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  1. Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

    Article • Clinical and Translational Science, October 2023, Wiley

    MD, PhD ANTONIO PORTOLES

  2. Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial

    Article • Arthroscopy The Journal of Arthroscopic and Related Surgery, June 2023, Elsevier

    MD, PhD ANTONIO PORTOLES

  3. Polypill Strategy in Secondary Cardiovascular Prevention

    Article • New England Journal of Medicine, September 2022, New England Journal of Medicine (NEJM/MMS)

    Prof HECTOR BUENO, MD, PhD ANTONIO PORTOLES

  4. Immune response and reactogenicity after immunization with two-doses of an experimental COVID-19 vaccine (CVnCOV) followed by a third-fourth shot with a standard mRNA vaccine (BNT162b2): RescueVacs multicenter cohort study

    Article • EClinicalMedicine, September 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  5. Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study

    Article • EClinicalMedicine, August 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  6. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

    Article • The Lancet, May 2022, Elsevier

    MD, PhD ANTONIO PORTOLES, M.D; Ph.D; FIDSA Carlos Alvarez-Moreno

  7. Carisoprodol Single and Multiple Dose PK-PD. Part II: Pharmacodynamics Evaluation Method for Central Muscle Relaxants. Double-Blind Placebo-Controlled Clinical Trial in Healthy Volunteers

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    MD, PhD ANTONIO PORTOLES

  8. Single and Multiple Dose PK–PD Characterization for Carisoprodol. Part I: Pharmacokinetics, Metabolites, and 2C19 Phenotype Influence. Double-Blind, Placebo-Controlled Clinical Trial in Healthy Volunteers

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    MD, PhD ANTONIO PORTOLES

  9. Immunological safety assessment of a single and repeated intra-articular administration of xenogeneic equine umbilical cord mesenchymal stem cells under field conditions in young healthy dogs: A randomized double-blind placebo-controlled study

    Article • January 2022, Scientific Scholar

    MD, PhD ANTONIO PORTOLES

  10. Effect of Obesity and Gastric Surgery on Omeprazole oral absorption and pharmacokinetics

    Article • Obesity Facts, January 2022, Karger Publishers

    Rivas Paterna, MD, PhD ANTONIO PORTOLES

  11. Immune Response and Reactogenicity After Immunization With a Suboptimal Two-Dose mRNA Vaccine Followed by a Full Vaccination With a Standard mRNA Vaccine Compared to a Prime-Boost Regimen of a Standard mRNA Vaccine: A Multicenter Cohort Study

    Article • SSRN Electronic Journal, January 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  12. Immunogenic Dynamics and SARS-CoV-2 Variants Neutralization of the Heterologous ChAdOx1-S/BNT162b2 Vaccination: Secondary Analysis of the CombiVacS Study

    Article • SSRN Electronic Journal, January 2022, Elsevier

    MD, PhD ANTONIO PORTOLES

  13. Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

    Article • The Lancet Infectious Diseases, November 2021, Elsevier

    MD, PhD ANTONIO PORTOLES

  14. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

    Article • The Lancet, July 2021, Elsevier

    MD, PhD ANTONIO PORTOLES

  15. Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

    Article • New England Journal of Medicine, February 2021, New England Journal of Medicine (NEJM/MMS)

    M.D; Ph.D; FIDSA Carlos Alvarez-Moreno, MD, PhD ANTONIO PORTOLES

  16. Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department

    Article • European Geriatric Medicine, July 2020, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  17. Chiral bioanalytical methods in bioequivalence studies of intravenous vs. oral formulations of ibuprofen

    Article • Chirality, June 2020, Wiley

    MD, PhD ANTONIO PORTOLES

  18. Clinical Trial on Glimepiride 2mg Single Oral Dose in Healthy Volunteers: Need for Preventive Management of Hypoglycaemia

    Article • Current Research in Diabetes & Obesity Journal, February 2020, Juniper Publishers

    MD, PhD ANTONIO PORTOLES

  19. European survey on national harmonization in clinical research

    Article • Learning Health Systems, February 2020, Wiley

    MD, PhD ANTONIO PORTOLES

  20. Effect of enantiomerism on the bioequivalence of a new ibuprofen 600‐mg tablet formulation obtained by roller compaction

    Article • Chirality, November 2019, Wiley

    MD, PhD ANTONIO PORTOLES

  21. European survey on national training activities in clinical research

    Article • Trials, October 2019, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  22. Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Article • Molecular Nutrition & Food Research, June 2019, Wiley

    MD, PhD ANTONIO PORTOLES

  23. Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?

