All Stories

  1. αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

    Article • Tissue Barriers, May 2018, Taylor & Francis

    Professor Cara J. Gottardi

  2. Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2017, American Thoracic Society

    Professor Cara J. Gottardi

  3. α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

    Article • The Journal of Cell Biology, September 2017, Rockefeller University Press

    Professor Cara J. Gottardi

  4. Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma

    Article • Allergy, July 2017, Wiley

    Professor Cara J. Gottardi

  5. Arginase 1 Is Negatively Regulated By β-Catenin Signaling In The Lung

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Professor Cara J. Gottardi

  6. Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

    Article • Journal of Cell Science, August 2016, The Company of Biologists

    Professor Cara J. Gottardi

  7. The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

    Article • Journal of Allergy and Clinical Immunology, July 2016, Elsevier

    Professor Cara J. Gottardi

  8. Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation

    Article • The EMBO Journal, February 2016, EMBO

    Professor Cara J. Gottardi

  9. Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

    Article • Biochemical and Biophysical Research Communications, February 2016, Elsevier

    Professor Cara J. Gottardi

  10. Beyond β-catenin: prospects for a larger catenin network in the nucleus

    Article • Nature Reviews Molecular Cell Biology, November 2015, Nature

    Professor Cara J. Gottardi

  11. Structural Determinants of the Mechanical Stability of α-Catenin

    Article • Journal of Biological Chemistry, June 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  12.  -Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism

    Article • Journal of Cell Science, February 2015, The Company of Biologists

    Professor Cara J. Gottardi

  13. The Increase in Maternal Expression ofaxin1andaxin2Contribute to the Zebrafish MutantIchabodVentralized Phenotype

    Article • Journal of Cellular Biochemistry, January 2015, Wiley

    Professor Cara J. Gottardi

  14. Nuclear Signaling from Cadherin Adhesion Complexes

    Article • January 2015, Elsevier

    Professor Cara J. Gottardi

  15. The cardiac protein αT-catenin contributes to chemical-induced asthma

    Article • AJP Lung Cellular and Molecular Physiology, December 2014, American Physiological Society

    Professor Cara J. Gottardi

  16. Wnt CoreceptorLrp5Is a Driver of Idiopathic Pulmonary Fibrosis

    Article • American Review of Respiratory Disease, July 2014, American Thoracic Society

    Professor Cara J. Gottardi

  17. E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

    Article • Molecular Biology of the Cell, June 2014, American Society for Cell Biology (ASCB)

    Professor Cara J. Gottardi

  18. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

    Article • Fertility and Sterility, May 2014, Elsevier

    Professor Cara J. Gottardi

  19. α-Catenin is an inhibitor of transcription

    Article • Proceedings of the National Academy of Sciences, March 2014, Proceedings of the National Academy of Sciences

    Professor Cara J. Gottardi

  20.  -Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

    Article • Journal of Cell Science, February 2014, The Company of Biologists

    Professor Cara J. Gottardi

  21. Fat in Fibrosis

    Article • American Review of Respiratory Disease, November 2013, American Thoracic Society

    Professor Cara J. Gottardi

  22. Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

    Article • Proceedings of the National Academy of Sciences, September 2013, Proceedings of the National Academy of Sciences

    Professor Cara J. Gottardi

  23. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

    Article • Biochemical Journal, May 2013, Portland Press Ltd.

    Professor Cara J. Gottardi

  24. Considerations for Targeting β-Catenin Signaling in Fibrosis

    Article • American Review of Respiratory Disease, March 2013, American Thoracic Society

    Professor Cara J. Gottardi

  25. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

    Article • Science Signaling, February 2013, American Association for the Advancement of Science

    Professor Cara J. Gottardi

  26. Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

    Article • Arthritis & Rheumatism, July 2012, Wiley

    Professor Cara J. Gottardi

  27. Fibrosis in systemic sclerosis: common and unique pathobiology

    Article • Fibrogenesis & Tissue Repair, January 2012, Springer Science + Business Media

    Professor Cara J. Gottardi

  28. Signaling from the Adherens Junction

    Article • January 2012, Springer Science + Business Media

    Professor Cara J. Gottardi

  29. Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2011, American Thoracic Society

    Professor Cara J. Gottardi

  30. β-catenin signaling

    Article • Current Opinion in Rheumatology, November 2011, Wolters Kluwer Health

    Professor Cara J. Gottardi

  31. UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes

    Article • Molecular Carcinogenesis, August 2011, Wiley

    Professor Cara J. Gottardi

  32. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

    Article • The FASEB Journal, June 2011, Federation of American Societies For Experimental Biology (FASEB)

