All Stories

  1. Fulminant Secondary HLH Following EBV Reactivation in an Adult With Trisomy 21 After Teplizumab Treatment for Stage 2 Type 1 Diabetes

    Article • Diabetes Care, July 2026, American Diabetes Association

    Dr. Christian Klemann

  2. Methotrexate Therapy in Juvenile Idiopathic Arthritis: No Clinically Relevant Pulmonary Impairment but Frequent Transient Liver Enzyme Elevations in a Longitudinal Single‐Center Pediatric Cohort of 274 Children Over 30 Years

    Article • ACR Open Rheumatology, March 2026, Wiley

    Dr. Christian Klemann

  3. Type-Specific Impacts of Protein Defects in Pathogenic NFKB2 Variants: Novel Clinical Findings From 138 Patients

    Article • The Journal of Allergy and Clinical Immunology In Practice, January 2025, Elsevier

    Dr. Christian Klemann

  4. Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening

    Article • Metabolomics, October 2024, Springer Science + Business Media

    Dr. Christian Klemann

  5. Evaluation of Anti-CAR Linker mAbs for CAR T Monitoring after BiTEs/bsAbs and CAR T-Cell Pretreatment

    Article • Biomedicines, July 2024, MDPI AG

    Dr. Christian Klemann

  6. Diagnostic evaluation of paediatric autoimmune lymphoproliferative immunodeficiencies (ALPID): a prospective cohort study

    Article • The Lancet Haematology, February 2024, Elsevier

    Dr. Christian Klemann

  7. Identification of disease-specific TCRs maintaining pathogenic T helper cell responses in postinfectious Lyme Arthritis

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Dr. Christian Klemann

  8. Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing

    Article • Journal of Allergy and Clinical Immunology, January 2024, Elsevier

    Dr. Christian Klemann

  9. Kinderrheumatologie

    Article • Kinder- und Jugendmedizin, October 2023, Thieme Publishing Group

    Dr. Christian Klemann

  10. Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity

    Article • Journal of Allergy and Clinical Immunology, October 2023, Elsevier

    Dr. Christian Klemann

  11. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 2023, Wolters Kluwer Health

    Dr. Christian Klemann

  12. Wichtige angeborenen Störungen des Immunsystems: CTLA-4 Defizienz

    Article • Zeitschrift für Gastroenterologie, July 2023, Thieme Publishing Group

    Dr. Christian Klemann

  13. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome

    Article • Journal of Allergy and Clinical Immunology, April 2023, Elsevier

    Dr. Christian Klemann

  14. Prospective Newborn Screening for SCID in Germany: A First Analysis by the Pediatric Immunology Working Group (API)

    Article • Journal of Clinical Immunology, February 2023, Springer Science + Business Media

    Dr. Christian Klemann

  15. Systematic genetic analysis of pediatric patients with autoinflammatory diseases

    Article • Frontiers in Genetics, January 2023, Frontiers

    Dr. Christian Klemann

  16. Prospective Newborn Screening for SCID in Germany: A first  analysis by the Pediatric Immunology Working Group (API)

    Article • December 2022, Springer Science + Business Media

    Dr. Christian Klemann

  17. Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases

    Article • Frontiers in Immunology, October 2022, Frontiers

    Dr. Christian Klemann

  18. Fokale Krampfanfälle und Posteriores Reversibles Enzephalopathie-Syndrom (PRES) als Erstmanifestation einer IgA-Vaskulitis

    Article • Arthritis und Rheuma, September 2022, Thieme Publishing Group

    Dr. Christian Klemann

  19. Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

    Article • Frontiers in Immunology, June 2022, Frontiers

    Oliver Blankenstein, Dr. Christian Klemann

  20. Erratum zu: Warnzeichen für und moderne Diagnostik von angeborenen Störungen des Immunsystems

    Article • Monatsschrift Kinderheilkunde, March 2022, Springer Science + Business Media

