All Stories

  1. The burden of hypercholesterolemia and ischemic heart disease in an ageing world

    Article • Pharmacological Research, July 2023, Elsevier

    Dr Angela Pirillo

  2. Lipid-lowering treatment and LDL-C goal attainment in high and very high cardiovascular risk patients: Evidence from the SANTORINI study-The Italian experience

    Article • European Atherosclerosis Journal, April 2023, S.I.Te.C.S Societa Italiana di Terapia Clinica e Sperimentale

    Dr Angela Pirillo

  3. Remnant cholesterol: a reliable prognostic marker?

    Article • European Journal of Preventive Cardiology, April 2023, Oxford University Press (OUP)

    Dr Angela Pirillo

  4. Lp(a) as a Cardiovascular Risk Factor

    Article • January 2023, Springer Science + Business Media

    Dr Angela Pirillo

  5. Inclisiran: How Widely and When Should We Use It?

    Article • Current Atherosclerosis Reports, July 2022, Springer Science + Business Media

    Dr Angela Pirillo

  6. Evinacumab: a new option in the treatment of homozygous familial hypercholesterolemia

    Article • Expert Opinion on Biological Therapy, June 2022, Taylor & Francis

    Dr Angela Pirillo

  7. Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

    Article • Journal of the American Heart Association, April 2022, Wolters Kluwer Health

    Dr Angela Pirillo

  8. Understanding the efficacy and safety of lomitapide in homozygous familial hypercholesterolaemia

    Article • European Journal of Preventive Cardiology, February 2022, Oxford University Press (OUP)

    Dr Angela Pirillo

  9. New insights into the role of bempedoic acid and ezetimibe in the treatment of hypercholesterolemia

    Article • Current Opinion in Endocrinology Diabetes and Obesity, January 2022, Wolters Kluwer Health

    Dr Angela Pirillo

  10. Monoclonal Antibodies in the Management of Familial Hypercholesterolemia: Focus on PCSK9 and ANGPTL3 Inhibitors

    Article • Current Atherosclerosis Reports, October 2021, Springer Science + Business Media

    Dr Angela Pirillo

  11. Lipoprotein remnants: to be or not to be

    Article • European Heart Journal, August 2021, Oxford University Press (OUP)

    Dr Angela Pirillo

  12. Omega-3 for Cardiovascular Diseases: Where Do We Stand After REDUCE-IT and STRENGTH?

    Article • Circulation, July 2021, Wolters Kluwer Health

    Dr Angela Pirillo

  13. HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases

    Article • Cells, April 2021, MDPI AG

    Dr Angela Pirillo

  14. Global epidemiology of dyslipidaemias

    Article • Nature Reviews Cardiology, April 2021, Springer Science + Business Media

    Dr Angela Pirillo

  15. Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors

    Article • European Journal of Preventive Cardiology, November 2020, Oxford University Press (OUP)

    Dr Angela Pirillo

  16. The cardiovascular benefit of Lp(a) reduction: not there yet

    Article • European Heart Journal, November 2020, Oxford University Press (OUP)

    Dr Angela Pirillo

  17. LDL-Cholesterol-Lowering Therapy

    Article • January 2020, Springer Science + Business Media

    Dr Angela Pirillo

  18. Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects

    Article • Atherosclerosis, November 2019, Elsevier

    Dr Angela Pirillo

  19. Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation

    Article • Current Opinion in Lipidology, October 2019, Wolters Kluwer Health

    Dr Angela Pirillo

  20. Cholesterol metabolism, pancreatic β-cell function and diabetes

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, September 2019, Elsevier

    Dr Angela Pirillo

  21. The role of red yeast rice (RYR) supplementation in plasma cholesterol control: A review and expert opinion

    Article • Atherosclerosis Supplements, August 2019, Elsevier

    Dr Angela Pirillo

  22. Statins increase Lp(a) plasma level: is this clinically relevant?

    Article • European Heart Journal, July 2019, Oxford University Press (OUP)

