All Stories

  1. Structural Origin of Anisotropic Thermal Expansion of Molecular Crystals and Implication for the Density Rule Probed with Four ROY Polymorphs
  2. Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping
  3. A Rheological Approach for Predicting Physical Stability of Amorphous Solid Dispersions
  4. Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle Engineering Methods
  5. Bioavailability-Enhancing Cocrystals: Screening, In Vivo Predictive Dissolution, and Supersaturation Maintenance
  6. Nanomechanical testing in drug delivery: Theory, applications, and emerging trends
  7. Mechanisms of Crystal Plasticization by Lattice Water
  8. Air entrapment during tablet compression – Diagnosis, impact on tableting performance, and mitigation strategies
  9. Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin and Ligustrazine through cocrystallization
  10. Effects of shear cell size on flowability of powders measured using a ring shear tester
  11. Formulation strategies for mitigating dissolution reduction of p-aminobenzoic acid by sodium lauryl sulfate through diffusion layer modulation
  12. Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity
  13. Profoundly improved photostability of dimetronidazole by cocrystallization
  14. Efficient development of sorafenib tablets with improved oral bioavailability enabled by coprecipitated amorphous solid dispersion
  15. Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  16. Exceptional Powder Tabletability of Elastically Flexible Crystals
  17. Pharmaceutical Lauryl Sulfate Salts: Prevalence, Formation Rules, and Formulation Implications
  18. An Elusive Drug–Drug Cocrystal Prepared Using a Heteroseeding Strategy
  19. Effect of Lipidic Excipients on the Particle Properties and Aerosol Performance of High Drug Load Spray Dried Particles for Inhalation
  20. Effects of compaction and storage conditions on stability of intravenous immunoglobulin – Implication on developing oral tablets of biologics
  21. Drug–Drug Cocrystallization Simultaneously Improves Pharmaceutical Properties of Genistein and Ligustrazine
  22. Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate
  23. Nanomechanical mapping and strain rate sensitivity of microcrystalline cellulose
  24. Novel Salt-Cocrystals of Berberine Hydrochloride with Aliphatic Dicarboxylic Acids: Odd–Even Alternation in Physicochemical Properties
  25. Direct compression tablet formulation of celecoxib enabled with a pharmaceutical solvate
  26. How Does the Dissimilarity of Screw Geometry Impact Twin-screw Melt Granulation?
  27. Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype
  28. Modulation of the powder properties of lamotrigine by crystal forms
  29. Structural Origins of Elastic and 2D Plastic Flexibility of Molecular Crystals Investigated with Two Polymorphs of Conformationally Rigid Coumarin
  30. Sweet Sulfamethazine Acesulfamate Crystals with Improved Compaction Property
  31. Mechanically responsive crystalline materials
  32. Reversible facile single-crystal-to-single-crystal polymorphic transition accompanied by unit cell volume expansion and twinning
  33. Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges
  34. The impact of solid-state form, water content and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolution
  35. Tabletability Flip – Role of Bonding Area and Bonding Strength Interplay
  36. Structural Insights into the Distinct Solid-State Properties and Interconversion of Celecoxib N-Methyl-2-pyrrolidone Solvates
  37. Discovery, Characterization, and Pharmaceutical Applications of Two Loratadine–Oxalic Acid Cocrystals
  38. The efficient development of a sildenafil orally disintegrating tablet using a material sparing and expedited approach
  39. Development of piroxicam mini-tablets enabled by spherical cocrystallization
  40. Profound tabletability deterioration of microcrystalline cellulose by magnesium stearate
  41. Novel Quasi-Emulsion Solvent Diffusion-Based Spherical Cocrystallization Strategy for Simultaneously Improving the Manufacturability and Dissolution of Indomethacin
  42. Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
  43. Material-Sparing and Expedited Development of a Tablet Formulation of Carbamazepine Glutaric Acid Cocrystal– a QbD Approach
  44. A microcrystalline cellulose based drug-composite formulation strategy for developing low dose drug tablets
  45. Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area – Bonding Strength Interplay
