All Stories

  1. Structural Origin of Anisotropic Thermal Expansion of Molecular Crystals and Implication for the Density Rule Probed with Four ROY Polymorphs

    Article • Crystals, February 2023, MDPI AG

    Professor Changquan Sun

  2. Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping

    Article • International Journal of Pharmaceutics, January 2023, Elsevier

    Professor Changquan Sun

  3. A Rheological Approach for Predicting Physical Stability of Amorphous Solid Dispersions

    Article • Journal of Pharmaceutical Sciences, January 2023, Elsevier

    Professor Changquan Sun

  4. Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle Engineering Methods

    Article • Pharmaceutics, September 2022, MDPI AG

    Professor Changquan Sun

  5. Bioavailability-Enhancing Cocrystals: Screening, In Vivo Predictive Dissolution, and Supersaturation Maintenance

    Article • Crystal Growth & Design, August 2022, American Chemical Society (ACS)

    Professor Changquan Sun

  6. Nanomechanical testing in drug delivery: Theory, applications, and emerging trends

    Article • Advanced Drug Delivery Reviews, April 2022, Elsevier

    Professor Changquan Sun

  7. Mechanisms of Crystal Plasticization by Lattice Water

    Article • Pharmaceutical Research, March 2022, Springer Science + Business Media

    Professor Changquan Sun

  8. Air entrapment during tablet compression – Diagnosis, impact on tableting performance, and mitigation strategies

    Article • International Journal of Pharmaceutics, March 2022, Elsevier

    Professor Changquan Sun

  9. Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin and Ligustrazine through cocrystallization

    Article • International Journal of Pharmaceutics, March 2022, Elsevier

    Professor Changquan Sun

  10. Effects of shear cell size on flowability of powders measured using a ring shear tester

    Article • Powder Technology, January 2022, Elsevier

    Professor Changquan Sun

  11. Formulation strategies for mitigating dissolution reduction of p-aminobenzoic acid by sodium lauryl sulfate through diffusion layer modulation

    Article • International Journal of Pharmaceutics, January 2022, Elsevier

    Professor Changquan Sun

  12. Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity

    Article • Powder Technology, January 2022, Elsevier

    Professor Changquan Sun

  13. Profoundly improved photostability of dimetronidazole by cocrystallization

    Article • CrystEngComm, January 2022, Royal Society of Chemistry

    Professor Changquan Sun

  14. Efficient development of sorafenib tablets with improved oral bioavailability enabled by coprecipitated amorphous solid dispersion

    Article • International Journal of Pharmaceutics, December 2021, Elsevier

    Professor Changquan Sun

  15. Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

    Article • International Journal of Pharmaceutics X, December 2021, Elsevier

    Professor Changquan Sun

  16. Exceptional Powder Tabletability of Elastically Flexible Crystals

    Article • Crystal Growth & Design, November 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  17. Pharmaceutical Lauryl Sulfate Salts: Prevalence, Formation Rules, and Formulation Implications

    Article • Molecular Pharmaceutics, October 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  18. An Elusive Drug–Drug Cocrystal Prepared Using a Heteroseeding Strategy

    Article • Crystal Growth & Design, September 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  19. Effect of Lipidic Excipients on the Particle Properties and Aerosol Performance of High Drug Load Spray Dried Particles for Inhalation

    Article • Journal of Pharmaceutical Sciences, September 2021, Elsevier

    Professor Changquan Sun

  20. Effects of compaction and storage conditions on stability of intravenous immunoglobulin – Implication on developing oral tablets of biologics

    Article • International Journal of Pharmaceutics, July 2021, Elsevier

    Professor Changquan Sun

  21. Drug–Drug Cocrystallization Simultaneously Improves Pharmaceutical Properties of Genistein and Ligustrazine

    Article • Crystal Growth & Design, May 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  22. Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate

    Article • Pharmaceutics, April 2021, MDPI AG

    Professor Changquan Sun

  23. Nanomechanical mapping and strain rate sensitivity of microcrystalline cellulose

    Article • Journal of Materials Research, March 2021, Springer Science + Business Media

    Professor Changquan Sun

  24. Novel Salt-Cocrystals of Berberine Hydrochloride with Aliphatic Dicarboxylic Acids: Odd–Even Alternation in Physicochemical Properties

    Article • Molecular Pharmaceutics, March 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  25. Direct compression tablet formulation of celecoxib enabled with a pharmaceutical solvate

    Article • International Journal of Pharmaceutics, March 2021, Elsevier

    Professor Changquan Sun

  26. How Does the Dissimilarity of Screw Geometry Impact Twin-screw Melt Granulation?

    Article • European Journal of Pharmaceutical Sciences, February 2021, Elsevier

    Professor Changquan Sun

  27. Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype

    Article • European Journal of Pharmaceutical Sciences, February 2021, Elsevier

    Professor Changquan Sun

  28. Modulation of the powder properties of lamotrigine by crystal forms

    Article • International Journal of Pharmaceutics, February 2021, Elsevier

    Professor Changquan Sun

  29. Structural Origins of Elastic and 2D Plastic Flexibility of Molecular Crystals Investigated with Two Polymorphs of Conformationally Rigid Coumarin

    Article • Chemistry of Materials, January 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  30. Sweet Sulfamethazine Acesulfamate Crystals with Improved Compaction Property

    Article • Crystal Growth & Design, January 2021, American Chemical Society (ACS)