    Professor Alberico L. Catapano, Dr Angela Pirillo

  23. Multilevel Models to Estimate Carotid Intima-Media Thickness Curves for Individual Cardiovascular Risk Evaluation

    Article • Stroke, July 2019, Wolters Kluwer Health

    Dr Angela Pirillo

  24. Biological Consequences of Dysfunctional HDL

    Article • Current Medicinal Chemistry, May 2019, Bentham Science Publishers

    Dr Angela Pirillo, Professor Alberico L. Catapano

  25. Cardiovascular events with PCSK9 inhibitors: an updated meta-analysis of randomised controlled trials

    Article • Pharmacological Research, May 2019, Elsevier

    Dr Angela Pirillo

  26. Novel strategies to target PCSK9: beyond monoclonal antibodies

    Article • Cardiovascular Research, January 2019, Oxford University Press (OUP)

    Professor Alberico L. Catapano, Dr Angela Pirillo

  27. Increasing high-density lipoprotein cholesterol levels for cardiovascular benefit: The end of a dream?

    Article • European Journal of Preventive Cardiology, December 2018, SAGE Publications

    Professor Alberico L. Catapano, Dr Angela Pirillo

  28. Lipid Lowering and Incidence of Cataract, a Role for Fibrates

    Article • Clinical Pharmacology & Therapeutics, December 2018, Wiley

    Dr Angela Pirillo

  29. High-density lipoprotein cholesterol levels, cardiovascular disease risk, and cancer: a relation which does not apply to all?

    Article • Cardiovascular Research, October 2018, Oxford University Press (OUP)

    Dr Angela Pirillo

  30. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

    Article • Atherosclerosis, October 2018, Elsevier

    Dr Angela Pirillo

  31. PCSK9 inhibition and Lp(a) reduction: another piece of the puzzle?

    Article • European Heart Journal, June 2018, Oxford University Press (OUP)

    Dr Angela Pirillo

  32. Proprotein Convertase Subtilisin Kexin 9 Inhibitors

    Article • Cardiology Clinics, May 2018, Elsevier

    Dr Angela Pirillo

  33. The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis

    Article • Current Atherosclerosis Reports, February 2018, Springer Science + Business Media

    Dr Angela Pirillo

  34. Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease: The heredity survey

    Article • International Journal of Cardiology, February 2018, Elsevier

    Dr Angela Pirillo

  35. Targeting Cholesterol in Non-ischemic Heart Failure: A Role for LDLR Gene Therapy?

    Article • Molecular Therapy, November 2017, Elsevier

    Dr Angela Pirillo

  36. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study

    Article • Atherosclerosis Supplements, October 2017, Elsevier

    Dr Angela Pirillo

  37. Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives

    Article • Vascular Health and Risk Management, September 2017, Dove Medical Press

    Professor Alberico L. Catapano, Dr Angela Pirillo

  38. Strategies for the use of nonstatin therapies

    Article • Current Opinion in Lipidology, September 2017, Wolters Kluwer Health

    Dr Angela Pirillo

  39. Statin use and risk of new-onset diabetes: a meta-analysis of observational studies

    Article • Atherosclerosis, August 2017, Elsevier

    Dr Angela Pirillo

  40. Effect of PSCK9 loss-of-function mutation R46l on plasma lipids, endothelial function and vascular inflammation in the post-prandial state

    Article • Atherosclerosis, August 2017, Elsevier

    Dr Angela Pirillo

  41. PCSK9 inhibition in statin-intolerant HeFH patients: What’s new?

    Article • European Journal of Preventive Cardiology, July 2017, SAGE Publications

