All Stories

  1. Epithelial PCSK6 Promotes Proliferation and Decreases Collagen Deposition by Fibroblasts Potentially via MMP Activation

    Article • International Journal of Molecular Sciences, June 2026, MDPI AG

    Arnold Spek

  2. Identification of C/EBPδ‐Modifying Compounds as Potential Anticancer Agents Using a High‐Throughput Drug Screen

    Article • Journal of Cellular and Molecular Medicine, January 2025, Wiley

    Arnold Spek

  3. Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery

    Article • Oncogenesis, November 2024, Springer Science + Business Media

    Arnold Spek

  4. Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer

    Article • International Journal of Molecular Sciences, August 2024, MDPI AG

    Arnold Spek

  5. Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer

    Article • International Journal of Molecular Sciences, June 2023, MDPI AG

    Arnold Spek

  6. PCSK6: The Endogenous PAR-1 Agonist Driving Pulmonary Fibrosis?

    Article • American Journal of Respiratory and Critical Care Medicine, March 2023, American Thoracic Society

    Arnold Spek

  7. C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Arnold Spek

  8. C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

    Article • Cells, October 2022, MDPI AG

    Arnold Spek

  9. Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation

    Article • June 2022, Springer Science + Business Media

    Arnold Spek

  10. Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

    Article • American Journal of Respiratory and Critical Care Medicine, April 2022, American Thoracic Society

    Arnold Spek

  11. Mesoporous Silica Nanoparticle-Based Drug Delivery Systems for the Treatment of Pancreatic Cancer: A Systematic Literature Overview

    Article • Pharmaceutics, February 2022, MDPI AG

    Arnold Spek

  12. Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner

    Article • Biomedicines, January 2022, MDPI AG

    Arnold Spek

  13. CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs

    Article • Cells, August 2021, MDPI AG

    Arnold Spek

  14. Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation

    Article • Biomolecules, July 2021, MDPI AG

    Arnold Spek

  15. ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

    Article • Cancers, July 2021, MDPI AG

    Arnold Spek

  16. Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma

    Article • Molecular Oncology, May 2021, Wiley

    Arnold Spek

  17. Alveolar epithelial TET2 is not involved in the development of bleomycin‐induced pulmonary fibrosis

    Article • The FASEB Journal, April 2021, Wiley

    Wanhai Qin, Arnold Spek

  18. Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion

    Article • BMC Cancer, December 2020, Springer Science + Business Media

    Arnold Spek

  19. Thrombin-mediated vasculogenic mimicry: important lessons to improve anticoagulant therapy of selected cancer patients

    Article • Signal Transduction and Targeted Therapy, October 2020, Springer Science + Business Media

    Arnold Spek

  20. CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells

    Article • Cancers, September 2020, MDPI AG

    Arnold Spek

  21. Idiopathic pulmonary fibrosis: do scientists focus on publishing rather than on clinical relevance?

    Article • European Respiratory Journal, June 2020, European Respiratory Society (ERS)

    Arnold Spek

  22. Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?

    Article • Biology, April 2020, MDPI AG

    Arnold Spek

  23. Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?

    Article • Journal of Clinical Medicine, September 2019, MDPI AG

    Arnold Spek

  24. Pharmacological PAR‐1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy

    Article • The FASEB Journal, July 2019, Wiley

    Arnold Spek

  25. Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling

    Article • Journal of Biological Chemistry, June 2019, Elsevier

    Arnold Spek

  26. Is idiopathic pulmonary fibrosis a cancer-like disease? Transcriptome analysis to fuel the debate

    Article • ERJ Open Research, February 2019, European Respiratory Society (ERS)

    Arnold Spek

  27. Protease‐activated receptor‐1 impedes prostate and intestinal tumor progression in mice: comment

    Article • Journal of Thrombosis and Haemostasis, January 2019, Elsevier

    Arnold Spek

  28. Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy

    Article • Journal of Cellular and Molecular Medicine, November 2018, Wiley

    Arnold Spek

  29. Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma

    Article • Carcinogenesis, October 2018, Oxford University Press (OUP)

    Arnold Spek

  30. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer

    Article • Oncotarget, August 2018, Impact Journals, LLC

    Arnold Spek

  31. Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice

    Article • Oncotarget, April 2018, Impact Journals, LLC

    Arnold Spek

  32. Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia

    Article • The Journal of Infectious Diseases, February 2018, Oxford University Press (OUP)

