All Stories

  1. Cell-active peptide inhibitors of the FANCM-RMI interaction

    Article • November 2025, American Chemical Society (ACS)

    Dr Andrew J Deans

  2. Cell-active peptide inhibitors of the FANCM-RMI interaction

    Article • September 2025, American Chemical Society (ACS)

    Dr Andrew J Deans

  3. Local nucleolar surveillance mechanisms maintain rDNA stability

    Article • January 2025, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  4. Clinical and Genetic Spectrum of Fanconi Anaemia in Australia and New Zealand

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  5. Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase

    Article • Nucleic Acids Research, August 2024, Oxford University Press (OUP)

    Dr Andrew J Deans

  6. FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair

    Article • DNA Repair, August 2024, Elsevier

    Dr Andrew J Deans

  7. Improved gene targeting in vivo using EoHR, a small molecule inhibitor of 53BP1

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  8. Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  9. Publisher Correction: Nuclear export of circular RNA

    Article • Nature, March 2024, Springer Science + Business Media

    Dr Andrew J Deans

  10. ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

    Article • Nature Communications, March 2024, Springer Science + Business Media

    Dr Andrew J Deans

  11. Nuclear export of circular RNA

    Article • Nature, February 2024, Springer Science + Business Media

    Dr Andrew J Deans

  12. A systematic review investigating advances in gene therapy for Fanconi anemia over the last three decades

    Article • Frontiers in Hematology, August 2023, Frontiers

    Dr Andrew J Deans

  13. Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

    Article • Cell Genomics, August 2023, Elsevier

    Dr Andrew J Deans

  14. Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal

    Article • Cell Reports, December 2022, Elsevier

    Dr Andrew J Deans

  15. Fancm regulates meiotic double-strand break repair pathway choice in mammals

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  16. Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

    Article • Proceedings of the National Academy of Sciences, February 2022, Proceedings of the National Academy of Sciences

    Dr Andrew J Deans

  17. Childhood acute myeloid leukemia shows a high level of germline predisposition

    Article • Blood, December 2021, American Society of Hematology

    Dr Andrew J Deans

  18. Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer

    Article • npj Breast Cancer, September 2021, Springer Science + Business Media

    Dr Andrew J Deans

  19. The ubiquitination machinery of the Fanconi Anemia DNA repair pathway

    Article • Progress in Biophysics and Molecular Biology, August 2021, Elsevier

    Dr Andrew J Deans

  20. Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

    Article • Molecular and Cellular Biology, August 2021, Taylor & Francis

    Dr Andrew J Deans

  21. The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target

    Article • Molecular Cell, June 2021, Elsevier

    Dr Andrew J Deans

  22. A Structural Guide to the Bloom Syndrome Complex

    Article • Structure, February 2021, Elsevier

    Dr Andrew J Deans

  23. Fanconi anemia, put to sleep

    Article • Blood, January 2021, American Society of Hematology

    Dr Andrew J Deans

  24. Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency

    Article • Molecular Cell, December 2020, Elsevier

    Dr Andrew J Deans

  25. CDK-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  26. Structural insight into FANCI–FANCD2 monoubiquitination

    Article • Essays in Biochemistry, July 2020, Portland Press Ltd.

    Dr Andrew J Deans

  27. CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

    Article • Nature Communications, May 2020, Springer Science + Business Media

    Dr Andrew J Deans

  28. Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Dr Andrew J Deans

  29. Association of clinical severity with FANCB variant type in Fanconi anemia

    Article • Blood, April 2020, American Society of Hematology

    Dr Andrew J Deans

  30. Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

    Article • eLife, March 2020, eLife

    Dr Andrew J Deans

  31. Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

    Article • PLOS One, February 2020, PLOS

    Dr Andrew J Deans

  32. ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

    Article • Frontiers in Cell and Developmental Biology, February 2020, Frontiers

    Dr Andrew J Deans

  33. Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays

    Article • December 2019, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  34. Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

    Article • Nature Communications, November 2019, Springer Science + Business Media

