All Stories

  1. DSN-assisted split aptamer strategy coupled with gold nanoparticle growth for colorimetric detection of estradiol

    Article • Talanta, April 2026, Elsevier

    Dr Chia-chen Chang

  2. Target-Induced DNAzyme Recycle amplification strategy for Colorimetric detection of cystatin C

    Article • Microchemical Journal, May 2025, Elsevier

    Dr Chia-chen Chang

  3. Naked-Eye LAMP Assay of M. tuberculosis in Sputum by In Situ Au Nanoprobe Identification: For the In Vitro Diagnostics of Tuberculosis

    Article • ACS Infectious Diseases, May 2024, American Chemical Society (ACS)

    Dr Chia-chen Chang

  4. Turn-off enzyme activity of histidine-rich peptides for the detection of lysozyme

    Article • Microchimica Acta, May 2024, Springer Science + Business Media

    Dr Chia-chen Chang

  5. Blocking pathogenic Leptospira invasion with aptamer molecules targeting outer membrane LipL32 protein

    Article • Microbes and Infection, May 2024, Elsevier

    Dr Chia-chen Chang

  6. Aptamer-based detection of serotonin based on the rapid in situ synthesis of colorimetric gold nanoparticles

    Article • Nanotechnology Reviews, January 2023, De Gruyter

    Dr Chia-chen Chang

  7. Target-induced recycling assembly of split aptamer fragments by DNA toehold-mediated displacement for the amplified colorimetric detection of estradiol

    Article • Sensors and Actuators B Chemical, August 2022, Elsevier

    Dr Chia-chen Chang

  8. Comparing the Fracture Resistance and Modes of Failure in Different Types of CAD/CAM Zirconia Abutments with Internal Hexagonal Implants: An In Vitro Study

    Article • Materials, April 2022, MDPI AG

    Dr Chia-chen Chang

  9. Rapid Detection of Virus Nucleic Acid via Isothermal Amplification on Plasmonic Enhanced Digitizing Biosensor

    Article • Biosensors, January 2022, MDPI AG

    Dr Chia-chen Chang

  10. Recent Advancements in Aptamer-Based Surface Plasmon Resonance Biosensing Strategies

    Article • Biosensors, July 2021, MDPI AG

    Dr Chia-chen Chang

  11. Multi-Layer Reflectivity Calculation Based Meta-Modeling of the Phase Mapping Function for Highly Reproducible Surface Plasmon Resonance Biosensing

    Article • Biosensors, March 2021, MDPI AG

    Dr Chia-chen Chang

  12. Using Simple-Structured Split Aptamer for Gold Nanoparticle-based Colorimetric Detection of Estradiol

    Article • Analytical Sciences, March 2021, Springer Science + Business Media

    Dr Chia-chen Chang

  13. Biosensing Amplification by Hybridization Chain Reaction on Phase-Sensitive Surface Plasmon Resonance

    Article • Biosensors, March 2021, MDPI AG

    Dr Chia-chen Chang

  14. The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI‐3 updates and global perspectives

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, January 2021, Wiley

    Dr Chia-chen Chang

  15. Interfacing DNA with Gold Nanoparticles for Heavy Metal Detection

    Article • Biosensors, November 2020, MDPI AG

    Dr Chia-chen Chang

  16. Enhancement of the Peroxidase-Like Activity of Iodine-Capped Gold Nanoparticles for the Colorimetric Detection of Biothiols

    Article • Biosensors, September 2020, MDPI AG

    Dr Chia-chen Chang

  17. Functional connectome and neuropsychiatric symptom clusters of Alzheimer's disease

    Article • Journal of Affective Disorders, August 2020, Elsevier

    Dr Chia-chen Chang

  18. Hybridization Chain Reactions Targeting the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

    Article • International Journal of Molecular Sciences, May 2020, MDPI AG

    Dr Chia-chen Chang

  19. <p>Simultaneous Real-Time Detection of Pregnancy-Associated Plasma Protein-a and -A2 Using a Graphene Oxide-Based Surface Plasmon Resonance Biosensor [Erratum]</p>

    Article • International Journal of Nanomedicine, April 2020, Taylor & Francis

    Dr Chia-chen Chang

  20. <p>Simultaneous Real-Time Detection of Pregnancy-Associated Plasma Protein-a and -A2 Using a Graphene Oxide-Based Surface Plasmon Resonance Biosensor</p>

    Article • International Journal of Nanomedicine, March 2020, Taylor & Francis

    Dr Chia-chen Chang

  21. Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

    Article • Nanomaterials, June 2019, MDPI AG

    Dr Chia-chen Chang

  22. Target-Recycling-Amplified Colorimetric Detection of Pollen Allergen Using Non-Cross-Linking Aggregation of DNA-Modified Gold Nanoparticles