    Arnold Spek

  33. Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner

    Article • Biochemistry and Biophysics Reports, July 2017, Elsevier

    Arnold Spek

  34. Association between protein C levels and mortality in patients with advanced prostate, lung and pancreatic cancer

    Article • Thrombosis Research, June 2017, Elsevier

    Arnold Spek

  35. Targeting coagulation factor receptors – protease‐activated receptors in idiopathic pulmonary fibrosis

    Article • Journal of Thrombosis and Haemostasis, April 2017, Elsevier

    Arnold Spek

  36. Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

    Article • BMC Cancer, February 2017, Springer Science + Business Media

    Arnold Spek

  37. Dabigatran Potentiates Gemcitabine-Induced Growth Inhibition of Pancreatic Cancer in Mice

    Article • Extremophiles, January 2017, Springer Science + Business Media

    Arnold Spek

  38. Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection

    Article • BMC Infectious Diseases, November 2016, Springer Science + Business Media

    Arnold Spek

  39. Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Arnold Spek

  40. High endogenous activated protein C levels attenuates bleomycin‐induced pulmonary fibrosis

    Article • Journal of Cellular and Molecular Medicine, June 2016, Wiley

    Arnold Spek

  41. CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis

    Article • Journal of Neuroinflammation, May 2015, Springer Science + Business Media

    Arnold Spek

  42. Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes

    Article • Scientific Reports, March 2015, Springer Science + Business Media

    Arnold Spek

  43. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    Article • Journal of Cellular and Molecular Medicine, February 2015, Wiley

    Arnold Spek

  44. Authors' reply-Re: Shi et al. Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model. J Pathol 2014;234: 398-409

    Article • The Journal of Pathology, January 2015, Wiley

    Arnold Spek

  45. Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model

    Article • The Journal of Pathology, September 2014, Wiley

    Arnold Spek

  46. Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance

    Article • International Journal of Cancer, June 2014, Wiley

    Arnold Spek

  47. The anti-coagulants ASIS or APC do not protect against renal ischemia/ reperfusion injury

    Article • ScienceOpen Research, June 2014, ScienceOpen

    Arnold Spek

  48. The Effect of Levothyroxine on Expression of Inflammation-Related Genes in Healthy Subjects: A Controlled Randomized Crossover Study

    Article • Hormone and Metabolic Research, April 2014, Thieme Publishing Group

    Arnold Spek

  49. CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy

    Article • Laboratory Investigation, January 2014, Elsevier

    Arnold Spek

  50. Protease‐activated receptor‐2 induces migration of pancreatic cancer cells in an extracellular ATP‐dependent manner

    Article • Journal of Thrombosis and Haemostasis, October 2013, Elsevier

    Arnold Spek

  51. Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

    Article • Thorax, September 2013, BMJ

    Arnold Spek

  52. Correction for Duitman et al., CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

    Article • Proceedings of the National Academy of Sciences, August 2013, Proceedings of the National Academy of Sciences

    Arnold Spek

  53. Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model

    Article • PLOS One, April 2013, PLOS

    Professor Paul HA Quax, Arnold Spek

  54. CCAAT/enhancer-binding protein delta (C/EBPδ) plays a minor role in renal host defense against uropathogenicEscherichia coli

    Article • Transplant Infectious Disease, April 2013, Wiley

    Arnold Spek

  55. CCAAT/Enhancer-Binding Protein δ

    Article • American Journal Of Pathology, April 2013, Elsevier

    Arnold Spek

  56. Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo

    Article • PLOS One, January 2013, PLOS

    Arnold Spek

  57. CCAAT-Enhancer Binding Protein Delta (C/EBPδ) Protects Against Klebsiella pneumoniae–Induced Pulmonary Infection: Potential Role for Macrophage Migration

    Article • The Journal of Infectious Diseases, December 2012, Oxford University Press (OUP)

    Arnold Spek

  58. Characterization of coagulation factor synthesis in nine human primary cell types

    Article • Scientific Reports, November 2012, Springer Science + Business Media

    Arnold Spek

  59. Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse

    Article • PLOS One, October 2012, PLOS

    Arnold Spek

  60. Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice: Figure 1–

    Article • European Respiratory Journal, September 2012, European Respiratory Society (ERS)

    Arnold Spek

  61. Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?

