All Stories

  1. Collaboration of Antipodes: Synergy of Branched and Linear F-Actin during Amoeboid Cell Movement and Chemotaxis

    Article • Cold Spring Harbor Perspectives in Biology, July 2025, Cold Spring Harbor Laboratory Press

    Arjan Kortholt

  2. Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism

    Article • eLife, December 2024, eLife

    Arjan Kortholt

  3. PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner

    Article • Cell Death and Disease, October 2024, Springer Science + Business Media

    Arjan Kortholt

  4. The effects of whole-body vibration therapy on immune and brain functioning: current insights in the underlying cellular and molecular mechanisms

    Article • Frontiers in Neurology, July 2024, Frontiers

    Arjan Kortholt

  5. Analysis of cGMP Signaling in Dictyostelium

    Article • January 2024, Springer Science + Business Media

    Arjan Kortholt

  6. GRminusRD: A Sensitive Assay to Detect Activation Processes at the Plasma Membrane in Living Cells

    Article • January 2024, Springer Science + Business Media

    Arjan Kortholt

  7. PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

    Article • Frontiers in Molecular Neuroscience, December 2023, Frontiers

    Arjan Kortholt

  8. Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

    Article • Nature Communications, October 2023, Springer Science + Business Media

    Arjan Kortholt

  9. Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization

    Article • ACS Chemical Neuroscience, May 2023, American Chemical Society (ACS)

    Arjan Kortholt

  10. LRRK2 Structure-Based Activation Mechanism and Pathogenesis

    Article • Biomolecules, March 2023, MDPI AG

    Arjan Kortholt

  11. Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Arjan Kortholt

  12. LRRK2 protects immune cells against erastin-induced ferroptosis

    Article • Neurobiology of Disease, December 2022, Elsevier

    Arjan Kortholt

  13. C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis

    Article • Frontiers in Immunology, November 2022, Frontiers

    Arjan Kortholt

  14. Component Analysis of Photon Counting Histograms in Fluorescence Fluctuation Spectroscopy Experiments

    Article • Journal of Applied Spectroscopy, November 2022, Springer Science + Business Media

    Arjan Kortholt

  15. The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids

    Article • Neurobiology of Disease, October 2022, Elsevier

    Arjan Kortholt

  16. Potential of Whole-Body Vibration in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Human and Animal Studies

    Article • Biology, August 2022, MDPI AG

    Arjan Kortholt

  17. Editorial: LRRK2—Fifteen Years From Cloning to the Clinic

    Article • Frontiers in Neuroscience, April 2022, Frontiers

    Arjan Kortholt

  18. A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

    Article • Cells, March 2022, MDPI AG

    Arjan Kortholt

  19. The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation

    Article • Brain Research, March 2022, Elsevier

    Arjan Kortholt

  20. Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2

    Article • Proceedings of the National Academy of Sciences, February 2022, Proceedings of the National Academy of Sciences

    Wim Versées, Arjan Kortholt

  21. The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats

    Article • Immunopharmacology and Immunotoxicology, January 2022, Taylor & Francis

    Arjan Kortholt

  22. Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

    Article • Molecular Biology of the Cell, October 2021, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  23. Allosteric Inhibition of Parkinson’s-Linked LRRK2 by Constrained Peptides

    Article • ACS Chemical Biology, September 2021, American Chemical Society (ACS)

    Arjan Kortholt

  24. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity

    Article • Frontiers in Cell and Developmental Biology, September 2021, Frontiers

    Arjan Kortholt

  25. Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

    Article • Frontiers in Cell and Developmental Biology, July 2021, Frontiers

    Arjan Kortholt

  26. LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease

    Article • Biomolecules, July 2021, MDPI AG

    Arjan Kortholt

  27. Combined FCS and PCH Analysis to Quantify Protein Dimerization in Living Cells

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Arjan Kortholt

  28. The tale of proteolysis targeting chimeras (PROTACs) for leucine‐rich repeat kinase 2 (LRRK2)

    Article • ChemMedChem, December 2020, Wiley

    Arjan Kortholt

  29. The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta

    Article • Neuroscience Letters, November 2020, Elsevier

    Arjan Kortholt

  30. Allosteric inhibition of LRRK2, where are we now

    Article • Biochemical Society Transactions, October 2020, Portland Press Ltd.

    Arjan Kortholt

  31. Complex Analysis of Fluorescence Intensity Fluctuations of Molecular Compounds

    Article • Journal of Applied Spectroscopy, September 2020, Springer Science + Business Media

    Arjan Kortholt

  32. Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria

    Article • Current Biology, August 2020, Elsevier

    Arjan Kortholt

  33. Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

    Article • Biochemical Journal, April 2020, Portland Press Ltd.

    Arjan Kortholt

  34. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity

    Article • Biomedicine & Pharmacotherapy, October 2019, Elsevier

    Arjan Kortholt

  35. Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

    Article • Biochemical Journal, January 2019, Portland Press Ltd.