  46. Intermolecular interactions and disorder in six isostructural celecoxib solvates
  47. Mitigating Punch Sticking Propensity of Celecoxib by Cocrystallization: An Integrated Computational and Experimental Approach
  48. Conformation Directed Interaction Anisotropy Leading to Distinct Bending Behaviors of Two ROY Polymorphs
  49. Recent Advances in Co-processed APIs and Proposals for Enabling Commercialization of These Transformative Technologies
  50. Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion
  51. Toward a Molecular Understanding of the Impact of Crystal Size and Shape on Punch Sticking
  52. Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet salts
  53. Extended Release of Highly Water Soluble Isoniazid Attained through Cocrystallization with Curcumin
  54. Reducing the Sublimation Tendency of Ligustrazine through Salt Formation
  55. The role of the screw profile on granular structure and mixing efficiency of a high-dose hydrophobic drug formulation during twin screw wet granulation
  56. A systematic evaluation of poloxamers as tablet lubricants
  57. Interfacial bonding in formulated bilayer tablets
  58. A material-saving and robust approach for obtaining accurate out-of-die powder compressibility
  59. Molecular Interpretation of Mechanical Behavior in Four Basic Crystal Packing of Isoniazid with Homologous Cocrystal Formers
  60. Microstructures and pharmaceutical properties of ferulic acid agglomerates prepared by different spherical crystallization methods
  61. Expedited Investigation of Powder Caking Aided by Rapid 3D Prototyping of Testing Devices
  62. The landscape of mechanical properties of molecular crystals
  63. Workshop Report: USP Workshop on Advancements in In Vitro Performance Testing of Drug Products
  64. Crystallographic and Energetic Insights into Reduced Dissolution and Physical Stability of a Drug–Surfactant Salt: The Case of Norfloxacin Lauryl Sulfate
  65. Molecular Interpretation of the Compaction Performance and Mechanical Properties of Caffeine Cocrystals: A Polymorphic Study
  66. Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition
  67. Correction to Fast Determination of Phase Stability of Hydrates Using Intrinsic Dissolution Rate Measurements
  68. Effect of particle size on interfacial bonding strength of bilayer tablets
  69. Structural Features of Sulfamethizole and Its Cocrystals: Beauty Within
  70. Fast Determination of Phase Stability of Hydrates Using Intrinsic Dissolution Rate Measurements
  71. Insights into the effect of compaction pressure and material properties on interfacial bonding strength of bilayer tablets
  72. Relationship between hydrate stability and accuracy of true density measured by helium pycnometry
  73. Minimum Interfacial Bonding Strength for Bilayer Tablets Determined Using a Survival Test
  74. Correction to Crystal Growth of Celecoxib from Amorphous State: Polymorphism, Growth Mechanism, and Kinetics
  75. Single-Crystal Plasticity Defies Bulk-Phase Mechanics in Isoniazid Cocrystals with Analogous Coformers
  76. Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis
  77. Crystal growth of celecoxib from amorphous state – polymorphism, growth mechanism, and kinetics
  78. Reduced Punch Sticking Propensity of Acesulfame by Salt Formation: Role of Crystal Mechanical Property and Surface Chemistry
  79. Twistable Pharmaceutical Crystal Exhibiting Exceptional Plasticity and Tabletability
  80. Expedited Tablet Formulation Development of a Highly Soluble Carbamazepine Cocrystal Enabled by Precipitation Inhibition in Diffusion Layer
  81. Effect of screw profile and processing conditions on physical transformation and chemical degradation of gabapentin during twin-screw melt granulation
  82. Direct Compression Tablet Containing 99% Active Ingredient—A Tale of Spherical Crystallization
  83. Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying
  84. Computational Techniques for Predicting Mechanical Properties of Organic Crystals: A Systematic Evaluation
  85. Profoundly Improved Plasticity and Tabletability of Griseofulvin by in Situ Solvation and Desolvation during Spherical Crystallization
  86. Spherical Cocrystallization—An Enabling Technology for the Development of High Dose Direct Compression Tablets of Poorly Soluble Drugs
  87. Effects of thermal binders on chemical stabilities and tabletability of gabapentin granules prepared by twin-screw melt granulation
  88. Effects of Water on Powder Flowability of Diverse Powders Assessed by Complimentary Techniques
