All Stories

  1. Foreword

    Article • January 2020, Elsevier

    Professor Bert L Semler

  2. Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells

    Article • mBio, September 2018, ASM Journals

    Professor Bert L Semler

  3. Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus

    Article • PLoS Pathogens, August 2018, PLOS

    Professor Bert L Semler

  4. Replication of the Poliovirus Genome

    Article • February 2018, Taylor & Francis

    Professor Bert L Semler

  5. Hijacking Host Functions for Translation and RNA Replication by Enteroviruses

    Article • January 2018, Caister Academic Press

    Professor Bert L Semler

  6. Functional Consequences of RNA 5′-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation

    Article • Journal of Virology, May 2017, ASM Journals

    Dr LAURENT ANDREOLETTI, Professor Bert L Semler

  7. Mammalian Polycistronic mRNAs and Disease

    Article • Trends in Genetics, February 2017, Elsevier

    Professor Bert L Semler

  8. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

    Article • Viruses, December 2016, MDPI AG

    Professor Bert L Semler

  9. Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells

    Article • Journal of Virological Methods, April 2016, Elsevier

    Professor Bert L Semler

  10. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5′ and 3′ Noncoding Regions of Genomic RNAs

    Article • Viruses, February 2016, MDPI AG

    Professor Bert L Semler

  11. Foreword

    Article • January 2016, Elsevier

    Professor Bert L Semler

  12. Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections

    Article • mBio, December 2015, ASM Journals

    Professor Bert L Semler

  13. Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

    Article • mSphere, November 2015, ASM Journals

    Professor Bert L Semler

  14. Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

    Article • Frontiers in Microbiology, June 2015, Frontiers

    Professor Bert L Semler

  15. A 21st Century Perspective of Poliovirus Replication

    Article • PLoS Pathogens, June 2015, PLOS

    Professor Bert L Semler

  16. Picornaviruses: Pathogenesis and Molecular Biology

    Article • January 2015, Elsevier

    Professor Bert L Semler

  17. Transformation

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  18. Evolutionary and Population Biology of Streptococcus Pneumoniae

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  19. Genome Replication II: the Process

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  20. Genome Replication I: the Players

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  21. Processing Determinants and Functions of Cleavage Products of Picornavirus Polyproteins

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  22. Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections

    Article • Journal of General Virology, April 2014, Society for General Microbiology

    Professor Bert L Semler

  23. Translation and Host Cell Shutoff

    Article • April 2014, ASM Journals

    Professor Bert L Semler

  24. In Memoriam John J. Holland (1929-2013): a Pioneer in Molecular Virology

    Article • Journal of Virology, March 2014, ASM Journals

    Professor Bert L Semler, Kathy Spindler

  25. Revelations from a bicistronic calcium channel gene

    Article • Cell Cycle, February 2014, Taylor & Francis

    Professor Bert L Semler

  26. Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus

    Article • Virology, January 2014, Elsevier

    Professor Bert L Semler

  27. Inhibition of Poliovirus-Induced Cleavage of Cellular Protein PCBP2 Reduces the Levels of Viral RNA Replication

    Article • Journal of Virology, December 2013, ASM Journals

    Professor Bert L Semler

  28. Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein

    Article • Virus Research, September 2013, Elsevier

    Professor Bert L Semler

  29. Cellular mRNA Decay Protein AUF1 Negatively Regulates Enterovirus and Human Rhinovirus Infections

    Article • Journal of Virology, July 2013, ASM Journals

    Professor Bert L Semler

  30. Methods to study RNA virus molecular biology

    Article • Methods, February 2013, Elsevier

    Professor Bert L Semler

  31. Viral Proteinase Requirements for the Nucleocytoplasmic Relocalization of Cellular Splicing Factor SRp20 during Picornavirus Infections

    Article • Journal of Virology, December 2012, ASM Journals

    Professor Bert L Semler

  32. MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

    Article • Cell Reports, November 2012, Elsevier

    Professor Bert L Semler

  33. Viral subversion of host functions for picornavirus translation and RNA replication

    Article • Future Virology, February 2012, Future Medicine

    Professor Bert L Semler

  34. SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

    Article • PLoS Pathogens, December 2011, PLOS

    Professor Bert L Semler

  35. Re-localization of Cellular Protein SRp20 during Poliovirus Infection: Bridging a Viral IRES to the Host Cell Translation Apparatus