    Article • Journal of Cellular and Molecular Medicine, August 2012, Wiley

    Arnold Spek

  62. Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors

    Article • Drug Resistance Updates, August 2012, Elsevier

    Arnold Spek

  63. The Acute-phase Response Is Not Predictive for the Development of Arthritis in Seropositive Arthralgia – A Prospective Cohort Study

    Article • The Journal of Rheumatology, August 2012, The Journal of Rheumatology

    Arnold Spek

  64. CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

    Article • Proceedings of the National Academy of Sciences, May 2012, Proceedings of the National Academy of Sciences

    Arnold Spek

  65. The protein C pathway in cancer metastasis

    Article • Thrombosis Research, April 2012, Elsevier

    Arnold Spek

  66. Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques

    Article • Extremophiles, February 2012, Springer Science + Business Media

    Arnold Spek

  67. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

    Article • Blood, September 2011, American Society of Hematology

    Arnold Spek

  68. Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation

    Article • Cancer Letters, July 2011, Elsevier

    Arnold Spek

  69. Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis

    Article • Extremophiles, June 2011, Springer Science + Business Media

    Arnold Spek

  70. mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient With Peutz-Jeghers Syndrome

    Article • Journal of Clinical Oncology, February 2011, American Society of Clinical Oncology (ASCO)

    Arnold Spek

  71. Blood coagulation factor Xa as an emerging drug target

    Article • Expert Opinion on Therapeutic Targets, January 2011, Informa Healthcare

    Arnold Spek

  72. The Role of Coagulation in Chronic Inflammatory Disorders: A Jack of All Trades

    Article • Current Pharmaceutical Design, January 2011, Bentham Science Publishers

    Arnold Spek

  73. Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury

    Article • American Journal Of Pathology, December 2010, Elsevier

    Arnold Spek

  74. Human Plasma Very Low Density Lipoprotein Carries Indian Hedgehog

    Article • Journal of Proteome Research, September 2010, American Chemical Society (ACS)

    Arnold Spek

  75. Hedgehog signaling maintains chemoresistance in myeloid leukemic cells

    Article • Oncogene, August 2010, Springer Science + Business Media

    Arnold Spek

  76. Assessing the efficacy of the Hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer

    Article • Cancer Biology & Therapy, July 2010, Taylor & Francis

    Arnold Spek

  77. A Low Molecular Weight Heparin Inhibits Experimental Metastasis in Mice Independently of the Endothelial Glycocalyx

    Article • PLOS One, June 2010, PLOS

    Arnold Spek

  78. Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation

    Article • Thrombosis Research, June 2010, Elsevier

    Arnold Spek

  79. Canonical Hedgehog signaling drives proangiogenic responses in endothelial cells

    Article • Cell Cycle, May 2010, Taylor & Francis

    Arnold Spek

  80. The role of activated protein C in cancer progression

    Article • Thrombosis Research, April 2010, Elsevier

    Arnold Spek

  81. Experimental and clinical effects of anticoagulants on cancer progression

    Article • Thrombosis Research, April 2010, Elsevier

    Arnold Spek

  82. The Hedgehog morphogen in myocardial ischemia–reperfusion injury

    Article • Experimental Biology and Medicine, April 2010, SAGE Publications

    Arnold Spek

  83. Prophylactic plasma levels of the low molecular weight heparin nadroparin does not affect colon cancer tumor development in mouse liver

    Article • Thrombosis Research, March 2010, Elsevier

    Arnold Spek

  84. Protease-Activated Receptor 2 Blocking Peptide Counteracts Endotoxin-Induced Inflammation and Coagulation and Ameliorates Renal Fibrin Deposition in a Rat Model of Acute Renal Failure

    Article • Shock, March 2010, Wolters Kluwer Health

    Arnold Spek

  85. Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department

    Article • Critical Care Medicine, February 2010, Wolters Kluwer Health

    Arnold Spek

  86. PTX3 predicts severe disease in febrile patients at the emergency department

    Article • Journal of Infection, February 2010, Elsevier

    Arnold Spek

  87. Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

    Article • AIDS Research and Therapy, January 2010, Springer Science + Business Media

    Arnold Spek

  88. The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

    Article • Journal of Cellular and Molecular Medicine, November 2009, Wiley

    Arnold Spek

  89. Alternatively spliced tissue factor induces angiogenesis through integrin ligation

    Article • Proceedings of the National Academy of Sciences, November 2009, Proceedings of the National Academy of Sciences