  89. Exceptionally Elastic Single-Component Pharmaceutical Crystals
  90. Developing Biologics Tablets: The Effects of Compression on the Structure and Stability of Bovine Serum Albumin and Lysozyme
  91. Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
  92. Robust bulk preparation and characterization of sulfamethazine and saccharine salt and cocrystal polymorphs
  93. A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach
  94. Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid
  95. Mechanism for the Reduced Dissolution of Ritonavir Tablets by Sodium Lauryl Sulfate
  96. Proportionality between powder cohesion and unconfined yield strength from shear cell testing
  97. Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine
  98. Structures and Properties of Granules Prepared By High Shear Wet Granulation
  99. A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer
  100. Mechanical Properties
  101. Cocrystallization of Curcumin with Benzenediols and Benzenetriols via Rapid Solvent Removal
  102. Preparation, Characterization, and Formulation Development of Drug–Drug Protic Ionic Liquids of Diphenhydramine with Ibuprofen and Naproxen
  103. Ribbon density and milling parameters that determine fines fraction in a dry granulation
  104. Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades
  105. Anion Exchange Reaction for Preparing Acesulfame Solid Forms
  106. Relating the tableting behavior of piroxicam polytypes to their crystal structures using energy-vector models
  107. Systematic evaluation of common lubricants for optimal use in tablet formulation
  108. The relationship among tensile strength, Young's modulus, and indentation hardness of pharmaceutical compacts
  109. Crystal and Particle Engineering Strategies for Improving Powder Compression and Flow Properties to Enable Continuous Tablet Manufacturing by Direct Compression
  110. Modulating Sticking Propensity of Pharmaceuticals Through Excipient Selection in a Direct Compression Tablet Formulation
  111. A mesoporous silica based platform to enable tablet formulations of low dose drugs by direct compression
  112. Identifying Slip Planes in Organic Polymorphs by Combined Energy Framework Calculations and Topology Analysis
  113. Reduced interface spin polarization by antiferromagnetically coupled Mn segregated to the Co2MnSi /GaAs (001) interface
  114. Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components
  115. Subsurface nucleation of supercooled acetaminophen
  116. Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer
  117. Relationships among Crystal Structures, Mechanical Properties, and Tableting Performance Probed Using Four Salts of Diphenhydramine
  118. Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures
  119. Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame
  120. The suitability of common compressibility equations for characterizing plasticity of diverse powders
  121. Tablets of multi-unit pellet system for controlled drug delivery
  122. Expedited Development of Diphenhydramine Orally Disintegrating Tablet through Integrated Crystal and Particle Engineering
  123. Ribbon thickness influences fine generation during dry granulation
  124. Dependence of Punch Sticking on Compaction Pressure—Roles of Particle Deformability and Tablet Tensile Strength
  125. Particle Engineering for Enabling a Formulation Platform Suitable for Manufacturing Low-Dose Tablets by Direct Compression
  126. Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin
  127. Superior Plasticity and Tabletability of Theophylline Monohydrate
  128. Gaining insight into tablet capping tendency from compaction simulation
  129. Tensile and shear methods for measuring strength of bilayer tablets
  130. Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals
  131. Lubrication with magnesium stearate increases tablet brittleness
  132. A top coating strategy with highly bonding polymers to enable direct tableting of multiple unit pellet system (MUPS)
  133. Mechanical Properties and Tableting Behavior of Amorphous Solid Dispersions
  134. Mechanism and Kinetics of Punch Sticking of Pharmaceuticals
  135. Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
  136. Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal
  137. The phenomenon of tablet flashing — Its impact on tableting data analysis and a method to eliminate it
  138. Harvesting Potential Dissolution Advantages of Soluble Cocrystals by Depressing Precipitation Using the Common Coformer Effect
