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  1. Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients

    Article • The EMBO Journal, November 2017, EMBO

    Dr Chrisostomos Prodromou

  2. The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

    Article • PLoS ONE, March 2017, PLOS

    Dr Chrisostomos Prodromou

  3. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

    Article • Cell Reports, August 2015, Elsevier

    Dr Chrisostomos Prodromou

  4. Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes

    Article • Acta Crystallographica Section D Biological Crystallography, April 2015, International Union of Crystallography

    Dr Chrisostomos Prodromou

  5. Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1

    Article • Structure, June 2014, Elsevier

    Dr Chrisostomos Prodromou

  6. Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Christopher J Moody, Dr Chrisostomos Prodromou

  7. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

    Article • Molecular Cell, January 2014, Elsevier

    Dr Chrisostomos Prodromou

  8. Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

    Article • Oncogene, December 2013, Nature

    Dr Chrisostomos Prodromou

  9. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

    Article • Nature Methods, May 2013, Nature

    Dr Chrisostomos Prodromou

  10. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

    Article • Nature Methods, March 2013, Nature

    Dr Chrisostomos Prodromou

  11. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

    Article • Nature Chemistry, March 2013, Nature

    Dr Chrisostomos Prodromou

  12. Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal α-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition

    Article • PLoS ONE, December 2012, PLOS

    Marta Korbonits, Dr Chrisostomos Prodromou

  13. CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression

    Article • Cell, December 2012, Elsevier

    Professor Sarah Perrett, Dr Chrisostomos Prodromou

  14. Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors

    Article • PLoS ONE, September 2012, PLOS

    Dr Chrisostomos Prodromou

  15. Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

    Article • Molecular Cell, August 2012, Elsevier

    Dr Chrisostomos Prodromou

  16. The ‘active life’ of Hsp90 complexes

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2012, Elsevier

    Dr Chrisostomos Prodromou

  17. Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

    Article • Proceedings of the National Academy of Sciences, February 2012, Proceedings of the National Academy of Sciences

    Dr Chrisostomos Prodromou

  18. Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90

    Article • The FASEB Journal, July 2011, Federation of American Societies For Experimental Biology (FASEB)

    Dr Chrisostomos Prodromou

  19. A combinatorial method to enable detailed investigation of protein–protein interactions

    Article • Future Medicinal Chemistry, March 2011, Future Science

    Dr Chrisostomos Prodromou

  20. Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

    Article • Molecular Cell, March 2011, Elsevier

    Dr Chrisostomos Prodromou

  21. Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

    Article • Chemistry - A European Journal, July 2010, Wiley

    Dr Chrisostomos Prodromou

  22. Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors

    Article • Molecular Cell, July 2010, Elsevier

    Dr Chrisostomos Prodromou

  23. A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90α/β

    Article • Biochemical Pharmacology, June 2010, Elsevier

    Dr Chrisostomos Prodromou

  24. Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

    Article • Molecular Cell, February 2010, Elsevier

    Dr Chrisostomos Prodromou

  25. Strategies for Stalling Malignancy: Targeting Cancers Addiction to Hsp90

    Article • Current Topics in Medicinal Chemistry, November 2009, Bentham Science Publishers

    Dr Chrisostomos Prodromou

  26. Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

    Article • Nature Structural & Molecular Biology, October 2009, Nature

    Dr Chrisostomos Prodromou

  27. Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90

    Article • Journal of Molecular Biology, October 2009, Elsevier

    Dr Chrisostomos Prodromou

  28. Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90

    Article • ACS Chemical Biology, April 2009, American Chemical Society (ACS)

    Dr Chrisostomos Prodromou

  29. The Hsp90 mosaic: a picture emerges

    Article • Nature Structural & Molecular Biology, January 2009, Nature

    Dr Chrisostomos Prodromou

  30. A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

    Article • FEBS Journal, November 2008, Wiley

    Dr Chrisostomos Prodromou

  31. Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors†

    Article • Journal of Medicinal Chemistry, September 2008, American Chemical Society (ACS)

    Dr Chrisostomos Prodromou

  32. Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

    Article • The EMBO Journal, September 2008, Wiley

    Dr Chrisostomos Prodromou

  33. Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37

    Article • Molecular Cell, September 2008, Elsevier

    Dr Chrisostomos Prodromou

  34. Chaperone ligand-discrimination by the TPR-domain protein Tah1

    Article • Biochemical Journal, July 2008, Portland Press Ltd.

    Dr Chrisostomos Prodromou

  35. Molecular Characterization of Macbecin as an Hsp90 Inhibitor#

    Article • Journal of Medicinal Chemistry, May 2008, American Chemical Society (ACS)

    Dr Chrisostomos Prodromou

  36. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

    Article • Cancer Research, April 2008, American Association for Cancer Research (AACR)

    Dr Chrisostomos Prodromou

  37. The Hsp90 molecular chaperone: an open and shut case for treatment

    Article • Biochemical Journal, March 2008, Portland Press Ltd.

