Journal of Immunology, December 1997, Oxford University Press (OUP)

    Dr Christophe F Grosset

  54. Effect of stem cell factor on leukemic progenitor cell growth and sensitivity to cytosine-arabinoside

    Article • Leukemia Research, November 1996, Elsevier

    Dr Christophe F Grosset