    Dr. Christian Klemann

  21. Warnzeichen für und moderne Diagnostik von angeborenen Störungen des Immunsystems

    Article • Monatsschrift Kinderheilkunde, March 2022, Springer Science + Business Media

    Dr. Christian Klemann

  22. Chronisch-entzündliche Darmerkrankung

    Article • Monatsschrift Kinderheilkunde, February 2022, Springer Science + Business Media

    Dr. Christian Klemann

  23. Genetics in inborn errors of immunity: pediatric autoinflammatory phenotypes and the underlying genetic causes in 125 families

    Article • February 2022, Springer Science + Business Media

    Dr. Christian Klemann

  24. Therapeutic options for CTLA-4 insufficiency

    Article • Journal of Allergy and Clinical Immunology, February 2022, Elsevier

    Dr. Christian Klemann

  25. The First 4 Years – Outcome of Children Identified by Newborn Screening for CF in Germany

    Article • Klinische Pädiatrie, January 2022, Thieme Publishing Group

    Dr. Christian Klemann

  26. Focal Seizures and Posterior Reversible Encephalopathy Syndrome as Presenting Signs of IgA Vasculitis/Henoch-Schoenlein Purpura—An Educative Case and Systematic Review of the Literature

    Article • Frontiers in Neurology, November 2021, Frontiers

    Dr. Christian Klemann

  27. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations

    Article • Journal of Allergy and Clinical Immunology, November 2021, Elsevier

    Dr. Christian Klemann

  28. Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies

    Article • Journal of Clinical Immunology, October 2021, Springer Science + Business Media

    Dr. Christian Klemann

  29. Lack of gamma delta T cells ameliorates inflammatory response after acute intestinal ischemia reperfusion in mice

    Article • Scientific Reports, September 2021, Springer Science + Business Media

    Dr. Christian Klemann

  30. Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations

    Article • Frontiers in Immunology, September 2021, Frontiers

    Dr. Christian Klemann

  31. Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

    Article • Journal of Allergy and Clinical Immunology, August 2021, Elsevier

    Dr. Christian Klemann

  32. The first 4 years - Outcome of children identified by newborn screening for CF in Germany

    Article • July 2021, Wiley

    Dr. Christian Klemann

  33. Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

    Article • Nucleic Acids Research, May 2021, Oxford University Press (OUP)

    Dr. Christian Klemann

  34. Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia

    Article • Journal of Clinical Medicine, May 2021, MDPI AG

    Dr. Christian Klemann

  35. Shared genetic etiology between Parkinson’s disease and blood levels of specific lipids

    Article • npj Parkinson s Disease, March 2021, Springer Science + Business Media

    Dr. Christian Klemann

  36. The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation

    Article • Science Immunology, March 2021, American Association for the Advancement of Science

    Dr. Christian Klemann

  37. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

    Article • Journal of Experimental Medicine, November 2020, Rockefeller University Press

    Dr. Christian Klemann

  38. Synthetic retinoid AM80 inhibits IL‐17 production of gamma delta T cells and ameliorates biliary atresia in mice

    Article • Liver International, September 2020, Wiley

    Dr. Christian Klemann

  39. Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency

    Article • Leukemia, June 2020, Springer Science + Business Media

    Dr. Christian Klemann

  40. Incidence of SCID in Germany from 2014 to 2015 an ESPED* Survey on Behalf of the API*** Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland (German Paediatric Surveillance Unit) ** Arbeitsgemeinschaft Pädiatrische Immunologie

    Article • Journal of Clinical Immunology, May 2020, Springer Science + Business Media

    Dr. Christian Klemann

  41. Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection

    Article • Transplantation, April 2020, Wolters Kluwer Health

    Dr. Christian Klemann

  42. A novel NFKBIA variant substituting serine 36 of IκBα causes immunodeficiency with warts, bronchiectasis and juvenile rheumatoid arthritis in the absence of ectodermal dysplasia

    Article • Clinical Immunology, January 2020, Elsevier

    Dr. Christian Klemann

  43. Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity

    Article • Clinical Immunology, January 2020, Elsevier

    Dr. Christian Klemann

  44. Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies

    Article • Journal of Allergy and Clinical Immunology, January 2020, Elsevier

    Dr. Christian Klemann

  45. Common pre-diagnostic features in individuals with different rare diseases represent a key for diagnostic support with computerized pattern recognition?

