All Stories

  1. IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity

    Article • Microbiome, June 2026, Springer Science + Business Media

    Ashutosh Mangalam

  2. The distinct roles of Negativicoccus and Fusobacterium in proximal- and late-onset colorectal cancer

    Article • Gut Microbes, April 2026, Taylor & Francis

    Ashutosh Mangalam

  3. Predicting Dietary Impact on Multiple Sclerosis‐Related Symptoms With the Gut Microbiome: A Pilot Study Using Unsupervised Machine Learning

    Article • Brain and Behavior, April 2026, Wiley

    Ashutosh Mangalam

  4. The effect of dietary interventions on peripheral markers of inflammation among people with multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials

    Article • Multiple Sclerosis and Related Disorders, February 2026, Elsevier

    Ashutosh Mangalam

  5. Efficacy of Diet on Quality of life in Multiple Sclerosis (EDQ-MS): a study protocol for a randomized controlled clinical trial

    Article • Trials, October 2025, Springer Science + Business Media

    Ashutosh Mangalam

  6. Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level

    Article • npj Biofilms and Microbiomes, October 2025, Springer Science + Business Media

    Ashutosh Mangalam

  7. Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

    Article • Annals of Clinical and Translational Neurology, October 2025, Wiley

    Ashutosh Mangalam

  8. Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice

    Article • Frontiers in Oncology, July 2025, Frontiers

    Ashutosh Mangalam

  9. Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture

    Article • Journal of Hazardous Materials, June 2025, Elsevier

    Ashutosh Mangalam

  10. Dysbiotic Microbiome–Metabolome Axis in Childhood Obesity and Metabolic Syndrome

    Article • Journal of Dental Research, May 2025, SAGE Publications

    Ashutosh Mangalam

  11. RiboTag-based RNA profiling uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis: implications for pathogenesis

    Article • Journal of Neuroinflammation, May 2025, Springer Science + Business Media

    Ashutosh Mangalam

  12. Decoding the Gut's Whisper: Could This Microbial Code Unlock Better MS Care?

    Article • Proceedings of the National Academy of Sciences, March 2025, Proceedings of the National Academy of Sciences

    Ashutosh Mangalam

  13. Gut Microbiome and Symptom Burden in Obese and Non-Obese Women Receiving Chemotherapy for Breast Cancer

    Article • Biological Research For Nursing, February 2025, SAGE Publications

    Ashutosh Mangalam

  14. RiboTag-based RNA-Seq uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis

    Article • December 2024, openRxiv

    Ashutosh Mangalam

  15. Inhalation of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract

    Article • Journal of Hazardous Materials, December 2024, Elsevier

    Ashutosh Mangalam

  16. Rigid crosslinking of the CD3 complex leads to superior T cell stimulation

    Article • Frontiers in Immunology, August 2024, Frontiers

    Ashutosh Mangalam

  17. Looking at the full picture, using topic modeling to observe microbiome communities associated with disease

    Article • Gut Microbes Reports, August 2024, Taylor & Francis

    Ashutosh Mangalam

  18. Game of microbes: the battle within – gut microbiota and multiple sclerosis

    Article • Gut Microbes, August 2024, Taylor & Francis

    Ashutosh Mangalam

  19. Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls

    Article • Biological Research For Nursing, October 2023, SAGE Publications

    Ashutosh Mangalam

  20. A UPLC-MS/MS Based Rapid, Sensitive, and Non-Enzymatic Methodology for Quantitation of Dietary Isoflavones in Biological Fluids

    Article • Molecules, September 2023, MDPI AG

    Ashutosh Mangalam

  21. Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria

    Article • European Journal of Immunology, September 2023, Wiley

    Ashutosh Mangalam

  22. Looking at the Full Picture: Utilizing Topic Modeling to Determine Disease-Associated Microbiome Communities

    Article • July 2023, openRxiv

    Ashutosh Mangalam

  23. Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases

    Article • Frontiers in Endocrinology, June 2023, Frontiers

    Ashutosh Mangalam

  24. Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis

    Article • Environmental Toxicology and Pharmacology, June 2023, Elsevier

    Ashutosh Mangalam

  25. Effect of a Fructose-Rich Diet on Gut Microbiota and Immunomodulation: Potential Factors for Multiple Sclerosis

    Article • ImmunoHorizons, March 2023, Oxford University Press (OUP)

    Ashutosh Mangalam

  26. Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria

    Article • Scientific Reports, January 2023, Springer Science + Business Media

    Ashutosh Mangalam

  27. Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism

    Article • Metabolomics, October 2022, Springer Science + Business Media

    Ashutosh Mangalam

  28. TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens

    Article • Journal of Dental Research, October 2022, SAGE Publications

    Ashutosh Mangalam

  29. Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation

    Article • Gut Microbes, September 2022, Taylor & Francis

    Ashutosh Mangalam

  30. Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis

    Article • Frontiers in Immunology, September 2022, Frontiers

    Ashutosh Mangalam

  31. Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed the testable therapeutic target