    Professor Alberico L. Catapano, Dr Angela Pirillo

  42. Pitavastatin and HDL: Effects on plasma levels and function(s)

    Article • Atherosclerosis Supplements, July 2017, Elsevier

    Dr Angela Pirillo

  43. Vascular inflammation and low-density lipoproteins: is cholesterol the link? A lesson from the clinical trials

    Article • British Journal of Pharmacology, May 2017, Wiley

    Dr Angela Pirillo

  44. Statin use and risk of new-onset diabetes: A meta-analysis of observational studies

    Article • Nutrition Metabolism and Cardiovascular Diseases, May 2017, Elsevier

    Dr Angela Pirillo

  45. Familial Hypercholesterolemia

    Article • January 2017, Elsevier

    Dr Angela Pirillo

  46. Advances in Hypercholesterolemia

    Article • January 2017, Elsevier

    Dr Angela Pirillo

  47. Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

    Article • Cardiovascular Research, August 2016, European Society of Cardiology

    Dr Angela Pirillo

  48. Niemann-Pick C1-Like 1 (NPC1L1) Inhibition and Cardiovascular Diseases

    Article • Current Medicinal Chemistry, April 2016, Bentham Science Publishers

    Dr Angela Pirillo

  49. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

    Article • Atherosclerosis, December 2015, Elsevier

    Dr Angela Pirillo

  50. Apolipoprotein C-III: From Pathophysiology to Pharmacology

    Article • Trends in Pharmacological Sciences, October 2015, Elsevier

    Dr Angela Pirillo

  51. Statin Intolerance: Diagnosis and Remedies

    Article • Current Cardiology Reports, April 2015, Springer Science + Business Media

    Dr Angela Pirillo

  52. Update on the management of severe hypertriglyceridemia – focus on free fatty acid forms of omega-3

    Article • Drug Design Development and Therapy, April 2015, Taylor & Francis

    Professor Alberico L. Catapano, Dr Angela Pirillo

  53. Statins and Lomitapide: A Suitable Response for Homozygous Familial Hypercholesterolemia?

    Article • January 2015, Springer Science + Business Media

    Dr Angela Pirillo

  54. HDL in Infectious Diseases and Sepsis

    Article • December 2014, Springer Science + Business Media

    Dr Angela Pirillo

  55. Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosus

    Article • Nutrition Metabolism and Cardiovascular Diseases, July 2014, Elsevier

    Dr Angela Pirillo

  56. HDL in innate and adaptive immunity

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Professor Alberico L. Catapano, Dr Angela Pirillo

  57. HDL: To Treat or Not To Treat?

    Article • Current Atherosclerosis Reports, June 2014, Springer Science + Business Media

    Dr Angela Pirillo

  58. Postprandial lipemia as a cardiometabolic risk factor

    Article • Current Medical Research and Opinion, May 2014, Informa Healthcare

    Dr Angela Pirillo

  59. 15-Lipoxygenase-Mediated Modification of HDL3 Impairs eNOS Activation in Human Endothelial Cells

    Article • Lipids, February 2014, Wiley

    Dr Angela Pirillo

  60. Omega-3 polyunsaturated fatty acids in the treatment of hypertriglyceridaemia

    Article • International Journal of Cardiology, December 2013, Elsevier

    Dr Angela Pirillo

  61. Prevalence of classical CD14++/CD16− but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia

    Article • International Journal of Cardiology, October 2013, Elsevier

    Dr Angela Pirillo

  62. Omega-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia

    Article • Atherosclerosis Supplements, August 2013, Elsevier

    Dr Angela Pirillo

  63. Production and Metabolism of Triglyceride-Rich Lipoproteins in Both the Normal and Diabetic States

    Article • July 2013, Springer Science + Business Media

    Dr Angela Pirillo

  64. Treating High Density Lipoprotein Cholesterol (HDL-C): Quantity Versus Quality

    Article • Current Pharmaceutical Design, April 2013, Bentham Science Publishers

    Dr Angela Pirillo

  65. LOX-1, OxLDL, and Atherosclerosis

    Article • Mediators of Inflammation, January 2013, Hindawi Publishing Corporation

    Dr Angela Pirillo

  66. High-Density Lipoprotein Subfractions - What the Clinicians Need to Know

    Article • Cardiology, January 2013, Karger Publishers

    Dr Angela Pirillo

  67. Soluble Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 as a Biochemical Marker for Atherosclerosis-Related Diseases

    Article • Disease Markers, January 2013, Hindawi Publishing Corporation

    Dr Angela Pirillo

  68. Upregulation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human endothelial cells by modified high density lipoproteins