    Arnold Spek

  90. Insider access: pepducin symposium explores a new approach to GPCR modulation

    Article • Annals of the New York Academy of Sciences, November 2009, Wiley

    Arnold Spek

  91. Letter in response to 'Coagulation and fibrosis in chronic liver disease'

    Article • Gut, October 2009, BMJ

    Arnold Spek

  92. Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus

    Article • Annals of the Rheumatic Diseases, September 2009, BMJ

    Arnold Spek

  93. Long‐term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis

    Article • Journal of Thrombosis and Haemostasis, September 2009, Elsevier

    Arnold Spek

  94. Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement

    Article • Blood, August 2009, American Society of Hematology

    Arnold Spek

  95. Corrigendum

    Article • Journal of Thrombosis and Haemostasis, August 2009, Elsevier

    Arnold Spek

  96. Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2009, Wolters Kluwer Health

    Arnold Spek

  97. Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation

    Article • Thrombosis Research, June 2009, Elsevier

    Arnold Spek

  98. C-Reactive Protein Elicits White Blood Cell Activation in Humans

    Article • The American Journal of Medicine, June 2009, Elsevier

    Arnold Spek

  99. Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency

    Article • Human Genetics, May 2009, Springer Science + Business Media

    Arnold Spek

  100. A mechanism for thrombin-dependent lung metastasis in patients with osteosarcoma

    Article • British Journal of Haematology, May 2009, Wiley

    Arnold Spek

  101. FXa-induced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, May 2009, Elsevier

    Arnold Spek

  102. Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity

    Article • Thrombosis Research, April 2009, Elsevier

    Arnold Spek

  103. Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice

    Article • Journal of Thrombosis and Haemostasis, February 2009, Elsevier

    Arnold Spek

  104. Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease?

    Article • Trends in Pharmacological Sciences, January 2009, Elsevier

    Arnold Spek

  105. Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung

    Article • Clinical & Experimental Metastasis, December 2008, Springer Science + Business Media

    Arnold Spek

  106. Gene Expression Profiles in Murine Influenza Pneumonia

    Article • Journal of Innate Immunity, October 2008, Karger Publishers

    Arnold Spek

  107. Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

    Article • Trends in Molecular Medicine, October 2008, Elsevier

    Arnold Spek

  108. Gene expression profile comparison of Barrett's esophagus epithelial cell cultures and biopsies

    Article • Diseases of the Esophagus, October 2008, Oxford University Press (OUP)

    Arnold Spek

  109. Hypoxia induces a hedgehog response mediated by HIF‐1α

    Article • Journal of Cellular and Molecular Medicine, September 2008, Wiley

    Arnold Spek

  110. TF:FVIIa‐specific activation of CREB upregulates proapoptotic proteins via protease‐activated receptor‐2

    Article • Journal of Thrombosis and Haemostasis, September 2008, Elsevier

    Arnold Spek

  111. Endogenous Hedgehog Expression Contributes to Myocardial Ischemia-Reperfusion–Induced Injury

    Article • Experimental Biology and Medicine, August 2008, SAGE Publications

    Arnold Spek

  112. Leukotriene Synthesis Is Required for Hedgehog‐Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation

    Article • Stem Cells, May 2008, Oxford University Press (OUP)

    Dr Henk Roelink, Arnold Spek

  113. Differential Gene Expression Changes in Children with Severe Dengue Virus Infections

    Article • PLoS Neglected Tropical Diseases, April 2008, PLOS

    Arnold Spek

  114. Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

    Article • Journal of Cellular and Molecular Medicine, March 2008, Wiley

    Arnold Spek

  115. Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

    Article • American Journal Of Pathology, February 2008, Elsevier

    Arnold Spek

  116. High factor VIIa levels do not promote tumor metastasis

    Article • Thrombosis and Haemostasis, January 2008, Thieme Publishing Group

    Arnold Spek

  117. (Pro-)vitamin D as treatment option for hedgehog-related malignancies

    Article • Medical Hypotheses, January 2008, Elsevier

    Arnold Spek

  118. Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

    Article • Cellular Signalling, December 2007, Elsevier

    Dr Henk Roelink, Arnold Spek

  119. Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation

    Article • Blood, November 2007, American Society of Hematology

    Arnold Spek

  120. Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice

    Article • Blood Coagulation & Fibrinolysis, October 2007, Wolters Kluwer Health

    Arnold Spek

  121. Gene Expression Profiling Identifies C/EBPδ as a Candidate Regulator of Endotoxin-induced Disseminated Intravascular Coagulation