    Professor Changquan Sun

  31. Mechanically responsive crystalline materials

    Article • CrystEngComm, January 2021, Royal Society of Chemistry

    Professor Changquan Sun

  32. Reversible facile single-crystal-to-single-crystal polymorphic transition accompanied by unit cell volume expansion and twinning

    Article • CrystEngComm, January 2021, Royal Society of Chemistry

    Professor Changquan Sun

  33. Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges

    Article • CrystEngComm, January 2021, Royal Society of Chemistry

    Professor Changquan Sun

  34. The impact of solid-state form, water content and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolution

    Article • Pharmaceutical Development and Technology, December 2020, Taylor & Francis

    Professor Changquan Sun

  35. Tabletability Flip – Role of Bonding Area and Bonding Strength Interplay

    Article • Journal of Pharmaceutical Sciences, December 2020, Elsevier

    Professor Changquan Sun

  36. Structural Insights into the Distinct Solid-State Properties and Interconversion of Celecoxib N-Methyl-2-pyrrolidone Solvates

    Article • Crystal Growth & Design, November 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  37. Discovery, Characterization, and Pharmaceutical Applications of Two Loratadine–Oxalic Acid Cocrystals

    Article • Crystals, November 2020, MDPI AG

    Professor Changquan Sun

  38. The efficient development of a sildenafil orally disintegrating tablet using a material sparing and expedited approach

    Article • International Journal of Pharmaceutics, November 2020, Elsevier

    Professor Changquan Sun

  39. Development of piroxicam mini-tablets enabled by spherical cocrystallization

    Article • International Journal of Pharmaceutics, November 2020, Elsevier

    Professor Changquan Sun

  40. Profound tabletability deterioration of microcrystalline cellulose by magnesium stearate

    Article • International Journal of Pharmaceutics, November 2020, Elsevier

    Professor Changquan Sun

  41. Novel Quasi-Emulsion Solvent Diffusion-Based Spherical Cocrystallization Strategy for Simultaneously Improving the Manufacturability and Dissolution of Indomethacin

    Article • Crystal Growth & Design, August 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  42. Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen

    Article • AAPS PharmSciTech, August 2020, Springer Science + Business Media

    Professor Changquan Sun

  43. Material-Sparing and Expedited Development of a Tablet Formulation of Carbamazepine Glutaric Acid Cocrystal– a QbD Approach

    Article • Pharmaceutical Research, July 2020, Springer Science + Business Media

    Professor Changquan Sun

  44. A microcrystalline cellulose based drug-composite formulation strategy for developing low dose drug tablets

    Article • International Journal of Pharmaceutics, July 2020, Elsevier

    Professor Changquan Sun

  45. Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area – Bonding Strength Interplay

    Article • Pharmaceutical Research, June 2020, Springer Science + Business Media

    Professor Changquan Sun

  46. Intermolecular interactions and disorder in six isostructural celecoxib solvates

    Article • Acta Crystallographica Section C Structural Chemistry, June 2020, International Union of Crystallography

    Professor Changquan Sun, Dr Andrew D. Bond

  47. Mitigating Punch Sticking Propensity of Celecoxib by Cocrystallization: An Integrated Computational and Experimental Approach

    Article • Crystal Growth & Design, June 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  48. Conformation Directed Interaction Anisotropy Leading to Distinct Bending Behaviors of Two ROY Polymorphs

    Article • Crystal Growth & Design, June 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  49. Recent Advances in Co-processed APIs and Proposals for Enabling Commercialization of These Transformative Technologies

    Article • Molecular Pharmaceutics, May 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  50. Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

    Article • Molecular Pharmaceutics, March 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  51. Toward a Molecular Understanding of the Impact of Crystal Size and Shape on Punch Sticking

    Article • Molecular Pharmaceutics, March 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  52. Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet salts

    Article • International Journal of Pharmaceutics, March 2020, Elsevier

    Professor Changquan Sun

  53. Extended Release of Highly Water Soluble Isoniazid Attained through Cocrystallization with Curcumin

    Article • Crystal Growth & Design, February 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  54. Reducing the Sublimation Tendency of Ligustrazine through Salt Formation

    Article • Crystal Growth & Design, February 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  55. The role of the screw profile on granular structure and mixing efficiency of a high-dose hydrophobic drug formulation during twin screw wet granulation

    Article • International Journal of Pharmaceutics, February 2020, Elsevier

    Professor Changquan Sun

  56. A systematic evaluation of poloxamers as tablet lubricants

    Article • International Journal of Pharmaceutics, February 2020, Elsevier

    Professor Changquan Sun

  57. Interfacial bonding in formulated bilayer tablets

    Article • European Journal of Pharmaceutics and Biopharmaceutics, February 2020, Elsevier

    Professor Changquan Sun

  58. A material-saving and robust approach for obtaining accurate out-of-die powder compressibility

    Article • Powder Technology, February 2020, Elsevier

    Professor Changquan Sun

  59. Molecular Interpretation of Mechanical Behavior in Four Basic Crystal Packing of Isoniazid with Homologous Cocrystal Formers

    Article • Crystal Growth & Design, January 2020, American Chemical Society (ACS)

    Professor Changquan Sun

  60. Microstructures and pharmaceutical properties of ferulic acid agglomerates prepared by different spherical crystallization methods