    Arjan Kortholt

  36. Roco Proteins: GTPases with a Baroque Structure and Mechanism

    Article • International Journal of Molecular Sciences, January 2019, MDPI AG

    Arjan Kortholt

  37. Biochemical and kinetic properties of the complex Roco G-protein cycle

    Article • Biological Chemistry, November 2018, De Gruyter

    Arjan Kortholt, Wim Versées

  38. The cytoskeleton regulates symmetry transitions in moving amoeboid cells

    Article • Journal of Cell Science, February 2018, The Company of Biologists

    Arjan Kortholt

  39. The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

    Article • Biological Chemistry, February 2018, De Gruyter

    Arjan Kortholt

  40. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis

    Article • Proceedings of the National Academy of Sciences, November 2017, Proceedings of the National Academy of Sciences

    Arjan Kortholt, Xuehua Xu

  41. A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

    Article • Nature Communications, October 2017, Springer Science + Business Media

    Arjan Kortholt

  42. The LRR-Roc-COR module of theChlorobium tepidumRoco protein: crystallization and X-ray crystallographic analysis

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2017, International Union of Crystallography

    Arjan Kortholt, Wim Versées

  43. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection

    Article • Small GTPases, June 2017, Taylor & Francis

    Arjan Kortholt

  44. Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

    Article • Molecular Biology of the Cell, April 2017, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  45. The unconventional G-protein cycle of LRRK2 and Roco proteins

    Article • Biochemical Society Transactions, December 2016, Portland Press Ltd.

    Arjan Kortholt

  46. Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization

    Article • Small GTPases, October 2016, Taylor & Francis

    Arjan Kortholt

  47. Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  48. A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

    Article • PLOS One, June 2016, PLOS

    Arjan Kortholt

  49. A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis

    Article • Developmental Cell, June 2016, Elsevier

    Arjan Kortholt

  50. The small GTPases Ras and Rap1 bind to and control TORC2 activity

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Arjan Kortholt

  51. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

    Article • International Journal of Molecular Sciences, January 2016, MDPI AG

    Arjan Kortholt

  52. Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

    Article • BMC Cell Biology, January 2016, Springer Science + Business Media

    Arjan Kortholt

  53. Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

    Article • Parkinson s Disease, January 2016, Hindawi Publishing Corporation

    Arjan Kortholt

  54. Abstract B48: Homer3 regulates the establishment of neutrophil polarity

    Article • Cancer Immunology Research, October 2015, American Association for Cancer Research (AACR)

    Arjan Kortholt

  55. Conformational heterogeneity of the Roc domains in C. tepidum Roc–COR and implications for human LRRK2 Parkinson mutations

    Article • Bioscience Reports, October 2015, Portland Press Ltd.

    Arjan Kortholt

  56. Structural Characterization of LRRK2 Inhibitors

    Article • Journal of Medicinal Chemistry, May 2015, American Chemical Society (ACS)

    Arjan Kortholt

  57. Homer3 regulates the establishment of neutrophil polarity

    Article • Molecular Biology of the Cell, May 2015, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  58. Revisiting the Roco G-protein cycle

    Article • Biochemical Journal, January 2015, Portland Press Ltd.

    Arjan Kortholt

  59. Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

    Article • Molecular Biology of the Cell, December 2014, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  60. Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

    Article • Frontiers in Molecular Neuroscience, May 2014, Frontiers

    Arjan Kortholt

  61. The Potential of Targeting LRRK2 in Parkinson’s Disease

    Article • March 2014, IntechOpen

    Arjan Kortholt

  62. Ras activation and symmetry breaking during Dictyostelium chemotaxis

    Article • Journal of Cell Science, July 2013, The Company of Biologists

    Arjan Kortholt

  63. Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  64. Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  65. Simple system – substantial share: The use of Dictyostelium in cell biology and molecular medicine

    Article • European Journal of Cell Biology, February 2013, Elsevier

    Professor Ludwig Eichinger, Arjan Kortholt

  66. Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

    Article • Molecular Biology of the Cell, January 2013, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  67. GxcC connects Rap and Rac signaling during Dictyostelium development

    Article • BMC Cell Biology, January 2013, Springer Science + Business Media

    Arjan Kortholt

  68. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

    Article • Proceedings of the National Academy of Sciences, June 2012, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  69. Dictyostelium discoideum: A Model System to Study LRRK2-Mediated Parkinson Disease

    Article • February 2012, IntechOpen

    Arjan Kortholt

  70. Multiple Regulatory Mechanisms for theDictyosteliumRoco Protein GbpC

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  71. Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

    Article • EMBO Reports, November 2011, Wiley

    Arjan Kortholt

  72. A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

    Article • Molecular Biology of the Cell, March 2010, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  73. Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  74. Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

    Article • Cellular Signalling, August 2008, Elsevier

    Arjan Kortholt

  75. Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

    Article • The EMBO Journal, July 2008, Wiley

    Arjan Kortholt

  76. Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphate-mediated Chemotaxis

    Article • Molecular Biology of the Cell, December 2007, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  77. Essential role of PI3-kinase and phospholipase A2 inDictyostelium discoideumchemotaxis

    Article • Journal of Cell Biology, May 2007, Rockefeller University Press

    Arjan Kortholt

  78. Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

    Article • Journal of Cell Biology, May 2007, Rockefeller University Press

    Arjan Kortholt

  79. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

    Article • EMBO Reports, March 2007, EMBO

    Profesor Robert Insall, Arjan Kortholt

  80. Regulation of Phagocytosis in Dictyostelium by the Inositol 5-Phosphatase OCRL Homolog Dd5P4

    Article • Traffic, March 2007, Wiley

    Arjan Kortholt

  81. SevenDictyostelium discoideumphosphodiesterases degrade three pools of cAMP and cGMP

    Article • Biochemical Journal, February 2007, Portland Press Ltd.

    Arjan Kortholt

  82. Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity inDictyostelium discoideum

    Article • Journal of Biological Chemistry, June 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  83. DdPDE4, a Novel cAMP-specific Phosphodiesterase at the Surface of Dictyostelium Cells

    Article • Journal of Biological Chemistry, April 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  84. Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins

    Article • The EMBO Journal, October 2003, Wiley

    Arjan Kortholt