All Stories

  1. The role of oxidative stress and antioxidant therapy in cisplatin neurotoxicity: preclinical evidence in the last decade

    Article • Archives of Toxicology, April 2026, Springer Science + Business Media

    Antonio Santos

  2. Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway

    Article • Journal of Venomous Animals and Toxins including Tropical Diseases, January 2024, FapUNIFESP (SciELO)

    Antonio Santos

  3. Baccharin from Brazilian green propolis induces neurotrophic signaling pathways in PC12 cells: potential for axonal and synaptic regeneration

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, March 2022, Springer Science + Business Media

    Renato Parreira, Antonio Santos

  4. The antibiotic doxycycline mimics the NGF signaling in PC12 cells: A relevant mechanism for neuroprotection

    Article • Chemico-Biological Interactions, May 2021, Elsevier

    Antonio Santos

  5. The Neurotrophic-Like Effect of Carvacrol: Perspective for Axonal and Synaptic Regeneration

    Article • Neurotoxicity Research, March 2021, Springer Science + Business Media

    Antonio Santos

  6. Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+

    Article • Journal of Pharmacy and Pharmacology, October 2020, Oxford University Press (OUP)

    Antonio Santos

  7. Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents

    Article • Food and Chemical Toxicology, February 2020, Elsevier

    Antonio Santos

  8. Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity by Activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt Signaling Pathways

    Article • Neurotoxicity Research, April 2019, Springer Science + Business Media

    Antonio Santos

  9. The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells

    Article • Neurotoxicity Research, August 2018, Springer Science + Business Media

    Antonio Santos

  10. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP + toxicity by activating the NGF-signaling pathway

    Article • Peptides, June 2018, Elsevier

    Antonio Santos

  11. Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells from Cisplatin-Induced Neurotoxicity by Activating the NGF-Signaling Pathway

    Article • Neurotoxicity Research, December 2017, Springer Science + Business Media

    Antonio Santos

  12. L- and T-type calcium channel blockers protect against the inhibitory effects of mipafox on neurite outgrowth and plasticity-related proteins in SH-SY5Y cells

    Article • Journal of Toxicology and Environmental Health Part A, September 2017, Taylor & Francis

    Antonio Santos

  13. High concentration of trichlorfon (1 mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells

    Article • Toxicology in Vitro, March 2017, Elsevier

    Antonio Santos

  14. The cannabinoid beta-caryophyllene (BCP) induces neuritogenesis in PC12 cells by a cannabinoid-receptor-independent mechanism

    Article • Chemico-Biological Interactions, January 2017, Elsevier

    Antonio Santos

  15. Non-cytotoxic Concentration of Cisplatin Decreases Neuroplasticity-Related Proteins and Neurite Outgrowth Without Affecting the Expression of NGF in PC12 Cells

    Article • Neurochemical Research, July 2016, Springer Science + Business Media

    Antonio Santos

  16. Carvedilol protects the kidneys of tumor-bearing mice without impairing the biodistribution or the genotoxicity of cisplatin

    Article • Chemico-Biological Interactions, February 2016, Elsevier

    Dr OSWALDO BAFFA , Antonio Santos

  17. The neuroprotection of cannabidiol against MPP + -induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease

    Article • Toxicology in Vitro, December 2015, Elsevier

    Antonio Santos

  18. In vitro study of the neuropathic potential of the organophosphorus compounds fenamiphos and profenofos: Comparison with mipafox and paraoxon

    Article • Toxicology in Vitro, August 2015, Elsevier

    Antonio Santos

  19. A tripeptide isolated from Bothrops atrox venom has neuroprotective and neurotrophic effects on a cellular model of Parkinson’s disease

    Article • Chemico-Biological Interactions, June 2015, Elsevier

    Antonio Santos

  20. In vitro study of the neuropathic potential of the organophosphorus compounds trichlorfon and acephate

    Article • Toxicology in Vitro, April 2015, Elsevier

    Antonio Santos

  21. Effect of diabetes on biodistribution, nephrotoxicity and antitumor activity of cisplatin in mice

    Article • Chemico-Biological Interactions, March 2015, Elsevier

    Antonio Santos

  22. Caffeic acid phenethyl ester (CAPE) protects PC12 cells from MPP+ toxicity by inducing the expression of neuron-typical proteins