    Article • PLoS Pathogens, July 2011, PLOS

    Professor Bert L Semler

  36. Engineered Picornavirus VPg-RNA Substrates: Analysis of a Tyrosyl-RNA Phosphodiesterase Activity

    Article • PLoS ONE, March 2011, PLOS

    Professor Bert L Semler

  37. Mechanistic Intersections Between Picornavirus Translation and RNA Replication

    Article • January 2011, Elsevier

    Professor Bert L Semler

  38. Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

    Article • Journal of Virology, November 2010, ASM Journals

    Professor Bert L Semler

  39. Stress-Inducible Alternative Translation Initiation of Human Cytomegalovirus Latency Protein pUL138

    Article • Journal of Virology, June 2010, ASM Journals

    Professor Bert L Semler

  40. Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins

    Article • Virology, May 2010, Elsevier

    Professor Bert L Semler

  41. Positive-Strand RNA Virus Replication in Vertebrate Hosts

    Article • March 2010, Wiley

    Professor Bert L Semler

  42. Mechanistic Consequences of hnRNP C Binding to Both RNA Termini of Poliovirus Negative-Strand RNA Intermediates

    Article • Journal of Virology, February 2010, ASM Journals

    Professor Bert L Semler

  43. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, September 2009, Elsevier

    Professor Bert L Semler

  44. Altered interactions between stem-loop IV within the 5′ noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: Effects on IRES-mediated translation and viral infectivity

    Article • Virology, June 2009, Elsevier

    Professor Bert L Semler

  45. The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation

    Article • Virology, September 2008, Elsevier

    Professor Bert L Semler

  46. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes

    Article • Trends in Microbiology, January 2008, Elsevier

    Professor Bert L Semler

  47. Alternative polyadenylation signals in the 3′ non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression

    Article • Gene, January 2008, Elsevier

    Professor Bert L Semler

  48. Picornaviruses: Molecular Biology

    Article • January 2008, Elsevier

    Professor Bert L Semler

  49. Cellular Protein Modification by Poliovirus: the Two Faces of Poly(rC)-Binding Protein

    Article • Journal of Virology, June 2007, ASM Journals

    Professor Bert L Semler

  50. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation

    Article • The EMBO Journal, December 2006, Wiley

    Professor Bert L Semler

  51. Gene Expression and Replication of Picornaviruses

    Article • September 2006, Wiley

    Professor Bert L Semler

  52. An Authentic 3′ Noncoding Region Is Necessary for Efficient Poliovirus Replication

    Article • Journal of Virology, September 2005, ASM Journals

    Professor Bert L Semler

  53. Resistance is futile

    Article • Nature Genetics, July 2005, Springer Science + Business Media

    Professor Bert L Semler

  54. Allosteric Effects of Ligands and Mutations on Poliovirus RNA-Dependent RNA Polymerase

    Article • Journal of Virology, June 2005, ASM Journals

    Professor Bert L Semler

  55. Functional Interaction of Heterogeneous Nuclear Ribonucleoprotein C with Poliovirus RNA Synthesis Initiation Complexes

    Article • Journal of Virology, March 2005, ASM Journals

    Professor Bert L Semler

  56. Atomic Force Microscopy Analysis of Icosahedral Virus RNA

    Article • Journal of Molecular Biology, March 2005, Elsevier

    Professor Bert L Semler

  57. Differential Rescue of Poliovirus RNA Replication Functions by Genetically Modified RNA Polymerase Precursors

    Article • Journal of Virology, December 2004, ASM Journals

    Professor Bert L Semler

  58. Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES

    Article • July 2004, Cold Spring Harbor Laboratory Press

    Professor Bert L Semler

  59. Poliovirus proves IRES-istible in vivo

    Article • Journal of Clinical Investigation, June 2004, American Society for Clinical Investigation

    Professor Bert L Semler

  60. Regulation of picornavirus gene expression

    Article • Microbes and Infection, June 2004, Elsevier

    Professor Bert L Semler

  61. Strand-Specific RNA Synthesis Determinants in the RNA-Dependent RNA Polymerase of Poliovirus

    Article • Journal of Virology, May 2004, ASM Journals

    Professor Bert L Semler

  62. Cell-Dependent Role for the Poliovirus 3′ Noncoding Region in Positive-Strand RNA Synthesis

    Article • Journal of Virology, February 2004, ASM Journals

    Professor Bert L Semler

  63. Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirus

    Article • Virology, September 2003, Elsevier

    Professor Bert L Semler

  64. Distinct Poly(rC) Binding Protein KH Domain Determinants for Poliovirus Translation Initiation and Viral RNA Replication