  139. Process optimization of dry granulation based tableting line: Extracting physical material characteristics from granules, ribbons and tablets using near-IR (NIR) spectroscopic measurement
  140. Analytical method development for powder characterization: Visualization of the critical drug loading affecting the processability of a formulation for direct compression
  141. Solid-state characterization of optically pure (+)Dihydromyricetin extracted from Ampelopsis grossedentata leaves
  142. Enhancing Bioavailability of Dihydromyricetin through Inhibiting Precipitation of Soluble Cocrystals by a Crystallization Inhibitor
  143. A classification system for tableting behaviors of binary powder mixtures
  144. Microstructure of Tablet—Pharmaceutical Significance, Assessment, and Engineering
  145. Resveratrol cocrystals with enhanced solubility and tabletability
  146. Macroindentation hardness measurement—Modernization and applications
  147. Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals
  148. Mini review: Mechanisms to the loss of tabletability by dry granulation
  149. Sweet Berberine
  150. Quantifying effects of moisture content on flow properties of microcrystalline cellulose using a ring shear tester
  151. A critical Examination of the Phenomenon of Bonding Area - Bonding Strength Interplay in Powder Tableting
  152. From molecular salt to pseudo CAB cocrystal: Expanding solid-state landscape of carboxylic acids based on charge-assisted COOH⋯COO− hydrogen bonds
  153. The development of carbamazepine-succinic acid cocrystal tablet formulations with improved in vitro and in vivo performance
  154. Dependence of tablet brittleness on tensile strength and porosity
  155. Tabletability Modulation Through Surface Engineering
  156. Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization
  157. Dependence of ejection force on tableting speed—A compaction simulation study
  158. A new tablet brittleness index
  159. Near-infrared chemical imaging (NIR-CI) as a process monitoring solution for a production line of roll compaction and tableting
  160. Validation and applications of an expedited tablet friability method
  161. Correlation Among Crystal Structure, Mechanical Behavior, and Tabletability in the Co-Crystals of Vanillin Isomers
  162. Designing Micellar Nanocarriers with Improved Drug Loading and Stability Based on Solubility Parameter
  163. Significant Expansion of the Solid State Landscape of Salicylic Acid Based on Charge-Assisted Hydrogen Bonding Interactions
  164. Solvent and additive interactions as determinants in the nucleation pathway: general discussion
  165. Nucleation in complex multi-component and multi-phase systems: general discussion
  166. Effect of Heating Rate and Kinetic Model Selection on Activation Energy of Nonisothermal Crystallization of Amorphous Felodipine
  167. Kinetic Entrapment of a Hidden Curcumin Cocrystal with Phloroglucinol
  168. Effect of Crystal Habit on Intrinsic Dissolution Behavior of Celecoxib Due to Differential Wettability
  169. Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production
  170. Design and Preparation of a 4:1 Lamivudine–Oxalic Acid CAB Cocrystal for Improving the Lamivudine Purification Process
  171. Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin
  172. A Formulation Strategy for Solving the Overgranulation Problem in High Shear Wet Granulation
  173. Enabling Tablet Product Development of 5-Fluorocytosine Through Integrated Crystal and Particle Engineering
  174. Evolution of Structure and Properties of Granules Containing Microcrystalline Cellulose and Polyvinylpyrrolidone During High-Shear Wet Granulation
  175. Improving manufacturability of an ibuprofen powder blend by surface coating with silica nanoparticles
  176. Enabling direct compression of formulated Danshen powder by surface engineering
  177. Impact of Crystal Habit on Biopharmaceutical Performance of Celecoxib
  178. Design, Synthesis, and Characterization of New 5-Fluorocytosine Salts
  179. A Pitfall in Analyzing Powder Compatibility Data Using Nonlinear Regression
  180. Protonation of Cytosine: Cytosinium vs Hemicytosinium Duplexes
  181. Synthon preference in O-protonated amide crystals – dominance of short strong hydrogen bonds
  182. Improved solid-state stability of salts by cocrystallization between conjugate acid–base pairs
  183. Cocrystallization for successful drug delivery
  184. Preparation and Characterization of Surface-Engineered Coarse Microcrystalline Cellulose Through Dry Coating with Silica Nanoparticles