    Article • ACS Sensors, January 2019, American Chemical Society (ACS)

    Dr Chia-chen Chang

  23. Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer’s Disease

    Article • BioMed Research International, December 2018, Hindawi Publishing Corporation

    Dr Chia-chen Chang

  24. Salience Network and Depressive Severities in Parkinson’s Disease with Mild Cognitive Impairment: A Structural Covariance Network Analysis

    Article • Frontiers in Aging Neuroscience, January 2018, Frontiers

    Dr Chia-chen Chang

  25. Iodine-Mediated Etching of Triangular Gold Nanoplates for Colorimetric Sensing of Copper Ion and Aptasensing of Chloramphenicol

    Article • ACS Applied Materials & Interfaces, September 2017, American Chemical Society (ACS)

    Dr Chia-chen Chang

  26. Ultra-high sensitivity of the non-immunological affinity of graphene oxide-peptide-based surface plasmon resonance biosensors to detect human chorionic gonadotropin

    Article • Biosensors and Bioelectronics, August 2017, Elsevier

    Dr Chia-chen Chang

  27. Bio-functionalized magnetic nanoparticles for the immunoassay of fetal fibronectin: a feasibility study for the prediction of preterm birth

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Dr Chia-chen Chang

  28. Reversion of gold nanoparticle aggregates for the detection of Cu2+and its application in immunoassays

    Article • The Analyst, January 2017, Royal Society of Chemistry

    Dr Chia-chen Chang, Professor Chii-Wann Lin

  29. Detection of KRAS mutations of colorectal cancer with peptide-nucleic-acid-mediated real-time PCR clamping

    Article • Biotechnology & Biotechnological Equipment, September 2016, Taylor & Francis

    Professor Chii-Wann Lin, Dr Chia-chen Chang

  30. Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease

    Article • Oncotarget, August 2016, Impact Journals, LLC

    Dr Chia-chen Chang

  31. Interictal serum brain-derived neurotrophic factor level reflects white matter integrity, epilepsy severity, and cognitive dysfunction in chronic temporal lobe epilepsy

    Article • Epilepsy & Behavior, June 2016, Elsevier

    Dr Chia-chen Chang

  32. Aptamer-based colorimetric detection of proteins using a branched DNA cascade amplification strategy and unmodified gold nanoparticles

    Article • Biosensors and Bioelectronics, April 2016, Elsevier

    Dr Chia-chen Chang, Professor Chii-Wann Lin

  33. DNA biosensor combining single-wavelength colorimetry and a digital lock-in amplifier within a smartphone

    Article • Lab on a Chip, January 2016, Royal Society of Chemistry

    Professor Chii-Wann Lin, Dr Chia-chen Chang

  34. DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing

    Article • Chemical Communications, January 2016, Royal Society of Chemistry

    Dr Chia-chen Chang, Professor Chii-Wann Lin

  35. Changes in painting patterns in an illiterate individual with artistic behavior: Comparisons of brain network blood flow by SPECT studies

    Article • Neuropsychiatry, January 2016, OMICS Publishing Group

    Dr Chia-chen Chang

  36. Complex visual hallucinations triggered by eye closure and condition-specific release phenomenon

    Article • Neuropsychiatry, January 2016, OMICS Publishing Group

    Dr Chia-chen Chang

  37. Demonstrating a Conceptual Framework to Provide Efficient Wound Management Service for a Wound Care Center in a Tertiary Hospital

    Article • Medicine, November 2015, Wolters Kluwer Health

    Dr Chia-chen Chang

  38. Clinical Significance of Cerebrovascular Biomarkers and White Matter Tract Integrity in Alzheimer Disease

    Article • Medicine, July 2015, Wolters Kluwer Health

    Dr Chia-chen Chang

  39. Quantitative analysis of total β-subunit of human chorionic gonadotropin concentration in urine by immunomagnetic reduction to assist in the diagnosis of ectopic pregnancy

    Article • International Journal of Nanomedicine, March 2015, Taylor & Francis

    Dr Chia-Chen Chang, Dr Chia-chen Chang

  40. Facile colorimetric detection of human chorionic gonadotropin based on the peptide-induced aggregation of gold nanoparticles

    Article • Analytical Methods, January 2015, Royal Society of Chemistry

    Dr Chia-Chen Chang, Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  41. Clinical application of immunomagnetic reduction for quantitative measurement of insulin-like growth factor binding protein-1 in the prediction of pregnant women with preterm premature rupture of membranes

    Article • Clinica Chimica Acta, January 2015, Elsevier

    Dr Chia-Chen Chang, Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  42. Comparison of a Novel Computerized Analysis Program and Visual Interpretation of Cardiotocography