    Article • American Journal of Respiratory and Critical Care Medicine, September 2007, American Thoracic Society

    Arnold Spek

  122. Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

    Article • Experimental Cell Research, July 2007, Elsevier

    Arnold Spek

  123. Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation

    Article • Journal of Cellular and Molecular Medicine, May 2007, Wiley

    Arnold Spek

  124. Protease-Activated Receptors, Apoptosis and Tumor Growth

    Article • Pathophysiology of Haemostasis and Thrombosis, January 2007, Karger Publishers

    Arnold Spek

  125. Factor V Leiden and the etiology of inflammatory bowel disease

    Article • Thrombosis and Haemostasis, January 2007, Thieme Publishing Group

    Arnold Spek

  126. Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment

    Article • British Journal of Pharmacology, November 2006, Wiley

    Arnold Spek

  127. Hedgehog Morphogen in Cardiovascular Disease

    Article • Circulation, October 2006, Wolters Kluwer Health

    Arnold Spek

  128. A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?

    Article • Development, October 2006, The Company of Biologists

    Arnold Spek

  129. Hedgehog Turns Lipoproteins Into Janus-Faced Particles

    Article • Trends in Cardiovascular Medicine, October 2006, Elsevier

    Arnold Spek

  130. Nuclear Receptors Nur77, Nurr1, and NOR-1 Expressed in Atherosclerotic Lesion Macrophages Reduce Lipid Loading and Inflammatory Responses

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2006, Wolters Kluwer Health

    Arnold Spek

  131. Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin

    Article • European Respiratory Journal, August 2006, European Respiratory Society (ERS)

    Arnold Spek

  132. Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice*

    Article • Critical Care Medicine, August 2006, Wolters Kluwer Health

    Arnold Spek

  133. Signal transduction induced by activated protein C: no role in protection against sepsis?

    Article • Trends in Molecular Medicine, August 2006, Elsevier

    Arnold Spek

  134. Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

    Article • PLoS Biology, July 2006, PLOS

    Arnold Spek

  135. Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia*

    Article • Critical Care Medicine, June 2006, Wolters Kluwer Health

    Arnold Spek

  136. Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae

    Article • Journal of Thrombosis and Haemostasis, April 2006, Elsevier

    Arnold Spek

  137. Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells

    Article • Thrombosis and Haemostasis, January 2006, Thieme Publishing Group

    Arnold Spek

  138. Article • Thrombosis Journal, January 2006, Springer Science + Business Media

    Arnold Spek

  139. Role of coagulation FVIII in septic peritonitis assessed in hemophilic mice

    Article • Journal of Thrombosis and Haemostasis, December 2005, Elsevier

    Arnold Spek

  140. Editorial [Hot Topic: Understanding and Treatment of Diseases in the Haemostatic System (Guest Editor: M.P. Peppelenbosch Co-Editor: C.A. Spek)]

    Article • Current Genomics, October 2005, Bentham Science Publishers

    Arnold Spek

  141. Functional Evolution of Tissue Factor, the Archetype of the Cytokine Receptor Family

    Article • Current Genomics, October 2005, Bentham Science Publishers

    Arnold Spek

  142. Inherited Coagulation Factor VII and X Deficiencies Associated with Severe Bleeding Diathesis: Molecular Genetics and Pathophysiology

    Article • Current Genomics, October 2005, Bentham Science Publishers

    Arnold Spek

  143. RNA-Based Gene Therapy for Haemophilia B

    Article • Current Genomics, October 2005, Bentham Science Publishers

    Arnold Spek

  144. Antiinflammatory Effects of Salmeterol after Inhalation of Lipopolysaccharide by Healthy Volunteers

    Article • American Journal of Respiratory and Critical Care Medicine, October 2005, American Thoracic Society

    Arnold Spek

  145. Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients

    Article • Journal of Molecular Medicine, July 2005, Springer Science + Business Media

    Arnold Spek

  146. Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation*

    Article • Critical Care Medicine, June 2005, Wolters Kluwer Health

    Arnold Spek

  147. High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells

    Article • Blood, March 2005, American Society of Hematology

    Arnold Spek

  148. Blood coagulation factors as inflammatory mediators

    Article • Blood Cells Molecules and Diseases, February 2005, Elsevier

    Arnold Spek

  149. Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice

    Article • Journal of Thrombosis and Haemostasis, December 2004, Elsevier

    Arnold Spek

  150. Inhibition of the Tissue Factor/Factor VIIa Pathway Does Not Influence the Inflammatory or Antibacterial Response to Abdominal Sepsis Induced byEscherichia coliin Mice

