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  1. Analgesic Effect of a Novel Intravenous Ibuprofen-Low-Dose Tramadol Combination: A Multimodal Approach to Moderate-to-Severe Postoperative Dental Pain

    Article • Pharmaceutics, September 2025, MDPI AG

    MD, PhD ANTONIO PORTOLES

  2. Comparison of treatment efficacy between topical insulin and autologous serum in persistent epithelial defects: a randomised controlled trial protocol in Spain

    Article • BMJ Open, September 2025, BMJ

    MD, PhD ANTONIO PORTOLES

  3. Long-Term Therapy With Transcranial Magnetic Stimulation in Primary Progressive Aphasia

    Article • JAMA Network Open, August 2025, American Medical Association (AMA)

    MD, PhD ANTONIO PORTOLES

  4. A scoping review of placebo and nocebo responses and effects: insights for clinical trials and practice

    Article • Health Psychology Review, March 2025, Taylor & Francis

    MD, PhD ANTONIO PORTOLES

  5. Bioequivalence Study of Two Oral Methocarbamol Formulations in Healthy Subjects Under Fasting Conditions: A Randomized, Open-Label, Crossover Clinical Trial

    Article • Pharmaceuticals, March 2025, MDPI AG

    MD, PhD ANTONIO PORTOLES

  6. Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations—Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Trial

    Article • Pharmaceuticals, February 2025, MDPI AG

    MD, PhD ANTONIO PORTOLES

  7. Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

    Article • iScience, September 2024, Elsevier

    MD, PhD ANTONIO PORTOLES

  8. Economic impact of immunoglobulin replacement therapy in secondary immunodeficiency to hematological cancer: a single center observational study

    Article • Frontiers in Immunology, June 2024, Frontiers

    MD, PhD ANTONIO PORTOLES

  9. Adverse drug reactions in paediatric surgery: prospective study on frequency and risk related factors

    Article • BMC Pediatrics, May 2024, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  10. Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial

    Article • BMJ Open, January 2024, BMJ

    MD, PhD ANTONIO PORTOLES

  11. Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

    Article • Clinical and Translational Science, October 2023, Wiley

    MD, PhD ANTONIO PORTOLES

  12. Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial

    Article • Arthroscopy The Journal of Arthroscopic and Related Surgery, June 2023, Elsevier

    MD, PhD ANTONIO PORTOLES

  13. Polypill Strategy in Secondary Cardiovascular Prevention

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2022, New England Journal of Medicine (NEJM/MMS)

    Prof HECTOR BUENO, MD, PhD ANTONIO PORTOLES, Prof. Francisco Marin , Prof. Vicente Andrés, Professor Deepak L Bhatt

  14. Immune response and reactogenicity after immunization with two-doses of an experimental COVID-19 vaccine (CVnCOV) followed by a third-fourth shot with a standard mRNA vaccine (BNT162b2): RescueVacs multicenter cohort study

    Article • EClinicalMedicine, September 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  15. Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study

    Article • EClinicalMedicine, August 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  16. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

    Article • The Lancet, May 2022, Elsevier

    MD, PhD ANTONIO PORTOLES, M.D; Ph.D; FIDSA Carlos Alvarez-Moreno, Prof. Dr. Abdullah M. Asiri

  17. Carisoprodol Single and Multiple Dose PK-PD. Part II: Pharmacodynamics Evaluation Method for Central Muscle Relaxants. Double-Blind Placebo-Controlled Clinical Trial in Healthy Volunteers

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    MD, PhD ANTONIO PORTOLES

  18. Against All Odds? Addiction History Associated with Better Viral Hepatitis Care: A Dutch Nationwide Claims Data Study

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    MD, PhD ANTONIO PORTOLES

  19. Single and Multiple Dose PK–PD Characterization for Carisoprodol. Part I: Pharmacokinetics, Metabolites, and 2C19 Phenotype Influence. Double-Blind, Placebo-Controlled Clinical Trial in Healthy Volunteers

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    MD, PhD ANTONIO PORTOLES

  20. Immunological safety assessment of a single and repeated intra-articular administration of xenogeneic equine umbilical cord mesenchymal stem cells under field conditions in young healthy dogs: A randomized double-blind placebo-controlled study