    Dr Andrew J Deans

  35. ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

    Article • Nucleus, October 2019, Taylor & Francis

    Dr Andrew J Deans

  36. Clinical severity in Fanconi anemia correlates with residual function of FANCB missense variants

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  37. ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

    Article • PLoS Genetics, July 2019, PLOS

    Dr Andrew J Deans

  38. FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

    Article • Nature Communications, May 2019, Springer Science + Business Media

    Dr Andrew J Deans

  39. The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

    Article • Nature Communications, May 2019, Springer Science + Business Media

    Dr Andrew J Deans

  40. Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation

    Article • Cell Cycle, July 2018, Taylor & Francis

    Dr Andrew J Deans, Hongyan Wang

  41. Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

    Article • Blood Cancer Journal, June 2018, Springer Science + Business Media

    Dr Andrew J Deans

  42. FANCM-family branchpoint translocases remove co-transcriptional R-loops

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Dr Andrew J Deans

  43. ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

    Article • DNA Repair, September 2017, Elsevier

    Dr Andrew J Deans

  44. Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

    Article • Diabetes, July 2017, American Diabetes Association

    Dr Andrew J Deans, Thomas Kay

  45. A defined role for multiple Fanconi anemia gene products in DNA-damage-associated ubiquitination

    Article • Experimental Hematology, June 2017, Elsevier

    Dr Andrew J Deans

  46. Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway

    Article • Molecular Cell, January 2017, Elsevier

    Dr Andrew J Deans

  47. The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

    Article • Cell Reports, January 2017, Elsevier

    Dr Andrew J Deans

  48. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair

    Article • Scientific Reports, November 2016, Nature

    Dr Andrew J Deans

  49. The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

    Article • Molecular Cell, November 2015, Elsevier

    Dr Andrew J Deans

  50. The Architecture and Evolution of Cancer Neochromosomes

    Article • Cancer Cell, November 2014, Elsevier

    Dr Andrew J Deans

  51. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

    Article • Journal of Clinical Investigation, June 2014, American Society for Clinical Investigation

    Dr Andrew J Deans

  52. The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

    Article • Annual Review of Biophysics, May 2014, Annual Reviews

    Dr Andrew J Deans

  53. Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex

    Article • Structure, September 2013, Elsevier

    Dr Andrew J Deans

  54. Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1

    Article • Cell Cycle, February 2013, Taylor & Francis

    Dr Andrew J Deans

  55. Fanconi proteins get histones moving

    Article • The EMBO Journal, August 2012, Wiley

    Dr Andrew J Deans

  56. The DNA translocase activity of FANCM protects stalled replication forks

    Article • Human Molecular Genetics, January 2012, Oxford University Press (OUP)

    Dr Andrew J Deans

  57. DNA interstrand crosslink repair and cancer

    Article • Nature Reviews Drug Discovery, June 2011, Nature

    Dr Andrew J Deans

  58. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    Article • Cell, July 2010, Elsevier

    Dr Andrew J Deans

  59. FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

    Article • Molecular Cell, December 2009, Elsevier

    Dr Andrew J Deans

  60. FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

    Article • Molecular Cell, November 2008, Elsevier

    Dr Andrew J Deans

  61. No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

    Article • Breast Cancer Research and Treatment, June 2008, Springer Science + Business Media

    Dr Andrew J Deans

  62. Cyclin-Dependent Kinase 2 Functions in Normal DNA Repair and Is a Therapeutic Target in BRCA1-Deficient Cancers

    Article • Cancer Research, August 2006, American Association for Cancer Research (AACR)

    Dr Andrew J Deans

  63. Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary gland

    Article • Oncogene, June 2004, Nature

    Dr Andrew J Deans

  64. BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Andrew J Deans

  65. MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

    Article • The International Journal of Developmental Biology, January 2004, UBC Press

    Dr Andrew J Deans

  66. MAD1 and p27KIP1 Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity

    Article • Molecular and Cellular Biology, May 2002, ASM Journals

    Dr Andrew J Deans

  67. Article • Transgenic Research, January 2002, Springer Science + Business Media

    Dr Andrew J Deans