    Article • PLOS One, October 2019, PLOS

    Dr. Christian Klemann

  46. Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

    Article • August 2019, Cold Spring Harbor Laboratory Press

    Dr. Christian Klemann

  47. Non-CF Bronchiectasis as a Possible Indicator of a Primary Immunodeficiency: Diagnosis, Clinical Course, and Quality of Life in a Pediatric Cohort

    Article • Klinische Pädiatrie, July 2019, Thieme Publishing Group

    Dr. Christian Klemann

  48. The German National Registry of Primary Immunodeficiencies (2012–2017)

    Article • Frontiers in Immunology, July 2019, Frontiers

    Dr. Christian Klemann

  49. Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia

    Article • Growth Factors, June 2019, Taylor & Francis

    Claus Petersen, Dr. Christian Klemann

  50. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2

    Article • Frontiers in Immunology, March 2019, Frontiers

    Dr. Christian Klemann

  51. Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

    Article • Journal of Allergy and Clinical Immunology, December 2018, Elsevier

    Dr. Christian Klemann

  52. Long-term outcome and necessity of liver transplantation in infants with biliary atresia are independent of cytokine milieu in native liver and serum

    Article • Cytokine, November 2018, Elsevier

    Dr. Christian Klemann

  53. Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

    Article • Kidney International, October 2018, Elsevier

    Dr. Christian Klemann

  54. CD59 deficiency presenting as polyneuropathy and Moyamoya syndrome with endothelial abnormalities of small brain vessels

    Article • European Journal of Paediatric Neurology, September 2018, Elsevier

    Dr. Christian Klemann

  55. Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease

    Article • Pediatric Blood & Cancer, August 2018, Wiley

    Dr. Christian Klemann

  56. CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome

    Article • Immunology and Cell Biology, June 2018, Wiley

    Dr. Christian Klemann

  57. Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency

    Article • Journal of Allergy and Clinical Immunology, June 2018, Elsevier

    Dr. Christian Klemann

  58. Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and Chronic Diarrhea

    Article • Inflammatory Bowel Diseases, December 2017, Oxford University Press (OUP)

    Dr. Christian Klemann

  59. Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation

    Article • Journal of Allergy and Clinical Immunology, December 2017, Elsevier

    Dr. Christian Klemann

  60. Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis

    Article • Journal of Clinical Immunology, September 2017, Springer Science + Business Media

    Dr. Christian Klemann, Professor Milen Minkov

  61. Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice

    Article • PLOS One, August 2017, PLOS

    Dr. Christian Klemann

  62. Inflammatory bowel disease caused by primary immunodeficiencies-Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

    Article • Pediatric Allergy and Immunology, August 2017, Wiley

    Dr. Christian Klemann

  63. Conventional alpha beta (αβ) T cells do not contribute to acute intestinal ischemia-reperfusion injury in mice

    Article • PLOS One, July 2017, PLOS

    Dr. Christian Klemann

  64. IL-17A blockade or deficiency does not affect progressive renal fibrosis following renal ischaemia reperfusion injury in mice

    Article • Journal of Pharmacy and Pharmacology, June 2017, Wiley

    Dr. Christian Klemann

  65. Patient’s Experience in Pediatric Primary Immunodeficiency Disorders: Computerized Classification of Questionnaires

    Article • Frontiers in Immunology, April 2017, Frontiers

    Dr. Christian Klemann

  66. Diagnostic needs for rare diseases and shared prediagnostic phenomena: Results of a German-wide expert Delphi survey

    Article • PLOS One, February 2017, PLOS

    Dr. Christian Klemann

  67. Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire

    Article • European Journal of Immunology, January 2017, Wiley

    Dr. Christian Klemann

  68. Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome

    Article • Haematologica, October 2016, Ferrata Storti Foundation (Haematologica)