    Article • International Journal of Pharmaceutics, January 2020, Elsevier

    Professor Changquan Sun

  61. Expedited Investigation of Powder Caking Aided by Rapid 3D Prototyping of Testing Devices

    Article • Journal of Pharmaceutical Sciences, January 2020, Elsevier

    Professor Changquan Sun

  62. The landscape of mechanical properties of molecular crystals

    Article • CrystEngComm, January 2020, Royal Society of Chemistry

    Professor Changquan Sun

  63. Workshop Report: USP Workshop on Advancements in In Vitro Performance Testing of Drug Products

    Article • Dissolution Technologies, January 2020, Dissolution Technologies

    Professor Changquan Sun

  64. Crystallographic and Energetic Insights into Reduced Dissolution and Physical Stability of a Drug–Surfactant Salt: The Case of Norfloxacin Lauryl Sulfate

    Article • Molecular Pharmaceutics, December 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  65. Molecular Interpretation of the Compaction Performance and Mechanical Properties of Caffeine Cocrystals: A Polymorphic Study

    Article • Molecular Pharmaceutics, December 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  66. Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition

    Article • Organic Process Research & Development, November 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  67. Correction to Fast Determination of Phase Stability of Hydrates Using Intrinsic Dissolution Rate Measurements

    Article • Crystal Growth & Design, November 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  68. Effect of particle size on interfacial bonding strength of bilayer tablets

    Article • Powder Technology, November 2019, Elsevier

    Professor Changquan Sun

  69. Structural Features of Sulfamethizole and Its Cocrystals: Beauty Within

    Article • Crystal Growth & Design, October 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  70. Fast Determination of Phase Stability of Hydrates Using Intrinsic Dissolution Rate Measurements

    Article • Crystal Growth & Design, September 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  71. Insights into the effect of compaction pressure and material properties on interfacial bonding strength of bilayer tablets

    Article • Powder Technology, September 2019, Elsevier

    Professor Changquan Sun

  72. Relationship between hydrate stability and accuracy of true density measured by helium pycnometry

    Article • International Journal of Pharmaceutics, August 2019, Elsevier

    Professor Changquan Sun

  73. Minimum Interfacial Bonding Strength for Bilayer Tablets Determined Using a Survival Test

    Article • Pharmaceutical Research, July 2019, Springer Science + Business Media

    Professor Changquan Sun

  74. Correction to Crystal Growth of Celecoxib from Amorphous State: Polymorphism, Growth Mechanism, and Kinetics

    Article • Crystal Growth & Design, July 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  75. Single-Crystal Plasticity Defies Bulk-Phase Mechanics in Isoniazid Cocrystals with Analogous Coformers

    Article • Crystal Growth & Design, July 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  76. Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis

    Article • International Journal of Pharmaceutics, July 2019, Elsevier

    Professor Changquan Sun

  77. Crystal growth of celecoxib from amorphous state – polymorphism, growth mechanism, and kinetics

    Article • Crystal Growth & Design, May 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  78. Reduced Punch Sticking Propensity of Acesulfame by Salt Formation: Role of Crystal Mechanical Property and Surface Chemistry

    Article • Molecular Pharmaceutics, April 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  79. Twistable Pharmaceutical Crystal Exhibiting Exceptional Plasticity and Tabletability

    Article • Chemistry of Materials, April 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  80. Expedited Tablet Formulation Development of a Highly Soluble Carbamazepine Cocrystal Enabled by Precipitation Inhibition in Diffusion Layer

    Article • Pharmaceutical Research, April 2019, Springer Science + Business Media

    Professor Changquan Sun

  81. Effect of screw profile and processing conditions on physical transformation and chemical degradation of gabapentin during twin-screw melt granulation

    Article • European Journal of Pharmaceutical Sciences, April 2019, Elsevier

    Professor Changquan Sun

  82. Direct Compression Tablet Containing 99% Active Ingredient—A Tale of Spherical Crystallization

    Article • Journal of Pharmaceutical Sciences, April 2019, Elsevier

    Professor Changquan Sun

  83. Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying

    Article • Crystal Growth & Design, April 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  84. Computational Techniques for Predicting Mechanical Properties of Organic Crystals: A Systematic Evaluation

    Article • Molecular Pharmaceutics, March 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  85. Profoundly Improved Plasticity and Tabletability of Griseofulvin by in Situ Solvation and Desolvation during Spherical Crystallization

    Article • Crystal Growth & Design, March 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  86. Spherical Cocrystallization—An Enabling Technology for the Development of High Dose Direct Compression Tablets of Poorly Soluble Drugs

    Article • Crystal Growth & Design, March 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  87. Effects of thermal binders on chemical stabilities and tabletability of gabapentin granules prepared by twin-screw melt granulation

    Article • International Journal of Pharmaceutics, March 2019, Elsevier

    Professor Changquan Sun

  88. Effects of Water on Powder Flowability of Diverse Powders Assessed by Complimentary Techniques

    Article • Journal of Pharmaceutical Sciences, March 2019, Elsevier

    Professor Changquan Sun

  89. Exceptionally Elastic Single-Component Pharmaceutical Crystals

    Article • Chemistry of Materials, February 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  90. Developing Biologics Tablets: The Effects of Compression on the Structure and Stability of Bovine Serum Albumin and Lysozyme

    Article • Molecular Pharmaceutics, February 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  91. Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

    Article • Molecular Pharmaceutics, February 2019, American Chemical Society (ACS)

