All Stories

  1. Structural analyses define the molecular basis of clusterin chaperone function

    Article • Nature Structural & Molecular Biology, August 2025, Springer Science + Business Media

    Dr. Andreas Bracher

  2. Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin

    Article • Journal of Molecular Biology, December 2024, Elsevier

    Dr. Andreas Bracher

  3. Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Dr. Andreas Bracher

  4. Hydrophobic tails enable diverse functions of the extracellular chaperone clusterin

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr. Andreas Bracher

  5. Cage-like complexes that protect folding proteins visualized in cells

    Article • Nature, September 2024, Springer Science + Business Media

    Dr. Andreas Bracher

  6. Visualizing chaperonin function in situ by cryo-electron tomography

    Article • Nature, August 2024, Springer Science + Business Media

    Dr. Andreas Bracher

  7. Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1

    Article • Cell, August 2024, Elsevier

    Dr. Andreas Bracher

  8. Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue

    Article • Bioorganic & Medicinal Chemistry Letters, May 2024, Elsevier

    Dr. Andreas Bracher

  9. Nucleotide Exchange Factors for Hsp70 Molecular Chaperones: GrpE, Hsp110/Grp170, HspBP1/Sil1, and BAG Domain Proteins

    Article • December 2022, Springer Science + Business Media

    Dr. Andreas Bracher

  10. Ebola and Marburg virus VP35 coiled-coil validated as antiviral target by tripartite split-GFP complementation

    Article • iScience, November 2022, Elsevier

    Dr. Andreas Bracher

  11. The chaperone Clusterin in neurodegeneration−friend or foe?

    Article • BioEssays, May 2022, Wiley

    Dr. Andreas Bracher

  12. The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Professor Michele Vendruscolo, Dr. Andreas Bracher

  13. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model

    Article • Nature Communications, August 2021, Springer Science + Business Media

    Dr. Andreas Bracher

  14. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr. Andreas Bracher

  15. Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity

    Article • Angewandte Chemie, May 2021, Wiley

    Dr. Andreas Bracher

  16. Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Dr. Andreas Bracher

  17. Protein Folding | Chaperonins

    Article • January 2021, Elsevier

    Dr. Andreas Bracher

  18. High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2

    Article • Biochemical and Biophysical Research Communications, January 2021, Elsevier

    Dr. Andreas Bracher

  19. Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes

    Article • Cell, October 2020, Elsevier

    Dr. Andreas Bracher

  20. Dual Role of a Rubisco Activase in Metabolic Repair and Carboxysome Organization

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr. Andreas Bracher

  21. Structure and conformational cycle of a bacteriophage-encoded chaperonin

    Article • PLOS One, April 2020, PLOS

    Dr. Andreas Bracher

  22. A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Dr. Andreas Bracher

  23. Structure of an enzyme that controls photosynthetic carbon fixation in response to light

    Article • Acta Crystallographica Section F Structural Biology Communications, April 2019, International Union of Crystallography

    Dr. Andreas Bracher, Robert Wilson

  24. Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2

    Article • Molecular Cell, April 2019, Elsevier

    Dr. Andreas Bracher

  25. Rubisco condensate formation by CcmM in β-carboxysome biogenesis

    Article • Nature, January 2019, Springer Science + Business Media

    Dr. Andreas Bracher

  26. Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species

    Article • Structure, January 2019, Elsevier

    Dr. Andreas Bracher

  27. Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins

    Article • Journal of Medicinal Chemistry, March 2018, American Chemical Society (ACS)

    Dr Can Murat Ünal, Dr. Andreas Bracher

  28. GroEL Ring Separation and Exchange in the Chaperonin Reaction

    Article • Cell, January 2018, Elsevier

    Dr. Andreas Bracher

  29. Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2

    Article • Science, December 2017, American Association for the Advancement of Science

    Dr. Andreas Bracher

  30. Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase

    Article • Molecular Cell, September 2017, Elsevier

    Dr. Andreas Bracher

  31. Crystal structure of theThermoplasma acidophilumprotein Ta1207

    Article • Acta Crystallographica Section F Structural Biology Communications, May 2017, International Union of Crystallography

