All Stories

  1. Employing Genome Mining to Unveil a Potential Contribution of Endophytic Bacteria to Antimicrobial Compounds in the Origanum vulgare L. Essential Oil
  2. FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022
  3. Bioactive Metabolite Survey of Actinobacteria Showing Plant Growth Promoting Traits to Develop Novel Biofertilizers
  4. Shaping 1,2,4-Triazolium Fluorinated Ionic Liquid Crystals
  5. Salphen metal complexes as potential anticancer agents: interaction profile and selectivity studies toward the three G-quadruplex units in the KIT promoter
  6. Antiproliferative Activity Predictor: A New Reliable In Silico Tool for Drug Response Prediction against NCI60 Panel
  7. Iodocyclization of 2‐Methylthiophenylacetylenes to 3‐Iodobenzothiophenes and their coupling Reactions under More Sustainable Conditions
  8. Endophytic Bacteria and Essential Oil from Origanum vulgare ssp. vulgare Share Some VOCs with an Antibacterial Activity
  9. Genomic Analysis of Endophytic Bacillus-Related Strains Isolated from the Medicinal Plant Origanum vulgare L. Revealed the Presence of Metabolic Pathways Involved in the Biosynthesis of Bioactive Compounds
  10. Bioactive Oxadiazoles 2.0
  11. Chemical composition, cytotoxic effects, antimicrobial and antibiofilm activity of Artemisia arborescens (Vaill.) L. growing wild in the province of Agrigento, Sicily, Italy
  12. Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and anti-biofilm activities
  13. WRKY Gene Family Drives Dormancy Release in Onion Bulbs
  14. Low mimosine content and nutrient-rich foliage of two Leucaena leucocephala varieties: a potential fodder resource in Mediterranean agroforestry systems
  15. Synthesis of oxazolidinones from N-aryl-carbamate and epichlorohydrin under mild conditions
  16. Bio-Waste Products of Mangifera indica L. Reduce Adipogenesis and Exert Antioxidant Effects on 3T3-L1 Cells
  17. Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered
  18. 1,2,4-Oxadiazoles
  19. Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles. Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity
  20. Oxadiazolyl-Pyridinium as Cationic Scaffold for Fluorinated Ionic Liquid Crystals
  21. Presence and biodistribution of perfluorooctanoic acid (PFOA) in Paracentrotus lividus highlight its potential application for environmental biomonitoring
  22. Multicomponent Synthesis of Benzothiophen‐2‐acetic Esters by a Palladium Iodide Catalyzed S‐cyclization – Alkoxycarbonylation Sequence
  23. Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway
  24. Can phthalates move into the eggs of the loggerhead sea turtle Caretta caretta? The case of the nests on the Linosa Island in the Mediterranean Sea
  25. Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo
  26. The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors
  27. Editorial for Special Issue “Bioactive Oxadiazoles”
  28. Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases
  29. Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors
  30. Antibacterial activity and HPLC analysis of extracts from Mediterranean brown algae
  31. Iodolactonization of 3‐Alkynylthiophene‐2‐Carboxylic and 3‐Alkynylpicolinic Acids for the Synthesis of Fused Heterocycles
  32. Curcumin Affects HSP60 Folding Activity and Levels in Neuroblastoma Cells
  33. Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
  34. Unexpected Substituent Effects in the Iso-Heterocyclic Boulton–Katritzky Rearrangement of 3-Aroylamino-5-methyl-1,2,4-oxadiazoles: A Mechanistic Study
  35. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells
  36. Catalytic Carbonylative Double Cyclization of 2-(3-Hydroxy-1-yn-1-yl)phenols in Ionic Liquids Leading to Furobenzofuranone Derivatives
  37. Polyaminoazide mixtures for the synthesis of pH-responsive calixarene nanosponges
  38. Synthesis, computational evaluation and pharmacological assessment of acetylsalicylic esters as anti-inflammatory agents