    Article • Journal of Virology, December 2002, ASM Journals

    Professor Bert L Semler

  65. Molecular Biology of Picornavirus

    Article • September 2002, ASM Journals

    Professor Bert L Semler

  66. Subdomain Specific Functions of the RNA Polymerase Region of Poliovirus 3CD Polypeptide

    Article • Virology, July 2002, Elsevier

    Professor Bert L Semler

  67. Requirements for Assembly of Poliovirus Replication Complexes and Negative-Strand RNA Synthesis

    Article • Journal of Virology, April 2001, ASM Journals

    Professor Bert L Semler

  68. A Group B Coxsackievirus/Poliovirus 5′ Nontranslated Region Chimera Can Act as an Attenuated Vaccine Strain in Mice

    Article • Journal of Virology, May 2000, ASM Journals

    Professor Bert L Semler

  69. Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements

    Article • RNA, December 1999, Cold Spring Harbor Laboratory Press

    Professor Bert L Semler

  70. Pyrimidine-Rich Region Mutations Compensate for a Stem-Loop V Lesion in the 5′ Noncoding Region of Poliovirus Genomic RNA

    Article • Virology, November 1999, Elsevier

    Professor Bert L Semler

  71. Modulation of the RNA Binding and Protein Processing Activities of Poliovirus Polypeptide 3CD by the Viral RNA Polymerase Domain

    Article • Journal of Biological Chemistry, April 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bert L Semler

  72. RNA structure adjacent to the attenuation determinant in the 5'-non-coding region influences poliovirus viability

    Article • Nucleic Acids Research, December 1998, Oxford University Press (OUP)

    Professor Bert L Semler

  73. Translation and Replication Properties of the Human Rhinovirus Genomein Vivoandin Vitro

    Article • Virology, March 1997, Elsevier

    Professor Bert L Semler

  74. RNA Determinants of Picornavirus Cap-Independent Translation Initiation

    Article • Seminars in Virology, January 1997, Elsevier

    Professor Bert L Semler

  75. Determinants of Membrane Association for Poliovirus Protein 3AB

    Article • Journal of Biological Chemistry, October 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bert L Semler

  76. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry.

    Article • Proceedings of the National Academy of Sciences, October 1996, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  77. Mutations in the Poliovirus 3CD Proteinase S1-Specificity Pocket Affect Substrate Recognition and RNA Binding

    Article • Virology, April 1996, Elsevier

    Professor Bert L Semler

  78. Stem-Loop Structure Synergy in Binding Cellular Proteins to the 5′| Noncoding Region of Poliovirus RNA

    Article • Virology, February 1995, Elsevier

    Professor Bert L Semler

  79. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes

    Article • Microbiological Reviews, December 1993, ASM Journals

    Professor Bert L Semler

  80. 3CD Cleavage of the Poliovirus P1 Precursor: A Model for Complex Proteinase/Substrate Interactions

    Article • January 1993, Springer Science + Business Media

    Professor Bert L Semler

  81. Alternate poliovirus nonstructural protein processing cascades generated by primary sites of 3C proteinase cleavage

    Article • Virology, November 1992, Elsevier

    Professor Bert L Semler

  82. High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus.

    Article • Proceedings of the National Academy of Sciences, April 1992, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  83. Self-cleaving proteases

    Article • Current Opinion in Cell Biology, December 1991, Elsevier

    Professor Bert L Semler

  84. Poliovirus translation initiation: Differential effects of directed and selected mutations in the 5′ noncoding region of viral RNAs

    Article • Virology, June 1991, Elsevier

    Professor Bert L Semler

  85. A genetic locus in mutant poliovirus genomes involved in overproduction of RNA polymerase and 3C proteinase

    Article • Virology, February 1990, Elsevier

    Professor Bert L Semler

  86. Polyprotein processing of Theiler's murine encephalomyelitis virus

    Article • Journal of Virology, December 1989, ASM Journals

    Professor Bert L Semler

  87. Protein 3CD is the major poliovirus proteinase responsible for cleavage of the p1 capsid precursor

    Article • Virology, September 1988, Elsevier

    Professor Bert L Semler

  88. Defined recombinants of poliovirus and coxsackievirus: Sequence-specific deletions and functional substitutions in the 5′-noncoding regions of viral RNAs

    Article • Virology, January 1988, Elsevier

    Professor Bert L Semler

  89. The Development of New Poliovirus Vaccines Based on Molecular Cloning

    Article • January 1988, Springer Science + Business Media

    Professor Bert L Semler

  90. Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.