    Dr. Christian Klemann

  69. DIVERGENT CELLULAR AND CLINICAL PHENOTYPE IN A PATIENT WITH CORONIN1A DEFICIENCY

    Article • September 2016, Morressier

    Dr. Christian Klemann

  70. Reply

    Article • Gastroenterology, June 2016, Elsevier

    Dr. Christian Klemann

  71. Review 2016 - CD26/DPP4 in the immune system

    Article • Clinical & Experimental Immunology, May 2016, Wiley

    Dr. Christian Klemann

  72. Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome

    Article • Blood, April 2016, American Society of Hematology

    Dr. Christian Klemann

  73. Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

    Article • Clinical & Experimental Immunology, March 2016, Wiley

    Dr. Christian Klemann

  74. Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency

    Article • Clinical Immunology, March 2016, Elsevier

    Dr. Christian Klemann

  75. Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients

    Article • Gastroenterology, January 2016, Elsevier

    Dr. Christian Klemann

  76. Immundefekte als Ursache von chronisch-entzündlichen Erkrankungen des Darmes

    Article • Kinder- und Jugendmedizin, January 2016, Thieme Publishing Group

    Dr. Christian Klemann

  77. The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice

    Article • Pediatric Research, December 2015, Nature

    Dr. Christian Klemann

  78. FP197γδ T-CELL AND IL-17A DEFICIENCY IN HYPOXIA INDUCED ACUTE KIDNEY INJURY (AKI)

    Article • Nephrology Dialysis Transplantation, May 2015, Oxford University Press (OUP)

    Dr. Christian Klemann

  79. Neutralization of interleukin-17 produced by gamma delta T cells constrains inflammation in experimental biliary atresia

    Article • Molecular and Cellular Pediatrics, January 2015, Springer Science + Business Media

    Dr. Christian Klemann

  80. Increased Inflammatory Reaction to Intestinal Ischemia-Reperfusion in Neonatal versus Adult Mice

    Article • European Journal of Pediatric Surgery, November 2014, Thieme Publishing Group

    Dr. Christian Klemann

  81. Renal PKC-  deficiency attenuates acute kidney injury and ischemic allograft injury via TNF- -dependent inhibition of apoptosis and inflammation

    Article • AJP Renal Physiology, July 2014, American Physiological Society

    Dr. Christian Klemann

  82. Rotavirus particles in the extrahepatic bile duct in experimental biliary atresia

    Article • Journal of Pediatric Surgery, April 2014, Elsevier

    Dr. Christian Klemann

  83. Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: a matter of dose, route, and time

    Article • Physiological Reports, October 2013, Wiley

    Dr. Christian Klemann

  84. Reduced airway inflammation in CD26/DPP4-deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins

    Article • Clinical & Experimental Allergy, November 2010, Wiley

    Dr. Christian Klemann

  85. Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis

    Article • American Journal Of Pathology, June 2009, Elsevier

    Dr. Christian Klemann

  86. CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently

    Article • Clinical & Experimental Immunology, February 2009, Wiley

    Dr. Christian Klemann

  87. Retinoid signals and Th17-mediated pathology

    Article • Japanese Journal of Clinical Immunology, January 2009, Japan Society for Clinical Immunology

    Dr. Christian Klemann

  88. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2009, De Gruyter

    Dr. Christian Klemann

  89. Regulation of Expression and Function of Dipeptidyl Peptidase 4 (DP4), DP8/9, and DP10 in Allergic Responses of the Lung in Rats

    Article • Journal of Histochemistry & Cytochemistry, October 2007, SAGE Publications

    Dr. Christian Klemann