All Stories

  1. Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome

    Article • Proceedings of the National Academy of Sciences, May 2016, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  2. Binding Affinities among DNA Helicase-Primase, DNA Polymerase, and Replication Intermediates in the Replisome of Bacteriophage T7

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  3. It Seems Like Only Yesterday

    Article • Annual Review of Biochemistry, June 2015, Annual Reviews

    Professor Charles C. Richardson

  4. Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase

    Article • Nucleic Acids Research, April 2015, Oxford University Press (OUP)

    Professor Charles C. Richardson

  5. Genetic Requirements for Sensitivity of Bacteriophage T7 to Dideoxythymidine

    Article • Journal of Bacteriology, May 2014, ASM Journals

    Professor Charles C. Richardson

  6. Flap Endonuclease Activity of Gene 6 Exonuclease of Bacteriophage T7

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  7. Flap endonuclease of bacteriophage T7

    Article • Bacteriophage, January 2014, Taylor & Francis

    Professor Charles C. Richardson

  8. Simultaneous Imaging of Leading- and Lagging-Strand Synthesis Reveals Distinct Operational Modes of Single Replication Machines

    Article • Biophysical Journal, January 2014, Elsevier

    Professor Charles C. Richardson

  9. Syn5 RNA polymerase synthesizes precise run-off RNA products

    Article • Nucleic Acids Research, November 2013, Oxford University Press (OUP)

    Professor Charles C. Richardson

  10. Molecular Crowding Enhanced ATPase Activity of the RNA Helicase eIF4A Correlates with Compaction of Its Quaternary Structure and Association with eIF4G

    Article • Journal of the American Chemical Society, July 2013, American Chemical Society (ACS)

    Professor Charles C. Richardson

  11. Impact of macromolecular crowding on DNA replication

    Article • Nature Communications, March 2013, Nature

    Professor Charles C. Richardson

  12. Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  13. Impact of Macromolecular Crowding on DNA Replication

    Article • Biophysical Journal, January 2012, Elsevier

    Professor Charles C. Richardson

  14. Essential protein interactions within the replisome regulate DNA replication

    Article • Cell Cycle, October 2011, Taylor & Francis

    Professor Charles C. Richardson

  15. Choreography of bacteriophage T7 DNA replication

    Article • Current Opinion in Chemical Biology, October 2011, Elsevier

    Professor Charles C. Richardson

  16. Bypass of a Nick by the Replisome of Bacteriophage T7

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  17. Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  18. A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7

    Article • Molecular Microbiology, May 2010, Wiley

    Professor Charles C. Richardson

  19. C-terminal Phenylalanine of Bacteriophage T7 Single-stranded DNA-binding Protein Is Essential for Strand Displacement Synthesis by T7 DNA Polymerase at a Nick in DNA

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  20. Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine

    Article • Molecular Microbiology, July 2009, Wiley

    Professor Charles C. Richardson

  21. Rescue of Bacteriophage T7 DNA Polymerase of Low Processivity by Suppressor Mutations Affecting Gene 3 Endonuclease

    Article • Journal of Virology, June 2009, ASM Journals

    Professor Charles C. Richardson

  22. Motors, Switches, and Contacts in the Replisome

    Article • Annual Review of Biochemistry, June 2009, Annual Reviews

    Professor Charles C. Richardson

  23. Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine

    Article • Molecular Microbiology, May 2009, Wiley

    Professor Charles C. Richardson

  24. DNA Recognition by the DNA Primase of Bacteriophage T7: A Structure−Function Study of the Zinc-Binding Domain †

    Article • Biochemistry, March 2009, American Chemical Society (ACS)

    Professor Charles C. Richardson

  25. Single-molecule Observations of Replisome Structure and Function

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Charles C. Richardson

  26. Dynamics Of DNA Replication Loops Reveal Temporal Control Of Lagging-strand Synthesis

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Charles C. Richardson

  27. Linear Diffusion of T7 DNA Polymerase: Thioredoxin is Required to Maintain Close Contact with DNA

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Charles C. Richardson

  28. Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

    Article • Nature, November 2008, Nature

    Professor Charles C. Richardson

  29. Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7

    Article • Proceedings of the National Academy of Sciences, July 2008, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  30. Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk

    Article • Molecular Microbiology, December 2007, Wiley

    Professor Charles C. Richardson

  31. Dynamic DNA Helicase-DNA Polymerase Interactions Assure Processive Replication Fork Movement

    Article • Molecular Cell, August 2007, Elsevier

    Professor Charles C. Richardson

  32. Oligomeric States of Bacteriophage T7 Gene 4 Primase/Helicase

    Article • Journal of Molecular Biology, July 2006, Elsevier

    Professor Charles C. Richardson

  33. Primer initiation and extension by T7 DNA primase

    Article • The EMBO Journal, April 2006, Wiley

    Professor Charles C. Richardson

  34. DNA primase acts as a molecular brake in DNA replication

    Article • February 2006, Nature

    Professor Charles C. Richardson

  35. DNA-Induced Switch from Independent to Sequential dTTP Hydrolysis in the Bacteriophage T7 DNA Helicase

    Article • Molecular Cell, January 2006, Elsevier

    Professor Charles C. Richardson

  36. The Highly Processive DNA Polymerase of Bacteriophage T5

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  37. Effect of Single-stranded DNA-binding Proteins on the Helicase and Primase Activities of the Bacteriophage T7 Gene 4 Protein

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  38. The Carboxyl-terminal Domain of Bacteriophage T7 Single-stranded DNA-binding Protein Modulates DNA Binding and Interaction with T7 DNA Polymerase

    Article • Journal of Biological Chemistry, May 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  39. A Single-stranded DNA-binding Protein of Bacteriophage T7 Defective in DNA Annealing

    Article • Journal of Biological Chemistry, May 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  40. Modular Architecture of the Bacteriophage T7 Primase Couples RNA Primer Synthesis to DNA Synthesis

    Article • Molecular Cell, May 2003, Elsevier

    Professor Charles C. Richardson

  41. Lagging strand synthesis in coordinated DNA synthesis by bacteriophage T7 replication proteins

    Article • Journal of Molecular Biology, February 2002, Elsevier

    Professor Charles C. Richardson

  42. Role of the C-terminal Residue of the DNA Polymerase of Bacteriophage T7

    Article • Journal of Biological Chemistry, July 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  43. DNA Primases

    Article • Annual Review of Biochemistry, June 2001, Annual Reviews

    Professor Charles C. Richardson

  44. Characterization of a Novel DNA Primase from the Salmonella typhimurium Bacteriophage SP6 †

    Article • Biochemistry, February 2000, American Chemical Society (ACS)

    Professor Charles C. Richardson

  45. Crystal Structure of the Helicase Domain from the Replicative Helicase-Primase of Bacteriophage T7

    Article • Cell, October 1999, Elsevier

    Professor Charles C. Richardson

  46. Coordinated Leading and Lagging Strand DNA Synthesis on a Minicircular Template

    Article • Molecular Cell, June 1998, Elsevier

    Professor Charles C. Richardson

  47. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

    Article • Nature, January 1998, Springer Science + Business Media

    Professor Charles C. Richardson

  48. Annual Review of Biochemistry. Charles C. Richardson John N. Abelson Christian R. H. Raetz

    Article • The Quarterly Review of Biology, March 1997, University of Chicago Press

    Professor Charles C. Richardson

  49. Structural and Functional Organization of the DNA Polymerase of Bacteriophage T7

    Article • Journal of Biological Chemistry, September 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  50. Amino Acid Residues Critical for the Interaction between Bacteriophage T7 DNA Polymerase andEscherichia coliThioredoxin

    Article • Journal of Biological Chemistry, August 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Charles C. Richardson

  51. Effects of Base Analog Substitutions in the Noncoding dC of the 3'-d(CTG)-5' Template Recognition Site of the Bacteriophage T7 Primase

    Article • Biochemistry, August 1995, American Chemical Society (ACS)

    Professor Charles C. Richardson

  52. Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7

    Article • Cell, April 1994, Elsevier

    Professor Charles C. Richardson

  53. Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin.

    Article • Proceedings of the National Academy of Sciences, October 1992, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  54. In vivo analysis of the initiation of bacteriophage T7 dna replication

    Article • Virology, February 1990, Elsevier

    Professor Charles C. Richardson

  55. Initiation of DNA replication at cloned origins of bacteriophage T7

    Article • Journal of Molecular Biology, December 1988, Elsevier

    Professor Charles C. Richardson

  56. DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

    Article • Proceedings of the National Academy of Sciences, July 1987, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  57. Bacteriophage T7: Minimal requirements for the replication of a duplex DNA molecule

    Article • Cell, June 1983, Elsevier

    Professor Charles C. Richardson

  58. Replication of Bacteriophage T7 DNA

    Article • January 1983, Springer Science + Business Media

    Professor Charles C. Richardson

  59. 1 DNA Ligases

    Article • January 1982, Elsevier

    Professor Charles C. Richardson

  60. Processing of mRNA by ribonuclease III regulates expression of gene 1.2 of bacteriophage T7

    Article • Cell, December 1981, Elsevier

    Professor Charles C. Richardson

  61. 16 Bacteriophage T4 Polynucleotide Kinase

    Article • January 1981, Elsevier

    Professor Charles C. Richardson

  62. INITIATION OF BACTERIOPHAGE T7 DNA REPLICATION1

    Article • January 1981, Elsevier

    Professor Charles C. Richardson

  63. REPLICATION OF BACTERIOPHAGE T7 DNA

    Article • January 1980, Elsevier

    Professor Charles C. Richardson

  64. Replication of Bacteriophage T7 DNA by Purified Proteins

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 1979, Cold Spring Harbor Laboratory Press