    Article • PLOS One, December 2014, PLOS

    Dr Chia-Chen Chang, Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  43. Plasmonics

    Article • Chemical Communications, October 2014, Royal Society of Chemistry

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  44. The Chinese Verbal Learning Test Specifically Assesses Hippocampal State

    Article • American Journal of Alzheimer s Disease & Other Dementias®, September 2014, SAGE Publications

    Dr Chia-chen Chang

  45. Label-free colorimetric aptasensor for IgE using DNA pseudoknot probe

    Article • The Analyst, January 2014, Royal Society of Chemistry

    Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-Chen Chang, Dr Chia-chen Chang

  46. Disposable SPR Sensor with simple microfluidic function for TB INF-gamma screening by Apatmer

    Article • Lab on a Chip, January 2014, Royal Society of Chemistry

    Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-Chen Chang, Dr Chia-chen Chang

  47. Comparative Assessment of Oriented Antibody Immobilization on Surface Plasmon Resonance Biosensing

    Article • Journal of the Chinese Chemical Society, September 2013, Wiley

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  48. Aptamer-based colorimetric detection of platelet-derived growth factor using unmodified goldnanoparticles

    Article • Biosensors and Bioelectronics, April 2013, Elsevier

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  49. Detection of Gray Matter Damage Using Brain MRI and SPECT in Carbon Monoxide Intoxication

    Article • Clinical Nuclear Medicine, February 2013, Wolters Kluwer Health

    Dr Chia-chen Chang

  50. Development of an Au/ZnO thin film surface plasmon resonance-based biosensor immunoassay for the detection of carbohydrate antigen 15‐3 in human saliva

    Article • Clinical Biochemistry, December 2012, Elsevier

    Dr Chia-Chen Chang, Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  51. A REVERSIBLE OPTICAL SENSOR BASED ON CHITOSAN FILM FOR THE SELECTIVE DETECTION OF COPPER IONS

    Article • Biomedical Engineering Applications Basis and Communications, October 2012, National Taiwan University

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  52. Amplified surface plasmon resonance immunosensor for interferon-Gamma based on a streptavidin-incorporated aptamer

    Article • Biosensors and Bioelectronics, August 2012, Elsevier

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  53. Diagnostic Devices for Isothermal Nucleic Acid Amplification

    Article • Sensors, June 2012, MDPI AG

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  54. Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection

    Article • Sensors, March 2012, MDPI AG

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  55. Rapid identification of Mycobacterium tuberculosis infection by a new array format-based surface plasmon resonance method

    Article • Nanoscale Research Letters, March 2012, Springer Science + Business Media

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  56. Surface plasmon resonance detection of silver ions and cysteine using DNA intercalator-based amplification

    Article • Analytical and Bioanalytical Chemistry, January 2012, Springer Science + Business Media

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  57. An amplified surface plasmon resonance “turn-on” sensor for mercury ion using gold nanoparticles

    Article • Biosensors and Bioelectronics, December 2011, Elsevier

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  58. IMMUNOMAGNETIC REDUCTION FOR FETAL FIBRONECTIN DETECTION — A NOVEL METHOD TO DETECT THE PRETERM BIOMARKER

    Article • Biomedical Engineering Applications Basis and Communications, August 2011, National Taiwan University

    Dr Chia-Chen Chang, Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  59. Detection of tip-enhanced fluorescence from loop-mediated isothermal amplification of hepatitis B virus by two-photon microscopy

    Article • August 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Chii-Wann Lin, Professor Chii-Wann Lin, Dr Chia-chen Chang

  60. Using Polyethylene Glycol-Modified Chitosan for Improvement of Carbohydrate Antigen 15-3 Detection on a Quartz Crystal Microbalance Biosensor

    Article • Sensor Letters, February 2011, American Scientific Publishers

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  61. A case of black urine and dark skin — cresol poisoning

    Article • Journal of Toxicology Clinical Toxicology, October 2010, Taylor & Francis

    Dr Chia-chen Chang

  62. High-Sensitivity Detection of Carbohydrate Antigen 15-3 Using a Gold/Zinc Oxide Thin Film Surface Plasmon Resonance-Based Biosensor

    Article • Analytical Chemistry, January 2010, American Chemical Society (ACS)

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang

  63. AN ELLIPSOMETRIC STUDY ON THE DENSITY AND FUNCTIONALITY OF ANTIBODY LAYERS IMMOBILIZED BY A RANDOMLY COVALENT METHOD AND A PROTEIN A-ORIENTED METHOD

    Article • Biomedical Engineering Applications Basis and Communications, October 2009, National Taiwan University

    Professor Chii-Wann Lin, Dr Chia-Chen Chang, Professor Chii-Wann Lin, Dr Chia-chen Chang