All Stories

  1. New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine

    Article • Diagnostics, June 2025, MDPI AG

    Biaoru Li

  2. Cholesterol‐conjugated miR‐29b induces fetal haemoglobin expression via γ‐globin promoter demethylation in the Townes mouse model for sickle cell anaemia

    Article • British Journal of Haematology, May 2025, Wiley

    Biaoru Li

  3. Precision Medicine Related to Landscape and Architecture of Tumor Specimen

    Article • Japan Journal of Research, May 2025, SciVision Publishers LLC

    Biaoru Li

  4. STAT3 down-regulation for IL-2 inducing TIL-A clinical clue for spatial quantitative pathway analysis

    Article • AIMS Allergy and Immunology, January 2024, American Institute of Mathematical Sciences (AIMS)

    Biaoru Li

  5. Editorial: Epigenetics in cancer: mechanisms and drug development-volume II

    Article • Frontiers in Genetics, July 2023, Frontiers

    Biaoru Li

  6. Spatial-timely Quantitative Network Analysis for TGF-β pathway of Tumor Infiltrating Lymphocytes

    Article • Journal of Cancer Science and Clinical Therapeutics, January 2023, Fortune Journals

    Biaoru Li

  7. Epigenetics in Cancer: Mechanisms and Drug Development - Volume II

    Article • January 2023, Frontiers

    Biaoru Li

  8. Personalized Immunotherapy of Patients: Defining by Single-cell RNA-seq with Artificial Intelligence

    Article • Medical Research Archives, January 2023, Knowledge Enterprise Journals

    Biaoru Li

  9. "Machine-learning Modeling for Personalized Immunotherapy- An Evaluation Module"

    Article • Biomedical Journal of Scientific & Technical Research, November 2022, Biomedical Research Network, LLC

    Biaoru Li

  10. Why do tumor-infiltrating lymphocytes have variable efficacy in the treatment of solid tumors?

    Article • Frontiers in Immunology, October 2022, Frontiers

    Biaoru Li

  11. Editorial: Epigenetics in Cancer: Mechanisms and Drug Development

    Article • Frontiers in Genetics, June 2022, Frontiers

    Biaoru Li

  12. Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

    Article • PLOS One, May 2022, PLOS

    Biaoru Li

  13. Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects

    Article • Blood Cells Molecules and Diseases, March 2022, Elsevier

    Biaoru Li

  14. Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Biaoru Li

  15. Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease

    Article • Blood Cells Molecules and Diseases, July 2021, Elsevier

    Biaoru Li

  16. Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

    Article • Blood Cells Molecules and Diseases, November 2019, Elsevier

    Biaoru Li

  17. In silico Modeling Personalized Therapy of Pulmonary Artery Hypertension

    Article • SSR Institute of International Journal of Life Sciences, July 2019, Marwah Infotech

    Biaoru Li

  18. MIR29B mediates epigenetic mechanisms of HBG gene activation

    Article • British Journal of Haematology, March 2019, Wiley

    Biaoru Li

  19. MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

    Article • Experimental Hematology, February 2019, Elsevier

    Biaoru Li

  20. Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease

    Article • Experimental Biology and Medicine, January 2019, SAGE Publications

    Biaoru Li

  21. Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain

    Article • Haematologica, April 2018, Ferrata Storti Foundation (Haematologica)

    Biaoru Li

  22. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease

    Article • JCI Insight, October 2017, American Society for Clinical Investigation

    Biaoru Li

  23. Pathway-Based Approaches for Analysis of Genome-wide Association Studies--A case report for metastatic small cell lung cancer

    Article • International Journal of Hematology and Therapy, June 2017, Ommega Online Publishers

    Biaoru Li

  24. NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors

    Article • Haematologica, May 2017, Ferrata Storti Foundation (Haematologica)

    Biaoru Li

  25. Personalized Chemotherapy of Tumor Disease Based on System Modeling

    Article • May 2016, Bentham Science Publishers

    Biaoru Li

  26. Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells

    Article • Experimental Biology and Medicine, March 2016, SAGE Publications

    Biaoru Li

  27. Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

    Article • PLOS One, December 2015, PLOS

    Dr Seyed Mehdi Nouraie, Biaoru Li

  28. Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease

    Article • Experimental Biology and Medicine, August 2015, Frontiers

    Biaoru Li

  29. Personalized Targeted Prevention and Therapy Relied on Detection of Global and Local Single Nucleotide Polymorphisms

    Article • International Journal of Hematology and Therapy, January 2015, Ommega Online Publishers

    Biaoru Li

  30. A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies

    Article • PLOS One, September 2014, PLOS

    Dr Kenneth R Peterson, Biaoru Li

  31. Characterization of Transcription Factor Networks Involved in Umbilical Cord Blood CD34+ Stem Cells-Derived Erythropoiesis

    Article • PLOS One, September 2014, PLOS

    Biaoru Li

  32. Monomethylfumarate Induces γ-Globin Expression and Fetal Hemoglobin Production in Cultured Human Retinal Pigment Epithelial (RPE) and Erythroid Cells, and in Intact Retina

    Article • Investigative Ophthalmology & Visual Science, August 2014, Association for Research in Vision and Ophthalmology (ARVO)

    Biaoru Li

  33. Feasibility of Whole RNA Sequencing from Single-Cell mRNA Amplification

    Article • Genetics Research International, December 2013, Wiley

    Biaoru Li

  34. Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

    Article • BMC Genomics, April 2012, Springer Science + Business Media

    Biaoru Li

  35. Gene Expression and Pathway Analysis of Quiescent CD8+ T Cells from Liver Cancer, Liver Sinusoid and Peripheral Blood - Study on Toxicogenomics and Prevention Targeting