    Article • NeuroToxicology, December 2014, Elsevier

    Antonio Santos

  23. Carvedilol efficiently protects kidneys without affecting the antitumor efficacy of cisplatin in mice

    Article • Chemico-Biological Interactions, October 2013, Elsevier

    Antonio Santos

  24. Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats

    Article • Neuroscience, March 2013, Elsevier

    Dr OSWALDO BAFFA , Antonio Santos

  25. Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy

    Article • Chemico-Biological Interactions, September 2012, Elsevier

    Antonio Santos

  26. Carvedilol Protects Against Apoptotic Cell Death Induced by Cisplatin in Renal Tubular Epithelial Cells

    Article • Journal of Toxicology and Environmental Health Part A, August 2012, Taylor & Francis

    Antonio Santos

  27. Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

    Article • Archives of Toxicology, March 2012, Springer Science + Business Media

    Antonio Santos

  28. Release of NO from a nitrosyl ruthenium complex through oxidation of mitochondrial NADH and effects on mitochondria

    Article • Nitric Oxide, March 2012, Elsevier

    Antonio Santos

  29. Protective effect of bixin on cisplatin-induced genotoxicity in PC12 cells

    Article • Food and Chemical Toxicology, February 2012, Elsevier

    Mrs Graciela C dos Santos, Antonio Santos

  30. Antioxidants and Inhibition of Cisplatin-Induced Kidney Injury: Role of Mitochondria

    Article • October 2011, Springer Science + Business Media

    Antonio Santos

  31. Characterization of the stimulus for reactive oxygen species generation in calcium-overloaded mitochondria

    Article • Redox Report, July 2011, Taylor & Francis

    Antonio Santos

  32. Carvedilol protects against cisplatin-induced oxidative stress, redox state unbalance and apoptosis in rat kidney mitochondria

    Article • Chemico-Biological Interactions, January 2011, Elsevier

    Antonio Santos

  33. Low-molecular-mass peptides from the venom of the Amazonian viper Bothrops atrox protect against brain mitochondrial swelling in rat: Potential for neuroprotection

    Article • Toxicon, August 2010, Elsevier

    Antonio Santos

  34. Impact of adenosine nucleotide translocase (ANT) proline isomerization on Ca2+-induced cysteine relative mobility/mitochondrial permeability transition pore

    Article • Journal of Bioenergetics and Biomembranes, July 2010, Springer Science + Business Media

    Antonio Santos

  35. Carvedilol protects against the renal mitochondrial toxicity induced by cisplatin in rats

    Article • Mitochondrion, January 2010, Elsevier

    Antonio Santos

  36. Coenzyme Q10 and its effects in the treatment of neurodegenerative diseases

    Article • Brazilian Journal of Pharmaceutical Sciences, December 2009, FapUNIFESP (SciELO)

    Mrs Graciela C dos Santos, Antonio Santos

  37. Effects of zinc phthalocyanine tetrasulfonate-based photodynamic therapy on rat brain isolated mitochondria

    Article • Chemico-Biological Interactions, May 2009, Elsevier

    Antonio Santos

  38. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, April 2009, Elsevier

    Antonio Santos

  39. Ca2+ binding to c-state of adenine nucleotide translocase (ANT)-surrounding cardiolipins enhances (ANT)-Cys56 relative mobility: A computational-based mitochondrial permeability transition study

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, March 2009, Elsevier

    Antonio Santos

  40. Effects on mitochondria of mitochondria-induced nitric oxide release from a ruthenium nitrosyl complex

    Article • Nitric Oxide, February 2009, Elsevier

    Antonio Santos

  41. Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs

    Article • Toxicology in Vitro, December 2008, Elsevier

    Antonio Santos

  42. Antioxidant activity of flavonoids in isolated mitochondria

    Article • Phytotherapy Research, August 2008, Wiley

    Antonio Santos

  43. Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver

    Article • Toxicology in Vitro, August 2008, Elsevier

    Antonio Santos

  44. Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats

    Article • Chemico-Biological Interactions, December 2007, Elsevier

    Antonio Santos

  45. Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline

    Article • Toxicon, October 2007, Elsevier

    Antonio Santos

  46. Potential toxicity of toluene and xylene evoked by mitochondrial uncoupling

    Article • Toxicology in Vitro, August 2007, Elsevier

    Antonio Santos

  47. 4-hydroxy nimesulide effects on mitochondria and HepG2 cells. A comparison with nimesulide