    Dr. Andreas Bracher

  32. Biogenesis and Metabolic Maintenance of Rubisco

    Article • Annual Review of Plant Biology, April 2017, Annual Reviews

    Dr. Andreas Bracher

  33. Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51

    Article • Journal of Medicinal Chemistry, March 2016, American Chemical Society (ACS)

    Dr. Andreas Bracher

  34. Structure of human heat-shock transcription factor 1 in complex with DNA

    Article • Nature Structural & Molecular Biology, January 2016, Springer Science + Business Media

    Dr. Andreas Bracher

  35. The GroEL–GroES Chaperonin Machine: A Nano-Cage for Protein Folding

    Article • Trends in Biochemical Sciences, January 2016, Elsevier

    Dr. Andreas Bracher

  36. Structure–Affinity Relationship Analysis of Selective FKBP51 Ligands

    Article • Journal of Medicinal Chemistry, September 2015, American Chemical Society (ACS)

    Dr. Andreas Bracher

  37. Structural Analysis of the Rubisco-Assembly Chaperone RbcX-II from Chlamydomonas reinhardtii

    Article • PLOS One, August 2015, PLOS

    Dr. Andreas Bracher

  38. Structure and mechanism of the Rubisco-assembly chaperone Raf1

    Article • Nature Structural & Molecular Biology, August 2015, Springer Science + Business Media

    Dr. Andreas Bracher

  39. The nucleotide exchange factors of Hsp70 molecular chaperones

    Article • Frontiers in Molecular Biosciences, April 2015, Frontiers

    Dr. Andreas Bracher

  40. Degradation of potent Rubisco inhibitor by selective sugar phosphatase

    Article • Nature Plants, January 2015, Springer Science + Business Media

    Dr. Andreas Bracher

  41. GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG Domain Proteins: Nucleotide Exchange Factors for Hsp70 Molecular Chaperones

    Article • December 2014, Springer Science + Business Media

    Dr. Andreas Bracher

  42. Selective inhibitors of the FK506-binding protein 51 by induced fit

    Article • Nature Chemical Biology, December 2014, Springer Science + Business Media

    Dr. Andreas Bracher

  43. Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506‐Binding Proteins (FKBPs)

    Article • Angewandte Chemie, November 2014, Wiley

    Dr. Andreas Bracher

  44. Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins

    Article • Organic Letters, October 2014, American Chemical Society (ACS)

    Dr. Andreas Bracher

  45. GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding

    Article • Cell, May 2014, Elsevier

    Dr. Kristina Popova, Dr. Andreas Bracher

  46. Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Dr. Andreas Bracher

  47. Crystal Structures of the Free and Ligand-Bound FK1–FK2 Domain Segment of FKBP52 Reveal a Flexible Inter-Domain Hinge

    Article • Journal of Molecular Biology, November 2013, Elsevier

    Dr. Andreas Bracher, Professor Martin Zacharias

  48. Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

    Article • Nature Structural & Molecular Biology, June 2013, Springer Science + Business Media

    Dr. Andreas Bracher

  49. Molecular Chaperone Functions in Protein Folding and Proteostasis

    Article • Annual Review of Biochemistry, June 2013, Annual Reviews

    Dr. Andreas Bracher

  50. Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

    Article • Journal of Medicinal Chemistry, May 2013, American Chemical Society (ACS)

    Dr. Andreas Bracher

  51. Maintaining photosynthetic CO2 fixation via protein remodelling: the Rubisco activases

    Article • Photosynthesis Research, March 2013, Springer Science + Business Media

    Dr. Andreas Bracher

  52. Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

    Article • Molecular and Cellular Biology, January 2013, ASM Journals

    Dr. Andreas Bracher

  53. Chaperonins

    Article • January 2013, Elsevier

    Dr. Andreas Bracher

  54. Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT

    Article • Proceedings of the National Academy of Sciences, November 2012, Proceedings of the National Academy of Sciences