    Professor Changquan Sun

  92. Robust bulk preparation and characterization of sulfamethazine and saccharine salt and cocrystal polymorphs

    Article • CrystEngComm, January 2019, Royal Society of Chemistry

    Professor Changquan Sun

  93. A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach

    Article • Powder Technology, January 2019, Elsevier

    Professor Changquan Sun

  94. Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid

    Article • International Journal of Pharmaceutics, January 2019, Elsevier

    Professor Changquan Sun

  95. Mechanism for the Reduced Dissolution of Ritonavir Tablets by Sodium Lauryl Sulfate

    Article • Journal of Pharmaceutical Sciences, January 2019, Elsevier

    Professor Changquan Sun

  96. Proportionality between powder cohesion and unconfined yield strength from shear cell testing

    Article • Heliyon, January 2019, Elsevier

    Professor Changquan Sun

  97. Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

    Article • RSC Advances, January 2019, Royal Society of Chemistry

    Professor Changquan Sun

  98. Structures and Properties of Granules Prepared By High Shear Wet Granulation

    Article • January 2019, Elsevier

    Professor Changquan Sun

  99. A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer

    Article • International Journal of Pharmaceutics, December 2018, Elsevier

    Professor Changquan Sun

  100. Mechanical Properties

    Article • September 2018, Wiley

    Professor Changquan Sun

  101. Cocrystallization of Curcumin with Benzenediols and Benzenetriols via Rapid Solvent Removal

    Article • Crystal Growth & Design, August 2018, American Chemical Society (ACS)

    Professor Changquan Sun

  102. Preparation, Characterization, and Formulation Development of Drug–Drug Protic Ionic Liquids of Diphenhydramine with Ibuprofen and Naproxen

    Article • Molecular Pharmaceutics, August 2018, American Chemical Society (ACS)

    Professor Changquan Sun

  103. Ribbon density and milling parameters that determine fines fraction in a dry granulation

    Article • Powder Technology, July 2018, Elsevier

    Professor Jukka Rantanen, Professor Changquan Sun

  104. Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades

    Article • International Journal of Pharmaceutics, July 2018, Elsevier

    Professor Changquan Sun

  105. Anion Exchange Reaction for Preparing Acesulfame Solid Forms

    Article • Crystal Growth & Design, June 2018, American Chemical Society (ACS)

    Professor Changquan Sun

  106. Relating the tableting behavior of piroxicam polytypes to their crystal structures using energy-vector models

    Article • International Journal of Pharmaceutics, May 2018, Elsevier

    Professor Changquan Sun

  107. Systematic evaluation of common lubricants for optimal use in tablet formulation

    Article • European Journal of Pharmaceutical Sciences, May 2018, Elsevier

    Professor Changquan Sun

  108. The relationship among tensile strength, Young's modulus, and indentation hardness of pharmaceutical compacts

    Article • Powder Technology, May 2018, Elsevier

    Professor Changquan Sun

  109. Crystal and Particle Engineering Strategies for Improving Powder Compression and Flow Properties to Enable Continuous Tablet Manufacturing by Direct Compression

    Article • April 2018, Elsevier

    Professor Changquan Sun

  110. Modulating Sticking Propensity of Pharmaceuticals Through Excipient Selection in a Direct Compression Tablet Formulation

    Article • Pharmaceutical Research, March 2018, Springer Science + Business Media

    Professor Changquan Sun

  111. A mesoporous silica based platform to enable tablet formulations of low dose drugs by direct compression

    Article • International Journal of Pharmaceutics, March 2018, Elsevier

    Professor Changquan Sun

  112. Identifying Slip Planes in Organic Polymorphs by Combined Energy Framework Calculations and Topology Analysis

    Article • Crystal Growth & Design, February 2018, American Chemical Society (ACS)

    Professor Changquan Sun

  113. Reduced interface spin polarization by antiferromagnetically coupled Mn segregated to the Co2MnSi /GaAs (001) interface

    Article • January 2018, American Physical Society (APS)

    Professor Changquan Sun

  114. Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

    Article • CrystEngComm, January 2018, Royal Society of Chemistry

    Professor Changquan Sun

  115. Subsurface nucleation of supercooled acetaminophen

    Article • CrystEngComm, January 2018, Royal Society of Chemistry

    Professor Changquan Sun

  116. Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer

    Article • Pharmaceutical Research, December 2017, Springer Science + Business Media

    Professor Changquan Sun

  117. Relationships among Crystal Structures, Mechanical Properties, and Tableting Performance Probed Using Four Salts of Diphenhydramine

    Article • Crystal Growth & Design, October 2017, American Chemical Society (ACS)

    Professor Changquan Sun

  118. Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures

    Article • Pharmaceutical Research, October 2017, Springer Science + Business Media

    Professor Changquan Sun

  119. Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame

    Article • International Journal of Pharmaceutics, October 2017, Elsevier

    Professor Changquan Sun

  120. The suitability of common compressibility equations for characterizing plasticity of diverse powders

    Article • International Journal of Pharmaceutics, October 2017, Elsevier

    Professor Changquan Sun

  121. Tablets of multi-unit pellet system for controlled drug delivery

    Article • Journal of Controlled Release, September 2017, Elsevier

    Professor Changquan Sun

  122. Expedited Development of Diphenhydramine Orally Disintegrating Tablet through Integrated Crystal and Particle Engineering

    Article • Molecular Pharmaceutics, August 2017, American Chemical Society (ACS)