    Article • Proceedings of the National Academy of Sciences, January 1988, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  91. The Molecular Biology of Poliovirus.Friedrich Koch , Gebhard Koch

    Article • The Quarterly Review of Biology, September 1987, University of Chicago Press

    Professor Bert L Semler

  92. Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids

    Article • Virology, April 1987, Elsevier

    Professor Bert L Semler

  93. Site-specific mutagenesis of cDNA clones expressing a poliovirus proteinase

    Article • Journal of Cellular Biochemistry, January 1987, Wiley

    Professor Bert L Semler

  94. in vitromolecular genetics as a tool for determining the differential cleavage specificities of the polivirus 3C proteinase

    Article • Nucleic Acids Research, January 1987, Oxford University Press (OUP)

    Professor Bert L Semler

  95. An Infectious cDNA clone of the poliovirus sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine

    Article • Virology, May 1986, Elsevier

    Professor Bert L Semler

  96. A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive.

    Article • Proceedings of the National Academy of Sciences, March 1986, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  97. Organization of the poliovirus genome and the sites for proteolytic processing

    Article • Biochemical Society Transactions, August 1984, Portland Press Ltd.

    Professor Bert L Semler

  98. Expression of a cloned gene segment of poliovirus in E. coli: Evidence for autocatalytic production of the viral proteinase

    Article • Cell, July 1984, Elsevier

    Professor Bert L Semler

  99. Structure, Proteolytic Processing, and Neutralization Antigenic Sites of Poliovirus

    Article • January 1984, Springer Science + Business Media

    Professor Bert L Semler

  100. Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals

    Article • Nucleic Acids Research, January 1984, Oxford University Press (OUP)

    Professor Bert L Semler

  101. Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides

    Article • Virology, July 1983, Elsevier

    Professor Bert L Semler

  102. Poliovirus RNA synthesis in Vitro: Structuralelements and antibody inhibition

    Article • Virology, April 1983, Elsevier

    Professor Bert L Semler

  103. Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs.

    Article • Proceedings of the National Academy of Sciences, July 1982, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  104. A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide

    Article • Cell, February 1982, Elsevier

    Professor Bert L Semler

  105. Cleavage sites in the polypeptide precursors of poliovirus protein P2-X

    Article • Virology, October 1981, Elsevier

    Professor Bert L Semler

  106. Primary structure, gene organization and polypeptide expression of poliovirus RNA

    Article • Nature, June 1981, Springer Science + Business Media

    Professor Bert L Semler

  107. Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing.

    Article • Proceedings of the National Academy of Sciences, June 1981, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  108. Structure, Possible Function, and Biosynthesis of VPg, the Genome-linked Protein of Poliovirus

    Article • January 1981, Springer Science + Business Media

    Professor Bert L Semler

  109. Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro

    Article • Nature, October 1980, Springer Science + Business Media

    Professor Bert L Semler

  110. Virus protein changes and RNA termini alterations evolving during persistent infection

    Article • Cell, April 1980, Elsevier

    Professor Bert L Semler

  111. Defective Interfering RNA Viruses and the Host-Cell Response

    Article • January 1980, Springer Science + Business Media

    Professor Bert L Semler

  112. VIRAL MUTATION IN PERSISTENT INFECTION

    Article • January 1980, Elsevier

    Professor Bert L Semler

  113. Internal genome deletions in two distinct classes of defective interfering particles of vesicular stomatitis virus.

    Article • Proceedings of the National Academy of Sciences, December 1979, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  114. Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini

    Article • Journal of Virology, November 1979, ASM Journals

    Professor Bert L Semler

  115. Evolution of multiple genome mutations during long-term persistent infection by vesicular stomatitis virus

    Article • Cell, March 1979, Elsevier

    Professor Bert L Semler

  116. The nucleotide sequence of the 5′ terminus of vesicular stomatitis virus RNA

    Article • Nucleic Acids Research, January 1979, Oxford University Press (OUP)

    Professor Bert L Semler

  117. Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus.

    Article • Proceedings of the National Academy of Sciences, October 1978, Proceedings of the National Academy of Sciences

    Professor Bert L Semler

  118. DEFECTIVE INTERFERING VIRUS PARTICLES ATTENUATE VIRUS LETHALITY IN VIVO AND IN VITRO

    Article • January 1976, Elsevier

    Professor Bert L Semler

  119. Genome Replication I: the Players

    Article • ASM Journals

    Professor Bert L Semler

  120. Genome Replication II: the Process

    Article • ASM Journals

    Professor Bert L Semler

  121. Coxsackievirus B RNA Replication: Lessons from Poliovirus

    Article • Springer Science + Business Media

    Professor Bert L Semler