    Article • January 2022, Scientific Scholar

    MD, PhD ANTONIO PORTOLES

  21. Effect of Obesity and Gastric Surgery on Omeprazole oral absorption and pharmacokinetics

    Article • Obesity Facts, January 2022, Karger Publishers

    Rivas Paterna, MD, PhD ANTONIO PORTOLES

  22. Immune Response and Reactogenicity After Immunization With a Suboptimal Two-Dose mRNA Vaccine Followed by a Full Vaccination With a Standard mRNA Vaccine Compared to a Prime-Boost Regimen of a Standard mRNA Vaccine: A Multicenter Cohort Study

    Article • SSRN Electronic Journal, January 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  23. Immunogenic Dynamics and SARS-CoV-2 Variants Neutralization of the Heterologous ChAdOx1-S/BNT162b2 Vaccination: Secondary Analysis of the CombiVacS Study

    Article • SSRN Electronic Journal, January 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  24. Immunogenic Dynamics and SARS-CoV-2 Variants Neutralization of the Heterologous ChAdOx1-S/BNT162b2 Vaccination: Secondary Analysis of the CombiVacS Study

    Article • SSRN Electronic Journal, January 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  25. Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

    Article • The Lancet Infectious Diseases, November 2021, Elsevier

    MD, PhD ANTONIO PORTOLES

  26. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

    Article • The Lancet, July 2021, Elsevier

    MD, PhD ANTONIO PORTOLES

  27. Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, February 2021, New England Journal of Medicine (NEJM/MMS)

    M.D; Ph.D; FIDSA Carlos Alvarez-Moreno, MD, PhD ANTONIO PORTOLES, Prof. Dr. Abdullah M. Asiri

  28. La isoapariencia farmacéutica un factor de riesgo de errores de medicación

    Article • Metas de Enfermería, September 2020, Grupo Paradigma

    MD, PhD ANTONIO PORTOLES

  29. Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department

    Article • European Geriatric Medicine, July 2020, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  30. Chiral bioanalytical methods in bioequivalence studies of intravenous vs. oral formulations of ibuprofen

    Article • Chirality, June 2020, Wiley

    MD, PhD ANTONIO PORTOLES

  31. Clinical Trial on Glimepiride 2mg Single Oral Dose in Healthy Volunteers: Need for Preventive Management of Hypoglycaemia

    Article • Current Research in Diabetes & Obesity Journal, February 2020, Juniper Publishers

    MD, PhD ANTONIO PORTOLES

  32. European survey on national harmonization in clinical research

    Article • Learning Health Systems, February 2020, Wiley

    MD, PhD ANTONIO PORTOLES

  33. Effect of enantiomerism on the bioequivalence of a new ibuprofen 600‐mg tablet formulation obtained by roller compaction

    Article • Chirality, November 2019, Wiley

    MD, PhD ANTONIO PORTOLES

  34. European survey on national training activities in clinical research

    Article • Trials, October 2019, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  35. Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Article • Molecular Nutrition & Food Research, June 2019, Wiley

    MD, PhD ANTONIO PORTOLES

  36. Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?

    Article • European Journal of Clinical Pharmacology, January 2019, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  37. Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry

    Article • Journal of the American Heart Association, October 2016, Wolters Kluwer Health

    Professor Tzung-Dau Wang, Francesc Formiga, Professor Deepak L Bhatt, Professor Yuriy M. Sirenko, MD, PhD ANTONIO PORTOLES

  38. Adverse drug reactions in neonates: a prospective study

    Article • Archives of Disease in Childhood, January 2016, BMJ

    MD, PhD ANTONIO PORTOLES

  39. Teaching of Pharmacology, clinical Pharmacology and Therapeutics in Spanish Medical Schools. preliminary results

    Article • Clinical Therapeutics, August 2015, Elsevier

    MD, PhD ANTONIO PORTOLES

  40. Scren: Spanish Research Netwok; one-Year Experience

    Article • Clinical Therapeutics, August 2015, Elsevier

    MD, PhD ANTONIO PORTOLES

  41. Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

    Article • International Archives of Allergy and Immunology, January 2015, Karger Publishers

    MD, PhD ANTONIO PORTOLES

  42. Integración de la tramitación del contrato de ensayo clínico en el plazo de evaluación por el Comité de Ética de Investigación Clínica. Estudio piloto MINT&R®-cec

    Article • Medicina Clínica, May 2013, Elsevier

    MD, PhD ANTONIO PORTOLES

  43. Response Letter to Malafarina and Colleagues

    Article • Journal of the American Geriatrics Society, April 2012, Wiley

    MD, PhD ANTONIO PORTOLES

  44. FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies

    Article • Clinical and Translational Allergy, March 2012, Springer Science + Business Media