    Professor Changquan Sun

  123. Ribbon thickness influences fine generation during dry granulation

    Article • International Journal of Pharmaceutics, August 2017, Elsevier

    Professor Changquan Sun

  124. Dependence of Punch Sticking on Compaction Pressure—Roles of Particle Deformability and Tablet Tensile Strength

    Article • August 2017, Elsevier

    Professor Changquan Sun

  125. Particle Engineering for Enabling a Formulation Platform Suitable for Manufacturing Low-Dose Tablets by Direct Compression

    Article • July 2017, Elsevier

    Professor Changquan Sun

  126. Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin

    Article • European Journal of Pharmaceutical Sciences, June 2017, Elsevier

    Professor Changquan Sun

  127. Superior Plasticity and Tabletability of Theophylline Monohydrate

    Article • Molecular Pharmaceutics, May 2017, American Chemical Society (ACS)

    Professor Changquan Sun

  128. Gaining insight into tablet capping tendency from compaction simulation

    Article • International Journal of Pharmaceutics, May 2017, Elsevier

    Professor Changquan Sun

  129. Tensile and shear methods for measuring strength of bilayer tablets

    Article • International Journal of Pharmaceutics, May 2017, Elsevier

    Professor Changquan Sun

  130. Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals

    Article • International Journal of Pharmaceutics, April 2017, Elsevier

    Professor Changquan Sun

  131. Lubrication with magnesium stearate increases tablet brittleness

    Article • Powder Technology, March 2017, Elsevier

    Professor Changquan Sun

  132. A top coating strategy with highly bonding polymers to enable direct tableting of multiple unit pellet system (MUPS)

    Article • Powder Technology, January 2017, Elsevier

    Professor Changquan Sun

  133. Mechanical Properties and Tableting Behavior of Amorphous Solid Dispersions

    Article • January 2017, Elsevier

    Professor Changquan Sun

  134. Mechanism and Kinetics of Punch Sticking of Pharmaceuticals

    Article • January 2017, Elsevier

    Professor Changquan Sun

  135. Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling

    Article • Asian Journal of Pharmaceutical Sciences, January 2017, Elsevier

    Professor Changquan Sun

  136. Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal

    Article • CrystEngComm, January 2017, Royal Society of Chemistry

    Professor Changquan Sun

  137. The phenomenon of tablet flashing — Its impact on tableting data analysis and a method to eliminate it

    Article • Powder Technology, January 2017, Elsevier

    Professor Changquan Sun

  138. Harvesting Potential Dissolution Advantages of Soluble Cocrystals by Depressing Precipitation Using the Common Coformer Effect

    Article • Crystal Growth & Design, October 2016, American Chemical Society (ACS)

    Professor Changquan Sun

  139. Process optimization of dry granulation based tableting line: Extracting physical material characteristics from granules, ribbons and tablets using near-IR (NIR) spectroscopic measurement

    Article • Powder Technology, October 2016, Elsevier

    Professor Jukka Rantanen, Professor Changquan Sun

  140. Analytical method development for powder characterization: Visualization of the critical drug loading affecting the processability of a formulation for direct compression

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2016, Elsevier

    Professor Jukka Rantanen, Professor Changquan Sun

  141. Solid-state characterization of optically pure (+)Dihydromyricetin extracted from Ampelopsis grossedentata leaves

    Article • International Journal of Pharmaceutics, September 2016, Elsevier

    Professor Changquan Sun

  142. Enhancing Bioavailability of Dihydromyricetin through Inhibiting Precipitation of Soluble Cocrystals by a Crystallization Inhibitor

    Article • Crystal Growth & Design, August 2016, American Chemical Society (ACS)

    Professor Changquan Sun

  143. A classification system for tableting behaviors of binary powder mixtures

    Article • Asian Journal of Pharmaceutical Sciences, August 2016, Elsevier

    Professor Changquan Sun

  144. Microstructure of Tablet—Pharmaceutical Significance, Assessment, and Engineering

    Article • Pharmaceutical Research, July 2016, Springer Science + Business Media

    Professor Changquan Sun

  145. Resveratrol cocrystals with enhanced solubility and tabletability

    Article • International Journal of Pharmaceutics, July 2016, Elsevier

    Professor Changquan Sun

  146. Macroindentation hardness measurement—Modernization and applications

    Article • International Journal of Pharmaceutics, June 2016, Elsevier

    Professor Changquan Sun

  147. Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals

    Article • June 2016, Elsevier

    Professor Changquan Sun

  148. Mini review: Mechanisms to the loss of tabletability by dry granulation

    Article • European Journal of Pharmaceutics and Biopharmaceutics, April 2016, Elsevier

    Professor Changquan Sun

  149. Sweet Berberine

    Article • Crystal Growth & Design, February 2016, American Chemical Society (ACS)

    Professor Changquan Sun

  150. Quantifying effects of moisture content on flow properties of microcrystalline cellulose using a ring shear tester

    Article • Powder Technology, February 2016, Elsevier

    Professor Changquan Sun

  151. A critical Examination of the Phenomenon of Bonding Area - Bonding Strength Interplay in Powder Tableting

    Article • Pharmaceutical Research, January 2016, Springer Science + Business Media

    Professor Changquan Sun

  152. From molecular salt to pseudo CAB cocrystal: Expanding solid-state landscape of carboxylic acids based on charge-assisted COOH⋯COO− hydrogen bonds