    Article • Proceedings of the National Academy of Sciences, June 2022, Proceedings of the National Academy of Sciences

    Ashutosh Mangalam

  32. Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness

    Article • PLOS One, April 2022, PLOS

    Ashutosh Mangalam

  33. IL-17A-mediated alterations in gut microbiota composition, particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

    Article • April 2022, openRxiv

    Ashutosh Mangalam

  34. Role of microbiome and metabolome in the pathobiology of MS

    Article • Clinical Immunology, February 2022, Elsevier

    Ashutosh Mangalam

  35. Administration of Human Derived Upper gut Commensal Prevotella histicola delays the onset of type 1 diabetes in NOD mice

    Article • BMC Microbiology, January 2022, Springer Science + Business Media

    Ashutosh Mangalam

  36. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

    Article • Immunity, January 2022, Elsevier

    Ashutosh Mangalam

  37. Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics

    Article • January 2022, Elsevier

    Ashutosh Mangalam

  38. Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease

    Article • Cell Reports, December 2021, Elsevier

    Ashutosh Mangalam

  39. Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects

    Article • Surgery for Obesity and Related Diseases, December 2021, Elsevier

    Ashutosh Mangalam

  40. The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice

    Article • Toxicological Sciences, November 2021, Oxford University Press (OUP)

    Ashutosh Mangalam

  41. Autoimmunity Increases Susceptibility to and Mortality from Sepsis

    Article • ImmunoHorizons, October 2021, Oxford University Press (OUP)

    Ashutosh Mangalam

  42. Fungal microbiome and multiple sclerosis: The not-so-new kid on the block

    Article • EBioMedicine, October 2021, Elsevier

    Ashutosh Mangalam

  43. Blood-based untargeted metabolomics in Relapsing-Remitting Multiple Sclerosis revealed the testable therapeutic target

    Article • September 2021, openRxiv

    Ashutosh Mangalam

  44. Multiple Sclerosis Patients have an Altered Gut Mycobiome and Increased Fungal to Bacterial Richness

    Article • September 2021, openRxiv

    Ashutosh Mangalam

  45. HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

    Article • ImmunoHorizons, August 2021, Oxford University Press (OUP)

    Ashutosh Mangalam

  46. Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer

    Article • BMC Cancer, July 2021, Springer Science + Business Media

    Ashutosh Mangalam

  47. Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis

    Article • Science Advances, July 2021, American Association for the Advancement of Science

    Ashutosh Mangalam

  48. Effect of bacterial contamination in bile on pancreatic cancer cell survival

    Article • Surgery, March 2021, Elsevier

    Ashutosh Mangalam

  49. The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges

    Article • Indian Journal of Rheumatology, March 2021, SAGE Publications

    Ashutosh Mangalam

  50. Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis

    Article • Frontiers in Immunology, December 2020, Frontiers

    Ashutosh Mangalam

  51. Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells

    Article • eLife, November 2020, eLife

    Ashutosh Mangalam

  52. Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases

    Article • Frontiers in Immunology, October 2020, Frontiers

    Ashutosh Mangalam

  53. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

    Article • Cell Reports, October 2020, Elsevier

    Ashutosh Mangalam

  54. Editorial: The Role of the Gut Microbiota in Health and Inflammatory Diseases

    Article • Frontiers in Immunology, September 2020, Frontiers

    Ashutosh Mangalam

  55. Beyond Metabolism: The Complex Interplay Between Dietary Phytoestrogens, Gut Bacteria, and Cells of Nervous and Immune Systems

    Article • Frontiers in Neurology, March 2020, Frontiers

    Ashutosh Mangalam

  56. Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Ashutosh Mangalam

  57. Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

    Article • Journal of Visualized Experiments, October 2019, MyJove Corporation

    Ashutosh Mangalam

  58. Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis

    Article • Frontiers in Immunology, March 2019, Frontiers

    Ashutosh Mangalam

  59. Utility of CD64 Expression on Neutrophils as a Marker to Differentiate Infectious versus Noninfectious Disease Flares in Autoimmune Disorders

    Article • Indian Journal of Rheumatology, March 2019, SAGE Publications

    Ashutosh Mangalam

  60. Drugs, bugs, and MS

    Article • Neurology Neuroimmunology & Neuroinflammation, January 2019, Wolters Kluwer Health

    Ashutosh Mangalam

  61. Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis

    Article • Expert Review of Neurotherapeutics, December 2018, Taylor & Francis

    Joseph Murray, Ashutosh Mangalam

  62. Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy

    Article • Gut Microbes, September 2018, Taylor & Francis

    Ashutosh Mangalam

  63. The “Gut Feeling”: Breaking Down the Role of Gut Microbiome in Multiple Sclerosis

    Article • Neurotherapeutics, January 2018, Elsevier

    Ashutosh Mangalam

  64. Reply

    Article • Arthritis & Rheumatology, December 2017, Wiley

    Joseph Murray, Ashutosh Mangalam

  65. Recovery from the Middle East respiratory syndrome is associated with antibody and T cell responses

    Article • Science Immunology, August 2017, American Association for the Advancement of Science

