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About my research

Dr. Rudolph is a world-renowned expert in bacterial DNA replication, repair and chromosome dynamics. His research focuses on DNA replication termination, how CRISPR-Cas systems connect to DNA processes, transcription-replication conflicts and how they shape bacterial chromosomes, and how antibiotics and antibiotic-like substances such as artificial sweeteners impact DNA replication. His goal is to understand how cells accurately duplicate genomes and what happens when these processes fail, with applications in antibiotic development and genomic instability diseases like cancer.

All Stories

  1. Article
    Finishing DNA replication can trigger genomic instability in normal cells
    Dr. Christian J Rudolph
  2. Article
    How saccharin disrupts bacteria and their biofilms.
    Dr. Christian J Rudolph
  3. Article
    Using BioID2 to map protein interactions in E. coli
    Dr. Christian J Rudolph
  4. Article
    How bacteria finish copying their DNA and why this matters
    Dr. Christian J Rudolph
  5. Article
    How DnaK helps control early CRISPR defence in E. coli.
    Dr. Christian J Rudolph
  6. Article
    How acesulfame-K affected drug-resistant bacteria and antibiotic activity.
    Dr. Christian J Rudolph
  7. Article
    E. coli replication forks can leave a small gap at Tus-ter barriers
    Dr. Christian J Rudolph
  8. Article
    A conserved DNA replication fork trap in E. coli
    Dr. Christian J Rudolph
  9. Article
    Termination of DNA Replication in Prokaryotes
    Dr. Christian J Rudolph
  10. Article
    Exonucleases help finish DNA replication in E. coli
    Dr. Christian J Rudolph
  11. Article
    How RecBCD protects E. coli DNA when copying and transcription collide
    Dr. Christian J Rudolph
  12. Article
    Testing extra replication origins in the E. coli chromosome
    Dr. Christian J Rudolph
  13. Article
    How RecG helps E. coli avoid extra DNA copying when replication forks meet
    Dr. Christian J Rudolph
  14. Article
    Modeling of DNA replication in rapidly growing bacteria with one and two replication origins
    Dr. Christian J Rudolph
  15. Article
    What the E. coli DNA replication fork trap may do
    Dr. Christian J Rudolph
  16. Article
    Origin-independent synthesis in cells lacking RecG and RNase HI
    Dr. Christian J Rudolph
  17. Article
    Shaping the landscape of the Escherichia coli chromosome: replication-transcription encounters in cells with an ectopic replication origin
    Dr. Christian J Rudolph
  18. Article
    Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus
    Dr. Christian J Rudolph
  19. Article
    Avoiding chromosome pathology when replication forks collide
    Dr. Christian J RudolphProf Conrad A Nieduszynski
  20. Article
    On the viability of Escherichia coli cells lacking DNA topoisomerase I
    Dr. Christian J Rudolph
  21. Article
    Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion
    Dr. Christian J Rudolph
  22. Article
    Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
    Dr. Christian J Rudolph
  23. Article
    RecG Protein and Single-Strand DNA Exonucleases Avoid Cell Lethality Associated With PriA Helicase Activity in Escherichia coli
    Dr. Christian J Rudolph
  24. Article
    Is RecG a general guardian of the bacterial genome?
    Dr. Christian J Rudolph
  25. Article
    Rep Provides a Second Motor at the Replisome to Promote Duplication of Protein-Bound DNA
    Dr. Christian J Rudolph
  26. Article
    Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase
    Dr. Christian J Rudolph
  27. Article
    Pathological replication in cells lacking RecG DNA translocase
    Dr. Christian J Rudolph
  28. Article
    Maintaining replication fork integrity in UV-irradiated Escherichia coli cells
    Dr. Christian J Rudolph
  29. Article
    Avoiding and resolving conflicts between DNA replication and transcription
    Dr. Christian J Rudolph
  30. Article
    Replication fork stalling and cell cycle arrest in UV-irradiated Escherichia coli
    Dr. Christian J Rudolph
  31. Article
    Yeast MPH1 Gene Functions in an Error-Free DNA Damage Bypass Pathway That Requires Genes From Homologous Recombination, but Not From Postreplicative Repair
    Dr. Christian J Rudolph
  32. Article
    Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing
    Dr. Christian J Rudolph