    Article • Journal of Molecular Structure, November 2015, Elsevier

    Professor Changquan Sun

  153. The development of carbamazepine-succinic acid cocrystal tablet formulations with improved in vitro and in vivo performance

    Article • Drug Development and Industrial Pharmacy, October 2015, Taylor & Francis

    Professor Changquan Sun

  154. Dependence of tablet brittleness on tensile strength and porosity

    Article • International Journal of Pharmaceutics, September 2015, Elsevier

    Professor Changquan Sun

  155. Tabletability Modulation Through Surface Engineering

    Article • Journal of Pharmaceutical Sciences, August 2015, Elsevier

    Professor Changquan Sun

  156. Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization

    Article • European Journal of Pharmaceutics and Biopharmaceutics, August 2015, Elsevier

    Professor Albert H.L. Chow, Professor Changquan Sun

  157. Dependence of ejection force on tableting speed—A compaction simulation study

    Article • Powder Technology, July 2015, Elsevier

    Professor Changquan Sun

  158. A new tablet brittleness index

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2015, Elsevier

    Professor Changquan Sun

  159. Near-infrared chemical imaging (NIR-CI) as a process monitoring solution for a production line of roll compaction and tableting

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2015, Elsevier

    Professor Changquan Sun, Professor Jukka Rantanen

  160. Validation and applications of an expedited tablet friability method

    Article • International Journal of Pharmaceutics, April 2015, Elsevier

    Professor Changquan Sun

  161. Correlation Among Crystal Structure, Mechanical Behavior, and Tabletability in the Co-Crystals of Vanillin Isomers

    Article • Crystal Growth & Design, April 2015, American Chemical Society (ACS)

    Professor Changquan Sun, Dr. Partha Pratim Bag

  162. Designing Micellar Nanocarriers with Improved Drug Loading and Stability Based on Solubility Parameter

    Article • Molecular Pharmaceutics, March 2015, American Chemical Society (ACS)

    Professor Changquan Sun

  163. Significant Expansion of the Solid State Landscape of Salicylic Acid Based on Charge-Assisted Hydrogen Bonding Interactions

    Article • Crystal Growth & Design, January 2015, American Chemical Society (ACS)

    Professor Changquan Sun

  164. Solvent and additive interactions as determinants in the nucleation pathway: general discussion

    Article • Faraday Discussions, January 2015, Royal Society of Chemistry

    Professor Changquan Sun

  165. Nucleation in complex multi-component and multi-phase systems: general discussion

    Article • Faraday Discussions, January 2015, Royal Society of Chemistry

    Dr Eric Breynaert, Professor Changquan Sun

  166. Effect of Heating Rate and Kinetic Model Selection on Activation Energy of Nonisothermal Crystallization of Amorphous Felodipine

    Article • Journal of Pharmaceutical Sciences, December 2014, Elsevier

    Professor Changquan Sun

  167. Kinetic Entrapment of a Hidden Curcumin Cocrystal with Phloroglucinol

    Article • Crystal Growth & Design, October 2014, American Chemical Society (ACS)

    Professor Changquan Sun, Professor Albert H.L. Chow

  168. Effect of Crystal Habit on Intrinsic Dissolution Behavior of Celecoxib Due to Differential Wettability

    Article • Crystal Growth & Design, October 2014, American Chemical Society (ACS)

    Professor Changquan Sun

  169. Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production

    Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2014, Elsevier

    Professor Changquan Sun, Professor Albert H.L. Chow

  170. Design and Preparation of a 4:1 Lamivudine–Oxalic Acid CAB Cocrystal for Improving the Lamivudine Purification Process

    Article • Crystal Growth & Design, August 2014, American Chemical Society (ACS)

    Professor Changquan Sun

  171. Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin

    Article • Crystal Growth & Design, August 2014, American Chemical Society (ACS)

    Professor Changquan Sun

  172. A Formulation Strategy for Solving the Overgranulation Problem in High Shear Wet Granulation

    Article • Journal of Pharmaceutical Sciences, August 2014, Elsevier

    Professor Changquan Sun

  173. Enabling Tablet Product Development of 5-Fluorocytosine Through Integrated Crystal and Particle Engineering

    Article • Journal of Pharmaceutical Sciences, April 2014, Elsevier

    Professor Changquan Sun

  174. Evolution of Structure and Properties of Granules Containing Microcrystalline Cellulose and Polyvinylpyrrolidone During High-Shear Wet Granulation

    Article • Journal of Pharmaceutical Sciences, January 2014, Elsevier

    Professor Changquan Sun

  175. Improving manufacturability of an ibuprofen powder blend by surface coating with silica nanoparticles

    Article • Powder Technology, November 2013, Elsevier

    Professor Changquan Sun

  176. Enabling direct compression of formulated Danshen powder by surface engineering

    Article • Powder Technology, June 2013, Elsevier

    Professor Changquan Sun

  177. Impact of Crystal Habit on Biopharmaceutical Performance of Celecoxib

    Article • Crystal Growth & Design, May 2013, American Chemical Society (ACS)

    Professor Changquan Sun

  178. Design, Synthesis, and Characterization of New 5-Fluorocytosine Salts

    Article • Molecular Pharmaceutics, May 2013, American Chemical Society (ACS)