    Article • Biochemical and Biophysical Research Communications, November 2012, Elsevier

    Dr Angela Pirillo

  69. Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia

    Article • European Journal of Clinical Pharmacology, July 2012, Springer Science + Business Media

    Dr Angela Pirillo

  70. Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models

    Article • Journal of the American Heart Association, June 2012, Wolters Kluwer Health

    Dr Angela Pirillo

  71. Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models

    Article • Journal of the American Heart Association, February 2012, Wolters Kluwer Health

    Dr Angela Pirillo

  72. Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population

    Article • PLoS ONE, February 2012, PLOS

    Dr Angela Pirillo

  73. Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels

    Article • Atherosclerosis, February 2012, Elsevier

    Dr Angela Pirillo

  74. Emerging role of high density lipoproteins as a player in the immune system

    Article • Atherosclerosis, January 2012, Elsevier

    Dr Angela Pirillo

  75. HDLs, immunity, and atherosclerosis

    Article • Current Opinion in Lipidology, October 2011, Wolters Kluwer Health

    Dr Angela Pirillo

  76. Therapy and clinical trials

    Article • Current Opinion in Lipidology, August 2011, Wolters Kluwer Health

    Dr Angela Pirillo

  77. Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro

    Article • Journal of Thrombosis and Haemostasis, August 2011, Wiley

    Dr Angela Pirillo

  78. Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells

    Article • Atherosclerosis, February 2011, Elsevier

    Dr Angela Pirillo

  79. Dual effect of hypochlorite in the modification of high density lipoproteins

    Article • Biochemical and Biophysical Research Communications, December 2010, Elsevier

    Dr Angela Pirillo

  80. The Challenge of Lipid Management in Patients with Diabetes or Other Endocrine Disorders

    Article • touchREVIEWS in Endocrinology, January 2010, Touch Digital Media, Ltd.

    Dr Angela Pirillo

  81. The 15-lipoxygenase-modified HDL3 fail to inhibit the TNF- -induced inflammatory response in human endothelial cells

    Article • The Journal of Immunology, December 2008, The American Association of Immunologists

    Dr Angela Pirillo

  82. The 15-Lipoxygenase-Modified High Density Lipoproteins 3 Fail to Inhibit the TNF- -Induced Inflammatory Response in Human Endothelial Cells

    Article • The Journal of Immunology, August 2008, The American Association of Immunologists

    Dr Angela Pirillo

  83. EFFECTS OF NATIVE AND MODIFIED HDL ON HUMAN IMMUNE FUNCTIONS

    Article • Atherosclerosis Supplements, May 2008, Elsevier

    Dr Angela Pirillo

  84. Long Pentraxin 3, a Key Component of Innate Immunity, Is Modulated by High-Density Lipoproteins in Endothelial Cells

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2008, Wolters Kluwer Health

    Dr Angela Pirillo

  85. Modification of HDL3 by mild oxidative stress increases ATP-binding cassette transporter 1-mediated cholesterol efflux

    Article • Cardiovascular Research, August 2007, European Society of Cardiology

    Dr Angela Pirillo

  86. Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

    Article • Atherosclerosis, April 2007, Elsevier

    Dr Angela Pirillo

  87. Modified HDL: Biological and physiopathological consequences

    Article • Nutrition Metabolism and Cardiovascular Diseases, July 2006, Elsevier

    Dr Angela Pirillo

  88. 15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophages

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, March 2006, Elsevier

    Dr Angela Pirillo

  89. In vitro isolation of circulating endothelial progenitor cells is related to the high density lipoprotein plasma levels

    Article • International Journal of Molecular Medicine, February 2006, Spandidos Publications

    Dr Angela Pirillo

  90. Th-P15:162 15-Lipoxygenase-mediated modification of high density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophages

    Article • Atherosclerosis Supplements, January 2006, Elsevier

    Dr Angela Pirillo

  91. Proteome of endothelial cell-derived procoagulant microparticles

    Article • PROTEOMICS, October 2005, Wiley

    Dr Angela Pirillo

  92. Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization

    Article • British Journal of Haematology, September 2004, Wiley

    Dr Angela Pirillo

  93. Native LDL and Oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-κB, CRE dependent pathway and affect PGE2 synthesis

