All Stories

  1. Establishment of a Cell Culture Model of Persistent Flaviviral Infection: Usutu Virus Shows Sustained Replication during Passages and Resistance to Extinction by Antiviral Nucleosides

    Article • Viruses, June 2019, MDPI AG

    Dr Armando Arias

  2. Development of a fluorescence-based method for the rapid determination of Zika virus polymerase activity and the screening of antiviral drugs

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Dr Armando Arias

  3. Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

    Article • Antimicrobial Agents and Chemotherapy, June 2018, ASM Journals

    Dr Armando Arias

  4. Virus genomes reveal factors that spread and sustained the Ebola epidemic

    Article • Nature, April 2017, Nature

    Professor (Associate) Bart L. Haagmans, Dr Armando Arias, Dr Jens H. Kuhn

  5. Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

    Article • mSphere, October 2016, ASM Journals

    Dr Armando Arias

  6. Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism

    Article • Virology, July 2016, Elsevier

    Dr Ana Grande-Perez, Dr Armando Arias

  7. Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial

    Article • PLoS Medicine, April 2016, PLOS

    Dr Armando Arias

  8. Advances Toward a Norovirus Antiviral: From Classical Inhibitors to Lethal Mutagenesis

    Article • The Journal of Infectious Diseases, January 2016, Oxford University Press (OUP)

    Dr Armando Arias

  9. Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases

    Article • Virus Evolution, January 2016, Oxford University Press (OUP)

    Dr Armando Arias

  10. Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015

    Article • Eurosurveillance, October 2015, European Centre for Disease Control and Prevention (ECDC)

    Professor (Associate) Bart L. Haagmans, Dr Armando Arias

  11. Favipiravir elicits antiviral mutagenesis during virus replication in vivo

    Article • eLife, October 2014, eLife

    Dr Armando Arias

  12. Murine Norovirus: Propagation, Quantification, and Genetic Manipulation

    Article • May 2014, Wiley

    Dr Christiane E Wobus, Dr Surender Vashist, Dr Armando Arias

  13. Inflammation and Host Defense

    Article • April 2014, ASM Journals

    Dr Armando Arias

  14. Progress towards the prevention and treatment of norovirus infections

    Article • Future Microbiology, November 2013, Future Medicine

    Dr Surender Vashist, Dr Armando Arias

  15. Influence of genome-scale RNA structure disruption on the replication of murine norovirus—similar replication kinetics in cell culture but attenuation of viral fitness in vivo

    Article • Nucleic Acids Research, April 2013, Oxford University Press (OUP)

    Dr Armando Arias

  16. Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load

    Article • Journal of General Virology, December 2012, Society for General Microbiology

    Dr Armando Arias

  17. Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

    Article • Journal of Visualized Experiments, June 2012, MyJove Corporation

    Dr Armando Arias

  18. Development of a reverse-genetics system for murine norovirus 3: long-term persistence occurs in the caecum and colon

    Article • Journal of General Virology, April 2012, Society for General Microbiology

    Dr Armando Arias

  19. Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability

    Article • PLoS Genetics, March 2011, PLOS

    Dr Armando Arias

  20. A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

    Article • PLoS Pathogens, August 2010, PLOS

    Dr Armando Arias

  21. Deletion Mutants of VPg Reveal New Cytopathology Determinants in a Picornavirus

    Article • PLoS ONE, May 2010, PLOS

    Dr Armando Arias

  22. Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin

    Article • Journal of Virology, April 2010, ASM Journals

    Dr Armando Arias

  23. Foot-and-Mouth Disease Virus Assembly: Processing of Recombinant Capsid Precursor by Exogenous Protease Induces Self-Assembly of Pentamers In Vitro in a Myristoylation-Dependent Manner

    Article • Journal of Virology, August 2009, ASM Journals

    Dr Armando Arias

  24. 5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus

    Article • Future Medicinal Chemistry, June 2009, Future Science

    Dr Armando Arias

  25. Molecular Characterization of a Dual Inhibitory and Mutagenic Activity of 5-Fluorouridine Triphosphate on Viral RNA Synthesis. Implications for Lethal Mutagenesis

    Article • Journal of Molecular Biology, October 2008, Elsevier

    Dr ALBERTO JORGE GARCÍA, Dr Armando Arias

  26. Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

    Article • Journal of Virology, October 2008, ASM Journals

    Dr Armando Arias

  27. Repeated Bottleneck Transfers Can Lead to Non-cytocidal Forms of a Cytopathic Virus: Implications for Viral Extinction

    Article • Journal of Molecular Biology, February 2008, Elsevier

    Dr Armando Arias

  28. Sequential structures provide insights into the fidelity of RNA replication

    Article • Proceedings of the National Academy of Sciences, May 2007, Proceedings of the National Academy of Sciences

    Dr Armando Arias

  29. Foot-and-Mouth Disease Virus Mutant with Decreased Sensitivity to Ribavirin: Implications for Error Catastrophe

    Article • Journal of Virology, December 2006, ASM Journals

    Dr Armando Arias

  30. The structure of a protein primer–polymerase complex in the initiation of genome replication

    Article • The EMBO Journal, February 2006, Wiley

    Dr Armando Arias

  31. A comparison of viral RNA-dependent RNA polymerases

    Article • Current Opinion in Structural Biology, February 2006, Elsevier

    Dr Armando Arias

  32. Mutant Viral Polymerase in the Transition of Virus to Error Catastrophe Identifies a Critical Site for RNA Binding

    Article • Journal of Molecular Biology, November 2005, Elsevier

    Dr Armando Arias

  33. Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA

    Article • Journal of Biological Chemistry, August 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Armando Arias

  34. Fitness Increase of Memory Genomes in a Viral Quasispecies

    Article • Journal of Molecular Biology, May 2004, Elsevier

    Dr Armando Arias

  35. Preextinction Viral RNA Can Interfere with Infectivity

    Article • Journal of Virology, April 2004, ASM Journals

    Dr Armando Arias

  36. Duration and fitness dependence of quasispecies memory

    Article • Journal of Molecular Biology, January 2002, Elsevier

    Dr Armando Arias

  37. Emergence and selection of RNA virus variants: memory and extinction

    Article • Virus Research, December 2001, Elsevier

    Dr Armando Arias

  38. Memory in Viral Quasispecies

    Article • Journal of Virology, April 2000, ASM Journals

    Dr Armando Arias