    Professor Cara J. Gottardi

  33. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

    Article • Arthritis & Rheumatism, May 2011, Wiley

    Professor Cara J. Gottardi

  34. Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin

    Article • Nature Structural & Molecular Biology, May 2011, Nature

    Professor Cara J. Gottardi

  35. Integrin Regulation of β-Catenin Signaling in Ovarian Carcinoma

    Article • Journal of Biological Chemistry, April 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  36. Regenerative Pathways and Emphysema

    Article • American Review of Respiratory Disease, March 2011, American Thoracic Society

    Professor Cara J. Gottardi

  37. Nesprin-2 Interacts with α-Catenin and Regulates Wnt Signaling at the Nuclear Envelope

    Article • Journal of Biological Chemistry, August 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  38. β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling

    Article • PLoS ONE, April 2010, PLOS

    Professor Cara J. Gottardi

  39. β-Catenin/T-cell Factor Signaling Is Activated during Lung Injury and Promotes the Survival and Migration of Alveolar Epithelial Cells

    Article • Journal of Biological Chemistry, November 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  40. The Terminal Region of β-Catenin Promotes Stability by Shielding the Armadillo Repeats from the Axin-scaffold Destruction Complex

    Article • Journal of Biological Chemistry, August 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  41. Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

    Article • The Journal of Cell Biology, July 2009, Rockefeller University Press

    Professor Cara J. Gottardi

  42. Regulation of Wnt/β-catenin signaling by protein kinases

    Article • Developmental Dynamics, January 2009, Wiley

    Professor Cara J. Gottardi

  43. Issues associated with assessing nuclear localization of N-terminally unphosphorylated β-catenin with monoclonal antibody 8E7

    Article • Biology Direct, January 2009, Springer Science + Business Media

    Professor Cara J. Gottardi

  44. Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

    Article • Oncogene, November 2008, Nature

    Professor Cara J. Gottardi

  45. Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

    Article • Human Molecular Genetics, July 2008, Oxford University Press (OUP)

    Professor Cara J. Gottardi

  46. Molecular components of the adherens junction

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2008, Elsevier

    Professor Cara J. Gottardi

  47. Terminal Regions of β-Catenin Come into View

    Article • Structure, March 2008, Elsevier

    Professor Cara J. Gottardi

  48. VE-cadherin and  -catenin binding dynamics during histamine-induced endothelial hyperpermeability

    Article • AJP Cell Physiology, February 2008, American Physiological Society

    Professor Cara J. Gottardi

  49. Phospho-regulation of  -Catenin Adhesion and Signaling Functions

    Article • Physiology, October 2007, American Physiological Society

    Professor Cara J. Gottardi

  50. Terminating Wnt signals

    Article • The Journal of Cell Biology, November 2005, Rockefeller University Press

    Professor Cara J. Gottardi

  51. When domestiques rebel: kinesins, cadherins and neuronal proliferation

    Article • Nature, May 2005, Nature

    Professor Cara J. Gottardi

  52. Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

    Article • The Journal of Cell Biology, October 2004, Rockefeller University Press

    Professor Cara J. Gottardi

  53. Adhesion signaling: How β-catenin interacts with its partners

    Article • Current Biology, October 2001, Elsevier

    Professor Cara J. Gottardi

  54. E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

    Article • The Journal of Cell Biology, May 2001, Rockefeller University Press

    Professor Cara J. Gottardi

  55. A Dileucine Motif Targets E-cadherin to the Basolateral Cell Surface in Madin-Darby Canine Kidney and LLC-PK1Epithelial Cells

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  56. A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

    Article • The EMBO Journal, July 1999, Wiley

    Professor Cara J. Gottardi, Professor Marc Lecuit

  57. Tyrosine-based Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1Epithelial Cells

    Article • Journal of Biological Chemistry, October 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Cara J. Gottardi

  58. Sorting of Ion Pumps in Polarized Epithelial Cells.

    Article • Annals of the New York Academy of Sciences, November 1997, Wiley

    Professor Cara J. Gottardi

  59. The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

    Article • Proceedings of the National Academy of Sciences, October 1996, Proceedings of the National Academy of Sciences

    Professor Cara J. Gottardi

  60. Expression of a Protein in Rat Kidney and Distal Colon That Is Related to the Gastric HK-ATPase

    Article • Cellular Physiology and Biochemistry, January 1995, Karger Publishers

    Professor Cara J. Gottardi

  61. Sorting of the Gastric H,K-ATPase in Endocrine and Epithelial Cells

    Article • Annals of the New York Academy of Sciences, September 1994, Wiley

    Professor Cara J. Gottardi

  62. Chapter 8 Synthesis and Sorting of Ion Pumps in Polarized Cells

    Article • January 1994, Elsevier

    Professor Cara J. Gottardi

  63. Tight Junctions in Simple and Stratified Epithelium

    Article • Wiley

    Professor Cara J. Gottardi