    Article • International Journal of Molecular Medicine, September 2004, Spandidos Publications

    Dr Angela Pirillo

  94. Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDL

    Article • Cardiovascular Research, July 2003, European Society of Cardiology

    Dr Angela Pirillo

  95. Statins and Oxidative Stress During Atherogenesis

    Article • European Journal of Cardiovascular Prevention & Rehabilitation, June 2003, Wolters Kluwer Health

    Dr Angela Pirillo

  96. Article • Journal of Cardiovascular Risk, June 2003, Wolters Kluwer Health

    Dr Angela Pirillo

  97. Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini

    Article • Biochemical Journal, March 2002, Portland Press Ltd.

    Dr Angela Pirillo

  98. Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini

    Article • Biochemical Journal, March 2002, Portland Press Ltd.

    Dr Angela Pirillo

  99. Overexpression of Inducible Heat Shock Protein 70 in COS-1 Cells Fails to Protect From Cytotoxicity of Oxidized LDLs

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2001, Wolters Kluwer Health

    Dr Angela Pirillo

  100. Modification of high density lipoproteins: Effects on OxLDL cytotoxicity and on cholesterol efflux

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Angela Pirillo

  101. Enhanced Macrophage Uptake of Elastase-Modified High-Density Lipoproteins

    Article • Biochemical and Biophysical Research Communications, May 2000, Elsevier

    Dr Angela Pirillo

  102. Oxidized Lipoproteins and Endothelium

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2000, De Gruyter

    Dr Angela Pirillo

  103. Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells

    Article • FEBS Letters, November 1999, Wiley

    Dr Angela Pirillo

  104. Procyanidines from vitis vinifera seeds protect low density lipoproteins from oxidation

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Angela Pirillo

  105. Endothelium and oxidised lipoproteins

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Angela Pirillo

  106. Chronic stimulation by insulin induces HSP60 expression in cultured eahy cells

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Angela Pirillo

  107. Overexpression of HSP72 in COS-1 cells does not protect from apoptosis induced by oxidized LDL

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Angela Pirillo

  108. 3.P.87 Two distinct components of oxidized LDL mediate the heat shock response and cytotoxicity triggered by OxLDL

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Angela Pirillo

  109. 3.P.255 Cholesterol biosynthesis pathway is involved in the heat shock protein and cytotoxic indicated by oxidized LDL in cultured human endothelial cells and smooth muscle cells

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Angela Pirillo

  110. Simvastatin Modulates the Heat Shock Response and Cytotoxicity Mediated by Oxidized LDL in Cultured Human Endothelial Smooth Muscle Cells

    Article • Biochemical and Biophysical Research Communications, February 1997, Elsevier

    Dr Angela Pirillo

  111. Human Endothelial Cells Exposed to Oxidized LDL Express hsp70 Only When Proliferating

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 1996, Wolters Kluwer Health

    Dr Angela Pirillo

  112. Oxidized Ldl Trigger the Expression of Hsp70 in Cultured Endothelial Cells

    Article • January 1996, Springer Science + Business Media

    Dr Angela Pirillo

  113. Oxidized LDL induce hsp70 expression in human smooth muscle cells

    Article • FEBS Letters, September 1995, Wiley

    Dr Angela Pirillo

  114. Oxidized lipoproteins induce long-lasting inhibition of nitric oxide synthase from a murine endothelioma cell line (bEnd.4)

    Article • Journal of Cardiovascular Risk, April 1995, Wolters Kluwer Health

    Dr Angela Pirillo

  115. Oxidized Lipoproteins Induce Long-Lasting Inhibition of Nitric Oxide Synthase from a Murine Endothelioma Cell Line (bEnd.4)

    Article • European Journal of Cardiovascular Prevention & Rehabilitation, April 1995, SAGE Publications

    Dr Angela Pirillo

  116. Constituents of Nothapodytes foetida

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Dr Angela Pirillo