    Professor Charles C. Richardson

  65. Genetic mapping of trxA, a gene affecting thioredoxin in Escherichia coli K12

    Article • January 1977, Springer Science + Business Media

    Professor Charles C. Richardson

  66. Bacteriophage T7 deoxyribonucleic acid replication in vitro

    Article • Journal of Molecular Biology, February 1976, Elsevier

    Professor Charles C. Richardson

  67. Bacteriophage T7 deoxyribonucleic acid replication in vitro

    Article • Journal of Molecular Biology, February 1976, Elsevier

    Professor Charles C. Richardson

  68. Exonuclease VII of Escherichia coli

    Article • January 1975, Springer Science + Business Media

    Professor Charles C. Richardson

  69. DNA Polymerases of Escherichia coli

    Article • January 1973, Springer Science + Business Media

    Professor Charles C. Richardson

  70. Isolation and Partial Characterization of a Mutant of Escherichia coli Deficient in DNA Polymerase II

    Article • Proceedings of the National Academy of Sciences, August 1972, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  71. Analysis of Host Range Restriction in Escherichia coli Treated with Toluene

    Article • Proceedings of the National Academy of Sciences, October 1971, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  72. [25] DNA ligase from Escherichia coli infected with bacteriophage T4

    Article • January 1971, Elsevier

    Professor Charles C. Richardson

  73. A new DNA polymerase activity of Escherichia coli. I. Purification and properties of the activity present in E. coli polAl

    Article • Biochemical and Biophysical Research Communications, December 1970, Elsevier

    Professor Charles C. Richardson

  74. A new DNA polymerase activity of Escherichia coli. II. Properties of the enzyme purified from wild-type E. coli and DNAts mutants

    Article • Biochemical and Biophysical Research Communications, December 1970, Elsevier

    Professor Charles C. Richardson

  75. Analysis of the interruptions in bacteriophage T5 DNA

    Article • Journal of Molecular Biology, February 1970, Elsevier

    Professor Charles C. Richardson

  76. The Structural Gene for a T7 Endonuclease Essential for Phage DNA Synthesis

    Article • Proceedings of the National Academy of Sciences, January 1970, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  77. Enzymes in DNA Metabolism

    Article • Annual Review of Biochemistry, June 1969, Annual Reviews

    Professor Charles C. Richardson

  78. Enzymatic breakage and joining of deoxyribonucleic acid. IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4.

    Article • Proceedings of the National Academy of Sciences, December 1968, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  79. Studies on the Joining of DNA by Polynucleotide Ligase of Phage T4

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 1968, Cold Spring Harbor Laboratory Press

    Professor Charles C. Richardson

  80. Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4.

    Article • Proceedings of the National Academy of Sciences, August 1967, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  81. Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.

    Article • Proceedings of the National Academy of Sciences, April 1967, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  82. Terminal repetition in permuted T2 bacteriophage DNA molecules

    Article • Journal of Molecular Biology, February 1967, Elsevier

    Professor Charles C. Richardson

  83. The 5′-terminal dinucleotides of the separated strands of T7 bacteriophage deoxyribonucleic acid

    Article • Journal of Molecular Biology, February 1967, Elsevier

    Professor Charles C. Richardson

  84. The 5′-terminal nucleotides of T7 bacteriophage deoxyribonucleic acid

    Article • Journal of Molecular Biology, January 1966, Elsevier

    Professor Charles C. Richardson

  85. End-Group Labeling of Nucleic Acids by Enzymatic Phosphorylation

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 1966, Cold Spring Harbor Laboratory Press

    Professor Charles C. Richardson

  86. Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli.

    Article • Proceedings of the National Academy of Sciences, July 1965, Proceedings of the National Academy of Sciences

    Professor Charles C. Richardson

  87. Enzymic synthesis of deoxyribonucleic acid

    Article • Journal of Molecular Biology, February 1965, Elsevier

    Professor Charles C. Richardson

  88. Enzymic synthesis of deoxyribonucleic acid

    Article • Journal of Molecular Biology, July 1964, Elsevier

    Professor Charles C. Richardson

  89. Enzymic synthesis of deoxyribonucleic acid

    Article • Journal of Molecular Biology, July 1964, Elsevier

    Professor Charles C. Richardson