    Dr. Andreas Bracher

  55. Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

    Article • Science, September 2012, American Association for the Advancement of Science

    Dr. Andreas Bracher

  56. The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

    Article • Structure, May 2012, Elsevier

    Dr. Andreas Bracher

  57. Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52

    Article • Journal of Medicinal Chemistry, April 2012, American Chemical Society (ACS)

    Dr. Andreas Bracher

  58. Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52

    Article • Journal of Medicinal Chemistry, April 2012, American Chemical Society (ACS)

    Dr. Andreas Bracher

  59. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Dr. Andreas Bracher

  60. Structure of green-type Rubisco activase from tobacco

    Article • Nature Structural & Molecular Biology, November 2011, Springer Science + Business Media

    Dr. Andreas Bracher

  61. Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase

    Article • Nature, November 2011, Springer Science + Business Media

    Dr. Andreas Bracher

  62. Firefly luciferase mutants as sensors of proteome stress

    Article • Nature Chemical Biology, September 2011, Springer Science + Business Media

    Dr. Andreas Bracher

  63. Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco

    Article • Nature Structural & Molecular Biology, July 2011, Springer Science + Business Media

    Dr. Andreas Bracher

  64. Molecular chaperones in protein folding and proteostasis

    Article • Nature, July 2011, Springer Science + Business Media

    Dr. Andreas Bracher

  65. Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90

    Article • Acta Crystallographica Section D Biological Crystallography, May 2011, International Union of Crystallography

    Dr. Andreas Bracher

  66. Interaction of the Hsp110 Molecular Chaperones from S. cerevisiae with Substrate Protein

    Article • Journal of Molecular Biology, September 2010, Elsevier

    Dr. Andreas Bracher

  67. Coupled chaperone action in folding and assembly of hexadecameric Rubisco

    Article • Nature, January 2010, Springer Science + Business Media

    Dr. Andreas Bracher

  68. Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

    Article • Cell, June 2008, Elsevier

    Dr. Andreas Bracher

  69. L25 functions as a conserved ribosomal docking site shared by nascent chain‐associated complex and signal‐recognition particle

    Article • EMBO Reports, October 2007, Springer Science + Business Media

    Dr. Andreas Bracher

  70. Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco

    Article • Cell, June 2007, Elsevier

    Dr. Andreas Bracher

  71. Nucleotide Exchange Factors for Hsp70 Molecular Chaperones

    Article • January 2007, Springer Science + Business Media

    Dr. Andreas Bracher

  72. Structural Basis for Subunit Assembly in UDP-glucose Pyrophosphorylase from Saccharomyces cerevisiae

    Article • Journal of Molecular Biology, December 2006, Elsevier

    Dr. Andreas Bracher

  73. Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p

    Article • Biological Chemistry, December 2006, De Gruyter

    Dr. Andreas Bracher

  74. Hsp90 structure: when two ends meet

    Article • Nature Structural & Molecular Biology, June 2006, Springer Science + Business Media

    Dr. Andreas Bracher

  75. Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s

    Article • The EMBO Journal, May 2006, Springer Science + Business Media

    Dr. Andreas Bracher

  76. Crystal Structure of an Archaeal Actin Homolog

    Article • Journal of Molecular Biology, April 2006, Elsevier

    Dr. Andreas Bracher

  77. L25 functions as a conserved ribosomal docking site shared by nascent chain‐associated complex and signal‐recognition particle

    Article • EMBO Reports, January 2006, Springer Science + Business Media

    Dr. Andreas Bracher

  78. Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum

    Article • FEBS Letters, November 2005, Wiley

    Dr. Andreas Bracher

  79. Towards a Complete Structure of Hsp90

    Article • Structure, April 2005, Elsevier

    Dr. Andreas Bracher

  80. Pathogenic Mutations Located in the Hydrophobic Core of the Prion Protein Interfere with Folding and Attachment of the Glycosylphosphatidylinositol Anchor