    Article • European Journal of Pharmacology, July 2007, Elsevier

    Antonio Santos

  48. Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver

    Article • Journal of Applied Toxicology, June 2007, Wiley

    Antonio Santos

  49. Antioxidant activity of isocoumarins isolated from Paepalanthus bromelioides on mitochondria

    Article • Phytochemistry, April 2007, Elsevier

    Antonio Santos

  50. Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria

    Article • Cancer Chemotherapy and Pharmacology, March 2007, Springer Science + Business Media

    Antonio Santos

  51. Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria

    Article • Archives of Toxicology, January 2007, Springer Science + Business Media

    Antonio Santos

  52. Mitochondrial Uncoupling by the Sulindac Metabolite, Sulindac Sulfide

    Article • Basic & Clinical Pharmacology & Toxicology, October 2006, Wiley

    Antonio Santos

  53. Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice

    Article • Journal of Photochemistry and Photobiology B Biology, July 2006, Elsevier

    Antonio Santos

  54. Effects of isocoumarins isolated from Paepalanthus bromelioides on mitochondria: Uncoupling, and induction/inhibition of mitochondrial permeability transition

    Article • Chemico-Biological Interactions, June 2006, Elsevier

    Antonio Santos

  55. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters

    Article • Food and Chemical Toxicology, June 2006, Elsevier

    Antonio Santos

  56. Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity

    Article • AAPS PharmSciTech, March 2006, Springer Science + Business Media

    Antonio Santos

  57. Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang's main component

    Article • Chemico-Biological Interactions, February 2006, Elsevier

    Antonio Santos

  58. The interaction of flavonoids with mitochondria: effects on energetic processes

    Article • Chemico-Biological Interactions, April 2005, Elsevier

    Antonio Santos

  59. Erratum

    Article • Free Radical Biology and Medicine, August 2004, Elsevier

    Antonio Santos

  60. Erratum

    Article • Free Radical Biology and Medicine, August 2004, Elsevier

    Antonio Santos

  61. In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus

    Article • The International Journal of Biochemistry & Cell Biology, January 2004, Elsevier

    Antonio Santos

  62. A proposed sequence of events for cadmium-induced mitochondrial impairment

    Article • Journal of Inorganic Biochemistry, November 2003, Elsevier

    Antonio Santos

  63. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis – potentially implicated mechanisms

    Article • British Journal of Pharmacology, May 2002, Wiley

    Antonio Santos

  64. Effects of H2-receptor antagonists on dapsone-induced methaemoglobinaemia in rats

    Article • Pharmacological Research, April 2002, Elsevier

    Antonio Santos

  65. The Critical Role of Mitochondrial Energetic Impairment in the Toxicity of Nimesulide to Hepatocytes

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2002, Elsevier

    Antonio Santos

  66. Effects of nimesulide and its reduced metabolite on mitochondria

    Article • British Journal of Pharmacology, November 2000, Wiley

    Antonio Santos

  67. Fluoxetine interacts with the lipid bilayer of the inner membrane in isolated rat brain mitochondria, inhibiting electron transport and F1F0-ATPase activity

    Article • Molecular and Cellular Biochemistry, September 1999, Springer Science + Business Media

    Antonio Santos

  68. Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved

    Article • The International Journal of Biochemistry & Cell Biology, September 1998, Elsevier

    Antonio Santos

  69. Effect of Naturally Occurring Flavonoids on Lipid Peroxidation and Membrane Permeability Transition in Mitochondria

    Article • Free Radical Biology and Medicine, June 1998, Elsevier

    Antonio Santos

  70. Diclofenac Sodium and Mefenamic Acid: Potent Inducers of the Membrane Permeability Transition in Renal Cortex Mitochondria

    Article • Archives of Biochemistry and Biophysics, June 1997, Elsevier

    Antonio Santos

  71. In VitroInteraction of Nonsteroidal Anti-inflammatory Drugs on Oxidative Phosphorylation of Rat Kidney Mitochondria: Respiration and ATP Synthesis

    Article • Archives of Biochemistry and Biophysics, October 1996, Elsevier

    Antonio Santos

  72. Occupational exposure to lead, kidney function tests, and blood pressure

    Article • American Journal of Industrial Medicine, November 1994, Wiley

    Antonio Santos

  73. An Improved Method for the Simultaneous Determination of Mandelic and Phenylglyoxylic Acids by Gas Chromatography

    Article • Journal of Analytical Toxicology, May 1994, Oxford University Press (OUP)

    Antonio Santos

  74. A new derivatization procedure for the analysis of hippuric acid and m-methyl-hippuric acid by gas chromatography

    Article • International Archives of Occupational and Environmental Health, May 1991, Springer Science + Business Media

    Antonio Santos