    Professor Changquan Sun

  179. A Pitfall in Analyzing Powder Compatibility Data Using Nonlinear Regression

    Article • Journal of Pharmaceutical Sciences, March 2013, Elsevier

    Professor Changquan Sun

  180. Protonation of Cytosine: Cytosinium vs Hemicytosinium Duplexes

    Article • Crystal Growth & Design, January 2013, American Chemical Society (ACS)

    Professor Changquan Sun

  181. Synthon preference in O-protonated amide crystals – dominance of short strong hydrogen bonds

    Article • CrystEngComm, January 2013, Royal Society of Chemistry

    Professor Changquan Sun

  182. Improved solid-state stability of salts by cocrystallization between conjugate acid–base pairs

    Article • CrystEngComm, January 2013, Royal Society of Chemistry

    Professor Changquan Sun

  183. Cocrystallization for successful drug delivery

    Article • Expert Opinion on Drug Delivery, December 2012, Informa Healthcare

    Professor Changquan Sun

  184. Preparation and Characterization of Surface-Engineered Coarse Microcrystalline Cellulose Through Dry Coating with Silica Nanoparticles

    Article • Journal of Pharmaceutical Sciences, November 2012, Elsevier

    Professor Changquan Sun

  185. Correction for Polymorphs, Salts and Cocrystals: What’s in a Name?

    Article • Crystal Growth & Design, June 2012, American Chemical Society (ACS)

    Professor Changquan Sun, Tejender Thakur

  186. Probing Interfaces between Pharmaceutical Crystals and Polymers by Neutron Reflectometry

    Article • Molecular Pharmaceutics, June 2012, American Chemical Society (ACS)

    Professor Changquan Sun, Dr John D Yeager

  187. Polymorphs, Salts, and Cocrystals: What’s in a Name?

    Article • Crystal Growth & Design, April 2012, American Chemical Society (ACS)

    Professor Changquan Sun, Tejender Thakur, Dr Srinivasulu Aitipamula

  188. Do not confuse hydrogen chloride with hydrochloric acid!

    Article • Chemistry - A European Journal, April 2012, Wiley

    Professor Changquan Sun

  189. Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide

    Article • Pharmaceutical Research, February 2012, Springer Science + Business Media

    Professor Changquan Sun, Professor Albert H.L. Chow

  190. Ionized form of acetaminophen with improved compaction properties

    Article • CrystEngComm, January 2012, Royal Society of Chemistry

    Professor Changquan Sun

  191. Design and synthesis of solid state structures with conjugate acid–base pair interactions

    Article • CrystEngComm, January 2012, Royal Society of Chemistry

    Professor Changquan Sun

  192. Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

    Article • CrystEngComm, January 2012, Royal Society of Chemistry

    Professor Changquan Sun, Dr. Partha Pratim Bag

  193. Origin of Two Modes of Non-isothermal Crystallization of Glasses Produced by Milling

    Article • Pharmaceutical Research, December 2011, Springer Science + Business Media

    Professor Changquan Sun

  194. Profoundly improving flow properties of a cohesive cellulose powder by surface coating with nano‐silica through comilling

    Article • Journal of Pharmaceutical Sciences, November 2011, Elsevier

    Professor Changquan Sun

  195. Reproducibility of flow properties of microcrystalline cellulose — Avicel PH102

    Article • Powder Technology, September 2011, Elsevier

    Professor Changquan Sun

  196. Initial moisture content in raw material can profoundly influence high shear wet granulation process

    Article • International Journal of Pharmaceutics, September 2011, Elsevier

    Professor Changquan Sun

  197. Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification

    Article • Pharmaceutical Research, June 2011, Springer Science + Business Media

    Professor Changquan Sun

  198. Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: A double-edged sword

    Article • European Journal of Pharmaceutical Sciences, May 2011, Elsevier

    Professor Changquan Sun

  199. Origin of profound changes in powder properties during wetting and nucleation stages of high-shear wet granulation of microcrystalline cellulose

    Article • Powder Technology, April 2011, Elsevier

    Professor Changquan Sun

  200. Understanding Size Enlargement and Hardening of Granules on Tabletability of Unlubricated Granules Prepared by Dry Granulation

    Article • Journal of Pharmaceutical Sciences, February 2011, Elsevier

    Professor Changquan Sun

  201. Decoding Powder Tabletability: Roles of Particle Adhesion and Plasticity

    Article • Journal of Adhesion Science and Technology, January 2011, Taylor & Francis

    Professor Changquan Sun

  202. The Manufacture of Low-Dose Oral Solid Dosage Form to Support Early Clinical Studies Using an Automated Micro-Filing System

    Article • AAPS PharmSciTech, December 2010, American Association of Pharmaceutical Scientists (AAPS)

    Professor Changquan Sun

  203. Transforming Powder Mechanical Properties by Core/Shell Structure: Compressible Sand

    Article • Journal of Pharmaceutical Sciences, November 2010, Elsevier

    Professor Changquan Sun

  204. Roles of Granule Size in Over-Granulation During High Shear Wet Granulation

    Article • Journal of Pharmaceutical Sciences, August 2010, Elsevier

    Professor Changquan Sun

  205. Setting the bar for powder flow properties in successful high speed tableting

    Article • Powder Technology, July 2010, Elsevier

    Professor Changquan Sun

  206. Understanding the relationship between crystal structure, plasticity and compaction behaviour of theophylline, methyl gallate, and their 1 : 1 co-crystal