    Enrico Scala, MD, PhD ANTONIO PORTOLES

  45. Truncated AUC in the Evaluation of Fluconazole Bioequivalence

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  46. Bioequivalence Study of Two Different Tablet Formulations of Carvedilol in Healthy Volunteers

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  47. Comparative Bioavailability/Bioequivalence of Two Different Sertraline Formulations

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  48. Truncated Area under the Urinary Excretion Rate Curve in the Evaluation of Alendronate Bioequivalence after a Single Dose in Healthy Volunteers

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  49. Risk of Cerebrovascular Accident Associated with Use of Antipsychotics: Population-Based Case-Control Study

    Article • Journal of the American Geriatrics Society, June 2011, Wiley

    MD, PhD ANTONIO PORTOLES

  50. Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol

    Article • European Journal of Clinical Pharmacology, March 2010, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  51. Recomendaciones para el tratamiento del dolor neuropático

    Article • Revista de la Sociedad Española del Dolor, November 2009, Instituto de Salud Carlos III/BNCS/SciELO Espana

    MD, PhD ANTONIO PORTOLES

  52. Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale

    Article • Journal of Psychopharmacology, September 2008, SAGE Publications

    MD, PhD ANTONIO PORTOLES

  53. Effects ofHypericum perforatumon Ivabradine Pharmacokinetics in Healthy Volunteers: An Open-Label, Pharmacokinetic Interaction Clinical Trial

    Article • The Journal of Clinical Pharmacology, October 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  54. Lack of Pharmacokinetic Interaction Between Omeprazole or Lansoprazole and Ivabradine in Healthy Volunteers: An Open-Label, Randomized, Crossover, Pharmacokinetic Interaction Clinical Trial

    Article • The Journal of Clinical Pharmacology, October 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  55. Effect of drug-test interactions on length of hospital stay

    Article • Pharmacoepidemiology and Drug Safety, January 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  56. A Survey of Danish, German and Spanish Ethics Committees Prior to the 2004 Implementation of the European Directive Covering the International Conference of Harmonisation ??? Good Clinical Practices (ICH-GCP)

    Article • International Journal of Pharmaceutical Medicine, January 2005, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  57. Bioequivalence study of two formulations of enalapril, at a single oral dose of 20 mg (tablets): A randomized, two-way, open-label, crossover study in healthy volunteers

    Article • Current Therapeutic Research, January 2004, Elsevier

    MD, PhD ANTONIO PORTOLES

  58. A new high-absorption-rate Paracetamol 500-mg formulation: a comparative bioavailability study in healthy volunteers

    Article • Current Therapeutic Research, July 2003, Elsevier

    MD, PhD ANTONIO PORTOLES

  59. Effect of adverse drug reactions on length of stay in surgical intensive care units

    Article • Critical Care Medicine, March 2003, Wolters Kluwer Health

    MD, PhD ANTONIO PORTOLES

  60. Pharmacokinetic Study of a New Ibuprofen 600mg plus Codeine 30mg Combination versus Ibuprofen or Codeine Alone in Single Oral Doses in Healthy Volunteers

    Article • Clinical Drug Investigation, January 2002, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  61. Comparative Single-Dose Bioavailability Study of Two Oral Formulations of Ibuprofen in Healthy Volunteers

    Article • Clinical Drug Investigation, January 2001, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  62. Modification of Albumin Use Pattern After an Educational Intervention

    Article • Disease Management & Health Outcomes, July 2000, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  63. Acute myocardial infarction associated with sildenafil

    Article • The Lancet, December 1998, Elsevier

    MD, PhD ANTONIO PORTOLES

  64. Use of albumin in two Spanish university hospitals

    Article • European Journal of Clinical Pharmacology, September 1997, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  65. Use of Intravenous Omeprazole in a University Hospital

    Article • Journal of Pharmacy Technology, January 1997, SAGE Publications

    MD, PhD ANTONIO PORTOLES

  66. Adverse Drug Reactions in a Cardiology Department

    Article • Clinical Drug Investigation, July 1996, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  67. Physical dependence to morphine diminishes the interferon response in mice

    Article • Immunopharmacology, October 1987, Elsevier

    MD, PhD ANTONIO PORTOLES

  68. Inmunoferon (Am3) Enhances the Activities of Early–Type Interferon Inducers and Natural Killer Cells.

    Article • Immunopharmacology and Immunotoxicology, January 1987, Taylor & Francis

    MD, PhD ANTONIO PORTOLES