  185. Correction for Polymorphs, Salts and Cocrystals: What’s in a Name?
  186. Probing Interfaces between Pharmaceutical Crystals and Polymers by Neutron Reflectometry
  187. Polymorphs, Salts, and Cocrystals: What’s in a Name?
  188. Do not confuse hydrogen chloride with hydrochloric acid!
  189. Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide
  190. Ionized form of acetaminophen with improved compaction properties
  191. Design and synthesis of solid state structures with conjugate acid–base pair interactions
  192. Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound
  193. Origin of Two Modes of Non-isothermal Crystallization of Glasses Produced by Milling
  194. Profoundly improving flow properties of a cohesive cellulose powder by surface coating with nano‐silica through comilling
  195. Reproducibility of flow properties of microcrystalline cellulose — Avicel PH102
  196. Initial moisture content in raw material can profoundly influence high shear wet granulation process
  197. Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification
  198. Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: A double-edged sword
  199. Origin of profound changes in powder properties during wetting and nucleation stages of high-shear wet granulation of microcrystalline cellulose
  200. Understanding Size Enlargement and Hardening of Granules on Tabletability of Unlubricated Granules Prepared by Dry Granulation
  201. Decoding Powder Tabletability: Roles of Particle Adhesion and Plasticity
  202. The Manufacture of Low-Dose Oral Solid Dosage Form to Support Early Clinical Studies Using an Automated Micro-Filing System
  203. Transforming Powder Mechanical Properties by Core/Shell Structure: Compressible Sand
  204. Roles of Granule Size in Over-Granulation During High Shear Wet Granulation
  205. Setting the bar for powder flow properties in successful high speed tableting
  206. Understanding the relationship between crystal structure, plasticity and compaction behaviour of theophylline, methyl gallate, and their 1 : 1 co-crystal
  207. Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles
  208. Improving Powder Flow Properties of Citric Acid by Crystal Hydration
  209. Materials Science Tetrahedron—A Useful Tool for Pharmaceutical Research and Development
  210. Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design
  211. Quantifying Effects of Particulate Properties on Powder Flow Properties Using a Ring Shear Tester
  212. On the Identification of Slip Planes in Organic Crystals Based on Attachment Energy Calculation
  213. Improving Mechanical Properties of Caffeine and Methyl Gallate Crystals by Cocrystallization
  214. Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose
  215. On the mechanism of reduced tabletability of granules prepared by roller compaction
  216. Influence of crystal structure on the tableting properties of n‐alkyl 4‐hydroxybenzoate esters (parabens)
  217. Thermal Expansion of Organic Crystals and Precision of Calculated Crystal Density: A Survey of Cambridge Crystal Database
  218. Insensitivity of Compaction Properties of Brittle Granules to Size Enlargement by Roller Compaction
  219. A material-sparing method for simultaneous determination of true density and powder compaction properties—Aspartame as an example
  220. Solid-state properties and crystallization behavior of PHA-739521 polymorphs
  221. Reduced tabletability of roller compacted granules as a result of granule size enlargement
  222. True Density of Microcrystalline Cellulose
  223. A Study of Sulfamerazine Single Crystals Using Atomic Force Microscopy, Transmission Light Microscopy, and Raman Spectroscopy
  224. Quantifying Errors in Tableting Data Analysis Using the Ryshkewitch Equation Due to Inaccurate True Density
  225. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction
  226. A Novel Method for Deriving True Density of Pharmaceutical Solids Including Hydrates and Water-Containing Powders
  227. Improved Tableting Properties of p-Hydroxybenzoic Acid by Water of Crystallization: A Molecular Insight
  228. Theophylline monohydrate
  229. Influence of Crystal Shape on the Tableting Performance of L‐Lysine Monohydrochloride Dihydrate
  230. Influence of crystal shape on the tableting performance of L‐lysine monohydrochloride dihydrate
  231. Influence of crystal shape on the tableting performance of L-lysine monohydrochloride dihydrate
  232. Effects of initial particle size on the tableting properties of l-lysine monohydrochloride dihydrate powder
  233. Influence of Elastic Deformation of Particles on Heckel Analysis