  39. Recent development in fluorinated antibiotics
  40. An integrated proteomic and metabolomic study to evaluate the effect of nucleus-cytoplasm interaction in a diploid citrus cybrid between sweet orange and lemon
  41. Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells
  42. Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications
  43. Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting
  44. Photochemically Produced Singlet Oxygen: Applications and Perspectives
  45. Dimethyl 2,2′-[Carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate]
  46. Perfluorocarbons–graphene oxide nanoplatforms as biocompatible oxygen reservoirs
  47. Rearrangements of 1,2,4-Oxadiazole: “One Ring to Rule Them All”
  48. Design, synthesis, and biological evaluation of a new class of benzo[b ]furan derivatives as antiproliferative agents, with in silico predicted antitubulin activity
  49. INVESTIGATING THE POTENTIAL OF NOVEL CURCUMIN DERIVATIVES IN TARGETING AND MODULATING TOXIC TAU OLIGOMERIC STRAINS
  50. The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex ( CubipyOXA ) leads to cell death in NCI-H292 cancer cells
  51. Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
  52. Cover Image
  53. Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease
  54. Editorial (Thematic Issue: Current and Perspective Therapeutic Strategies for Alzheimer's Disease)
  55. The Binding Mechanism of Epolactaene to Hsp60 Unveiled by in Silico Modelling
  56. Curcumin-Like Compounds Designed to Modify Amyloid Beta Peptide Aggregation Pattern
  57. Structure and Stability of Hsp60 and Groel in Solution
  58. Synthesis of a fluorinated graphene oxide–silica nanohybrid: improving oxygen affinity
  59. Ru(bpy) 2 Cl 2 : a catalyst able to shift the course of the photorearrangement in the Boulton–Katritzky reaction
  60. Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring
  61. On the rearrangement of some Z-arylhydrazones of 3-benzoyl-5-phenylisoxazoles into 2-aryl-4-phenacyl-2H-1,2,3-triazoles: a kinetic study of the substituent effects in Boulton–Katritzky reactions
  62. Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[b]thiophene derivatives
  63. Photo-inhibition of Aβ fibrillation mediated by a newly designed fluorinated oxadiazole
  64. Quaternary structures of GroEL and naïve-Hsp60 chaperonins in solution: a combined SAXS-MD study
  65. Recent Advances in the Chemistry of 1,2,4-OxadiazolesaaDedicated to Professor Nicolò Vivona on the occasion of his 75th birthday.
  66. Chaperonotherapy for Alzheimer’s Disease: Focusing on HSP60
  67. New potent antibacterials against Gram-positive multiresistant pathogens: Effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles
  68. The Boulton-Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1,2,4-oxadiazoles
  69. Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
  70. Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay
  71. Perfluorocarbon functionalized hyaluronic acid derivatives as oxygenating systems for cell culture
  72. Chemistry of Fluorinated Oxadiazoles and Thiadiazoles
  73. Photochemical synthesis of pyrene perfluoroalkyl derivatives and their embedding in a polymethylmethacrylate matrix: a spectroscopic and structural study
  74. Hsp60 chaperonopathies and chaperonotherapy: targets and agents
  75. Photochemical functionalization of allyl benzoates by C–H insertion
  76. New antibacterial linezolid-like 1,2,4-oxadiazoles
  77. Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design
  78. Synthesis of Isoxazoline Derivatives through Boulton–Katritzky Rearrangement of 1,2,4‐Oxadiazoles
  79. Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction
  80. Synthesis of Tetrasubstituted 4,4′-Biimidazoles
  81. Fluorinated and pegylated polyaspartamide derivatives to increase solubility and efficacy of Flutamide
  82. Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives
  83. Synthesis of fluorinated oxadiazoles with gelation and oxygen storage ability
  84. Tandem Reactions of 1,2,4-Oxadiazoles with Allylamines
  85. Synthesis and chemical characterization of CuII, NiII and ZnII complexes of 3,5-bis(2′-pyridyl)-1,2,4-oxadiazole and 3-(2′-pyridyl)5-(phenyl)-1,2,4-oxadiazole ligands
  86. A new palladium(II)-catalyzed [3,3] aza-Claisen rearrangement of 3-allyloxy-5-aryl-1,2,4-oxadiazoles
  87. Synthesis of 4(5)-phenacyl-imidazoles from isoxazole side-chain rearrangements
  88. Bioactive Compounds Containing Benzoxadiazole, Benzothiadiazole, Benzotriazole
  89. Synthesis of Amino-1,2,4-triazoles by Reductive ANRORC Rearrangements of 1,2,4-Oxadiazoles
  90. Fluorescent Hg2+ Sensors: Synthesis and Evaluation of a Tren‐Based Starburst Molecule Containing Fluorinated 1,2,4‐Oxadiazoles
  91. Exploiting the CNC Side Chain in Heterocyclic Rearrangements: Synthesis of 4(5)-Acylamino-imidazoles
  92. Synthesis, characterization, cellular uptake and interaction with native DNA of a bis(pyridyl)-1,2,4-oxadiazole copper(ii) complex
  93. Synthesis of Heteroaromatics via Rearrangement Reactions
  94. Gas phase behavior of radical cations of perfluoroalkyl-1,2,4-triazines: an experimental and theoretical study
  95. Extended Investigation of the Aqueous Self-Assembling Behavior of a Newly Designed Fluorinated Surfactant
  96. 1,2,4-Oxadiazole Rearrangements Involving an NNC Side-Chain Sequence
  97. An ANRORC approach to the synthesis of perfluoroalkylated 1,2,4-triazole-carboxamides
  98. Synthesis of fluorinated 1,2,4-oxadiazin-6-ones through ANRORC rearrangement of 1,2,4-oxadiazoles
  99. Solvent dependent photochemical reactivity of 3-allyloxy-1,2,4-oxadiazoles
  100. On the reaction of some 5-polyfluoroaryl-1,2,4-oxadiazoles with methylhydrazine: synthesis of fluorinated indazoles
  101. Fluorinated derivatives of a polyaspartamide bearing polyethylene glycol chains as oxygen carriers
  102. Effect of protonation and deprotonation on the gas-phase reactivity of fluorinated 1,2,4-triazines
  103. Synthesis of trifluoromethylated 2-benzoyl- and 2-aminoimidazoles from ring rearrangement of 1,2,4-oxadiazole derivatives
  104. Hydration/elimination reactions of trapped protonated fluoroalkyl triazines
  105. Experimental and DFT Studies on Competitive Heterocyclic Rearrangements. Part 2:1 A One-Atom Side-Chain versus the Classic Three-Atom Side-Chain (Boulton−Katritzky) Ring Rearrangement of 3-Acylamino-1,2,4-oxadiazoles
  106. Fluoropolymer Based on a Polyaspartamide containing 1,2,4-Oxadiazole Units: A Potential Artificial Oxygen (O2) Carrier
  107. On the Photoreaction of Some 1,2,4-Oxadiazoles in the Presence of 2,3-Dimethyl-2-butene. Synthesis of N-Imidoylaziridines
  108. Synthesis of fluorinated first generation starburst molecules containing a triethanolamine core and 1,2,4-oxadiazoles
  109. Lower rim arylation of calix[n]arenes with extended perfluorinated domains
  110. Five-to-Six Membered Ring-Rearrangements in the Reaction of 5-Perfluoroalkyl-1,2,4-oxadiazoles with Hydrazine and Methylhydrazine
  111. Synthesis of fluorinated indazoles through ANRORC-like rearrangement of 1,2,4-oxadiazoles with hydrazine
  112. One-pot synthesis of fluorinated 2-amino-pyrimidine-N-oxides. Competing pathways in the four-atom side-chain rearrangements of 1,2,4-oxadiazoles
  113. Synthesis and Characterization of a Series of Alkyloxadiazolylpyridinium Salts as Perspective Ionic Liquids
  114. Fluorinated Heterocyclic Compounds. An Effective Strategy for the Synthesis of Fluorinated Z-Oximes of 3-Perfluoroalkyl-6-phenyl-2H-1,2,4-triazin- 5-ones via a Ring-Enlargement Reaction of 3-Benzoyl-5-perfluoroalkyl-1,2,4-oxadiazoles and ...
  115. Fluorinated Heterocyclic Compounds. A Photochemical Approach to a Synthesis of Polyfluoroaryl-1,2,4-triazoles
  116. Fluorinated Heterocyclic Compounds. A Photochemical Approach to a Synthesis of Fluorinated Quinazolin-4-ones