    Ashutosh Mangalam

  66. Gut microbiome in multiple sclerosis: The players involved and the roles they play

    Article • Gut Microbes, August 2017, Taylor & Francis

    Ashutosh Mangalam

  67. Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

    Article • Cell Reports, August 2017, Elsevier

    Ashutosh Mangalam

  68. Suppression of Inflammatory Arthritis by Human Gut‐Derived Prevotella histicola in Humanized Mice

    Article • Arthritis & Rheumatology, November 2016, Wiley

    Ashutosh Mangalam

  69. Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

    Article • Journal of Cell Science, October 2016, The Company of Biologists

    Ashutosh Mangalam

  70. AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis

    Article • The Journal of Immunology, August 2016, Oxford University Press (OUP)

    Ashutosh Mangalam

  71. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Ashutosh Mangalam

  72. Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

    Article • Immunity, June 2016, Elsevier

    Ashutosh Mangalam

  73. Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis

    Article • Journal of Biological Chemistry, December 2015, Elsevier

    Ashutosh Mangalam

  74. IM-TORNADO: A Tool for Comparison of 16S Reads from Paired-End Libraries

    Article • PLOS One, December 2014, PLOS

    Ashutosh Mangalam

  75. Absence of IFN-γ Increases Brain Pathology in Experimental Autoimmune Encephalomyelitis–Susceptible DRB1*0301.DQ8 HLA Transgenic Mice through Secretion of Proinflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the Central N...

    Article • The Journal of Immunology, November 2014, Oxford University Press (OUP)

    Ashutosh Mangalam

  76. HLA Class II Molecules Influence Susceptibility versus Protection in Inflammatory Diseases by Determining the Cytokine Profile

    Article • The Journal of Immunology, January 2013, Oxford University Press (OUP)

    Ashutosh Mangalam

  77. WASH Knockout T Cells Demonstrate Defective Receptor Trafficking, Proliferation, and Effector Function

    Article • Molecular and Cellular Biology, December 2012, ASM Journals

    Ashutosh Mangalam

  78. Two discreet subsets of CD8 T cells modulate PLP91–110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

    Article • Journal of Autoimmunity, June 2012, Elsevier

    Ashutosh Mangalam

  79. Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: Studies using HLA transgenic mice

    Article • Journal of Autoimmunity, September 2011, Elsevier

    Dikshya Bastakoty, Ashutosh Mangalam

  80. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

    Article • Biochemical and Biophysical Research Communications, August 2009, Elsevier

    Ashutosh Mangalam

  81. HLA-DQ8 (DQB1*0302)-Restricted Th17 Cells Exacerbate Experimental Autoimmune Encephalomyelitis in HLA-DR3-Transgenic Mice

    Article • The Journal of Immunology, April 2009, Oxford University Press (OUP)

    Ashutosh Mangalam

  82. HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases

    Article • January 2008, Elsevier

    Ashutosh Mangalam

  83. A New Humanized HLA Transgenic Mouse Model of Multiple Sclerosis Expressing Class II on Mouse CD4 T Cells

    Article • Annals of the New York Academy of Sciences, April 2007, Wiley

    Ashutosh Mangalam

  84. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans

    Article • Autoimmunity, January 2007, Taylor & Francis

    Ashutosh Mangalam

  85. Distinct local immunogenic stimuli dictate differential requirements for CD4+and CD8+T cell subsets in the pathogenesis of spontaneous autoimmune diabetes

    Article • Autoimmunity, January 2007, Taylor & Francis

    Ashutosh Mangalam

  86. New humanized HLA–DR4–transgenic mice that mimic the sex bias of rheumatoid arthritis

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Ashutosh Mangalam

  87. Role of MHC class II expressing CD4+ T cells in proteolipid protein91–110‐induced EAE in HLA‐DR3 transgenic mice

    Article • European Journal of Immunology, November 2006, Wiley

    Ashutosh Mangalam

  88. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice

    Article • Journal of Neuroimmunology, December 2005, Elsevier

    Ashutosh Mangalam

  89. Delineation of the minimal encephalitogenic epitope of proteolipid protein peptide91–110 and critical residues required for induction of EAE in HLA-DR3 transgenic mice

    Article • Journal of Neuroimmunology, April 2005, Elsevier

    Ashutosh Mangalam

  90. Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II‐transgenic mice

    Article • European Journal of Immunology, December 2003, Wiley

    Ashutosh Mangalam

  91. Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-α through ceramide pathway

    Article • Cellular Immunology, September 2002, Elsevier

    Ashutosh Mangalam

  92. Mechanism of action of disease modifying anti-rheumatic agent, gold sodium thiomalate (GSTM)

    Article • International Immunopharmacology, June 2001, Elsevier

    Ashutosh Mangalam