    Article • The Journal of Infectious Diseases, June 2004, Oxford University Press (OUP)

    Arnold Spek

  151. Tissue factor

    Article • Blood Coagulation & Fibrinolysis, May 2004, Wolters Kluwer Health

    Arnold Spek

  152. FVIIa:TF Induces Cell Survival via G 12 /G 13 -Dependent Jak/STAT Activation and Bcl XL Production

    Article • Circulation Research, April 2004, Wolters Kluwer Health

    Arnold Spek

  153. Concerted action of coagulation factors on cell survival

    Article • Journal of Thrombosis and Haemostasis, April 2004, Elsevier

    Arnold Spek

  154. Blood cell-derived tissue factor influences host response during murine endotoxemia

    Article • Blood Cells Molecules and Diseases, April 2004, Elsevier

    Arnold Spek

  155. Coagulation factors VIIa and Xa inhibit apoptosis and anoikis

    Article • Oncogene, January 2004, Springer Science + Business Media

    Arnold Spek

  156. Hedgehog: an unusual signal transducer

    Article • BioEssays, January 2004, Wiley

    Arnold Spek

  157. Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways

    Article • Extremophiles, January 2004, Springer Science + Business Media

    Arnold Spek

  158. Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways

    Article • Nucleic Acids Research, December 2003, Oxford University Press (OUP)

    Arnold Spek

  159. Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis

    Article • Basic Research in Cardiology, November 2003, Springer Science + Business Media

    Arnold Spek

  160. Regulation of the p21Ras-MAP kinase pathway by factor VIIa

    Article • Journal of Thrombosis and Haemostasis, May 2003, Elsevier

    Arnold Spek

  161. Tissue factor signal transduction in angiogenesis

    Article • Carcinogenesis, April 2003, Oxford University Press (OUP)

    Arnold Spek

  162. Article • Journal of Clinical Immunology, January 2003, Springer Science + Business Media

    Arnold Spek

  163. Effects of IC14, an Anti‐CD14 Antibody, on Coagulation and Fibrinolysis during Low‐Grade Endotoxemia in Humans

    Article • The Journal of Infectious Diseases, January 2003, Oxford University Press (OUP)

    Arnold Spek

  164. Disseminated intravascular coagulation

    Article • The Hematology Journal, January 2003, Springer Science + Business Media

    Arnold Spek

  165. Type I diabetes: a role for tissue factor in pancreatic islet transplantation?

    Article • The Lancet, December 2002, Elsevier

    Arnold Spek

  166. Microvascular coagulopathy and disseminated intravascular coagulation

    Article • Critical Care Medicine, July 2001, Wolters Kluwer Health

    Arnold Spek

  167. Genetic Risk Factors for Venous Thrombosis

    Article • Molecular Genetics and Metabolism, September 2000, Elsevier

    Arnold Spek

  168. Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity

    Article • Biochemical Journal, May 1999, Portland Press Ltd.

    Arnold Spek

  169. Type-I Protein-C Deficiency Caused by Disruption of a Hepatocyte Nuclear Factor (HNF)-6/HNF-1 Binding Site in the Human Protein-C Gene Promoter

    Article • Trends in Cardiovascular Medicine, May 1999, Elsevier

    Arnold Spek

  170. Identification of Evolutionarily Invariant Sequences in the Protein C Gene Promoter

    Article • Journal of Molecular Evolution, December 1998, Springer Science + Business Media

    Arnold Spek

  171. Type I Protein C Deficiency Caused by Disruption of a Hepatocyte Nuclear Factor (HNF)-6/HNF-1 Binding Site in the Human Protein C Gene Promoter

    Article • Journal of Biological Chemistry, April 1998, Elsevier

    Arnold Spek

  172. Two Mutations in the Promoter Region of the Human Protein C Gene Both Cause Type I Protein C Deficiency by Disruption of Two HNF-3 Binding Sites

    Article • Journal of Biological Chemistry, October 1995, Elsevier

    Arnold Spek

  173. Genotypic Variation in the Promoter Region of the Protein C Gene Is Associated With Plasma Protein C Levels and Thrombotic Risk

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 1995, Wolters Kluwer Health

    Arnold Spek