    Article • European Journal of Clinical Pharmacology, January 2019, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  24. Adverse drug reactions in neonates: a prospective study

    Article • Archives of Disease in Childhood, January 2016, BMJ

    MD, PhD ANTONIO PORTOLES

  25. Teaching of Pharmacology, clinical Pharmacology and Therapeutics in Spanish Medical Schools. preliminary results

    Article • Clinical Therapeutics, August 2015, Elsevier

    MD, PhD ANTONIO PORTOLES

  26. Scren: Spanish Research Netwok; one-Year Experience

    Article • Clinical Therapeutics, August 2015, Elsevier

    MD, PhD ANTONIO PORTOLES

  27. Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

    Article • International Archives of Allergy and Immunology, January 2015, Karger Publishers

    MD, PhD ANTONIO PORTOLES

  28. Integración de la tramitación del contrato de ensayo clínico en el plazo de evaluación por el Comité de Ética de Investigación Clínica. Estudio piloto MINT&R®-cec

    Article • Medicina Clínica, May 2013, Elsevier

    MD, PhD ANTONIO PORTOLES

  29. Response Letter to Malafarina and Colleagues

    Article • Journal of the American Geriatrics Society, April 2012, Wiley

    MD, PhD ANTONIO PORTOLES

  30. FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies

    Article • Clinical and Translational Allergy, March 2012, Springer Science + Business Media

    Enrico Scala, MD, PhD ANTONIO PORTOLES

  31. Truncated AUC in the Evaluation of Fluconazole Bioequivalence

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  32. Bioequivalence Study of Two Different Tablet Formulations of Carvedilol in Healthy Volunteers

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  33. Comparative Bioavailability/Bioequivalence of Two Different Sertraline Formulations

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  34. Truncated Area under the Urinary Excretion Rate Curve in the Evaluation of Alendronate Bioequivalence after a Single Dose in Healthy Volunteers

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    MD, PhD ANTONIO PORTOLES

  35. Risk of Cerebrovascular Accident Associated with Use of Antipsychotics: Population-Based Case-Control Study

    Article • Journal of the American Geriatrics Society, June 2011, Wiley

    MD, PhD ANTONIO PORTOLES

  36. Use of non-specific intravenous human immunoglobulins in Spanish hospitals; need for a hospital protocol

    Article • European Journal of Clinical Pharmacology, March 2010, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  37. Recomendaciones para el tratamiento del dolor neuropático

    Article • Revista de la Sociedad Española del Dolor, November 2009, Instituto de Salud Carlos III/BNCS/SciELO Espana

    MD, PhD ANTONIO PORTOLES

  38. Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale

    Article • Journal of Psychopharmacology, September 2008, SAGE Publications

    MD, PhD ANTONIO PORTOLES

  39. Effects ofHypericum perforatumon Ivabradine Pharmacokinetics in Healthy Volunteers: An Open-Label, Pharmacokinetic Interaction Clinical Trial

    Article • The Journal of Clinical Pharmacology, October 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  40. Lack of Pharmacokinetic Interaction Between Omeprazole or Lansoprazole and Ivabradine in Healthy Volunteers: An Open-Label, Randomized, Crossover, Pharmacokinetic Interaction Clinical Trial

    Article • The Journal of Clinical Pharmacology, October 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  41. Effect of drug-test interactions on length of hospital stay

    Article • Pharmacoepidemiology and Drug Safety, January 2006, Wiley

    MD, PhD ANTONIO PORTOLES

  42. Bioequivalence study of two formulations of enalapril, at a single oral dose of 20 mg (tablets): A randomized, two-way, open-label, crossover study in healthy volunteers

    Article • Current Therapeutic Research, January 2004, Elsevier

    MD, PhD ANTONIO PORTOLES

  43. A new high-absorption-rate Paracetamol 500-mg formulation: a comparative bioavailability study in healthy volunteers

    Article • Current Therapeutic Research, July 2003, Elsevier

    MD, PhD ANTONIO PORTOLES

  44. Effect of adverse drug reactions on length of stay in surgical intensive care units

    Article • Critical Care Medicine, March 2003, Wolters Kluwer Health

    MD, PhD ANTONIO PORTOLES

  45. Pharmacokinetic Study of a New Ibuprofen 600mg plus Codeine 30mg Combination versus Ibuprofen or Codeine Alone in Single Oral Doses in Healthy Volunteers

    Article • Clinical Drug Investigation, January 2002, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  46. Comparative Single-Dose Bioavailability Study of Two Oral Formulations of Ibuprofen in Healthy Volunteers

    Article • Clinical Drug Investigation, January 2001, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  47. Modification of Albumin Use Pattern After an Educational Intervention

    Article • Disease Management & Health Outcomes, July 2000, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  48. Acute myocardial infarction associated with sildenafil

    Article • The Lancet, December 1998, Elsevier

    MD, PhD ANTONIO PORTOLES

  49. Use of albumin in two Spanish university hospitals

    Article • European Journal of Clinical Pharmacology, September 1997, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  50. Use of Intravenous Omeprazole in a University Hospital

    Article • Journal of Pharmacy Technology, January 1997, SAGE Publications

    MD, PhD ANTONIO PORTOLES

  51. Adverse Drug Reactions in a Cardiology Department

    Article • Clinical Drug Investigation, July 1996, Springer Science + Business Media

    MD, PhD ANTONIO PORTOLES

  52. Physical dependence to morphine diminishes the interferon response in mice

    Article • Immunopharmacology, October 1987, Elsevier

    MD, PhD ANTONIO PORTOLES

  53. Inmunoferon (Am3) Enhances the Activities of Early–Type Interferon Inducers and Natural Killer Cells.

    Article • Immunopharmacology and Immunotoxicology, January 1987, Taylor & Francis

    MD, PhD ANTONIO PORTOLES