    Dr Chrisostomos Prodromou

  38. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis

    Article • Development, February 2008, The Company of Biologists

    Dr Chrisostomos Prodromou

  39. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

    Article • Journal of Medicinal Chemistry, January 2008, American Chemical Society (ACS)

    Dr Chrisostomos Prodromou

  40. DNA fragmentation based combinatorial approaches to soluble protein expression

    Article • Drug Discovery Today, November 2007, Elsevier

    Dr Chrisostomos Prodromou

  41. DNA fragmentation-based combinatorial approaches to soluble protein expression

    Article • Drug Discovery Today, November 2007, Elsevier

    Dr Chrisostomos Prodromou

  42. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

    Article • Molecular Cancer Therapeutics, April 2007, American Association for Cancer Research (AACR)

    Dr Chrisostomos Prodromou

  43. In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

    Article • Cancer Research, March 2007, American Association for Cancer Research (AACR)

    Dr Chrisostomos Prodromou

  44. In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity

    Article • Eukaryotic Cell, February 2007, ASM Journals

    Dr Chrisostomos Prodromou

  45. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

    Article • Chemistry & Biology, November 2006, Elsevier

    Dr Chrisostomos Prodromou

  46. Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

    Article • Protein Science, October 2006, Wiley

    Dr Chrisostomos Prodromou

  47. Expressed in the Yeast Saccharomyces cerevisiae, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase

    Article • Eukaryotic Cell, September 2006, ASM Journals

    Dr Chrisostomos Prodromou

  48. Structure of an Hsp90-Cdc37-Cdk4 Complex

    Article • Molecular Cell, September 2006, Elsevier

    Dr Chrisostomos Prodromou

  49. Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

    Article • Annual Review of Biochemistry, June 2006, Annual Reviews

    Dr Chrisostomos Prodromou

  50. Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

    Article • Nature, April 2006, Nature

    Dr Chrisostomos Prodromou

  51. Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex

    Article • Molecular Cell, November 2005, Elsevier

    Dr Chrisostomos Prodromou

  52. The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, July 2005, Elsevier

    Dr Chrisostomos Prodromou

  53. A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p)

    Article • Eukaryotic Cell, May 2005, ASM Journals

    Dr Chrisostomos Prodromou

  54. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex

    Article • Molecular Microbiology, February 2005, Wiley

    Dr Chrisostomos Prodromou

  55. Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Chrisostomos Prodromou

  56. High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

    Article • Analytical Biochemistry, April 2004, Elsevier

    Dr Chrisostomos Prodromou

  57. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

    Article • The EMBO Journal, March 2004, Wiley

    Dr Chrisostomos Prodromou

  58. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

    Article • The EMBO Journal, January 2004, Wiley

    Dr Chrisostomos Prodromou

  59. Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach

    Article • Cell Stress and Chaperones, January 2004, Springer Science + Business Media

    Dr Chrisostomos Prodromou

  60. The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37

    Article • Cell, January 2004, Elsevier

    Dr Chrisostomos Prodromou

  61. Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast

    Article • FEBS Journal, November 2003, Wiley

    Dr Chrisostomos Prodromou

  62. Structure and Functional Relationships of Hsp90

    Article • Current Cancer Drug Targets, October 2003, Bentham Science Publishers

    Dr Chrisostomos Prodromou

  63. Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

    Article • Molecular Cell, March 2003, Elsevier

    Dr Chrisostomos Prodromou

  64. Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90β, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

    Article • Gene, January 2003, Elsevier

    Dr Chrisostomos Prodromou

  65. Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1

    Article • Molecular Cell, December 2002, Elsevier

    Dr Chrisostomos Prodromou

  66. Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50cdc37

    Article • Journal of Biological Chemistry, March 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Chrisostomos Prodromou

  67. Article • Journal of Biomolecular NMR, January 2002, Springer Science + Business Media

    Dr Chrisostomos Prodromou

  68. Structure, function, and mechanism of the Hsp90 molecular chaperone

    Article • January 2001, Elsevier

    Dr Chrisostomos Prodromou

  69. Structure and in vivo function of Hsp90

    Article • Current Opinion in Structural Biology, February 2000, Elsevier

    Dr Chrisostomos Prodromou

  70. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Article • The EMBO Journal, February 1999, Wiley

    Dr Chrisostomos Prodromou

  71. Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

    Article • Journal of Medicinal Chemistry, January 1999, American Chemical Society (ACS)

    Dr Chrisostomos Prodromou

  72. Cloning, expression and structure determination of the major extracellular domain of the PepT***1 oligopeptide transporter

    Article • Journal of Pharmacy and Pharmacology, September 1998, Wiley

    Dr Chrisostomos Prodromou

  73. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

    Article • The EMBO Journal, August 1998, Wiley

    Dr Chrisostomos Prodromou

  74. Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

    Article • Cell, July 1997, Elsevier

    Dr Chrisostomos Prodromou

  75. A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

    Article • Nature Structural Biology, June 1997, Nature

    Dr Chrisostomos Prodromou

  76. Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x‐ray diffraction studies of the amino‐terminal domain

    Article • Proteins Structure Function and Bioinformatics, August 1996, Wiley

    Dr Chrisostomos Prodromou

  77. Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect

    Article • Gene, January 1996, Elsevier

    Dr Chrisostomos Prodromou

  78. Cloning of theHIS3 gene ofYarrowia lipolytica

    Article • Antonie van Leeuwenhoek, August 1991, Springer Science + Business Media

    Dr Chrisostomos Prodromou