    Article • Journal of Biological Chemistry, March 2005, Elsevier

    Dr. Andreas Bracher

  81. Regulation of Hsp70 Function by HspBP1

    Article • Molecular Cell, February 2005, Elsevier

    Dr. Andreas Bracher

  82. Structure and Function of GimC/Prefoldin

    Article • January 2005, Wiley

    Dr. Andreas Bracher

  83. Article • BMC Structural Biology, January 2004, Springer Science + Business Media

    PhD Ismael Mingarro, Dr. Andreas Bracher

  84. The Matrix Protein VP40 from Ebola Virus Octamerizes into Pore-like Structures with Specific RNA Binding Properties

    Article • Structure, April 2003, Elsevier

    Dr. Andreas Bracher

  85. Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I

    Article • Journal of Molecular Biology, February 2003, Elsevier

    Dr. Andreas Bracher

  86. Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p

    Article • The EMBO Journal, November 2002, Springer Science + Business Media

    Dr. Andreas Bracher

  87. X-ray Structure of a Neuronal Complexin-SNARE Complex from Squid

    Article • Journal of Biological Chemistry, July 2002, Elsevier

    Dr. Andreas Bracher

  88. Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

    Article • Journal of Molecular Biology, February 2002, Elsevier

    Dr. Andreas Bracher

  89. Crystal structure of the GABAA‐receptor‐associated protein, GABARAP

    Article • EMBO Reports, February 2002, Springer Science + Business Media

    Dr. Andreas Bracher

  90. Biosynthesis of Riboflavin

    Article • Journal of Biological Chemistry, November 2001, Elsevier

    Dr. Andreas Bracher

  91. Biosynthesis of Pteridines. Stopped-Flow Kinetic Analysis of GTP Cyclohydrolase I

    Article • Biochemistry, June 2001, American Chemical Society (ACS)

    Dr. Andreas Bracher

  92. Biosynthesis of Riboflavin

    Article • Journal of Biological Chemistry, June 2001, Elsevier

    Dr. Andreas Bracher

  93. Crystal structures of neuronal squid Sec1 implicate inter-domain hinge movement in the release of t-SNAREs11Edited by R. Huber

    Article • Journal of Molecular Biology, February 2001, Elsevier

    Dr. Andreas Bracher

  94. Ring Opening Is Not Rate-limiting in the GTP Cyclohydrolase I Reaction

    Article • Journal of Biological Chemistry, January 2001, Elsevier

    Dr. Andreas Bracher

  95. Zinc plays a key role in human and bacterial GTP cyclohydrolase I

    Article • Proceedings of the National Academy of Sciences, November 2000, Proceedings of the National Academy of Sciences

    Dr. Andreas Bracher

  96. The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis

    Article • Structure, July 2000, Elsevier

    Dr Anastassis Perrakis, Dr. Andreas Bracher

  97. Crystallization and preliminary X-ray analysis of squid neuronal Sec1

    Article • Acta Crystallographica Section D Biological Crystallography, April 2000, International Union of Crystallography

    Dr. Andreas Bracher

  98. Histidine 179 Mutants of GTP Cyclohydrolase I Catalyze the Formation of 2-Amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone Triphosphate

    Article • Journal of Biological Chemistry, June 1999, Elsevier

    Dr. Andreas Bracher

  99. Complementation of thefol2Deletion inSaccharomyces cerevisiaeby Human andEscherichia coliGenes Encoding GTP Cyclohydrolase I

    Article • Biochemical and Biophysical Research Communications, February 1999, Elsevier

    Dr. Andreas Bracher

  100. Biosynthesis of Pteridines

    Article • Journal of Biological Chemistry, October 1998, Elsevier

    Dr. Andreas Bracher

  101. Active site topology and reaction mechanism of GTP cyclohydrolase I.

    Article • Proceedings of the National Academy of Sciences, December 1995, Proceedings of the National Academy of Sciences

    Dr. Andreas Bracher