    Article • CrystEngComm, January 2010, Royal Society of Chemistry

    Professor Changquan Sun

  207. Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles

    Article • International Journal of Pharmaceutics, August 2009, Elsevier

    Professor Changquan Sun

  208. Improving Powder Flow Properties of Citric Acid by Crystal Hydration

    Article • Journal of Pharmaceutical Sciences, May 2009, Elsevier

    Professor Changquan Sun

  209. Materials Science Tetrahedron—A Useful Tool for Pharmaceutical Research and Development

    Article • Journal of Pharmaceutical Sciences, May 2009, Elsevier

    Professor Changquan Sun

  210. Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design

    Article • Journal of Pharmaceutical Sciences, January 2009, Elsevier

    Professor Changquan Sun

  211. Quantifying Effects of Particulate Properties on Powder Flow Properties Using a Ring Shear Tester

    Article • Journal of Pharmaceutical Sciences, September 2008, Elsevier

    Professor Changquan Sun

  212. On the Identification of Slip Planes in Organic Crystals Based on Attachment Energy Calculation

    Article • Journal of Pharmaceutical Sciences, August 2008, Elsevier

    Professor Changquan Sun

  213. Improving Mechanical Properties of Caffeine and Methyl Gallate Crystals by Cocrystallization

    Article • Crystal Growth & Design, April 2008, American Chemical Society (ACS)

    Professor Changquan Sun

  214. Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose

    Article • International Journal of Pharmaceutics, January 2008, Elsevier

    Professor Changquan Sun

  215. On the mechanism of reduced tabletability of granules prepared by roller compaction

    Article • International Journal of Pharmaceutics, January 2008, Elsevier

    Professor Changquan Sun

  216. Influence of crystal structure on the tableting properties of n‐alkyl 4‐hydroxybenzoate esters (parabens)

    Article • Journal of Pharmaceutical Sciences, December 2007, Elsevier

    Professor Changquan Sun

  217. Thermal Expansion of Organic Crystals and Precision of Calculated Crystal Density: A Survey of Cambridge Crystal Database

    Article • Journal of Pharmaceutical Sciences, May 2007, Elsevier

    Professor Changquan Sun

  218. Insensitivity of Compaction Properties of Brittle Granules to Size Enlargement by Roller Compaction

    Article • Journal of Pharmaceutical Sciences, May 2007, Elsevier

    Professor Changquan Sun

  219. A material-sparing method for simultaneous determination of true density and powder compaction properties—Aspartame as an example

    Article • International Journal of Pharmaceutics, December 2006, Elsevier

    Professor Changquan Sun

  220. Solid-state properties and crystallization behavior of PHA-739521 polymorphs

    Article • International Journal of Pharmaceutics, August 2006, Elsevier

    Professor Changquan Sun

  221. Reduced tabletability of roller compacted granules as a result of granule size enlargement

    Article • Journal of Pharmaceutical Sciences, January 2006, Elsevier

    Professor Changquan Sun

  222. True Density of Microcrystalline Cellulose

    Article • Journal of Pharmaceutical Sciences, October 2005, Elsevier

    Professor Changquan Sun

  223. A Study of Sulfamerazine Single Crystals Using Atomic Force Microscopy, Transmission Light Microscopy, and Raman Spectroscopy

    Article • Journal of Pharmaceutical Sciences, September 2005, Elsevier

    Professor Changquan Sun

  224. Quantifying Errors in Tableting Data Analysis Using the Ryshkewitch Equation Due to Inaccurate True Density

    Article • Journal of Pharmaceutical Sciences, September 2005, Elsevier

    Professor Changquan Sun

  225. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction

    Article • Journal of Pharmaceutical Sciences, March 2005, Elsevier

    Professor Changquan Sun

  226. A Novel Method for Deriving True Density of Pharmaceutical Solids Including Hydrates and Water-Containing Powders

    Article • Journal of Pharmaceutical Sciences, March 2004, Elsevier

    Professor Changquan Sun

  227. Improved Tableting Properties of p-Hydroxybenzoic Acid by Water of Crystallization: A Molecular Insight

    Article • Pharmaceutical Research, February 2004, Springer Science + Business Media

    Professor Changquan Sun

  228. Theophylline monohydrate

    Article • Acta Crystallographica Section E Structure Reports Online, March 2002, International Union of Crystallography

    Professor Changquan Sun

  229. Influence of Crystal Shape on the Tableting Performance of L‐Lysine Monohydrochloride Dihydrate

    Article • Journal of Pharmaceutical Sciences, May 2001, Elsevier

    Professor Changquan Sun

  230. Influence of crystal shape on the tableting performance of L‐lysine monohydrochloride dihydrate

    Article • Journal of Pharmaceutical Sciences, May 2001, Elsevier

    Professor Changquan Sun

  231. Influence of crystal shape on the tableting performance of L-lysine monohydrochloride dihydrate

    Article • Journal of Pharmaceutical Sciences, May 2001, Elsevier

    Professor Changquan Sun

  232. Effects of initial particle size on the tableting properties of l-lysine monohydrochloride dihydrate powder

    Article • International Journal of Pharmaceutics, March 2001, Elsevier

    Professor Changquan Sun

  233. Influence of Elastic Deformation of Particles on Heckel Analysis

    Article • Pharmaceutical Development and Technology, January 2001, Taylor & Francis

    Professor Changquan Sun

  234. Article • January 2001, Springer Science + Business Media

    Professor Changquan Sun

  235. Article • January 2001, Springer Science + Business Media

    Professor Changquan Sun