    Article • October 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Biaoru Li

  36. Genomic expression analysis by single‐cell mRNA differential display of quiescent CD8 T cells from tumour‐infiltrating lymphocytes obtained from in vivo liver tumours

    Article • Immunology, March 2009, Wiley

    Biaoru Li

  37. SRY-directed DNA Bending and Human Sex Reversal: Reassessment of a Clinical Mutation Uncovers a Global Coupling between the HMG Box and its Tail

    Article • Journal of Molecular Biology, July 2006, Elsevier

    Biaoru Li

  38. Regulation of Sexual Dimorphism: Mutational and Chemogenetic Analysis of the Doublesex DM Domain

    Article • Molecular and Cellular Biology, January 2006, ASM Journals

    Biaoru Li

  39. A strategy to identify genomic expression at single-cell level or a small number of cells

    Article • Electronic Journal of Biotechnology, April 2005, Elsevier

    Biaoru Li

  40. Enhancing the Activity of Insulin at the Receptor Interface:  Crystal Structure and Photo-Cross-Linking of A8 Analogues

    Article • Biochemistry, November 2004, American Chemical Society (ACS)

    Biaoru Li

  41. How Insulin Binds: the B-Chain α-Helix Contacts the L1 β-Helix of the Insulin Receptor

    Article • Journal of Molecular Biology, August 2004, Elsevier

    Biaoru Li

  42. Expression, crystallization and preliminary X-ray characterization of theDrosophilatranscription factor Doublesex

    Article • Acta Crystallographica Section D Biological Crystallography, June 2004, International Union of Crystallography

    Biaoru Li

  43. The Effects of the Farnesyl Transferase Inhibitor FTI L-778,123 on Normal, Myelodysplastic, and Myeloid Leukemia Bone Marrow Progenitor Proliferation In Vitro

    Article • Leukemia & Lymphoma, January 2003, Taylor & Francis

    Biaoru Li

  44. Sex-specific Gene Regulation

    Article • Journal of Biological Chemistry, November 2002, Elsevier

    Biaoru Li

  45. Abnormalities of molecular regulators of proliferation and apoptosis in carcinoma of the oral cavity and oropharynx

    Article • Auris Nasus Larynx, April 2002, Elsevier

    Biaoru Li

  46. Experimental and bioinformatics comparison of gene expression between T cells from TIL of liver cancer and T cells from UniGene

    Article • Journal of Gastroenterology, April 2002, Springer Science + Business Media

    Biaoru Li

  47. Human Sex Reversal Due to Impaired Nuclear Localization of SRY

    Article • Journal of Biological Chemistry, December 2001, Elsevier

    Biaoru Li

  48. P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

    Article • Leukemia Supplements, October 2001, Springer Science + Business Media

    Biaoru Li

  49. Poor prognosis acute myelogenous leukemia: 3—biological and molecular biological changes during remission induction therapy

    Article • Leukemia Research, September 2001, Elsevier

    Biaoru Li

  50. Alterations in IRF1/IRF2 expression in acute myelogenous leukemia

    Article • American Journal of Hematology, July 2001, Wiley

    Biaoru Li

  51. SRY and Architectural Gene Regulation: The Kinetic Stability of a Bent Protein-DNA Complex Can Regulate Its Transcriptional Potency

    Article • Molecular Endocrinology, March 2001, Endocrine Society

    Biaoru Li

  52. Quantitation of Interferon Regulatory Factor Transcripts in Patients with Acute Myeloid Leukemia

    Article • Cancer Investigation, January 2001, Taylor & Francis

    Biaoru Li

  53. In VivoEffects of IL-4, IL-10, and Amifostine on Cytokine Production in Patients with Acute Myelogenous Leukemia

    Article • Leukemia & Lymphoma, January 2001, Taylor & Francis

    Biaoru Li

  54. Poor prognosis acute myelogenous leukemia 2 — biological and molecular biological characteristics and treatment outcome

    Article • Leukemia Research, September 2000, Elsevier

    Biaoru Li

  55. Identification of mRNAs expressed in tumor-infiltrating lymphocytes by a strategy for rapid and high throughput screening

    Article • Gene, September 2000, Elsevier

    Biaoru Li

  56. Immunologic character of tumor infiltrating lymphocytes in ovarian carcinoma

    Article • Chinese Journal of Cancer Research, June 2000, Chinese Journal of Cancer Research

    Biaoru Li

  57. SCF, IL-1β, IL-1ra AND GM-CSF IN THE BONE MARROW AND SERUM OF NORMAL INDIVIDUALS AND OF AML AND CML PATIENTS

    Article • Cytokine, June 2000, Elsevier

    Biaoru Li

  58. Signal antonymy unique to myelodysplastic marrows correlates with altered expression of E2F1

    Article • British Journal of Haematology, May 2000, Wiley

    Biaoru Li

  59. Telomerase Activity In Preleukemia And Acute Myelogenous Leukemia

    Article • Leukemia & Lymphoma, January 2000, Taylor & Francis

    Biaoru Li

  60. Marrow Cytokine Transcripts and the Secondary Hematologic Disorders

    Article • Leukemia & Lymphoma, January 1999, Taylor & Francis

    Biaoru Li

  61. Cytokine gene activity in AML cells in vivo in patients

    Article • Leukemia Research, May 1998, Elsevier

    Biaoru Li

  62. Abnormal regulation of the myc gene in myeloid leukemia

    Article • Medical Oncology and Tumor Pharmacotherapy, September 1992, Springer Science + Business Media

    Biaoru Li